High Frequency EEG and Its Relationship to Cognitive Function

BACKGROUND Cognitive symptoms are common in major depressive disorder, and may help to identify patients that need treatment or who are not experiencing adequate treatment response. Digital tools to provide real time data assessing cognitive function could help to support patients treatment and remediation of cognitive and mood symptoms. OBJECTIVE This study examined adherence, feasibility, and validity of a wearable high-frequency cognitive and mood assessment app over 6 weeks, corresponding to when antidepressant pharmacotherapy begins to show efficacy. METHODS Thirty patients (aged 19−63; 19 women) with mild-moderate depression participated. The new Cognition Kit application was delivered via the Apple Watch, providing a high-resolution touch screen display for task presentation and logging responses. Cognition was assessed by the n-back task up to 3 times daily and depressed mood by 3 short questions once daily. Selected tests sensitive to depression from the Cambridge Neuropsychological Test Automated Battery and validated questionnaires of depression symptom severity were administered on 4 occasions (baseline, weeks 1, 3, and 6). Adherence was defined as participants completing at least one assessment daily. RESULTS Adherence was excellent for mood and cognitive assessments (95% and 96%, respectively), did not deteriorate over time, and was not influenced by depression symptom severity or cognitive function at study onset. Daily mood assessments showed good correspondence with validated depression questionnaires (correlations range from .45 to .69 for total daily mood score) and daily cognitive assessments showed good correspondence with cognitive tests sensitive to depression (correlations ranged from .37 to .50 for mean n-back). CONCLUSIONS The study supports the feasibility and validity of high-frequency assessment of cognitive function and mood function using wearable devices over an extended period in patients with major depressive disorder. CLINICALTRIAL clinicaltrials.gov NCT03067506

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High-Frequency rTMS Improves Cognitive Function by Regulating Synaptic Plasticity in Cerebral Ischemic Rats

Neurochemical Research ◽

10.1007/s11064-020-03161-5 ◽

2020 ◽

Author(s):

Jiena Hong ◽

Jiemei Chen ◽

Chao Li ◽

Delian An ◽

Zhiming Tang ◽

...

Keyword(s):

Synaptic Plasticity ◽

Cognitive Function ◽

High Frequency ◽

Cerebral Ischemic

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THE EFFECT OF COGNITIVE TRAINING AND PHYSICAL ACTIVITY PROGRAM IN COGNITIVE FUNCTION OF ELDERLY FACILITY RESIDENTS

Innovation in Aging ◽

10.1093/geroni/igz038.3135 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S852-S852

Author(s):

Chien-Ning Tseng

Keyword(s):

Physical Activity ◽

Cognitive Function ◽

Cognitive Training ◽

High Frequency ◽

Low Frequency ◽

Control Treatment ◽

Control Group ◽

Wait List ◽

Wait List Control ◽

Treatment Groups

Abstract This study evaluated the effectiveness of a combined cognitive training (CT) and physical activity (PA) intervention in improving cognitive function for institutionalized older residents with cognitive impairment. An experimental design with pre/post-test evaluations in a double-blind assessments at three points (baseline, T0; post-treatment, T1; 8-weeks-follow-up, T2), conducted an 8-week-CTPA intervention. Participants (N=134) were recruited from 12 institutions. Centers were randomly assigned into wait-list control, treatment I or treatment II groups. Treatment I group (low frequency) underwent combined 30-minutes sessions of individual-non-computer-based multi-domain CT (twice a week) with 30-minutes-group-chair-based PA (3 times a week). Treatment II group underwent the same protocol as Treatment I group, but with high frequency, 5 days per week for both CT and PA. The primary outcome, Cognitive Assessment Screening Instrument(CASI) total scores showed significant improvement in the treatment I and treatment II groups at T1-T0 and T2-T0, compared to the wait-list control group(10.55±9.60, 12.75±11.64, -8.01±6.61, p=0.000; 8.32±7.81, 11.75±10.19, -7.11±5.78, p=0.000), however there were no significant differences between two treatment groups. In CASI’s nine sub-domains, all the mean difference between groups were also significant at T1-T0 and T2-T0 (all p<0.05). The two treatment groups only significantly differ on CASI-ORIENT domain at T2-T0 (p=0.02). The findings revealed that a combined CT-and-PA intervention have positive immediate (T1-T0) and delayed (T2-T0) effects in cognitive function for older institutional residents with cognition-impairment. The two treatment groups did not show dose-response relationship. Even more, the low frequency intervention was more effective on several domains than high frequency intervention did.

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Association between tea consumption and cognitive impairment in middle-aged and older adults

BMC Geriatrics ◽

10.1186/s12877-020-01848-6 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Jia Zhang ◽

Anxin Wang ◽

Xiaoli Zhang ◽

Shuohua Chen ◽

Shouling Wu ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Cognitive Function ◽

Green Tea ◽

High Frequency ◽

Epidemiological Studies ◽

Neuroprotective Activity ◽

Tea Consumption ◽

Older Individuals ◽

Middle Aged

Abstract Background Biologic studies have suggested that tea may have neuroprotective activity. However, tea’s protective effect on cognitive function is controversial in human epidemiological studies, and no data, including the middle-aged, are available. The objective of this study was to investigate the association of habit, frequency, and types of tea consumption with incident cognitive impairment in middle-aged and older adults. Methods Data from the Asymptomatic Polyvascular Abnormalities in Community study were used (aged over 40y). We gathered information on tea consumption, including habit, frequency, and types, via a standardized questionnaire and assessed cognitive function by Mini-Mental State Examination (MMSE) and/or Montreal Cognitive Assessment (MoCA). Three thousand eight hundred sixty-eight and 806 participants were selected in MMSE and MoCA subgroups. Multivariate logistic regression models were utilized to examine associations between tea consumption and cognitive impairment in middle-aged and older participants. Results In MMSE analyses, after adjustment for potential confounding factors, habitual (odds ratio (OR) 0.47, [95% confidence interval (CI) 0.33–0.68], p < 0.001) and high frequency (p trend < 0.001) of tea intake were associated with a lower risk of cognitive impairment. The risk of cognitive impairment was lower in green tea consumption (OR 0.36, [95% CI 0.22–0.61], p < 0.001) than other types (OR 0.59, [95% CI 0.38–0.91], p = 0.017). In MoCA analyses, we got similar results. Conclusions Habitual tea consumption, especially high-frequency and green tea consumption, was significantly associated with a lower prevalence of cognitive impairment in middle-aged and older individuals.

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Wearable Technology for High-Frequency Cognitive and Mood Assessment in Major Depressive Disorder: Longitudinal Observational Study

JMIR Mental Health ◽

10.2196/12814 ◽

2019 ◽

Vol 6 (11) ◽

pp. e12814 ◽

Cited By ~ 6

Author(s):

Francesca Cormack ◽

Maggie McCue ◽

Nick Taptiklis ◽

Caroline Skirrow ◽

Emilie Glazer ◽

...

Keyword(s):

Major Depressive Disorder ◽

Cognitive Function ◽

Depressive Disorder ◽

Symptom Severity ◽

High Frequency ◽

Depression Symptom ◽

Cognitive Assessments ◽

Major Depressive ◽

Adequate Treatment ◽

The Relationship

Background Cognitive symptoms are common in major depressive disorder and may help to identify patients who need treatment or who are not experiencing adequate treatment response. Digital tools providing real-time data assessing cognitive function could help support patient treatment and remediation of cognitive and mood symptoms. Objective The aim of this study was to examine feasibility and validity of a wearable high-frequency cognitive and mood assessment app over 6 weeks, corresponding to when antidepressant pharmacotherapy begins to show efficacy. Methods A total of 30 patients (aged 19-63 years; 19 women) with mild-to-moderate depression participated in the study. The new Cognition Kit app was delivered via the Apple Watch, providing a high-resolution touch screen display for task presentation and logging responses. Cognition was assessed by the n-back task up to 3 times daily and depressed mood by 3 short questions once daily. Adherence was defined as participants completing at least 1 assessment daily. Selected tests sensitive to depression from the Cambridge Neuropsychological Test Automated Battery and validated questionnaires of depression symptom severity were administered on 3 occasions (weeks 1, 3, and 6). Exploratory analyses examined the relationship between mood and cognitive measures acquired in low- and high-frequency assessment. Results Adherence was excellent for mood and cognitive assessments (95% and 96%, respectively), did not deteriorate over time, and was not influenced by depression symptom severity or cognitive function at study onset. Analyses examining the relationship between high-frequency cognitive and mood assessment and validated measures showed good correspondence. Daily mood assessments correlated moderately with validated depression questionnaires (r=0.45-0.69 for total daily mood score), and daily cognitive assessments correlated moderately with validated cognitive tests sensitive to depression (r=0.37-0.50 for mean n-back). Conclusions This study supports the feasibility and validity of high-frequency assessment of cognition and mood using wearable devices over an extended period in patients with major depressive disorder.

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Different combinations of high-frequency rTMS and cognitive training improve the cognitive function of cerebral ischemic rats

Brain Research Bulletin ◽

10.1016/j.brainresbull.2021.07.012 ◽

2021 ◽

Author(s):

Jiena Hong ◽

Jiemei Chen ◽

Yan Zeng ◽

Xue Zhang ◽

Mengshu Xie ◽

...

Keyword(s):

Cognitive Function ◽

Cognitive Training ◽

High Frequency ◽

Cerebral Ischemic

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Exposure to Radiofrequency Electromagnetic Field in the High-Frequency Band and Cognitive Function in Children and Adolescents: A Literature Review

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17249179 ◽

2020 ◽

Vol 17 (24) ◽

pp. 9179

Author(s):

Toru Ishihara ◽

Keiko Yamazaki ◽

Atsuko Araki ◽

Yuri Teraoka ◽

Naomi Tamura ◽

...

Keyword(s):

Electromagnetic Field ◽

Cognitive Function ◽

Literature Review ◽

Children And Adolescents ◽

Mobile Phones ◽

Frequency Band ◽

High Frequency ◽

High Frequency Band ◽

Related Factors ◽

Radiofrequency Electromagnetic Field

With increasing use of mobile phones, exposure to radiofrequency electromagnetic field (RF-EMF) in the high-frequency band associated with mobile phones has become a public concern, with potentially adverse effects on cognitive function in children and adolescents. However, findings regarding the relation of RF-EMF and cognitive function in children and adolescents have been inconsistent due to a number of study design-related factors, such as types of exposure and outcome measures, age of participants, and the era of study conduction. The present literature review focused on these possible factors that could explain this inconsistency. This review identified 12 eligible studies (participants ages 4 to 17 years) and extracted a total 477 relations. In total, 86% of the extracted relations were not statistically significant; in the remaining 14%, a negative relation between RF-EMF and cognitive performance was detected under limited conditions: when (1) RF-EMF was assessed using objective measurement not subjective measurement (i.e., questionnaire), (2) participants were relatively older (12 years and above) and had greater opportunity of exposure to RF-EMF, and (3) the collection of cognitive function data was conducted after 2012. Given that 86% of the extracted relations in this analysis were not statistically significant, the interpretation should be approached with caution due to the possibility of the 14% of significant relationships, extracted in this review, representing chance findings.

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