Matrix Metalloproteinase and Its Inhibitors in Cancer Progression

2013 ◽  
pp. 147-158 ◽  
Author(s):  
Ajay K. Chaudhary ◽  
Anita H. Nadkarni ◽  
Shruti Pandya ◽  
Kanjaksha Ghosh
Keyword(s):  
Matrix Metalloproteinase ◽  
Cancer Progression

Molecular Docking Analysis of Flavonoid Compounds with Matrix Metalloproteinase-8 for the Identification of Potential Effective Inhibitors

2020 ◽  
Vol 17 ◽  
Author(s):  
Amir Taherkhani ◽  
Athena Orangi ◽  
Shirin Moradkhani ◽  
Zahra Khamverdi
Keyword(s):  
Amino Acids ◽  
Molecular Docking ◽  
Amino Acid ◽  
Matrix Metalloproteinase ◽  
Ligand Binding ◽  
Chronic Inflammation ◽  
Cancer Progression ◽  
Dimensional Structure ◽  
Control Test ◽  
Therapeutic Procedures

Background: Matrix metalloproteinase-8 (MMP-8) participates in degradation of different types of collagens in the extracellular matrix and basement membrane. Up-regulation of the MMP-8 has been demonstrated in many of disorders including cancer development, tooth caries, periodontal/peri-implant soft and hard tissue degeneration, and acute/chronic inflammation. Therefore, MMP-8 has become an encouraging target for therapeutic procedures for scientists. We carried out molecular docking approach to study the binding affinity of 29 flavonoids, as drug candidates, with the MMP-8. Pharmacokinetic and toxicological properties of the compounds were also studied. Moreover, it was attempted to identify the most important amino acids participating in ligand binding based on degree of each of the amino acids in the ligand-amino acid interaction network for MMP-8. Methods: Three-dimensional structure of the protein was gained from the RCSB database (PDB ID: 4QKZ). AutoDock version 4.0 and Cytoscape 3.7.2 were used for molecular docking and network analysis, respectively. Notably, the inhibitor of the protein in the crystalline structure of the 4QKZ was considered as a control test. Pharmacokinetic and toxicological features of compounds were predicted using bioinformatic web tools. Post-docking analyses were performed using BIOVIA Discovery Studio Visualizer version 19.1.0.18287. Results and Discussions: According to results, 24 of the studied compounds considered to be top potential inhibitors for MMP-8 based on their salient estimated free energy of binding and inhibition constant as compared with the control test: Apigenin-7-glucoside, nicotiflorin, luteolin, glabridin, taxifolin, apigenin, licochalcone A, quercetin, isorhamnetin, myricetin, herbacetin, kaemferol, epicatechin, chrysin, amentoflavone, rutin, orientin, epiafzelechin, quercetin-3-rhamnoside, formononetin, isoliquiritigenin, vitexin, catechine, isoquercitrin. Moreover, His-197 was found to be the most important amino acid involved in the ligand binding for the enzyme. Conclusion: The results of the current study could be used in the prevention and therapeutic procedures of a number of disorders such as cancer progression and invasion, oral diseases, and acute/chronic inflammation. Although, in vitro and in vivo tests are inevitable in the future.

Plasma matrix metalloproteinase 9 as biomarker of prostate cancer progression in Dunning (Copenhagen) rats

The Prostate ◽  
2002 ◽  
Vol 54 (3) ◽  
pp. 206-211 ◽  
Author(s):  
Klaus Jung ◽  
Hans-Willi Krell ◽  
Bernhard Ortel ◽  
Tayyaba Hasan ◽  
Andreas Römer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Matrix Metalloproteinase 9 ◽  
Prostate Cancer Progression ◽  
Metalloproteinase 9

scholarly journals miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14

Oncotarget ◽  
2016 ◽  
Vol 7 (26) ◽  
pp. 40314-40328 ◽  
Author(s):  
Liduan Zheng ◽  
Wanju Jiao ◽  
Hong Mei ◽  
Huajie Song ◽  
Dan Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Matrix Metalloproteinase ◽  
Zinc Finger ◽  
Cancer Progression ◽  
Myeloid Zinc Finger ◽  
Gastric Cancer Progression

Relationship between Matrix Metalloproteinase 2 and Lung Cancer Progression

2007 ◽  
Vol 11 (3) ◽  
pp. 183-192 ◽  
Author(s):  
Chun-Bao Guo ◽  
Shan Wang ◽  
Chun Deng ◽  
Dian-Liang Zhang ◽  
Fu-Ling Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Matrix Metalloproteinase 2

scholarly journals Oxidative Stress and Prostate Cancer Progression Are Elicited by Membrane-Type 1 Matrix Metalloproteinase

2011 ◽  
Vol 9 (10) ◽  
pp. 1305-1318 ◽  
Author(s):  
Hoang-Lan Nguyen ◽  
Stanley Zucker ◽  
Kevin Zarrabi ◽  
Pournima Kadam ◽  
Cathleen Schmidt ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Membrane Type

scholarly journals Secernin-1 Contributes to Colon Cancer Progression through Enhancing Matrix Metalloproteinase-2/9 Exocytosis

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Shengtao Lin ◽  
Tao Jiang ◽  
Yang Yu ◽  
Huamei Tang ◽  
Su Lu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Bioinformatics Analysis ◽  
Tumor Development ◽  
Matrix Metalloproteinase 2 ◽  
Cancer Cell Proliferation ◽  
Colon Cancer Progression

Emerging evidence shows that exocytosis plays a key role in tumor development and metastasis. Secernin-1 (SCRN1) is a novel regulator of exocytosis. Our previous work identified SCRN1 as a tumor-associated gene by bioinformatics analysis of transcriptomes. In this study, we demonstrated the aberrant overexpression of SCRN1 at mRNA and protein level in colon cancer. We also revealed that overexpression of SCRN1 was significantly associated with the tumor development and poor prognosis. Experimentsin vitrovalidated that SCRN1 may promote cancer cell proliferation and secretion of matrix metalloproteinase-2/9 (MMP-2/9) proteins to accelerate tumor progression.

Role of serum matrix metalloproteinase-2 and -9 to predict breast cancer progression

2011 ◽  
Vol 44 (10-11) ◽  
pp. 869-872 ◽  
Author(s):  
Suprava Patel ◽  
G. Sumitra ◽  
B.C. Koner ◽  
Alpana Saxena
Keyword(s):  
Breast Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Matrix Metalloproteinase 2

scholarly journals Plasma levels of the tissue inhibitor matrix metalloproteinase-3 as a potential biomarker in oral cancer progression

2017 ◽  
Vol 14 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Chun-Wen Su ◽  
Bo-Feng Su ◽  
Whei-Ling Chiang ◽  
Shun-Fa Yang ◽  
Mu-Kuan Chen ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Plasma Levels ◽  
Tissue Inhibitor ◽  
Matrix Metalloproteinase 3 ◽  
Potential Biomarker
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