An Unprecedented Thousandfold Enhancement of Antimicrobial Activity of Metal Ions by Selective Anion Treatment

2019 ◽  
pp. 433-435
Author(s):  
Jakka Ravindran Swathy ◽  
Ligy Philip ◽  
Thalappil Pradeep
Keyword(s):  
Antimicrobial Activity ◽  
Metal Ions

scholarly journals Design and fabrication of photoactive imidazole-based poly(ether-imide)s and a polyimide/HBP-modified SiO2 composite: toward high heat-resistance, antimicrobial activity and removal of heavy metal ions

RSC Advances ◽  
2021 ◽  
Vol 11 (38) ◽  
pp. 23574-23588
Author(s):  
Diyari Khaki ◽  
Hassan Namazi ◽  
S. Mojtaba Amininasab
Keyword(s):  
Heavy Metal ◽  
Antimicrobial Activity ◽  
Heat Resistance ◽  
Metal Ions ◽  
Heavy Metal Ions ◽  
High Heat ◽  
High Heat Resistance

Novel thermostable, photoactive, and solvable poly(ether-imide)s containing imidazole-based pendant groups and a BTDA-PIb/HBP@SiO2 composite were synthesized and used due to their antimicrobial activity and as an adsorbent to remove heavy metal ions.

scholarly journals Syntheses, Characterization and Biological Activity of Coordination Compounds of Propanedioic Acid and its Mixed Ligand Complexes with N,N'-Dihydroxy-2,3-butanediimine

2021 ◽  
Vol 33 (8) ◽  
pp. 1911-1918
Author(s):  
T.O. Aiyelabola ◽  
E.O. Akinkunmi ◽  
O Osungunna
Keyword(s):  
Antimicrobial Activity ◽  
Metal Ions ◽  
Coordination Compounds ◽  
Mixed Ligand Complex ◽  
Octahedral Geometry ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Planar Geometry ◽  
Acid Complex ◽  
Square Planar

The coordination compounds of propanedioic acid with cobalt(II), nickel(II) and copper(II) ions were synthesized using metal:ligand 1:2. In addition to this, mixed ligand complexes using the same metal ions with propanedioic acid as the primary ligand and N,N'-dihydroxy-2,3-butanediimine as the secondary ligand were also synthesized using M:L1:L2 (1:1:1) where L1 = propanedioic acid, L2 = N,N'-dihydroxy-2,3-butanediimine and M = Cu(II), Ni(II) and Cu(II). The synthesized compounds were characterized using FTIR, UV-vis, magnetic susceptibility measurement and percentage metal composition. The ligand and its metal complexes were tested for their cytotoxic and antibacterial activities. Results indicated that a dimeric square planar geometry was assumed by the cobalt(II) and nickel(II) propanedioic acid complexes. Octahedral geometry was proposed for both cobalt(II) and copper(II) mixed ligand complexes. A dinuclear square pyramidal geometry was suggested for the copper(II) propanedioic acid complex and square planar/octahedral geometry for the nickel(II) mixed ligand complex. The copper(II) propanedioic acid complex elicited the best cytotoxic activity. On the other hand, the nickel(II) propanedioic acid complex showed the remarkable antimicrobial activity. The compounds exhibited good antimicrobial activity in most of the cases with the exception of the cobalt(II) propanedioic acid complex. It was concluded that coordination of the ligands to the metal ions lowered the toxicity of the ligands. It was further concluded that the antimicrobial activity of the compounds was partly dependent on the synergism/additive effect of the intrinsic therapeutic properties of the metal ion and the ligands within the coordination sphere of the complexes synthesized. And this is also in part a function of the geometry assumed by the complexes.

scholarly journals Synthesis and Characterization of Activated Carbon/ZnO Nanocomposite from Water Hyacinth for Heavy Metals Adsorption and its Antimicrobial Activity

2021 ◽  
Vol 33 (3) ◽  
pp. 551-556
Author(s):  
Shivakumar Lakshmipurada ◽  
Kankara Ramakrishna Reddy ◽  
Sureshkumar Sundaravel
Keyword(s):  
Heavy Metal ◽  
Antimicrobial Activity ◽  
Activated Carbon ◽  
Metal Ions ◽  
Zno Nanoparticles ◽  
Water Hyacinth ◽  
Heavy Metal Ions ◽  
Electrostatic Interactions ◽  
Cadmium Lead ◽  
Heavy Metal Ions Removal

In present work, the activated carbon was prepared from water hyacinth (Eichhornia crassipes) and ZnO nanoparticles synthesized by chemical process. Nanocomposites were formed using activated carbon and ZnO nanoparticles to get improved electrostatic interactions for the successful adsorption of heavy metal ions such as nickel, cadmium, lead and chromium from aqueous solution. The prepared nanocomposites were further characterized using XRD, SEM and EDAX techniques. The heavy metal ions removal efficacy was evaluated through ICP-OES. The result showed that the prepared nanocomposite efficiently adsorbed 76.75-92.40% nickel, 75.80-92.25% cadmium, 86.25-96.30% lead and 76.37-95.26% chromium. Nanocomposites showed a significant antimicrobial activity against Streptococci and B. subtilis.

scholarly journals Biological Activity of Au(III) Complexes

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Ana S. Stankovic ◽  
Marijana P. Kasalovic ◽  
Andriana M. Bukonjic ◽  
Marina Z. Mijajlovic ◽  
Dusan Lj. Tomovic ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Antimicrobial Activity ◽  
Biological Activity ◽  
Metal Ions ◽  
Lupus Erythematosus ◽  
Modern Medicine ◽  
Discoid Lupus Erythematosus ◽  
Central Metal ◽  
Physiological Conditions ◽  
Gold Compounds

Abstract The earliest therapy use of gold compounds dated in 2500 AD. In 1960s gold compounds were used in the treatment of rheumatoid arthritis, discoid lupus erythematosus, etc. Although the compounds of Au(I) are well-known and used in the modern medicine, new complexes of Au(III) and ligands with different donor atoms are synthetized and examined for their biological (antitumor, antimicrobial) activity. So far conducted studies show that complexes with Au(III) as central metal ions have greater activity compared with free ligands. Future syntheses should be based on the increase of biological activity with complexes that have necessary stability under physiological conditions.

scholarly journals Metal ions and graphene-based compounds as alternative treatment options for burn wounds infected by antibiotic-resistant Pseudomonas aeruginosa

2020 ◽  
Vol 202 (5) ◽  
pp. 995-1004 ◽  
Author(s):  
Nathalie Karaky ◽  
Andrew Kirby ◽  
Andrew J. McBain ◽  
Jonathan A. Butler ◽  
Mohamed El Mohtadi ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Metal Ions ◽  
Treatment Options ◽  
Major Complication ◽  
Antimicrobial Effect ◽  
Bacterial Cells ◽  
Biofilm Inhibition ◽  
Antibiotic Resistant ◽  
Topical Antimicrobials

AbstractBurn infections caused by Pseudomonas aeruginosa pose a major complication in wound healing. This study aimed to determine the antimicrobial effect of metal ions, graphene (Gr), and graphene oxide (GO), individually and in combination, against the planktonic and biofilm states of two antimicrobially resistant clinical strains of P. aeruginosa each with different antibiotic resistance profiles. Minimum inhibitory, minimum bactericidal, and fractional inhibitory concentrations were performed to determine the efficacy of the metal ions and graphene composites individually and their synergy in combination. Crystal violet biofilm and XTT assays measured the biofilm inhibition and metabolic activity, respectively. Molybdenum, platinum, tin, gold, and palladium ions exhibited the greatest antimicrobial activity (MIC = 7.8–26.0 mg/L), whilst GO and Gr demonstrated moderate-to-no effect against the planktonic bacterial cells, irrespective of their antibiograms. Biofilms were inhibited by zinc, palladium, silver, and graphene. In combination, silver–graphene and molybdenum–graphene inhibited both the planktonic and biofilm forms of the bacteria making them potential candidates for development into topical antimicrobials for burns patients infected with antibiotic-resistant P. aeruginosa.

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