This chapter will help you understand the importance of, and the relationships between, health, health and care systems, sustainable development, and climate change, and to do so locally and globally. The specific objectives of the chapter are to help you: make the case for action by understanding how science, law, policies, and values can be framed and translated into specific and system wide actions; translate what is known and what protects and creates health into policy and practice, and help address barriers to implementation and quality improvement in health and care systems; engage a wide range of stakeholders to ensure appropriate cross-system action involving a diverse group of people, skills, and influences across the health and care system.