Ionizing Radiation Induced Mutagenesis: Molecular Genetic Changes and Role of DNA Lesions and Repair

1988 ◽  
pp. 277-299
Author(s):  
L. H. Breimer
Keyword(s):  
Ionizing Radiation ◽  
Molecular Genetic ◽  
Dna Lesions ◽  
Genetic Changes ◽  
Radiation Induced ◽  
Induced Mutagenesis

scholarly journals Role of the main cytosine radiolytic product in ionizing radiation-induced mutagenesis.

1987 ◽  
Vol 28 (4) ◽  
pp. 254-261 ◽  
Author(s):  
HITOSHI AYAKI ◽  
OSAMU YAMAMOTO ◽  
SHOZO SAWADA
Keyword(s):  
Ionizing Radiation ◽  
Radiolytic Product ◽  
Radiation Induced ◽  
Induced Mutagenesis

scholarly journals Role of Ferulic Acid in the Amelioration of Ionizing Radiation Induced Inflammation: A Murine Model

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97599 ◽  
Author(s):  
Ujjal Das ◽  
Krishnendu Manna ◽  
Mahuya Sinha ◽  
Sanjukta Datta ◽  
Dipesh Kr Das ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Ferulic Acid ◽  
Murine Model ◽  
Radiation Induced

Role of a DNA Damage Checkpoint Pathway in Ionizing Radiation-Induced Glioblastoma Cell Migration and Invasion

2012 ◽  
Vol 32 (7) ◽  
pp. 1199-1208 ◽  
Author(s):  
Issai Vanan ◽  
Zhiwan Dong ◽  
Elena Tosti ◽  
Gregg Warshaw ◽  
Marc Symons ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Migration ◽  
Ionizing Radiation ◽  
Migration And Invasion ◽  
Dna Damage Checkpoint ◽  
Glioblastoma Cell ◽  
Cell Migration And Invasion ◽  
Checkpoint Pathway ◽  
Radiation Induced

Flavonoids, the Family of Plant-derived Antioxidants making inroads into Novel Therapeutic Design against IR-induced Oxidative Stress in Parkinson’s Disease

2021 ◽  
Vol 19 ◽  
Author(s):  
Tapan Behl ◽  
Gagandeep Kaur ◽  
Aayush Sehgal ◽  
Gokhan Zengin ◽  
Sukhbir Singh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Ionizing Radiation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Radiation Induced ◽  
Novel Therapeutic

Background: Ionizing radiation from telluric sources is unceasingly an unprotected pitfall to humans. Thus, the foremost contributors to human exposure are global and medical radiations. Various pieces of evidences assembled during preceding years reveal the pertinent role of ionizing radiation-induced oxidative stress in the progression of neurodegenerative insults such as Parkinson’s disease, which have been contributing to increased proliferation and generation of reactive oxygen species. Objective: This review delineates the role of ionizing radiation-induced oxidative stress in Parkinson’s disease and proposes novel therapeutic interventions of flavonoid family offering effective management and slowing down the progression of Parkinson’s disease. Method: Published papers were searched via MEDLINE, PubMed, etc. published to date for in-depth database collection. Results: The potential of oxidative damage may harm the non-targeted cells. It can also modulate the functions of central nervous system, such as protein misfolding, mitochondria dysfunction, increased levels of oxidized lipids, and dopaminergic cell death, which accelerates the progression of Parkinson’s disease at the molecular, cellular, or tissue levels. In Parkinson’s disease, reactive oxygen species exacerbate the production of nitric oxides and superoxides by activated microglia, rendering death of dopaminergic neuronal cell through different mechanisms. Conclusion: Rising interest has extensively engrossed on the clinical trial designs based on the plant derived family of antioxidants. They are known to exert multifarious impact either way in neuroprotection via directly suppressing ionizing radiation-induced oxidative stress and reactive oxygen species production or indirectly increasing the dopamine levels and activating the glial cells.

Molecular genetic studies of the Cdc7 protein kinase and induced mutagenesis in yeast.

Genetics ◽  
1992 ◽  
Vol 132 (1) ◽  
pp. 53-62 ◽  
Author(s):  
R E Hollingsworth ◽  
R M Ostroff ◽  
M B Klein ◽  
L A Niswander ◽  
R A Sclafani
Keyword(s):  
Protein Kinase ◽  
Insertional Mutagenesis ◽  
Molecular Genetic ◽  
Dna Lesions ◽  
Temperature Sensitive ◽  
Permissive Temperature ◽  
Wild Type ◽  
Mutant Proteins ◽  
Repair Enzymes ◽  
Induced Mutagenesis

Abstract The Saccharomyces cerevisiae CDC7 gene encodes a protein kinase that functions in DNA replication, repair, and meiotic recombination. The sequence of several temperature-sensitive (ts) cdc7 mutations was determined and correlated with protein kinase consensus domain structure. The positions of these ts alleles suggests some general principles for predicting ts protein kinase mutations. Pedigree segregation lag analysis demonstrated that all of the mutant proteins are less active or less stable than wild-type Cdc7p. Two new mutations were constructed, one by site-directed and the other by insertional mutagenesis. All of the cdc7 mutants were assayed for induced mutagenesis in response to mutagenic agents at the permissive temperature. Some cdc7 mutants were found to be hypomutable, while others are hypermutable. The differences in mutability are observed most clearly when log phase cells are used. Both hypo- and hypermutability are recessive to wild type. Cdc7p may participate in DNA repair by phosphorylating repair enzymes or by altering chromatin structure to allow accessibility to DNA lesions.

scholarly journals Recovery of a low mutant frequency after ionizing radiation-induced mutagenesis during spermatogenesis

2008 ◽  
Vol 654 (2) ◽  
pp. 150-157 ◽  
Author(s):  
Guogang Xu ◽  
Gabriel W. Intano ◽  
John R. McCarrey ◽  
Ronald B. Walter ◽  
C. Alex McMahan ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Radiation Induced ◽  
Induced Mutagenesis ◽  
Mutant Frequency

scholarly journals Evaluating the Protective Effect of a Combination of Curcumin and Selenium-L-Methionine on Radiation Induced Dual Oxidase Upregulation

2018 ◽  
Vol 24 (4) ◽  
pp. 340-345 ◽  
Author(s):  
Peyman Amini ◽  
Saeed Rezapoor ◽  
Dheyauldeen Shabeeb ◽  
Ahmed Eleojo Musa ◽  
Masoud Najafi ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Atomic Bomb ◽  
Heart Diseases ◽  
Experimental Studies ◽  
Epidemiological Studies ◽  
Left Breast ◽  
Interleukin 4 ◽  
Breast Cancer Patients ◽  
Radiation Induced

Background: Epidemiological studies have shown an increased incidence of heart diseases among survivors of Chernobyl disaster as well as Hiroshima and Nagasaki atomic bomb explosion. Similar results were observed for lung and left breast cancer patients. Experimental studies have proposed the chronic upregulation of some pro-inflammatory and pro-fibrotic cytokines. Recent studies have shown that upregulation of pro-oxidant enzymes play a key role in the development of late effects of ionizing radiation such as fibrosis. Interleukin-4 (IL-4) and Interleukin-13 (IL-13) are two important cytokines that have shown ability to induce production of free radicals through dual oxidases (Duox) i.e. Duox1 and Duox2. In this study, we aimed to detect the expression of IL-4 receptor-a1 (IL-4Ra1), IL-13 receptor-a2 (IL-13Ra2), Duox1 and Duox2 genes following irradiation of rat’s heart. In addition, we evaluated the possible role of the combination of curcumin and selenium-L-methionine on the regulation of these genes. Methods: Twenty rats were divided into 4 groups as follows; G1: control; G2: treatment with the combination of curcumin and selenium-L-methionine; G3: radiation; G4: radiation plus treatment with the combination of curcumin and selenium-L-methionine. Rats were sacrificed 10 weeks after irradiation for detecting the expression of IL-4Ra1, IL-13Ra2, Duox1 and Duox2. Results: Results showed that exposure to ionizing radiation caused upregulation of IL-4Ra1 by more than 4-fold as well as Duox1 and Duox2 by more than 5-fold. However, results showed no detectable expression for IL-13Ra2. Treatment with the combination of curcumin and selenium-L-methionine could attenuate the upregulation of all genes. Conclusion: This study has shown that exposing rat’s heart tissues to radiation leads to chronic upregulation of IL-4Ra1, Duox1 and Duox2 as well as pro-oxidant enzymes. Treatment with the combination of curcumin and selenium-L-methionine showed ability to attenuate the upregulation of these genes.

The Role of Ionizing Radiation-Induced Mutations in the Development of Rice Cultivars

2020 ◽  
pp. 129-144
Author(s):  
Abdul Majeed ◽  
Zahir Muhammad ◽  
Rehmanullah ◽  
Saira Siyar
Keyword(s):  
Ionizing Radiation ◽  
Rice Cultivars ◽  
Induced Mutations ◽  
Radiation Induced

scholarly journals Endogenous natural and radiation-induced DNA lesions: differences and similarities and possible implications for human health and radiological protection

2018 ◽  
Vol 53 (4) ◽  
pp. 241-248 ◽  
Author(s):  
J.-L. Ravanat
Keyword(s):  
Oxidative Stress ◽  
Ionizing Radiation ◽  
Human Health ◽  
Chemical Nature ◽  
Dna Lesions ◽  
Radiological Protection ◽  
Dna Damage And Repair ◽  
Radiation Induced ◽  
Living Organisms ◽  
Ionizing Radiations

During the last few decades, a considerable amount of work has been done to better assess the effects of ionizing radiation on living organisms. In particular a lot of attention has been focused on the consequences of modifications of the DNA macromolecule, the support of the genetic information. Detailed information is now available on the formation of radiation-induced DNA lesions at the physical, chemical and biological levels. Emphasis will be placed in this review article on the differences and similarities, in term of DNA lesions formation and outcome, between endogenous oxidative stress and ionizing radiation, both stresses that could produce oxidative DNA lesions through similar mechanistic pathways involving mostly reactive oxygen species. If the chemical nature of the generated lesions is similar, the differences in term of biological consequences could be attributed to their spatial distribution in genomic DNA, since ionizing radiations produce lesions in cluster. These clusters of lesions represent a challenge for the DNA repair machinery. In contrast, endogenous oxidative stress generates scattered lesions that could be repaired with a much higher efficacy and fidelity. Possible implication of the use of DNA damage and repair for human health purposes and radiological protection will be discussed.

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