Sweet-Taste Receptor Signaling Network and Low-Calorie Sweeteners

2018 ◽  
pp. 393-407
Author(s):  
Menizibeya O. Welcome ◽  
Nikos E. Mastorakis ◽  
Vladimir A. Pereverzev
Keyword(s):  
Taste Receptor ◽  
Sweet Taste ◽  
Signaling Network ◽  
Receptor Signaling ◽  
Low Calorie ◽  
Sweet Taste Receptor

scholarly journals Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive Functioning

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Menizibeya O. Welcome ◽  
Nikos E. Mastorakis ◽  
Vladimir A. Pereverzev
Keyword(s):  
Cognitive Functioning ◽  
Transmembrane Protein ◽  
Taste Receptor ◽  
Sweet Taste ◽  
The Body ◽  
Taste Receptors ◽  
Receptor Signaling ◽  
Sweet Taste Receptor ◽  
Sweet Taste Receptors

Sweet taste receptors are transmembrane protein network specialized in the transmission of information from special “sweet” molecules into the intracellular domain. These receptors can sense the taste of a range of molecules and transmit the information downstream to several acceptors, modulate cell specific functions and metabolism, and mediate cell-to-cell coupling through paracrine mechanism. Recent reports indicate that sweet taste receptors are widely distributed in the body and serves specific function relative to their localization. Due to their pleiotropic signaling properties and multisubstrate ligand affinity, sweet taste receptors are able to cooperatively bind multiple substances and mediate signaling by other receptors. Based on increasing evidence about the role of these receptors in the initiation and control of absorption and metabolism, and the pivotal role of metabolic (glucose) regulation in the central nervous system functioning, we propose a possible implication of sweet taste receptor signaling in modulating cognitive functioning.

scholarly journals Low Calorie Sweeteners Differ in Their Physiological Effects in Humans

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2717 ◽  
Author(s):  
Stephanie R. Hunter ◽  
Evan J. Reister ◽  
Eunjin Cheon ◽  
Richard D. Mattes
Keyword(s):  
Body Weight ◽  
Health Outcomes ◽  
Functional Property ◽  
Chemical Structure ◽  
Taste Receptor ◽  
Gut Hormones ◽  
Sweet Taste ◽  
Physiological Effects ◽  
Low Calorie ◽  
Sweet Taste Receptor

Low calorie sweeteners (LCS) are prevalent in the food supply for their primary functional property of providing sweetness with little or no energy. Though tested for safety individually, there has been extremely limited work on the efficacy of each LCS. It is commonly assumed all LCS act similarly in their behavioral and physiological effects. However, each LCS has its own chemical structure that influences its metabolism, making each LCS unique in its potential effects on body weight, energy intake, and appetite. LCS may have different behavioral and physiological effects mediated at the sweet taste receptor, in brain activation, with gut hormones, at the microbiota and on appetitive responses. Further elucidation of the unique effects of the different commercially available LCS may hold important implications for recommendations about their use for different health outcomes.

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