Patient’s Guide in Colorectal Cancer: Prophylaxis, Diet, and Lifestyle

2017 ◽  
pp. 155-166
Author(s):  
Marta Zielińska ◽  
Jakub Włodarczyk
Keyword(s):  
Colorectal Cancer ◽  
Diet And Lifestyle

scholarly journals The Role of Probiotics in Colorectal Cancer Management

2020 ◽  
Vol 2020 ◽  
pp. 1-17 ◽  
Author(s):  
Bhagavathi Sundaram Sivamaruthi ◽  
Periyanaina Kesika ◽  
Chaiyavat Chaiyasut
Keyword(s):  
Colorectal Cancer ◽  
Scientific Evidence ◽  
Survival Rates ◽  
Probiotic Supplementation ◽  
Cancer Management ◽  
Beneficial Impact ◽  
Probiotic Intervention ◽  
Probiotic Strains ◽  
Unhealthy Diet ◽  
Diet And Lifestyle

Colorectal cancer (CRC) is one of the most common cancerous diseases worldwide and causes leading cancer-associated deaths. Several factors are related to the incidence of CRC such as unhealthy diet and lifestyle, heredity, metabolic disorders, and genetic factors. Even though several advanced medical procedures are available for CRC treatment, the survival rates are poor with many adverse treatments associated side effects, which affects the quality of life. Probiotics are a well-known bioactive candidate for the treatment of several diseases and ill-health conditions. The recent scientific evidence suggested that probiotic supplementation protects the CRC patients from treatment-associated adverse effects. The manuscript summarizes the influence of probiotic supplementation on the health status of CRC patients and discusses the possible mechanism behind the protective effect of probiotics against CRC. The literature survey revealed that beneficial impact of probiotic supplementation depends on several factors such as strain, dosage, duration of the intervention, host physiology, and other food supplements. The probiotic intervention improves the microbiota, releases antimicrobials and anticarcinogenic agents, helps to remove carcinogens, and improves the intestinal permeability, tight junction function, and enzyme activity in CRC patients. Besides, not all probiotic strains exhibit anti-CRC activities; it is necessary to screen the potent strain for the development of a probiotic-based therapeutic agent to control or prevent the incidence of CRC.

scholarly journals Primary and Secondary Prevention of Colorectal Cancer

2014 ◽  
Vol 7 ◽  
pp. CGast.S14039 ◽  
Author(s):  
Pedro J. Tárraga López ◽  
Juan Solera Albero ◽  
José Antonio Rodríguez-Montes
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Early Detection ◽  
Secondary Prevention ◽  
Cause Of Death ◽  
Meta Analysis ◽  
Brown Rice ◽  
Primary And Secondary Prevention ◽  
The Third ◽  
Diet And Lifestyle

Introduction Cancer is a worldwide problem as it will affect one in three men and one in four women during their lifetime. Colorectal cancer (CRC) is the third most frequent cancer in men, after lung and prostate cancer, and is the second most frequent cancer in women after breast cancer. It is also the third cause of death in men and women separately, and is the second most frequent cause of death by cancer if both genders are considered together. CRC represents approximately 10% of deaths by cancer. Modifiable risk factors of CRC include smoking, physical inactivity, being overweight and obesity, eating processed meat, and drinking alcohol excessively. CRC screening programs are possible only in economically developed countries. However, attention should be paid in the future to geographical areas with ageing populations and a western lifestyle. 19 , 20 Sigmoidoscopy screening done with people aged 55-64 years has been demonstrated to reduce the incidence of CRC by 33% and mortality by CRC by 43%. Objective To assess the effect on the incidence and mortality of CRC diet and lifestyle and to determine the effect of secondary prevention through early diagnosis of CRC. Methodology A comprehensive search of Medline and Pubmed articles related to primary and secondary prevention of CRC and subsequently, a meta-analysis of the same blocks are performed. Results 225 articles related to primary or secondary prevention of CRC were retrieved. Of these 145 were considered valid on meta-analysis: 12 on epidemiology, 56 on diet and lifestyle, and over 77 different screenings for early detection of CRC. Cancer is a worldwide problem as it will affect one in three men and one in four women during their lifetime. There is no doubt whatsoever which environmental factors, probably diet, may account for these cancer rates. Excessive alcohol consumption and cholesterol-rich diet are associated with a high risk of colon cancer. A diet poor in folic acid and vitamin B6 is also associated with a higher risk of developing colon cancer with an overexpression of p53. Eating pulses at least three times a week lowers the risk of developing colon cancer by 33%, after eating less meat, while eating brown rice at least once a week cuts the risk of CRC by 40%. These associations suggest a dose–response effect. Frequently eating cooked green vegetables, nuts, dried fruit, pulses, and brown rice has been associated with a lower risk of colorectal polyps. High calcium intake offers a protector effect against distal colon and rectal tumors as compared with the proximal colon. Higher intake of dairy products and calcium reduces the risk of colon cancer. Taking an aspirin (ASA) regularly after being diagnosed with colon cancer is associated with less risk of dying from this cancer, especially among people who have tumors with COX-2 overexpression. 16 Nonetheless, these data do not contradict the data obtained on a possible genetic predisposition, even in sporadic or non-hereditary CRC. CRC is susceptible to screening because it is a serious health problem given its high incidence and its associated high morbidity/mortality. Conclusions (1) Cancer is a worldwide problem. (2) A modification of diet and lifestyle could reduce morbidity and mortality. (3) Early detection through screening improves prognosis and reduces mortality.

scholarly journals Indonesian Genomic Landscape of Pathogenic Mutation of APC, KRAS, TP53, PIK3CA, and MLH1 in Colorectal Cancer

2021 ◽  
Author(s):  
Vania Myralda Giamour Marbun ◽  
Toar Jean Maurice Lalisang ◽  
Linda Erlina
Keyword(s):  
Colorectal Cancer ◽  
Dna Analysis ◽  
Locally Advanced ◽  
Pathogenic Mutation ◽  
Silent Mutation ◽  
Dynamic Features ◽  
Biological Behaviour ◽  
Genomic Landscape ◽  
Diet And Lifestyle ◽  
Generation Sequencing

Abstract Background : Knowing colorectal cancer’s heterogeneity and dynamic features, recognizing its biological behaviour requires detailed identification of mutated genes involved. Colorectal cancer (CRC) requires several mutated genes to occur and those are dissimilar in each person hence essential to be discovered in specific population. Until recently, there is no known study describing genomic landscape of CRC in Indonesian population. This study aims to describe profile of pathogenic mutation of APC, TP53, PIK3CA, KRAS, and MLH1 in CRC patients treated at 3 different hospitals in Jakarta. Methods : This is a descriptive study conducted on CRC patients who underwent neoadjuvant, surgical, and adjuvant therapy at RSCM, RSKJ, and MRCCC in 2017-2018. DNA analysis was performed using next-generation sequencing and aligned against GRCh38. Pathogenic variant was identified using ACMG classification and FATHMM score. Data related to behaviour and survival were collected from medical records. Results : There were total 22 subjects in which APC, TP53, and PIKCA were mutated. KRAS mutation occurred in 64%, while MLH1 in 45%. Five types of mutation were identified, including nonsense, missense, frameshift, splice-site, and silent mutation. There are 4 groups of co-occurring mutations, which are APC, TP53, PIK3CA (triple mutation/TM) alone; TM+KRAS; TM+MLH1; and TM+KRAS+MLH1, presenting different nature and survival. Conclusion : Indonesia having various ethnicities with diverse diet and lifestyle has distinct profile of pathogenic mutation presenting mostly with locally-advanced stage with various outcome and survival rate.

MLH1 Promoter Methylation, Diet, and Lifestyle Factors in Mismatch Repair Deficient Colorectal Cancer Patients From EPIC-Norfolk

2011 ◽  
Vol 63 (7) ◽  
pp. 1000-1010 ◽  
Author(s):  
Laura J. Gay ◽  
Mark J. Arends ◽  
Panagiota N. Mitrou ◽  
Richard Bowman ◽  
Ashraf E. Ibrahim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Mismatch Repair ◽  
Promoter Methylation ◽  
Lifestyle Factors ◽  
Mlh1 Promoter ◽  
Colorectal Cancer Patients ◽  
Diet And Lifestyle

scholarly journals Indonesian Genomic Landscape of Pathogenic Mutation of APC, KRAS, TP53, PIK3CA, and MLH1 in Colorectal Cancer

2021 ◽  
Author(s):  
Vania Myralda Giamour Marbun ◽  
Toar Jean Maurice Lalisang ◽  
Linda Erlina
Keyword(s):  
Colorectal Cancer ◽  
Dna Analysis ◽  
Locally Advanced ◽  
Pathogenic Mutation ◽  
Silent Mutation ◽  
Dynamic Features ◽  
Biological Behaviour ◽  
Genomic Landscape ◽  
Diet And Lifestyle ◽  
Generation Sequencing

Abstract Background : Knowing colorectal cancer’s heterogeneity and dynamic features, recognizing its biological behaviour requires detailed identification of mutated genes involved. Colorectal cancer (CRC) requires several mutated genes to occur and those are dissimilar in each person hence essential to be discovered in specific population. Until recently, there is no known study describing genomic landscape of CRC in Indonesian population. This study aims to describe profile of pathogenic mutation of APC, TP53, PIK3CA, KRAS, and MLH1 in CRC patients treated at 3 different hospitals in Jakarta. Methods : This is a descriptive study conducted on CRC patients who underwent neoadjuvant, surgical, and adjuvant therapy at RSCM, RSKJ, and MRCCC in 2017-2018. DNA analysis was performed using next-generation sequencing and aligned against GRCh38. Pathogenic variant was identified using ACMG classification and FATHMM score. Data related to behaviour and survival were collected from medical records. Results : There were total 22 subjects in which APC, TP53, and PIKCA were mutated. KRAS mutation occurred in 64%, while MLH1 in 45%. Five types of mutation were identified, including nonsense, missense, frameshift, splice-site, and silent mutation. There are 4 groups of co-occurring mutations, which are APC, TP53, PIK3CA (triple mutation/TM) alone; TM+KRAS; TM+MLH1; and TM+KRAS+MLH1, presenting different nature and survival. Conclusion : Indonesia having various ethnicities with diverse diet and lifestyle has distinct profile of pathogenic mutation presenting mostly with locally-advanced stage with various outcome and survival rate.

scholarly journals Colorectal cancer: influence of diet and lifestyle factors

2005 ◽  
Vol 97 (6) ◽  
Author(s):  
A. Franco ◽  
A. K. Sikalidis ◽  
J. A. Solís Herruzo
Keyword(s):  
Colorectal Cancer ◽  
Lifestyle Factors ◽  
Diet And Lifestyle

OC.07.6 DIET AND LIFESTYLE HABITS IN EARLY-ONSET COLORECTAL CANCER: A PILOT CASE CONTROL STUDY

2021 ◽  
Vol 53 ◽  
pp. S121
Author(s):  
M. Puzzono ◽  
M. Di Leo ◽  
R.A. Zuppardo ◽  
A. Mannucci ◽  
M. Russo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Onset ◽  
Case Control Study ◽  
Case Control ◽  
Lifestyle Habits ◽  
Diet And Lifestyle ◽  
Early Onset Colorectal Cancer ◽  
Control Study

scholarly journals Colorectal Cancer, Diet and Lifestyle Factors: Opportunities for Prevention

1998 ◽  
Vol 13 (2) ◽  
pp. 141-150 ◽  
Author(s):  
I. Robertson ◽  
R. Bound ◽  
L. Segal
Keyword(s):  
Colorectal Cancer ◽  
Lifestyle Factors ◽  
Diet And Lifestyle ◽  
Cancer Diet
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