Metastatic Tumor Cell Attachment to Vascular Endothelial Cells and Destruction of Their Basal Lamina-Like Matrix

1983 ◽  
pp. 35-46
Author(s):  
Tatsuro Irimura ◽  
Motowo Nakajima ◽  
Garth L. Nicolson
Keyword(s):  
Endothelial Cells ◽  
Tumor Cell ◽  
Basal Lamina ◽  
Cell Attachment ◽  
Vascular Endothelial Cells ◽  
Metastatic Tumor ◽  
Vascular Endothelial ◽  
Metastatic Tumor Cell ◽  
Tumor Cell Attachment

scholarly journals Metastatic tumor cell attachment and invasion assay utilizing vascular endothelial cell monolayers.

1982 ◽  
Vol 30 (3) ◽  
pp. 214-220 ◽  
Author(s):  
G L Nicolson
Keyword(s):  
Extracellular Matrix ◽  
Endothelial Cells ◽  
Endothelial Cell ◽  
Tumor Cell ◽  
Basal Lamina ◽  
Cell Monolayer ◽  
Vascular Endothelial Cell ◽  
Metastatic Tumor ◽  
Vascular Endothelial ◽  
Metastatic Tumor Cell

Two of the more important steps in blood-borne tumor metastasis are attachment of the circulating malignant cells to the vascular endothelium and subsequent extravasation or invasion out of the blood vessel. A model for this process has been developed using cultured monolayers of vascular endothelial cells that synthesize a basal lamina or extracellular matrix (Kramer and Nicolson, Proc Natl Acad Sci USA 76:504, 1979). We have used this model to study metastatic tumor cell-endothelial cell interactions such as attachment to endothelial cells and their subsequent retraction and exposure of endothelial basal lamina as well as the interactions of metastatic tumor cells with the basal lamina leading to invasion and solubilization of this extracellular matrix. Morphological, immunological, and enzymological analysis of these steps in the metastatic process can be obtained using the vascular endothelial cell monolayer model for attachment and invasion.

scholarly journals VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice

Blood ◽  
2013 ◽  
Vol 121 (16) ◽  
pp. 3289-3297 ◽  
Author(s):  
Špela Ferjančič ◽  
Ana M. Gil-Bernabé ◽  
Sally A. Hill ◽  
Philip D. Allen ◽  
Peter Richardson ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Survival ◽  
Therapeutic Target ◽  
Cell Attachment ◽  
Myeloid Cells ◽  
Metastatic Tumor ◽  
Metastatic Tumor Cell ◽  
Key Points ◽  
Tumor Cell Survival ◽  
Tumor Cell Attachment

Key PointsMetastatic tumor cell attachment induces endothelial VCAM-1 and VAP-1. VCAM-1 and VAP-1 promote metastatic tumor cell survival by recruiting myeloid cells, pointing to VAP-1 as a therapeutic target.

scholarly journals DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration

Oncogene ◽  
2010 ◽  
Vol 29 (20) ◽  
pp. 3010-3016 ◽  
Author(s):  
Y Lin ◽  
N-T Chen ◽  
Y-P Shih ◽  
Y-C Liao ◽  
L Xue ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Attachment ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
And Migration

Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival

2003 ◽  
Vol 18 (2) ◽  
pp. 326-328 ◽  
Author(s):  
Siqing Shan ◽  
Nicole D. Robson ◽  
Yiting Cao ◽  
Tong Qiao ◽  
Chuan Y. Li ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tumor Cell ◽  
Cell Survival ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Tumor Cell Survival

Tumor cell-enhanced sensitivity of vascular endothelial cells to photodynamic therapy

1994 ◽  
Vol 15 (4) ◽  
pp. 342-350 ◽  
Author(s):  
Zhengang Yang ◽  
Xiaochen Lu ◽  
Donita L. Frazier ◽  
Masoud Panjehpour ◽  
Mike A. Breider
Keyword(s):  
Endothelial Cells ◽  
Photodynamic Therapy ◽  
Tumor Cell ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Enhanced Sensitivity

Tumor cell-conditioned medium stimulates expression of the urokinase receptor in vascular endothelial cells

1996 ◽  
Vol 169 (2) ◽  
pp. 300-308 ◽  
Author(s):  
Graziano Seghezzi ◽  
Rosaria Marelli ◽  
Stefano J. Mandriota ◽  
Maria Luisa Nolli ◽  
Roberta Mazzieri ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tumor Cell ◽  
Conditioned Medium ◽  
Vascular Endothelial Cells ◽  
Urokinase Receptor ◽  
Vascular Endothelial ◽  
Cell Conditioned Medium
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