Antimicrobial Peptides and Peptidomimetics for the Control of Antimicrobial Resistance

2021 ◽  
pp. 205-249
Author(s):  
Richard Weeks ◽  
Ammar Algburi ◽  
Michael Chikindas
Keyword(s):  
Antimicrobial Resistance ◽  
Antimicrobial Peptides

Antimicrobial Peptides: A Promising Therapeutic Strategy in Tackling Antimicrobial Resistance

2017 ◽  
Vol 24 (38) ◽  
Author(s):  
Ramya Nuti ◽  
Nerella S. Goud ◽  
A. Prasanth Saraswati ◽  
Ravi Alvala ◽  
Mallika Alvala
Keyword(s):  
Antimicrobial Resistance ◽  
Antimicrobial Peptides ◽  
Therapeutic Strategy

scholarly journals Antimicrobial Peptides and Their Analogs: Searching for New Potential Therapeutics

2014 ◽  
Vol 6 ◽  
pp. PMC.S13215 ◽  
Author(s):  
Krystyna Midura-Nowaczek ◽  
Agnieszka Markowska
Keyword(s):  
Innate Immunity ◽  
Antimicrobial Resistance ◽  
Antimicrobial Peptides ◽  
Broad Spectrum ◽  
Active Peptides ◽  
Basic Features ◽  
Potential Therapeutics

Antimicrobial peptides (AMPs) are an essential part of innate immunity. These compounds have been considered as potential therapeutics because of their broad-spectrum activities and proven ability to avoid antimicrobial resistance, but their clinical and commercial developments have some limitations, such as susceptibility to proteases and a high cost of peptide production. To overcome these problems, many researchers have tried to develop short active peptides, their modifications and mimics with better properties while retaining their basic features of natural AMPs such as cationic charge and the amphipathic structure.

scholarly journals Peptides and Dendrimers: How to Combat Viral and Bacterial Infections

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 101
Author(s):  
Annarita Falanga ◽  
Valentina Del Genio ◽  
Stefania Galdiero
Keyword(s):  
Antimicrobial Resistance ◽  
Antimicrobial Peptides ◽  
Broad Spectrum ◽  
Bacterial Infections ◽  
Cell Penetrating Peptides ◽  
High Potential ◽  
Permanent Damage ◽  
Antiviral Peptides ◽  
Cell Penetrating ◽  
Novel Approaches

The alarming growth of antimicrobial resistance and recent viral pandemic events have enhanced the need for novel approaches through innovative agents that are mainly able to attach to the external layers of bacteria and viruses, causing permanent damage. Antimicrobial molecules are potent broad-spectrum agents with a high potential as novel therapeutics. In this context, antimicrobial peptides, cell penetrating peptides, and antiviral peptides play a major role, and have been suggested as promising solutions. Furthermore, dendrimers are to be considered as suitable macromolecules for the development of advanced nanosystems that are able to complement the typical properties of dendrimers with those of peptides. This review focuses on the description of nanoplatforms constructed with peptides and dendrimers, and their applications.

d-Amino acids in antimicrobial peptides: a potential approach to treat and combat antimicrobial resistance

2020 ◽  
pp. 1-19
Author(s):  
Shikha Kapil ◽  
Vipasha Sharma
Keyword(s):  
Amino Acids ◽  
Antimicrobial Resistance ◽  
Antimicrobial Peptides ◽  
De Novo ◽  
Wide Spectrum ◽  
New Drugs ◽  
Novel Treatments ◽  
Gram Positive Bacteria ◽  
Increasing Demand ◽  
Bacteria And Fungi

Antimicrobial resistance is one of the leading challenges in the human healthcare segment. Advances in antimicrobial resistance have triggered exploration of natural alternatives to stabilize its seriousness. Antimicrobial peptides are small, positively charged oligopeptides that are as potent as commercially available antibiotics against a wide spectrum of organisms, such as Gram-positive bacteria, Gram-negative bacteria, viruses, and fungal strains. In addition to their antibiotic capabilities, these peptides possess anticancer activity, activate the immune response, and regulate inflammation. Peptides have distinct modes of action and fall into various categories due to their amino acid composition. Although antimicrobial peptides specifically target the bacterial cytoplasmic membrane, they can also target the cell nucleus and protein synthesis. Owing to the increasing demand for novel treatments against the threat of antimicrobial resistance, naturally synthesized peptides are a beneficial development concept. Antimicrobial peptides are pervasive and can easily be modified using de-novo synthesis technology. Antimicrobial peptides can be isolated from natural resources such as humans, plants, bacteria, and fungi. This review gives a brief overview of antimicrobial peptides and their diastereomeric composition. Other current trends, the future scope of antimicrobial peptides, and the role of d-amino acids are also discussed, with a specific emphasis on the design and development of new drugs.

scholarly journals Bacterial infections in COVID-19 patients and their possible treatments. A review

2021 ◽  
Vol 27 (1) ◽  
pp. 6-14
Author(s):  
A'liyatur Rosyidah ◽  
Mohamad Padri ◽  
Paulus Damar Bayu Murti
Keyword(s):  
Antimicrobial Resistance ◽  
Severe Acute Respiratory Syndrome ◽  
Antimicrobial Peptides ◽  
Bacterial Infections ◽  
Phage Therapy ◽  
Treatment Decisions ◽  
Prevention And Treatment ◽  
The Future ◽  
In The Beginning

The COVID-19 pandemic, which started in the beginning of 2020 was triggered by a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, severely affected various sectors, especially health. The effect of COVID-19 on patients is exacerbated by bacterial co-infections and secondary bacterial infections. There are few studies on how bacterial co-infections and secondary bacterial infections worsen COVID-19 patients, including in Indonesia. Therefore, it is necessary to update and summarize the understanding of bacterial infections characteristics to help optimize the diagnosis, prevention, and treatment decisions. Antibiotics have been used in COVID-19 patients to treat bacterial infections to date, which could contribute to antimicrobial resistance in the future. The review s objective is to summarize bacterial infections in COVID-19 patients and several possible treatments, including antibiotics, phage therapy, probiotics/prebiotics, and nanomedicine for antimicrobial peptides (AMPs) delivery

scholarly journals The Emergence of Multidrug-Resistant Helicobacter pylori in Southeast Asia: A Systematic Review on the Trends and Intervention Strategies Using Antimicrobial Peptides

Antibiotics ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1061
Author(s):  
Asif Sukri ◽  
Bruno S. Lopes ◽  
Alfizah Hanafiah
Keyword(s):  
Systematic Review ◽  
Antimicrobial Resistance ◽  
Antimicrobial Peptides ◽  
Multidrug Resistant ◽  
World Health ◽  
Public Healthcare ◽  
Antibiofilm Activity ◽  
Asian Countries ◽  
Primary Resistance ◽  
H Pylori

The emergence of multidrug-resistant H. pylori poses a public healthcare threat, particularly in low- and middle-income countries. Recently, the World Health Organization has classified clarithromycin-resistant H. pylori as high priority in the research and discovery of novel antibiotics. This study was aimed to systematically review the prevalence of primary antibiotic resistance in H. pylori in Southeast Asian countries (SEAC) and to review current studies of antimicrobial peptides against H. pylori. We systematically searched through electronic databases of studies conducted on antimicrobial resistance of H. pylori in SEA countries. Furthermore, we searched articles that conducted studies on antimicrobial peptides, naturally occurring host’s defense molecules, against H. pylori. After a series of screening processes, 15 studies were included in our systematic review. Our analysis revealed that primary resistance of H. pylori to metronidazole, clarithromycin, and levofloxacin were high in SEAC, although the primary resistance to amoxicillin and tetracycline remains low. Multidrug-resistant H. pylori are emerging in SE Asian countries. The antimicrobial peptides show promising antibacterial and antibiofilm activity against drug-resistant H. pylori. The research and discovery of antimicrobial peptides against H. pylori in SEAC will help in limiting the spread of antimicrobial resistance of H. pylori.

scholarly journals FISH MUCUS: A NEGLECTED RESERVOIR FOR ANTIMICROBIAL PEPTIDES

2018 ◽  
Vol 6 (4) ◽  
pp. 6-11 ◽  
Author(s):  
Okella Hedmon
Keyword(s):  
Antimicrobial Resistance ◽  
Antimicrobial Peptides ◽  
Modern Society ◽  
Journal Articles ◽  
Key Word ◽  
Recent Developments ◽  
Spectrum Activity ◽  
Fish Mucus ◽  
Word Search ◽  
Broad Spectrum Activity

Antimicrobial resistance has posed a great global burden, with the fear that by 2050 it would have killed more people than cancer if nothing much is done about it. Alongside several attempts in place, zoo-therapy is becoming one of important remedies in the modern society, with hope for solution believed to be hidden in nature. In this study, the authors present a review of journal articles and reports obtained through key word search of several literature databases on recent developments in the battle against the antimicrobial resistance using fish derived antimicrobial peptides. The findings indicate despite some limitations of these antimicrobial peptides, their very broad spectrum activity against pathogens keeps them among  promising antibiotics as far as the battle against multidrug resistance is concerned. Much as various methods to study antimicrobial peptides do exist, fish mucus remains less explored. The study recommends aquatic habitat exploration in search for novel bacterial antimicrobial peptides.

Liposome-Encapsulated Antimicrobial Peptides

2015 ◽  
pp. 301-332
Author(s):  
Anju Gupta ◽  
Reetu Gupta ◽  
Sudarshan Kurwardkar
Keyword(s):  
Antimicrobial Resistance ◽  
Infectious Diseases ◽  
Antimicrobial Peptides ◽  
Antimicrobial Therapy ◽  
Final Section ◽  
Model Membrane ◽  
Delivery Strategy ◽  
Effective Delivery ◽  
Biophysical Techniques ◽  
Potential Use

The purpose of this chapter is to review the potential use of liposomes and peptides to address the ongoing challenges in infectious diseases involving antimicrobial resistance. The First section of this chapter describes and discusses the use of liposomes as model membrane to gain an insight on the membrane binding and disruption behavior of the potent peptides. Under this section, various biophysical techniques used to characterize the interactions are reviewed. In the second section, the use of antimicrobial peptides as an alternative to conventional antimicrobial therapy is presented. The final section of this chapter reviews liposomal encapsulation of antimicrobial peptides as an effective delivery strategy.

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