Proteomic Analysis of Protein Complexes in Toll-Like Receptor Biology

2009 ◽  
pp. 91-104
Author(s):  
Kiva Brennan ◽  
Caroline A. Jefferies
Keyword(s):  
Proteomic Analysis ◽  
Protein Complexes ◽  
Toll Like Receptor ◽  
Receptor Biology

scholarly journals Upstream – News in Genomics

2002 ◽  
Vol 3 (3) ◽  
pp. 221-225
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Ovarian Cancer ◽  
Oryza Sativa ◽  
Schizosaccharomyces Pombe ◽  
Fission Yeast ◽  
Proteomic Analysis ◽  
Large Scale ◽  
Protein Complexes ◽  
The Other ◽  
Blood Samples

In recent months a bumper crop of genomes has been completed, including the fission yeast (Schizosaccharomyces pombe) and rice (Oryza sativa). Two large-scale studies ofSaccharomyces cerevisiaeprotein complexes provided a picture of the eukaryotic proteome as a network of complexes. Amongst the other stories of interest was a demonstration that proteomic analysis of blood samples can be used to detect ovarian cancer, perhaps even as early as stage I.

Proteomic analysis of protein complexes

PROTEOMICS ◽  
2007 ◽  
Vol 7 (16) ◽  
pp. 2688-2697 ◽  
Author(s):  
Ming Zhou ◽  
Timothy D. Veenstra
Keyword(s):  
Proteomic Analysis ◽  
Protein Complexes

scholarly journals Prostate cancer serum biomarker discovery through proteomic analysis of alpha-2 macroglobulin protein complexes

2008 ◽  
Vol 2 (9) ◽  
pp. 1223-1233 ◽  
Author(s):  
Earle F. Burgess ◽  
Amy-Joan L. Ham ◽  
David L. Tabb ◽  
Dean Billheimer ◽  
Bruce J. Roth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Proteomic Analysis ◽  
Biomarker Discovery ◽  
Protein Complexes ◽  
Serum Biomarker

303 Toll-like receptor 4/MyD88 pathway mediates microglial proinflammatory cytokine responses to thrombin-associated coagulation protein complexes

Cytokine ◽  
2008 ◽  
Vol 43 (3) ◽  
pp. 315
Author(s):  
Jörg Scheffel ◽  
Denise van Rossum ◽  
Jonathan R. Weinstein ◽  
Hassan Dihazi ◽  
Tommy Regen ◽  
...  
Keyword(s):  
Proinflammatory Cytokine ◽  
Protein Complexes ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Cytokine Responses ◽  
Coagulation Protein ◽  
Myd88 Pathway

Native proteomic analysis of protein complexes in murine intestinal brush border membranes

PROTEOMICS ◽  
2007 ◽  
Vol 7 (1) ◽  
pp. 121-129 ◽  
Author(s):  
Marek Babušiak ◽  
Petr Man ◽  
Jiri Petrak ◽  
Daniel Vyoral
Keyword(s):  
Brush Border ◽  
Proteomic Analysis ◽  
Protein Complexes ◽  
Brush Border Membranes ◽  
Intestinal Brush Border

scholarly journals TAM Receptors in the Pathophysiology of Liver Disease

Livers ◽  
2022 ◽  
Vol 2 (1) ◽  
pp. 15-29
Author(s):  
Emilio Flint ◽  
Evangelos Triantafyllou ◽  
Christine Bernsmeier
Keyword(s):  
Liver Disease ◽  
Acute Liver Injury ◽  
Current Knowledge ◽  
Innate Immune ◽  
Tyrosine Kinase Receptors ◽  
Toll Like Receptor ◽  
Tam Receptors ◽  
Receptor Inhibition ◽  
Receptor Biology ◽  
Parenchymal Cells

TAM receptors (Tyro3, Axl and MerTK) are a family of tyrosine kinase receptors that are expressed in a variety of cell populations, including liver parenchymal and non-parenchymal cells. These receptors are vital for immune homeostasis, as they regulate the innate immune response by suppressing inflammation via toll-like receptor inhibition and by promoting tissue resolution through efferocytosis. However, there is increasing evidence indicating that aberrant TAM receptor signaling may play a role in pathophysiological processes in the context of liver disease. This review will explore the roles of TAM receptors and their ligands in liver homeostasis as well as a variety of disease settings, including acute liver injury, steatosis, fibrosis, cirrhosis-associated immune dysfunction and hepatocellular carcinoma. A better understanding of our current knowledge of TAM receptors in liver disease may identify new opportunities for disease monitoring as well as novel therapeutic targets. Nonetheless, this review also aims to highlight areas where further research on TAM receptor biology in liver disease is required.

Proteomic analysis of the crayfish gastrolith chitinous extracellular matrix reveals putative protein complexes and a central role for GAP 65

2015 ◽  
Vol 128 ◽  
pp. 333-343 ◽  
Author(s):  
Lilah Glazer ◽  
Ziv Roth ◽  
Simy Weil ◽  
Eliahu D. Aflalo ◽  
Isam Khalaila ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Proteomic Analysis ◽  
Protein Complexes ◽  
Putative Protein
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