scholarly journals The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agent: proposed mechanisms based on a systematic review

2021 ◽  
Vol 10 (2) ◽  
pp. 166-178
Author(s):  
David Andi Wijaya ◽  
Melva Louisa ◽  
Heri Wibowo ◽  
Aslim Taslim ◽  
Tiara Bunga Mayang Permata ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Cell ◽  
Bioactive Compounds ◽  
Annona Muricata ◽  
Annonaceous Acetogenins ◽  
Technological Advances ◽  
Anticancer Mechanism ◽  
Future Potential ◽  
Radio Sensitivity ◽  
Made In

Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent.

scholarly journals Evaluation of Annona muricata Acetogenins as Potential Anti-SARS-CoV-2 Agents Through Computational Approaches

2021 ◽  
Vol 8 ◽  
Author(s):  
Shashanka K. Prasad ◽  
Sushma Pradeep ◽  
Chandan Shimavallu ◽  
Shiva Prasad Kollur ◽  
Asad Syed ◽  
...  
Keyword(s):  
Cell Growth ◽  
Bioactive Compounds ◽  
In Silico ◽  
Spike Protein ◽  
Annona Muricata ◽  
Annonaceous Acetogenins ◽  
Tropical Plant ◽  
Wide Range

Annona muricata, a tropical plant which has been extensively used in ethnomedicine to treat a wide range of diseases, from malaria to cancer. Interestingly, this plant has been reported to demonstrate significant antiviral properties against the human immunodeficiency virus, herpes simplex virus, human papilloma virus, hepatitis C virus and dengue virus. Additionally, the bioactive compounds responsible for antiviral efficacy have also shown to be selectively cytotoxic while inhibiting tumorigenic cell growth without affecting the normal cell growth. Annonaceous Acetogenins are a class of bioactive compounds exclusive to the Annonaceae family at which the plant A. muricata belongs. In the current study, we have created a library of Acetogenins unique to the plant, comprising of Annomuricin A, Annomuricin B, Annomuricin C, Muricatocin C, Muricatacin, cis-Annonacin, Annonacin-10-one, cis-Goniothalamicin, Arianacin and Javoricin, for in silico and theoretical evaluations against the SARS-CoV-2 spike protein in an attempt toward promotion of plant based drug development for the current pandemic of coronavirus disease 2019 (COVID-19). We found that all the Acetogenins showing in silico spike protein significantly docking with good binding affinities. Moreover, we envision A. muricata Acetogenins can be further studied by in vitro and in vivo models to identify potential anti-SARS-CoV-2 agents.

Studi Taksonomi dan Potensi Beberapa Jamur Liar di Pulau Belitong

2020 ◽  
Vol 3 (1) ◽  
pp. 24
Author(s):  
Ivan Permana Putra
Keyword(s):  
Bioactive Compounds ◽  
Schizophyllum Commune ◽  
Ecological Role ◽  
Future Potential

Abstract : Macrofungi or mushroom are cosmopolitan heterotrophic organisms which have a very important ecological role. Information on the presence and description of macrofungi can be used as a reference for conservation steps and future potential utilization. The purpose of this study was to provide  description of macro fungi and their potential utilization at Belitong Island. All macro fungi found were Basidiomycota. The identification results showd there were 11 species of mushrooms, i.e. Chlorophyllum molybdites, Lepiota sp., Marasmius sp., Parasola sp., Phallus indusiatus, Lentinus sp.1, Lentinus sp.2, Microporus sp., Polyporus cf. tricholoma, Russula sp., dan Schizophyllum commune. All mushrooms are decomposer at the study site. Some mushrooms have potential as food, medicine and source of other bioactive compounds. This paper explains how to use macroscopic characters to help the identification of macrofungi.Abstrak : Jamur makro merupakan organisme heterotof kosmopolitan yang memiliki peran ekologis yang sangat penting. Informasi mengenai keberadaan dan deskripsi jamur makro dapat dijadikan acuan untuk langkah konservasi serta pemanfaatan potensinya di masa mendatang. Tujuan dari penelitian ini adalah untuk menyediakan deskripsi jamur makro dan potensi pemanfaatannya di Pulau Belitong. Seluruh jamur makro yang ditemukan merupakan Filum Basidiomycota. Hasil identifikasi menunjukan terdapat 11 spesies jamur yaitu Chlorophyllum molybdites, Lepiota sp., Marasmius sp., Parasola sp., Phallus indusiatus, Lentinus sp.1, Lentinus sp.2, Microporus sp., Polyporus cf. tricholoma, Russula sp., dan Schizophyllum commune. Seluruh jamur merupakan dekomposer pada lokasi penelitian. Beberapa jamur berpotensi sebagai bahan pangan, obat, dan sumber senyawa bioaktif lainnya. Pada tulisan ini dijelaskan cara menggunakan karakter makroskopik untuk membantu identifikasi jamur.

Philippine Archaeology: Status and Prospects

1987 ◽  
Vol 18 (2) ◽  
pp. 235-249 ◽  
Author(s):  
Karl L. Hutterer
Keyword(s):  
Present Form ◽  
Historical Events ◽  
Research Practices ◽  
Future Directions ◽  
Historical Perspectives ◽  
Present Essay ◽  
History Of ◽  
Future Potential ◽  
Made In

The purpose of the present essay is not to present a history of Philippine archaeology; several preliminary attempts have been made in this regard which may be consulted. Rather, the aim of this paper is to pause for a moment and look across the landscape of Philippine archaeology to assess what has been accomplished to date, to ponder strength and weaknesses of the field at this time, and to consider future directions. Nevertheless, the shape of any landscape is the result of historical events and processes that need to be taken into account if we want to understand its present form and assess its future potential and development. Thus, it will be necessary to include in the following thoughts historical perspectives which will help to explain how and why certain concepts, methods and research practices arose in the context of Philippine archaeology and came to determine our picture of Philippine prehistory.

Practical Isolation of Bullatacin from Annona muricata Leaves Extract Using an Open Column Chromatography Technique

2013 ◽  
Vol 789 ◽  
pp. 545-550 ◽  
Author(s):  
Kamarza Mulia ◽  
Silvester W. Winarcahyo ◽  
Elsa Krisanti ◽  
Dewi Kurniasuci
Keyword(s):  
Column Chromatography ◽  
Separation Procedure ◽  
Annona Muricata ◽  
Methanol Fraction ◽  
Annonaceous Acetogenins ◽  
Anti Cancer ◽  
Standard Compound ◽  
Lactone Group ◽  
Dark Green ◽  
Ethanol Fraction

Annonaceous acetogenins are bioactive compounds present in the leaves of Annona muricata (soursop) with significant anti-cancer activities. In this study, acetogenin-rich ethanol fraction extracted from soursop leaves was further separated and isolated using a simple open column chromatography technique with silica gel as the stationary phase. The separation procedure consists of three steps, each step employing sequential elution with organic solvents having different polarity as the eluent. Eluted fractions rich in acetogenin compounds were identified using the Kedde reagent which formed a distinctive dark green complex with the unsaturated γ-lactone group present in all of the annonaceous acetogenin compounds. HPLC analysis showed that the initial methanol fraction, as well as isolates from the second and the third isolation steps, contain bullatacin, squamocin, squamostatin-A, and squamostatin-D. Bullatacin produced from this study can be used further as a standard compound for quantitative analysis of other acetogenin compounds contained in soursop leaves extract.

scholarly journals From Nanoparticles to Cancer Nanomedicine: Old Problems with New Solutions

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1727
Author(s):  
Chi-Ling Chiang ◽  
Ming-Huei Cheng ◽  
Chih-Hsin Lin
Keyword(s):  
Surface Modification ◽  
Immune Responses ◽  
Cancer Patients ◽  
Tumor Tissue ◽  
Developmental Process ◽  
Engineered Nanomaterials ◽  
Technological Advances ◽  
Cancer Nanomedicine ◽  
Made In ◽  
Target Cancer

Anticancer nanomedicines have been studied over 30 years, but fewer than 10 formulations have been approved for clinical therapy today. Despite abundant options of anticancer drugs, it remains challenging to have agents specifically target cancer cells while reducing collateral toxicity to healthy tissue. Nanocompartments that can be selective toward points deeply within malignant tissues are a promising concept, but the heterogeneity of tumor tissue, inefficiency of cargo loading and releasing, and low uniformity of manufacture required from preclinical to commercialization are major obstacles. Technological advances have been made in this field, creating engineered nanomaterials with improved uniformity, flexibility of cargo loading, diversity of surface modification, and less inducible immune responses. This review highlights the developmental process of approved nanomedicines and the opportunities for novel materials that combine insights of tumors and nanotechnology to develop a more effective nanomedicine for cancer patients.

scholarly journals Telementoring of Surgeons: A Systematic Review

2018 ◽  
Vol 26 (1) ◽  
pp. 95-111 ◽  
Author(s):  
Simon Erridge ◽  
Derek K. T. Yeung ◽  
Hitendra R. H. Patel ◽  
Sanjay Purkayastha
Keyword(s):  
Systematic Review ◽  
Study Quality ◽  
Review Of The Literature ◽  
Exact Role ◽  
Technological Advances ◽  
Training Modality ◽  
Potential Benefits ◽  
Video And Audio ◽  
Meta Analyses ◽  
Efficacy Profile

Background. Telementoring is a technique that has shown potential as a surgical training aid. Previous studies have suggested that telementoring is a safe training modality. This review aimed to review both the technological capabilities of reported telementoring systems as well as its potential benefits as a mentoring modality. Methods. A systematic review of the literature, up to July 2017, was carried out in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Study quality was assessed using the Oxford Levels of Evidence proforma. Data were extracted regarding technical capabilities, bandwidth, latency, and costs. Additionally, the primary aim and key results were extracted from each study and analyzed. Results. A total of 66 studies were identified for inclusion. In all, 48% of studies were conducted in general surgery; 22 (33%), 24 (36%), and 20 (30%) of studies reported telementoring that occurred within the same hospital, outside the hospital, and outside the country, respectively. Sixty-four (98%) of studies employed video and audio and 38 (58%) used telestration. Twelve separate studies directly compared telementoring against on-site mentoring. Seven (58%) showed no difference in outcomes between telementoring and on-site mentoring. No study found telementoring to result in poorer postoperative outcomes. Conclusions. The results of this review suggest that telementoring has a similar safety and efficacy profile as on-site mentoring. Future analysis to determine the potential benefits and pitfalls to surgical education through telementoring are required to determine the exact role it shall play in the future. Technological advances to improve remote connectivity would also aid the uptake of telementoring on a larger scale.

Bioactive Compounds of Soursop (Annona muricata L.) Fruit

2020 ◽  
pp. 175-189
Author(s):  
Luis M. Anaya Esparza ◽  
Efigenia Montalvo-González
Keyword(s):  
Bioactive Compounds ◽  
Annona Muricata

scholarly journals Anti-bacterial activity of Annona muricata Linnaeus extracts: a systematic review

2021 ◽  
Author(s):  
Ricardo Mendes da SILVA ◽  
Isabella de Matos Mendes da SILVA ◽  
Maria Manuela ESTEVINHO ◽  
Leticia M. ESTEVINHO
Keyword(s):  
Systematic Review ◽  
Bacterial Activity ◽  
Annona Muricata
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