A Graphical Tool for the Exploration and Visual Analysis of Biomolecular Networks

Author(s):  
Cheick Tidiane Ba ◽  
Elena Casiraghi ◽  
Marco Frasca ◽  
Jessica Gliozzo ◽  
Giuliano Grossi ◽  
...  
2019 ◽  
Vol 50 (4) ◽  
pp. 693-702 ◽  
Author(s):  
Christine Holyfield ◽  
Sydney Brooks ◽  
Allison Schluterman

Purpose Augmentative and alternative communication (AAC) is an intervention approach that can promote communication and language in children with multiple disabilities who are beginning communicators. While a wide range of AAC technologies are available, little is known about the comparative effects of specific technology options. Given that engagement can be low for beginning communicators with multiple disabilities, the current study provides initial information about the comparative effects of 2 AAC technology options—high-tech visual scene displays (VSDs) and low-tech isolated picture symbols—on engagement. Method Three elementary-age beginning communicators with multiple disabilities participated. The study used a single-subject, alternating treatment design with each technology serving as a condition. Participants interacted with their school speech-language pathologists using each of the 2 technologies across 5 sessions in a block randomized order. Results According to visual analysis and nonoverlap of all pairs calculations, all 3 participants demonstrated more engagement with the high-tech VSDs than the low-tech isolated picture symbols as measured by their seconds of gaze toward each technology option. Despite the difference in engagement observed, there was no clear difference across the 2 conditions in engagement toward the communication partner or use of the AAC. Conclusions Clinicians can consider measuring engagement when evaluating AAC technology options for children with multiple disabilities and should consider evaluating high-tech VSDs as 1 technology option for them. Future research must explore the extent to which differences in engagement to particular AAC technologies result in differences in communication and language learning over time as might be expected.


2019 ◽  
Vol 62 (9) ◽  
pp. 3397-3412
Author(s):  
Michelle I. Brown ◽  
David Trembath ◽  
Marleen F. Westerveld ◽  
Gail T. Gillon

Purpose This pilot study explored the effectiveness of an early storybook reading (ESR) intervention for parents with babies with hearing loss (HL) for improving (a) parents' book selection skills, (b) parent–child eye contact, and (c) parent–child turn-taking. Advancing research into ESR, this study examined whether the benefits from an ESR intervention reported for babies without HL were also observed in babies with HL. Method Four mother–baby dyads participated in a multiple baseline single-case experimental design across behaviors. Treatment effects for parents' book selection skills, parent–child eye contact, and parent–child turn-taking were examined using visual analysis and Tau-U analysis. Results Statistically significant increases, with large to very large effect sizes, were observed for all 4 participants for parent–child eye contact and parent–child turn-taking. Limited improvements with ceiling effects were observed for parents' book selection skills. Conclusion The findings provide preliminary evidence for the effectiveness of an ESR intervention for babies with HL for promoting parent–child interactions through eye contact and turn-taking.


2013 ◽  
Vol 3 (1) ◽  
pp. 29-50 ◽  
Author(s):  
Evinç Doğan ◽  
Ibrahim Sirkeci

This study examines the ways in which the city image of Istanbul is re-created through the mega-events within the context of the European Capital of Culture (ECoC) 2010. Istanbul “took the stage” as one of the three ECoC cities (Essen for the Ruhr in Germany and Pécs in Hungary), where the urban spaces were projected as the theatre décor while residents and visitors became the spectators of the events. Organisers and agents of the ECoC 2010 seemed to rebrand Istanbul as a “world city” rather than a “European capital”. With a series of transnational connotations, this can be considered as part of an attempt to turn Istanbul to a global city. In this study we examine posters used during the ECoC 2010 to see whether this was evident in the promoted images of Istanbul. The research employs a hermeneutic approach in which representations, signs and language are the means of symbolic meaning, which is analysed through qualitative methods for the visual data (Visual Analysis Methods), namely Semiotics and Discourse Analysis. The analysed research material comes from a sample of posters released during the ECoC 2010 to promote 549 events throughout the year. Using stratified random sampling we have drawn 28 posters (5% of the total) reflecting the thematic groups of events in the ECoC 2010. Particular attention is also paid to the reflexivity of the researchers and researchers’ embeddedness to the object of research. The symbolic production and visual representation are therefore investigated firstly through the authoritative and historically constituted discourses in the making of Istanbul image and secondly through the orders of cultural consumption and mediatisation of culture through spectacular events. Hence enforcing a transnationalisation of the image of the city where the image appears to be almost stateless transcending the national boundaries. Findings and methodology used in this study can be useful in understanding similar cases and further research into the processes of city and place branding and image relationships. 


2016 ◽  
Vol 2016 (1) ◽  
pp. 1-11
Author(s):  
BradE. Hollister ◽  
Alex Pang
Keyword(s):  

Author(s):  
Edgars Rencis ◽  
Janis Barzdins ◽  
Sergejs Kozlovics

Towards Open Graphical Tool-Building Framework Nowadays, there are many frameworks for developing domain-specific tools. However, if we want to create a really sophisticated tool with specific functionality requirements, it is not always an easy task to do. Although tool-building platforms offer some means for extending the tool functionality and accessing it from external applications, it usually requires a deep understanding of various technical implementation details. In this paper we try to go one step closer to a really open graphical tool-building framework that would allow both to change the behavior of the tool and to access the tool from the outside easily. We start by defining a specialization of metamodels which is a great and powerful facility itself. Then we go on and show how this can be applied in the field of graphical domain-specific tool building. The approach is demonstrated on an example of a subset of UML activity diagrams. The benefits of the approach are also clearly indicated. These include a natural and intuitive definition of tools, a strict logic/presentation separation and the openness for extensions as well as for external applications.


2019 ◽  
Vol 69 (0) ◽  
pp. 345-356
Author(s):  
Yan Chai ◽  
Won-jun Chung

Author(s):  
С.Н. Шатохина ◽  
Н.А. Кузнецова ◽  
В.Н. Шабалин

Цель проведённого исследования состояла в оценке эффективности визуального анализа твёрдофазных структур спинномозговой жидкости для диагностики ранних форм нейросифилиса. Методы. Использован метод краевой дегидратации биологических жидкостей, входящий в состав авторской диагностической технологии «Литос-система». Диагностика раннего асимптомного нейросифилиса заключается в выявлении деструктивных образований в форме овалов в морфологической картине твёрдой фазы спинномозговой жидкости. Результаты. Проведён сравнительный анализ результатов исследования спинномозговой жидкости у 19 больных с подтверждённым диагнозом «ранний асимптомный нейросифилис», полученных традиционными лабораторными методами и методом краевой дегидратации. Выявлено, что локализация овалов внутри сферолитов указывает на длительность заболевания нейросифилисом менее трёх лет, а вне сферолитов - от трех до пяти лет. Заключение. Метод краевой дегидратации позволяет диагностировать ранний асимптомный нейросифилис по наличию деструктивных образований в форме овалов в морфологической картине твёрдой фазы спинномозговой жидкости. The aim of this study was to evaluate effectiveness of visual analysis of solid-phase structures in cerebrospinal fluid to diagnose early forms of neurosyphilis. Methods. We used a method of marginal dehydration of biological fluids as a part of the author’s diagnostic technology, Litos-System. Early asymptomatic neurosyphilis is diagnosed based on detection of destructive, oval-shaped formations in the morphological picture of cerebrospinal fluid solid phase. Results. Data from analyses of cerebrospinal fluid performed with traditional laboratory methods and the method of marginal dehydration were compared for 19 patients with documented diagnosis of early asymptomatic neurosyphilis. A localization of ovals within spherulites indicated a less than a three-year duration of neurosyphilis while a localization outside spherulites indicated a duration of three to five years. Conclusion. The method of marginal dehydration allows detecting early asymptomatic neurosyphilis based on the presence of destructive, oval-shaped formations in the morphological picture of cerebrospinal fluid solid phase.


2017 ◽  
Vol 9 (5) ◽  
pp. 137-143 ◽  
Author(s):  
P.Y. Leonov ◽  
A.K. Zavalishina

Author(s):  
A. G. Belova ◽  
E. V. Zimina ◽  
N. P. Simbirtsev

During a pathoanatomic autopsy, it is very important to correctly assess the color change of the organs. However, it is not always clear because the color depends on the spectrum of the incident light. There is also a subjective assessment of color. In addition, in animals with large amounts of circulating blood, for example, dogs, early imbibition occurs, which makes it difficult to assess the color of the organ and pathoanatomical diagnosis. We have proposed a simple and visual method of recognition of two pathological processes – inflammation and edema using colored filters. This technique also allows to accurately differentiate inflammation from postmortem imbibition, to recognize fibrin and hemorrhage well. Postmortem examination of different types of animals (predacious families of mustelids, canids, felids) was performed in accordance with Shore’s method in the prosectorium of the Pathonomy Department, K.I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology visual analysis – under various artificial lights (fluorescent lamps with banded spectrum and halogen lamps). In the red filter are well identified the pathological processes associated with the venous blood presence in the tissues (venous hyperemia and pulmonary edema). The focus of venous hyperemia or edema in the red filter looks like a dark zone, and tissues, where arterial bloods predominated, aren’t detected in red filter. In the yellow – green filter the inflammation is clearly detected: the zone is brightly red and surrounding tissues become dark. Red colour filters have rather narrow band of transmittance from 600 to 700 nm. Yellow-green have a width zone – from 500 to 700 nm, including both red, and yellow-green part of spectrum. Oxidized hemoglobin in red part of spectrum absorbs ten time weaker, has more high reflectivity and looks red. Surrounding tissues reflect the red rays, which incident on them also red. Therefore, the zone of edema, venous hyperemia and hemorrhaging, containing venous blood, are detected the dark spot, and inflammation zone merges with the red background. Oxidized hemoglobin in the red spectrum part absorbs ten time weaker than reduced hemoglobin, has high reflectivity of the red spectrum part and looks brightly red, surrounding tissues reflect yellow-green spectrum part and look green. Therefore, the zones of inflammation, active hyperemia and hemorrhaging, containing arterial blood, sharp contrast with green background and are clearly visible. Diagnoses made with the help of color filters are confirmed by histological studies.


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