Biological Activities of Marine Products and Nutritional Importance

2020 ◽  
pp. 587-616
Author(s):  
Dilipkumar Pal ◽  
Khushboo Raj
Keyword(s):  
Biological Activities ◽  
Nutritional Importance ◽  
Marine Products

scholarly journals Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications

Marine Drugs ◽  
2021 ◽  
Vol 19 (5) ◽  
pp. 241
Author(s):  
Shaden A. M. Khalifa ◽  
Eslam S. Shedid ◽  
Essa M. Saied ◽  
Amir Reza Jassbi ◽  
Fatemeh H. Jamebozorgi ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Biomedical Applications ◽  
Large Scale ◽  
Biological Activities ◽  
Scale Production ◽  
Pharmacological Activities ◽  
Large Scale Production ◽  
Marine Products ◽  
Hiv 1 ◽  
Successful Phase

Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.

scholarly journals Structures, Activities and Drug-Likeness of Anti-Infective Xanthone Derivatives Isolated from the Marine Environment: A Review

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 243 ◽  
Author(s):  
Daniela R. P. Loureiro ◽  
José X. Soares ◽  
Joana C. Costa ◽  
Álvaro F. Magalhães ◽  
Carlos M. G. Azevedo ◽  
...  
Keyword(s):  
Molecular Descriptors ◽  
Chemical Space ◽  
Biological Activities ◽  
Chemical Properties ◽  
Pharmacokinetic Parameters ◽  
Bioactive Substances ◽  
Xanthone Derivatives ◽  
Development Of Resistance ◽  
Marine Products ◽  
Infective Activity

Marine organisms represent almost half of total biodiversity and are a very important source of new bioactive substances. Within the varied biological activities found in marine products, their antimicrobial activity is one of the most relevant. Infectious diseases are responsible for high levels of morbidity and mortality and many antimicrobials lose their effectiveness with time due to the development of resistance. These facts justify the high importance of finding new, effective and safe anti-infective agents. Among the variety of biological activities of marine xanthone derivatives, one that must be highlighted is their anti-infective properties. In this work, a literature review of marine xanthones with anti-infective activity, namely antibacterial, antifungal, antiparasitic and antiviral, is presented. Their structures, biological activity, sources and the methods used for bioactivity evaluation are described. The xanthone derivatives are grouped in three sets: xanthones, hydroxanthones and glycosylated derivatives. Moreover, molecular descriptors, biophysico-chemical properties, and pharmacokinetic parameters were calculated, and the chemical space occupied by marine xanthone derivatives is recognized. The chemical space was compared with marketed drugs and framed accordingly to the drug-likeness concept in order to profile the pharmacokinetic of anti-infective marine xanthone derivatives.

scholarly journals Antiviral Effect of Caulerpin Against Chikungunya

2019 ◽  
Vol 14 (10) ◽  
pp. 1934578X1987829 ◽  
Author(s):  
Priscilla O. Esteves ◽  
Mariana C. de Oliveira ◽  
Caroline de Souza Barros ◽  
Claudio C. Cirne-Santos ◽  
Valeria T. Laneuvlille ◽  
...  
Keyword(s):  
Green Alga ◽  
Biological Activities ◽  
Antiviral Effect ◽  
Vero Cells ◽  
Inhibitory Effect ◽  
Marine Products ◽  
Low Cytotoxicity ◽  
Inhibitory Potential ◽  
Isolated Compound ◽  
Therapy Studies

The discovery of new substances that present innumerable biological activities for the development of drugs is increasingly difficult. Natural marine products are a source of substances with a diversified chemical structure, a broad spectrum of biological activities and low cytotoxicity, which are the essential characteristics for the development of a new drug. An increasing number of reports of Chikungunya virus (CHIKV) infections, in addition to the lack of specific antiviral therapy or vaccines, emphasizes the importance of searching for effective therapy. Studies with the marine green alga Caulerpa racemosa showed antiviral potential. Hence, the aim of this work was to evaluate the anti-CHIKV activity of a marine alkaloid isolated from green alga C. racemosa. Vero cells were used in antiviral assays, submitted to CHIKV, and treated with different concentrations of caulerpin. In the antiviral activity, we observed that the isolated compound showed a much significant and promising EC50 inhibitory effect of 0.8 µM. When evaluating the virucidal activity, we observed that caulerpin was very efficient against CHIKV, being able to inhibit around 90% of the viral infectivity when treated with 5 μM of the compound. We observed that caulerpin added at times 0, 1, 2, and 3 postinfection still maintains a 100% inhibitory potential of viral replication for CHIKV. These studies suggest that the said compounds might be potentially studied for use in the prevention and treatment of CHIKV infections. Derivatives can be considered as a promising new anti-CHIKV drug and can be used for clinical testing.

Improvement of cytoprotective and antioxidant activity of Rosa canina L. and Salix alba L. by controlled differential sieving process against H2O2-induced oxidative stress in mouse primary splenocytes

2017 ◽  
Vol 87 (3-4) ◽  
pp. 191-200 ◽  
Author(s):  
Nidhal Soualeh ◽  
Aliçia Stiévenard ◽  
Elie Baudelaire ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Good Alternative ◽  
Activity Levels ◽  
Salix Alba ◽  
Rosa Canina ◽  
Free Process ◽  
Plant Powders ◽  
Sieving Process

Abstract. In this study, cytoprotective and antioxidant activities of Rosa canina (RC) and Salix alba (SA), medicinal plants, were studied on mouse primary splenocytes by comparing Controlled Differential Sieving process (CDSp), which is a novel green solvent-free process, versus a conventional technique, employing hydroethanolic extraction (HEE). Thus, preventive antioxidant activity of three plant powders of homogeneous particle sizes, 50–100 µm, 100–180 µm and 180–315 µm, dissolved directly in the cellular buffer, were compared to those of hydroethanolic (HE) extract, at 2 concentrations (250 and 500 µg/mL) in H2O2-treated spleen cells. Overall, compared to HE extract, the superfine powders, i. e., fractions < 180 µm, at the lowest concentration, resulted in greater reactive oxygen species (ROS) elimination, increased glutathione peroxidase (GPx) activity and lower malondialdehyde (MDA) production. Better antioxidant and preventive effects in pre-treated cells were found with the superfine powders for SA (i. e., 50–100 µm and 100–180 µm, both p < 0.001), and with the intermediate powder for RC (i. e., 100–180 µm, p < 0.05) versus HE extract. The activity levels of catalase (CAT) and superoxide dismutase (SOD) in pretreated splenocytes exposed to H2O2, albeit reduced, were near to those in unexposed cells, suggesting that pretreatment with the fine powders has relatively restored the normal levels of antioxidant-related enzymes. These findings supported that CDSp improved the biological activities of plants, avoiding the use of organic solvents and thus it could be a good alternative to conventional extraction techniques.

Shape‐controlled silver NPs for shape‐dependent biological activities

2017 ◽  
Vol 12 (9) ◽  
pp. 647-651 ◽  
Author(s):  
Fatemeh Sadeghi ◽  
Abolfazl Yazdanpanah ◽  
Amirbabak Abrishamkar ◽  
Fatholah Moztarzadeh ◽  
Arash Ramedani ◽  
...  
Keyword(s):  
Biological Activities ◽  
Silver Nps ◽  
Shape Controlled

Research into chemistry and biological activities of Prangos Lindl. (Apiaceae) species of Turkey

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
KHC Baser ◽  
B Demirci ◽  
G Ozek ◽  
A Duran ◽  
N Tabanca ◽  
...  
Keyword(s):  
Biological Activities

Studies on the chemical constituents and their biological activities of the fruit of Garcinia multiflora

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
JJ Chen ◽  
CW Ting ◽  
MH Yen ◽  
TL Hwang ◽  
C Peng ◽  
...  
Keyword(s):  
Biological Activities ◽  
Chemical Constituents

Biological Activities of Andrographolide and Some Semi-synthesis Nonbitter Andrographolides

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
C Aromdee ◽  
N Sriubolmas ◽  
T Ekalaksananan ◽  
C Pientong ◽  
S Seubsasana ◽  
...  
Keyword(s):  
Biological Activities

Chemical analysis and biological activities of methanol extracts from Astragalus gombiformis Pomel (Fabaceae)

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
H Teyeb ◽  
O Houta ◽  
A Lamari ◽  
M Neffati ◽  
W Douki ◽  
...  
Keyword(s):  
Chemical Analysis ◽  
Biological Activities ◽  
Methanol Extracts

Biological Activities of Essential Oils

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
G Buchbauer
Keyword(s):  
Essential Oils ◽  
Biological Activities
Sign in / Sign up

Export Citation Format

Share Document