Peripheral Muscle Changes

AbstractThe influence of peripheral muscle strength on prognosis after extubation and subsequent functional outcomes is not evident. The objectives of this study were to determine (1) whether peripheral muscle strength can be used as a predictor for patients’ prognoses after extubation, and (2) whether the peripheral muscle strength before extubation is correlated with patients’ subsequent ambulation ability and in-hospital mortality. This study was a prospective observational cohort study. A hand-held dynamometer was used for evaluated the muscle strength of the biceps and quadriceps right before extubation. Besides, after the patients had been transferred from the ICU to the general ward, a 2-minute walk test was performed. A total of 52 patients were enrolled in this study, and the rate of extubation failure was 15%. The muscle strength of the quadriceps was significantly correlated with the prognosis after extubation, 48% of the patients were able to ambulate after being transferred to the general ward. The overall mortality rate was 11%, and there was a significant correlation between the biceps muscle strength and in-hospital mortality. Peripheral muscle strength may serve as an important predictor of a patients’ prognoses after extubation. Poor peripheral muscle strength is indicative of not only a higher risk of re-intubation but also higher in-hospital mortality and poorer functional outcomes.Trial registration: ISRCTN16370134. Registered 30 May 2019, prospectively registered. https://www.isrctn.com/ISRCTN16370134.

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A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life

Metabolites ◽

10.3390/metabo11060404 ◽

2021 ◽

Vol 11 (6) ◽

pp. 404

Author(s):

Gabriela de Matuoka e Chiocchetti ◽

Leisa Lopes-Aguiar ◽

Natália Angelo da Silva Miyaguti ◽

Lais Rosa Viana ◽

Carla de Moraes Salgado ◽

...

Keyword(s):

Skeletal Muscle ◽

Time Course ◽

Cancer Cachexia ◽

Tumour Bearing ◽

Walker 256 Tumour ◽

Walker 256 ◽

Muscle Changes ◽

The Right ◽

Biomarker Research ◽

Host Metabolism

Cancer cachexia is a severe wasting condition that needs further study to find ways to minimise the effects of damage and poor prognosis. Skeletal muscle is the most impacted tissue in cancer cachexia; thus, elucidation of its metabolic alterations could provide a direct clue for biomarker research and be applied to detect this syndrome earlier. In addition, concerning the significant changes in the host metabolism across life, this study aimed to compare the metabolic muscle changes in cachectic tumour-bearing hosts at different ages. We performed 1H-NMR metabolomics in the gastrocnemius muscle in weanling and young adult Walker-256 tumour-bearing rats at different stages of tumour evolution (initial, intermediate, and advanced). Among the 49 metabolites identified, 24 were significantly affected throughout tumour evolution and 21 were significantly affected regarding animal age. The altered metabolites were mainly related to increased amino acid levels and changed energetic metabolism in the skeletal muscle, suggesting an expressive catabolic process and diverted energy production, especially in advanced tumour stages in both groups. Moreover, these changes were more severe in weanling hosts throughout tumour evolution, suggesting the distinct impact of cancer cachexia regarding the host’s age, highlighting the need to adopting the right animal age when studying cancer cachexia.

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Radiological Assessment of Postoperative Paraspinal Muscle Changes After Lumbar Interbody Fusion With or Without Minimally Invasive Techniques

Global Spine Journal ◽

10.1177/2192568221994794 ◽

2021 ◽

pp. 219256822199479

Author(s):

Keigo Kameyama ◽

Tetsuro Ohba ◽

Tomoka Endo ◽

Marina Katsu ◽

Fujita Koji ◽

...

Keyword(s):

Minimally Invasive ◽

Interbody Fusion ◽

Cross Sectional Area ◽

Paraspinal Muscle ◽

Lumbar Interbody Fusion ◽

Sectional Area ◽

Paraspinal Muscles ◽

Cross Sectional ◽

Muscle Density ◽

Muscle Changes

Study Design: Retrospective cohort study. Background: Percutaneous pedicle screws (PPS) have the advantage of being able to better preserve the paraspinal muscles when compared with a traditional open approach. However, the nature of changes in postoperative paraspinal muscle after damage by lumbar fusion surgery has remained largely unknown. It is clinically important to clarify and compare changes in paraspinal muscles after the various surgeries. Objective: (1) To determine postoperative changes of muscle density and cross-sectional area using computed tomography (CT), and (2) to compare paraspinal muscle changes after posterior lumbar interbody fusion (PLIF) with traditional open approaches and minimally invasive lateral lumbar interbody fusions (LLIF) with PPS. Methods: We included data from 39 consecutive female patients who underwent open PLIF and 23 consecutive patients who underwent single-staged treatment with LLIF followed by posterior PPS fixation at a single level (L4-5). All patients underwent preoperative, 6 months postoperative, and 1-year postoperative CT imaging. Measurements of the cross-sectional area (CSA) and muscle densities of paraspinal muscles were obtained using regions of interest defined by manual tracing. Results: We did not find any decrease of CSA in any paraspinal muscles. We did find a decrease of muscle density in the multifidus at 1 year after surgery in patients in the PILF group, but not in those in LLIF/PPS group. Conclusions: One year after surgery, a significant postoperative decrease of muscle density of the multifidi was observed only in patients who underwent open PLIF, but not in those who underwent LLIF/PPS.

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Peripheral muscle strength in young males with cystic fibrosis

Journal of Cystic Fibrosis ◽

10.1016/s1569-1993(02)00074-7 ◽

2002 ◽

Vol 1 (3) ◽

pp. 116-121 ◽

Cited By ~ 31

Author(s):

J. Hussey ◽

J. Gormley ◽

G. Leen ◽

P. Greally

Keyword(s):

Cystic Fibrosis ◽

Muscle Strength ◽

Young Males ◽

Peripheral Muscle

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The Use of Near Infrared Spectroscopy to Evaluate the Effect of Exercise on Peripheral Muscle Oxygenation in Patients with Lower Extremity Artery Disease: A Systematic Review

European Journal of Vascular and Endovascular Surgery ◽

10.1016/j.ejvs.2021.02.008 ◽

2021 ◽

Author(s):

Nils Cornelis ◽

Panagiotis Chatzinikolaou ◽

Roselien Buys ◽

Inge Fourneau ◽

Jomme Claes ◽

...

Keyword(s):

Systematic Review ◽

Infrared Spectroscopy ◽

Lower Extremity ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Muscle Oxygenation ◽

Peripheral Muscle ◽

Artery Disease ◽

Lower Extremity Artery Disease

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Reliability and validity of the modified Heckmatt scale in evaluating muscle changes with ultrasound in spasticity

Toxicon ◽

10.1016/j.toxicon.2020.11.447 ◽

2021 ◽

Vol 190 ◽

pp. S50-S51

Author(s):

Marisa C. Moreta ◽

Alana Fleet ◽

Rajiv Reebye ◽

Gina P. McKernan ◽

Michael Berger ◽

...

Keyword(s):

Reliability And Validity ◽

Muscle Changes

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Muscle Changes in Lambs with Surgically Created Scoliosis Produced in Utero

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100024355 ◽

1978 ◽

Vol 5 (3) ◽

pp. 283-287 ◽

Cited By ~ 1

Author(s):

G.M. Kent ◽

W. Zingg ◽

D. Armstrong

Keyword(s):

Musculoskeletal Diseases ◽

Fiber Type ◽

Surgical Techniques ◽

Spinal Curvature ◽

Surgical Trauma ◽

Developmental Defect ◽

Type I ◽

Type Ii ◽

Muscle Changes ◽

Type Ii Fibers

SUMMARY:Spinal curves may be produced in fetal lambs with three surgical techniques. These procedures vary from mere exposure of the costo-vertebral junction of three ribs through a paravertebral incision, to resection of the head and part of the adjacent shaft of three ribs. The fetal age varies from forty-nine to seventy-three days. The degree of curvature present at birth seems to increase in severity with decreasing fetal age at the time of surgery, but the type of surgical procedure does not appear to influence the severity of the curve, suggesting that the mechanical presence of the ribs does not prevent the development of scoliosis in these animals.Histological studies of the m. longissimus dorsi at the apices of the curves reveal two main types of abnormality in the muscle fibers. Both Type I and Type II fibers were significantly reduced in size in the biopsies taken from the side on which the surgery was performed, and there was marked alteration in the proportion of one fiber type to the other in most biopsies taken from both operated sides when compared with biopsies from unoperated twin animals.The fetal age and amount of surgical trauma appeared to play no role in the degree of muscle alteration, suggesting that even minimal surgical trauma to the paraspinal region at any fetal age between 49–73 days is sufficient to produce significant muscle fiber abnormality and spinal curvature.A parallel is drawn between these muscle findings and those in a number of human musculoskeletal diseases, and suggests the possibility of a developmental defect in the pathogenesis of these diseases.

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