The Unmysterious Roles of HSP90: Ovarian Pathology and Autoantibodies

Ovarian Dysfunction in Fetally Irradiated Beagles

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100080717 ◽

1977 ◽

Vol 35 ◽

pp. 658-659

Author(s):

T. M. Seed ◽

M. H. Sanderson ◽

D. L. Gutzeit ◽

T. E. Fritz ◽

D. V. Tolle ◽

...

Keyword(s):

Gamma Rays ◽

Low Dose ◽

Long Term Effects ◽

Ovarian Dysfunction ◽

Dose Rates ◽

Highly Sensitive ◽

Microscopic Evaluation ◽

Ovarian Pathology ◽

Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

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Ovarian Pathology Surgically Removed in Pregnancy. A Ten Years Retrospective Analysis Based in Histopathological Diagnosis

Medical Connections ◽

10.33311/medcon.2013.28.4.6 ◽

2013 ◽

Vol 28 (4/2013) ◽

Keyword(s):

Retrospective Analysis ◽

Histopathological Diagnosis ◽

Ovarian Pathology ◽

In Pregnancy

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A review of ovarian pathology in 336 laparotomies

American Journal of Obstetrics and Gynecology ◽

10.1016/0002-9378(48)90450-5 ◽

1948 ◽

Vol 56 (5) ◽

pp. 907-912

Author(s):

Mary DeWitt Pettit

Keyword(s):

Ovarian Pathology

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Pcsk6 mutant mice exhibit progressive loss of ovarian function, altered gene expression, and formation of ovarian pathology

Reproduction ◽

10.1530/rep-10-0451 ◽

2011 ◽

Vol 141 (3) ◽

pp. 343-355 ◽

Cited By ~ 5

Author(s):

Michelle L Mujoomdar ◽

Laura M Hogan ◽

Albert F Parlow ◽

Mark W Nachtigal

Keyword(s):

Gene Expression ◽

Ovarian Function ◽

Elevated Serum ◽

Cell Types ◽

Reproductive Capacity ◽

Wide Range ◽

Altered Gene ◽

Ovarian Pathology ◽

Targeted Gene Expression ◽

Benign Ovarian Tumors

Bioactivation of precursor proteins by members of the proprotein convertase (PC) family is essential for normal reproduction. ThePcsk6gene is a member of the PC family that is expressed in numerous ovarian cell types including granulosa cells and oocytes. We hypothesized that loss of PCSK6 would produce adverse effects in the mouse ovary. Mice incapable of expressing PCSK6 (Pcsk6tm1Rob) were obtained, and reproductive parameters (serum hormones, whelping interval, estrus cyclicity, and fertility) were compared toPcsk6+/+mice. WhilePcsk6tm1Robfemale mice are fertile, they manifest reduced reproductive capacity at an accelerated rate relative toPcsk6+/+mice. Reproductive senescence is typically reached by 9 months of age and is correlated with loss of estrus cyclicity, elevated serum FSH levels, and gross alterations in ovarian morphology. A wide range of ovarian morphologies were identified encompassing mild, such as an apparent reduction in follicle number, to moderate – ovarian atrophy with a complete absence of follicles – to severe, manifesting as normal ovarian structures replaced by benign ovarian tumors, including tubulostromal adenomas. Targeted gene expression profiling highlighted changes in RNA expression of molecules involved in processes such as steroidogenesis, gonadotropin signaling, transcriptional regulation, autocrine/paracrine signaling, cholesterol handling, and proprotein bioactivation. These results show that PCSK6 activity plays a role in maintaining normal cellular and tissue homeostasis in the ovary.

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Primary ovarian failure

Oxford Textbook of Endocrinology and Diabetes ◽

10.1093/med/9780199235292.003.0833 ◽

2011 ◽

pp. 1206-1212

Author(s):

Gerard S. Conway ◽

Jacqueline Doyle ◽

Melanie C. Melanie

Keyword(s):

Premature Ovarian Failure ◽

Early Onset ◽

Ovarian Follicles ◽

Ovarian Failure ◽

Ovarian Activity ◽

Hypergonadotropic Hypogonadism ◽

Primary Amenorrhoea ◽

Ovarian Pathology ◽

Genetic And Environmental Factors ◽

Definition Of

The average age of menopause, denoted by the last menstrual period, occurs at an average age of 50.7 years in the western world (1) and this age has been found to be constant across generations, although one group have reported a secular trend to advancing menopausal age (2). The age of menopause in an individual is determined by both genetic and environmental factors (1, 3). Menopause before the age of 40 is most commonly taken to be the definition of ‘premature ovarian failure’ and this coincides approximately with youngest one percent of the frequency distribution of the age of menopause (Fig. 8.1.5.1). For every decade before 40 the prevalence of POF is estimated to decrease by a factor of 10. Thus, in presence of normal karyotype, 1:1000 of women at 30 has POF, 1:10 000 at 20 and 1:100 000 of women will present with gonadal failure and primary amenorrhoea. In terms of the mode of presentation, premature ovarian failure (POF) is the aetiology of 20% of cases with primary amenorrhoea and 10% of those with secondary amenorrhoea. Premature ovarian failure (POF) refers to the cessation of ovarian function at an earlier than expected age due to ovarian pathology. Primary ovarian failure is used in two contexts—to describe very early onset ovarian failure presenting with primary amenorrhoea and also to differentiate ovarian pathology from secondary ovarian failure, which refers to lack of ovarian activity as a result of gonadotropin deficiency. Primary ovarian insufficiency is recently favoured as an all-encompassing term that accounts for the variable course and occasional remission (4). The term hypergonadotropic hypogonadism is also used to emphasize ovarian origin. Resistant ovary syndrome (ROS) is an obsolete term, used to describe the coexistence of hypergonadotropic hypogonadism with normal ovarian follicles on histology of the ovary. It was soon realized that women with ROS progressed to complete ovarian failure and that ovarian follicles on histology were commonly found in established ovarian failure, negating the usefulness of this diagnostic label. Very early onset ovarian failure with a known genetic cause is often labelled inaccurately as ‘gonadal dysgenesis’ as in most situations it is thought that early ovarian development is normal.

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Histopathological patterns of benign lesions in hysterectomy specimens

Nepal Journal of Obstetrics and Gynaecology ◽

10.3126/njog.v14i1.26628 ◽

2019 ◽

Vol 14 (1) ◽

pp. 48-51

Author(s):

Ujwal Rai ◽

Monasha Vaidya ◽

Gehanath Baral ◽

Smrity Mool Joshi ◽

Sunita Ray

Keyword(s):

Abnormal Uterine Bleeding ◽

Cross Sectional Study ◽

Uterovaginal Prolapse ◽

Histopathological Analysis ◽

Fallopian Tubes ◽

Vaginal Route ◽

Surgical Indications ◽

Cross Sectional ◽

The Common ◽

Ovarian Pathology

Aims: To audit and evaluate the surgical indications, routes of surgery and types of hysterectomies performed along with histopathological analysis of those hysterectomies in respect to disease of endometrium, myometrium, cervix and fallopian tubes and ovaries for benign conditions. Methods: This is retrospective cross sectional study of all hysterectomy specimens received in the department of Pathology, B and C teaching hospital and research center, Jhapa, Birtamode, Nepal from May 2017 to May 2019. Clinical details were received from the data provided by gynecologists in histopathological requisition forms. Only specimens received for the benign indication for hysterectomy were taken. Results: Out of 115 specimens, the number was equal on both abdominal and vaginal route. The common indications were leiomyoma (60%, n=69), abnormal uterine bleeding (24%, n=28) and uterine prolapsed in 11% (n=13). Uterovaginal prolapse was seen commonest indication for hysterectomy in age group of 5th and 6th decade of life. Myometrial pathology was seen in 74% (n=75) comprising mostly of leiomyoma. Endometrial pathology was present in 14% (n=16) and chronic non-specific cervicitis in 24% (n=28). Abnormal tubo-ovarian pathology was found in 40% (n=51). Conclusions: Leiomyoma, abnormal uterine bleding and uterovaginal prolapsed are the common benign conditions undergoing hysterectomy.

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