Recent Therapeutic Strategies for the Treatment of Colon Cancer

2021 ◽  
pp. 73-90
Author(s):  
Vinita Sharma ◽  
Priya Chouhan ◽  
Rajan Kumar Pandey ◽  
Vijay Kumar Prajapati
Keyword(s):  
Colon Cancer ◽  
Therapeutic Strategies

scholarly journals Gut Microbiota Influences Experimental Outcomes in Mouse Models of Colorectal Cancer

Genes ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 900 ◽  
Author(s):  
Alyssa A. Leystra ◽  
Margie L. Clapper
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Experimental Design ◽  
Gut Microbiota ◽  
Mouse Models ◽  
Therapeutic Strategies ◽  
Response To Therapy ◽  
Valuable Resource ◽  
Disease Phenotypes ◽  
Experimental Findings

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Mouse models are a valuable resource for use throughout the development and testing of new therapeutic strategies for CRC. Tumorigenesis and response to therapy in humans and mouse models alike are influenced by the microbial communities that colonize the gut. Differences in the composition of the gut microbiota can confound experimental findings and reduce the replicability and translatability of the resulting data. Despite this, the contribution of resident microbiota to preclinical tumor models is often underappreciated. This review does the following: (1) summarizes evidence that the gut microbiota influence CRC disease phenotypes; (2) outlines factors that can influence the composition of the gut microbiota; and (3) provides strategies that can be incorporated into the experimental design, to account for the influence of the microbiota on intestinal phenotypes in mouse models of CRC. Through careful experimental design and documentation, mouse models can continue to rapidly advance efforts to prevent and treat colon cancer.

scholarly journals Multi-Species Probiotic Modulates Cytokine Production and the Interplay between Immune and Colon Cancer Cells

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Meir Djaldetti ◽  
Chiya Moshe Leibovitch ◽  
Hanna Bessler ◽  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Mononuclear Cells ◽  
Cytokine Production ◽  
Human Peripheral Blood ◽  
Therapeutic Strategies ◽  
Colon Cancer Cells ◽  
Peripheral Blood Mononuclear ◽  
The Impact ◽  
Ht 29

The current study aimed to investigate the effect of a multi-species probiotic (MSP) on cytokine production by human peripheral blood mononuclear cells (PBMCs) and their immune dialogue with HT-29 colon cancer cells. PBMCs were incubated with MSP and their effect on cell proliferation and TNFα, IL-1β, IL-2, IL-6, IFNγ, IL-10, and IL-1ra production was evaluated. The impact of MSP on the cytokine production by PBMC stimulated by HT-29 cells was detected. Not-stimulated PBMC incubated with MSP showed increased production of TNFα, IL-1β, IL-6, and IL-10, but no change in IL-6, IFNγ, and IL-1ra. The stimulatory effect of MSP on lipopolysaccharide (LPS)-promoted PBMC was less pronounced for TNFα, IL-1β, and IFNγ, and the IL-6 production was decreased; phorbol 12-myristate 13- acetate (PMA)-induced IL-2 and IFNγ secretion was inhibited. The addition of MSP to co-cultures of PBMC and HT-29 cancer cells caused a remarkable increase in TNFα and IL-1β secretion, with no change in remaining cytokines. The multi-species probiotics modulated cytokine production by PBMC and affected the cross-talk between PBMC and HT-29 cancer cells. We conclude that probiotics may serve as supplements to the therapeutic strategies applied for the treatment of chronic inflammatory and malignant diseases, especially colorectal cancers.

scholarly journals Mechanisms of drug resistance in colon cancer and its therapeutic strategies

2016 ◽  
Vol 22 (30) ◽  
pp. 6876 ◽  
Author(s):  
Tao Hu ◽  
Zhen Li ◽  
Chun-Ying Gao ◽  
Chi Hin Cho
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Therapeutic Strategies

scholarly journals Current Management of Appendiceal Neoplasms

2021 ◽  
pp. 1-15
Author(s):  
Richard S. Hoehn ◽  
Caroline J. Rieser ◽  
M. Haroon Choudry ◽  
Nelya Melnitchouk ◽  
Jaclyn Hechtman ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Diagnostic Criteria ◽  
Therapeutic Strategies ◽  
Review Article ◽  
Malignant Potential ◽  
Classification Systems ◽  
Molecular Characteristics ◽  
Current Management ◽  
Appendiceal Neoplasms ◽  
Growing Body

Appendiceal neoplasms include a heterogeneous group of epithelial and nonepithelial tumors that exhibit varying malignant potential. This review article summarizes current diagnostic criteria, classification systems, and optimal therapeutic strategies for the five main histopathologic subtypes of appendiceal neoplasms. In particular, the management of epithelial appendiceal neoplasms has evolved. Although their treatment has historically been extrapolated from colon cancer, improved understanding of their unique histopathologic and molecular characteristics and a growing body of published clinical data support a more nuanced approach to their management.

Anthocyanin-rich extract from black rice inhibits colon cancer formation in mice

2010 ◽  
Vol 34 (8) ◽  
pp. S44-S44
Author(s):  
Bo Dong ◽  
Xinmei Zhou ◽  
Xun Xu ◽  
Huang Xu ◽  
Yongxia Zheng ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Black Rice

VEGF is regulated by the WNT pathway in colon cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A4-A4
Author(s):  
X ZHANG ◽  
J GASPARD ◽  
D CHUNG
Keyword(s):  
Colon Cancer ◽  
Wnt Pathway

NF-κB regulates colon cancer cell proliferation and tumorigenicity

2001 ◽  
Vol 120 (5) ◽  
pp. A615-A615
Author(s):  
S KUWADA ◽  
C SCAIFE ◽  
J KUANG ◽  
R DAYNES
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Cancer Cell Proliferation

Leptin is a growth factor for human colon cancer cells

2001 ◽  
Vol 120 (5) ◽  
pp. A493-A493
Author(s):  
J HARDWICK ◽  
G VANDENBRINK ◽  
S VANDEVENTER ◽  
M PEPPELENBOSCH
Keyword(s):  
Colon Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells
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