The Role of Heme Oxygenase-1 in the Mammalian Stress Response: Molecular Aspects of Regulation and Function

1997 ◽  
pp. 343-386 ◽  
Author(s):  
Stefan W. Ryter ◽  
Rex M. Tyrrell
Keyword(s):  
Stress Response ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Molecular Aspects ◽  
And Function

scholarly journals Induction of heme oxygenase-1 and heat shock protein 70 in rat hepatocytes: The role of calcium signaling

2007 ◽  
Vol 12 (1) ◽  
Author(s):  
Malte Silomon ◽  
Inge Bauer ◽  
Michael Bauer ◽  
Julia Nolting ◽  
Markus Paxian ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stress Response ◽  
Heat Shock ◽  
Heme Oxygenase ◽  
Rat Hepatocytes ◽  
Glutathione Depletion ◽  
Heme Oxygenase 1 ◽  
Hsp70 Gene ◽  
Stress Response Genes

AbstractStress response genes including heat shock proteins are induced under a variety of conditions to confer cellular protection. This study investigated the role of calcium signaling in the induction of two stress response genes, heme oxygenase-1/hsp32 and hsp70, in isolated rat hepatocytes. Both genes were induced by cellular glutathione depletion. This induction could be inhibited by BAPTA-AM. Culturing in a calcium-free medium prevented the induction of hsp70 gene expression after glutathione depletion without affecting heme oxygenase-1 gene expression. Thapsigargin increased the gene expression of heme oxygenase-1 but not that of hsp70. Thapsigargin-induced heme oxygenase-1 induction was completely inhibited by BAPTA-AM. Incubation with the Ca2+-ionophore A23187 augmented heme oxygenase-1 (two-fold) and hsp70 (5.2-fold) mRNA levels. Our data suggests a significant role of Ca2+-dependent pathways in the induction of the two stress genes. An increase in the cytoplasmic Ca2+ activity seems to play a key role in the cascade of signaling leading to the induction of the two genes. However, the source of Ca2+ that fluxes into the cytoplasm seems to be different. Our data provides evidence for a compartmentalization of calcium fluxes, i.e. the Ca2+ flux from intracellular stores (e.g. the endoplasmic reticulum) plays a major role in the induction of heme oxygenase-1. By contrast, Ca2+ flux from the extracellular medium seems to be a mechanism initiating the cellular signaling cascade leading to hsp70 gene induction.

Involvement of Heme Oxygenase-1 in Neuropsychiatric and Neurodegenerative Diseases

2018 ◽  
Vol 24 (20) ◽  
pp. 2283-2302 ◽  
Author(s):  
Vivian B. Neis ◽  
Priscila B. Rosa ◽  
Morgana Moretti ◽  
Ana Lucia S. Rodrigues
Keyword(s):  
Neurodegenerative Diseases ◽  
Heme Oxygenase ◽  
Therapeutic Potential ◽  
Redox Homeostasis ◽  
Antioxidant Defenses ◽  
Heme Oxygenase 1 ◽  
Physiological Conditions ◽  
And Oxidative Stress ◽  
Defensive Mechanism

Heme oxygenase (HO) family catalyzes the conversion of heme into free iron, carbon monoxide and biliverdin. It possesses two well-characterized isoforms: HO-1 and HO-2. Under brain physiological conditions, the expression of HO-2 is constitutive, abundant and ubiquitous, whereas HO-1 mRNA and protein are restricted to small populations of neurons and neuroglia. HO-1 is an inducible enzyme that has been shown to participate as an essential defensive mechanism for neurons exposed to oxidant challenges, being related to antioxidant defenses in certain neuropathological conditions. Considering that neurodegenerative diseases (Alzheimer’s Disease (AD), Parkinson’s Disease (PD) and Multiple Sclerosis (MS)) and neuropsychiatric disorders (depression, anxiety, Bipolar Disorder (BD) and schizophrenia) are associated with increased inflammatory markers, impaired redox homeostasis and oxidative stress, conditions that may be associated with alterations in HO-levels/activity, the purpose of this review is to present evidence on the possible role of HO-1 in these Central Nervous System (CNS) diseases. In addition, the possible therapeutic potential of targeting brain HO-1 is explored in this review.

The Role of Statins in the Activation of Heme Oxygenase-1 in Cardiovascular Diseases

2017 ◽  
Vol 18 (6) ◽  
pp. 674-686 ◽  
Author(s):  
Aleksandra Piechota-Polanczyk ◽  
Alicja Jozkowicz
Keyword(s):  
Cardiovascular Diseases ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1

scholarly journals Potential role of heme oxygenase-1 in the progression of rat adjuvant arthritis

2004 ◽  
Vol 85 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Isabel Devesa ◽  
Maria Luisa Ferrándiz ◽  
Isabel Guillén ◽  
José Miguel Cerdá ◽  
Maria José Alcaraz
Keyword(s):  
Heme Oxygenase ◽  
Adjuvant Arthritis ◽  
Potential Role ◽  
Heme Oxygenase 1 ◽  
Rat Adjuvant Arthritis

Inhibition of neointimal formation by trans-resveratrol: Role of phosphatidyl inositol 3-kinase-dependent Nrf2 activation in heme oxygenase-1 induction

2010 ◽  
Vol 54 (10) ◽  
pp. 1497-1505 ◽  
Author(s):  
Jung Woo Kim ◽  
Sung Chul Lim ◽  
Moo Yeol Lee ◽  
Jeong Woon Lee ◽  
Won Keun Oh ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Phosphatidyl Inositol ◽  
Heme Oxygenase 1 ◽  
Neointimal Formation ◽  
Nrf2 Activation

Systemic perfluorohexane attenuates lung injury induced by lipopolysaccharide in rats: the role of heme oxygenase-1

2010 ◽  
Vol 62 (1) ◽  
pp. 170-177 ◽  
Author(s):  
Zhi-Jun Ge ◽  
Guo-Jun Jiang ◽  
Yan-Ping Zhao ◽  
Guo-Xiang Wang ◽  
Yong-Fei Tan
Keyword(s):  
Lung Injury ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1
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