Bioactive Compounds of Soursop (Annona muricata L.) Fruit

2019 ◽  
pp. 1-15
Author(s):  
Luis M. Anaya Esparza ◽  
Efigenia Montalvo-González
Keyword(s):  
Bioactive Compounds ◽  
Annona Muricata

Bioactive Compounds of Soursop (Annona muricata L.) Fruit

2020 ◽  
pp. 175-189
Author(s):  
Luis M. Anaya Esparza ◽  
Efigenia Montalvo-González
Keyword(s):  
Bioactive Compounds ◽  
Annona Muricata

scholarly journals Concentration of hydroalcoholic extracts of graviola (Annona muricata L.) pruning waste by ultra and nanofiltration: Recovery of bioactive compounds and prediction of energy consumption

2018 ◽  
Vol 174 ◽  
pp. 1412-1421 ◽  
Author(s):  
Ingrid V. M. de Moraes ◽  
Renata S. Rabelo ◽  
Júlia A. de L. Pereira ◽  
Miriam D. Hubinger ◽  
Flávio L. Schmidt
Keyword(s):  
Energy Consumption ◽  
Bioactive Compounds ◽  
Annona Muricata

scholarly journals Intensified green-based extraction process as a circular economy approach to recover bioactive compounds from soursop seeds (Annona muricata L.)

2021 ◽  
pp. 100164
Author(s):  
Patricia C. Mesquita ◽  
Luiz Gustavo G. Rodrigues ◽  
Simone Mazzutti ◽  
Mayara da Silva ◽  
Luciano Vitali ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Circular Economy ◽  
Extraction Process ◽  
Annona Muricata

scholarly journals Larvicidal and Enzymatic Inhibition Effects of Annona muricata Seed Extract and Main Constituent Annonacin against Aedes aegypti and Aedes albopictus (Diptera: Culicidae)

2019 ◽  
Vol 12 (3) ◽  
pp. 112 ◽  
Author(s):  
Rodrigues ◽  
Silva ◽  
Pinto ◽  
Lima dos Santos ◽  
Carneiro de Freitas ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Bioactive Compounds ◽  
Larvicidal Activity ◽  
Aedes Albopictus ◽  
New Products ◽  
Seed Extract ◽  
Annona Muricata ◽  
Main Constituent ◽  
Environmentally Sustainable ◽  
Lc50 And Lc90

The mosquitoes Aedes aegypti and Aedes albopictus are vectors of arboviruses that cause dengue, zika and chikungunya. Bioactive compounds from plants are environmentally sustainable alternatives to control these vectors and thus the arboviruses transmitted by them. The present study evaluated the larvicidal activity of an acetogenin-rich fraction (ACERF) and its main constituent annonacin obtained from Annona muricata seeds on Ae. aegypti and Ae. albopictus. The larvicidal assays were performed using different concentrations to calculate the LC50 and LC90 values observed 24 h after exposure to the treatment. Annonacin was more active against Ae. aegypti (LC50 2.65 μg·mL−1) in comparison with Ae. albopictus (LC50 8.34 μg·mL−1). In contrast, the acetogenin-rich fraction was more active against Ae. albopictus (LC50 3.41 μg·mL−1) than Ae. aegypti (LC50 12.41 μg·mL−1). ACERF and annonacin treated larvae of Ae. aegypti and Ae. albopictus showed significant differences in the inhibition of their metabolic enzymes when compared to untreated larvae. The results demonstrate the relevant larvicidal action of the acetogenin-rich fraction and annonacin showing the potential to develop new products for the control of Ae. aegypti and Ae. albopictus.

scholarly journals Antimicrobial and Antioxidant Properties of kaempferol-3-O-glucoside and 1-(4-Hydroxyphenyl)-3-phenylpropan-1-one Isolated from the Leaves of Annona muricata (Linn.)

2019 ◽  
pp. 1-13
Author(s):  
Festus O. Taiwo ◽  
Olaoluwa Oyedeji ◽  
Moyosore T. Osundahunsi
Keyword(s):  
Bioactive Compounds ◽  
Leaf Extract ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Antimicrobial Activities ◽  
Annona Muricata ◽  
Dpph Radical ◽  
Plant Leaf Extract ◽  
Dpph Radical Scavenging

Aim: To evaluate the antimicrobial and antioxidant activities of bioactive compounds isolated from Annona muricata (Linn.) leaf extract. Study Design: In vitro antimicrobial assay of bioactive compounds isolated from solvent fractions of plant leaf extract against selected clinical bacterial and fungal isolates. Antioxidant assay of plant leaf extract. Place and Duration of Study: All the work was carried out in the Departments of Chemistry and Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria between March, 2015 and January, 2016. Methodology: Isolation of bioactive compounds was by column and thin layer chromatographic techniques. Isolated compounds were characterized by nuclear magnetic resonance spectroscopic analysis. Antimicrobial activities were evaluated by disc diffusion and broth microdilution methods while antioxidant activity was investigated using the 2,2-dipheny-1-picrylhydrazyl (DPPH) radical-scavenging assay. Results: Two compounds kaempferol-3-O-glucoside (1) and 1-(4-Hydroxyphenyl)-3-Phenylpropan-1-one (2) were isolated from the ethyl acetate fraction of leaf extract of A. muricata. The two compounds showed broad spectrum antimicrobial activities with zones of inhibition ranging from 26.00 ± 1.73 to 31 ± 1.00 mm and 17.33 ± 1.15 to 31.33 ± 1.15 mm respectively, for compounds 1 and 2 for the test bacteria species and 15.33 ± 1.15 to 31.33 ± 1.15 mm and 17.67 ± 0.58 to 29.67 ±1.53 mm respectively, for compounds 1 and 2 for the test fungi. Minimum inhibitory concentrations ranged between 0.625-5.00 µg/mL and 1.25-5.00 µg/ml respectively, for compounds 1 and 2. Minimum bactericidal concentrations ranged between 2.5-10.00 µg/mL for both compounds which compared favourably with the reference drugs used. DPPH radical-scavenging activities were IC50 = 13.41 ± 0.64 µg/mL and 7.42 ± 0.90 µg/mL for compounds 1 and 2 respectively, compared with IC50 = 51.99 ± 1.44 µg/ml obtained for the standard ascorbic acid. The results show that both isolated compounds from A. muricata leaf possess in vitro antimicrobial and antioxidant properties and they may be useful as active ingredients in antimicrobial drug formulations and as agents for the control of free radical-related pathological disorders.

Molecular docking studies of bioactive compounds from Annona muricata Linn as potential inhibitors for Bcl-2, Bcl-w and Mcl-1 antiapoptotic proteins

APOPTOSIS ◽  
2017 ◽  
Vol 23 (1) ◽  
pp. 27-40 ◽  
Author(s):  
Mohamad Norisham Mohamad Rosdi ◽  
Shahkila Mohd Arif ◽  
Mohamad Hafizi Abu Bakar ◽  
Siti Aisyah Razali ◽  
Razauden Mohamed Zulkifli ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Bioactive Compounds ◽  
Docking Studies ◽  
Annona Muricata ◽  
Molecular Docking Studies ◽  
Antiapoptotic Proteins ◽  
Potential Inhibitors

scholarly journals The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agent: proposed mechanisms based on a systematic review

2021 ◽  
Vol 10 (2) ◽  
pp. 166-178
Author(s):  
David Andi Wijaya ◽  
Melva Louisa ◽  
Heri Wibowo ◽  
Aslim Taslim ◽  
Tiara Bunga Mayang Permata ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Cell ◽  
Bioactive Compounds ◽  
Annona Muricata ◽  
Annonaceous Acetogenins ◽  
Technological Advances ◽  
Anticancer Mechanism ◽  
Future Potential ◽  
Radio Sensitivity ◽  
Made In

Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent.

scholarly journals Evaluation of Annona muricata Acetogenins as Potential Anti-SARS-CoV-2 Agents Through Computational Approaches

2021 ◽  
Vol 8 ◽  
Author(s):  
Shashanka K. Prasad ◽  
Sushma Pradeep ◽  
Chandan Shimavallu ◽  
Shiva Prasad Kollur ◽  
Asad Syed ◽  
...  
Keyword(s):  
Cell Growth ◽  
Bioactive Compounds ◽  
In Silico ◽  
Spike Protein ◽  
Annona Muricata ◽  
Annonaceous Acetogenins ◽  
Tropical Plant ◽  
Wide Range

Annona muricata, a tropical plant which has been extensively used in ethnomedicine to treat a wide range of diseases, from malaria to cancer. Interestingly, this plant has been reported to demonstrate significant antiviral properties against the human immunodeficiency virus, herpes simplex virus, human papilloma virus, hepatitis C virus and dengue virus. Additionally, the bioactive compounds responsible for antiviral efficacy have also shown to be selectively cytotoxic while inhibiting tumorigenic cell growth without affecting the normal cell growth. Annonaceous Acetogenins are a class of bioactive compounds exclusive to the Annonaceae family at which the plant A. muricata belongs. In the current study, we have created a library of Acetogenins unique to the plant, comprising of Annomuricin A, Annomuricin B, Annomuricin C, Muricatocin C, Muricatacin, cis-Annonacin, Annonacin-10-one, cis-Goniothalamicin, Arianacin and Javoricin, for in silico and theoretical evaluations against the SARS-CoV-2 spike protein in an attempt toward promotion of plant based drug development for the current pandemic of coronavirus disease 2019 (COVID-19). We found that all the Acetogenins showing in silico spike protein significantly docking with good binding affinities. Moreover, we envision A. muricata Acetogenins can be further studied by in vitro and in vivo models to identify potential anti-SARS-CoV-2 agents.

Investigation of bioactive compounds in the genus Garcinia (Guttiferae) of Cameroon

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
B Biloa Messi ◽  
R Ho ◽  
A Meli Lannang ◽  
JG Tangmouo ◽  
A Marston ◽  
...  
Keyword(s):  
Bioactive Compounds
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