Han Chinese Representations of South Sea Merchants in Song China

2019 ◽  
pp. 295-315
Author(s):  
John W. Chaffee
Keyword(s):  
Han Chinese ◽  
South Sea

The mitochondrial tRNAMet/tRNAGlnA4401G and tRNACysG5821A mutations may be associated with hypertension in two Han Chinese families

2014 ◽  
Vol 36 (2) ◽  
pp. 127-134
Author(s):  
Xu Meifen ◽  
He Yiqun ◽  
Geng Junwei ◽  
Meng Yanzi ◽  
Yu Han ◽  
...  
Keyword(s):  
Han Chinese ◽  
Chinese Families

South Sea Tales

2008 ◽  
Author(s):  
Robert Louis Stevenson
Keyword(s):  
Nineteenth Century ◽  
Cross Cultural ◽  
Robert Louis Stevenson ◽  
Global Culture ◽  
Cultural Encounters ◽  
Post Colonial ◽  
The Pacific ◽  
South Sea ◽  
The Subject ◽  
Subject Material

The literary world was shocked when in 1889, at the height of his career, Robert Louis Stevenson announced his intention to settle permanently on the Pacific island of Samoa. His readers were equally shocked when he began to use the subject material offered by his new environment, not to promote a romance of empire, but to produce some of the most ironic and critical treatments of imperialism in nineteenth-century fiction. In these stories, as in his work generally, Stevenson shows himself to be a virtuoso of narrative styles: his Pacific fiction includes the domestic realism of ‘The Beach at Falesé, the folktale plots of ‘The Bottle Imp’ and ‘The Isle of Voices’, and the modernist blending of naturalism and symbolism in The Ebb-Tide. But beyond their generic diversity the stories are linked by their concern with representing the multiracial society of which their author had become a member. In this collection - the first to bring together all his shorter Pacific fiction in one volume - Stevenson emerges as a witness both to the cross- cultural encounters of nineteenth-century imperialism and to the creation of the global culture which characterizes the post-colonial world.

Riding the South Sea Bubble

2003 ◽  
Author(s):  
Peter Temin ◽  
Hans-Joachim Voth
Keyword(s):  
The South ◽  
South Sea

Dietary Choline Intake during Pregnancy and PEMT rs7946 Polymorphism on Risk of Preterm Birth: A Case-Control Study

2021 ◽  
pp. 1-10
Author(s):  
Jie Zhu ◽  
Yu-Hong Liu ◽  
Xiang-Long He ◽  
Martin Kohlmeier ◽  
Li-Li Zhou ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Case Control Study ◽  
Chinese Women ◽  
Case Control ◽  
Han Chinese ◽  
Food Frequency ◽  
Term Delivery ◽  
Choline Intake ◽  
Dietary Choline ◽  
Control Study

<b><i>Introduction and Aims:</i></b> Choline-metabolizing genetic variation may interact with choline intake on fetal programming and pregnancy outcome. This case-control study aims to explore the association of maternal choline consumption and phosphatidylethanolamine N-methyltransferase (PEMT) gene polymorphism rs7946 with preterm birth risk. <b><i>Methods:</i></b> 145 Han Chinese women with preterm delivery and 157 Han Chinese women with term delivery were recruited in Shanghai. Dietary choline intake during pregnancy was assessed using a validated food frequency questionnaire. Additionally, DNA samples were genotyped for PEMT rs7946 (G5465A) with plasma homocysteine (Hcy) levels measured. <b><i>Results:</i></b> Compared with the lowest quartile of choline intake, women within the highest consumption quartile had adjusted odds ratio (aOR) for preterm birth of 0.48 (95% confidence interval, CI [0.24, 0.95]). There was a significant interaction between maternal choline intake and PEMT rs7946 (<i>p</i> for interaction = 0.04), where the AA genotype carriers who consumed the energy-adjusted choline &#x3c;255.01 mg/day had aOR for preterm birth of 3.75 (95% CI [1.24, 11.35]), compared to those with GG genotype and choline intake &#x3e;255.01 mg/day during pregnancy. Additionally, the greatest elevated plasma Hcy was found in the cases with AA genotype and choline consumption &#x3c;255.01 mg/day (<i>p</i> &#x3c; 0.001). <b><i>Conclusion:</i></b> The AA genotype of PEMT rs7946 may be associated with increased preterm birth in these Han Chinese women with low choline intake during pregnancy.

scholarly journals Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Juan Xia ◽  
Chunyue Guo ◽  
Kuo Liu ◽  
Yunyi Xie ◽  
Han Cao ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Cardiovascular Disease ◽  
Chinese Population ◽  
Left Ventricular Mass Index ◽  
Mendelian Randomization ◽  
Left Ventricular ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Internal Dimension

Abstract Background There is a well-documented empirical relationship between lipoprotein (a) [Lp(a)] and cardiovascular disease (CVD); however, causal evidence, especially from the Chinese population, is lacking. Therefore, this study aims to estimate the causal association between variants in genes affecting Lp(a) concentrations and CVD in people of Han Chinese ethnicity. Methods Two-sample Mendelian randomization analysis was used to assess the causal effect of Lp(a) concentrations on the risk of CVD. Summary statistics for Lp(a) variants were obtained from 1256 individuals in the Cohort Study on Chronic Disease of Communities Natural Population in Beijing, Tianjin and Hebei. Data on associations between single-nucleotide polymorphisms (SNPs) and CVD were obtained from recently published genome-wide association studies. Results Thirteen SNPs associated with Lp(a) levels in the Han Chinese population were used as instrumental variables. Genetically elevated Lp(a) was inversely associated with the risk of atrial fibrillation [odds ratio (OR), 0.94; 95% confidence interval (95%CI), 0.901–0.987; P = 0.012)], the risk of arrhythmia (OR, 0.96; 95%CI, 0.941–0.990; P = 0.005), the left ventricular mass index (OR, 0.97; 95%CI, 0.949–1.000; P = 0.048), and the left ventricular internal dimension in diastole (OR, 0.97; 95%CI, 0.950–0.997; P = 0.028) according to the inverse-variance weighted method. No significant association was observed for congestive heart failure (OR, 0.99; 95% CI, 0.950–1.038; P = 0.766), ischemic stroke (OR, 1.01; 95%CI, 0.981–1.046; P = 0.422), and left ventricular internal dimension in systole (OR, 0.98; 95%CI, 0.960–1.009; P = 0.214). Conclusions This study provided evidence that genetically elevated Lp(a) was inversely associated with atrial fibrillation, arrhythmia, the left ventricular mass index and the left ventricular internal dimension in diastole, but not with congestive heart failure, ischemic stroke, and the left ventricular internal dimension in systole in the Han Chinese population. Further research is needed to identify the mechanism underlying these results and determine whether genetically elevated Lp(a) increases the risk of coronary heart disease or other CVD subtypes.

scholarly journals Distributive characteristics of the CYP2C9 and AGTR1 genetic polymorphisms in Han Chinese hypertensive patients: a retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Keping Chen ◽  
Peng Xiao ◽  
Guochun Li ◽  
Chunling Wang ◽  
Chuankun Yang
Keyword(s):  
Genetic Polymorphisms ◽  
Venous Blood ◽  
Gene Chip ◽  
Han Chinese ◽  
Genotype Frequency ◽  
Wild Type ◽  
Angiotensin Ii Receptor ◽  
Hypertensive Patients ◽  
Genotype Frequencies ◽  
Combined Genotypes

Abstract Background There is an individual variation in response to antihypertensive effect of the angiotensin II receptor antagonist. This study aimed to determine the allele and genotype frequencies of CYP2C9 and AGTR1 genetic polymorphisms and explore the potential role of these polymorphisms in guiding the selection of angiotensinIIreceptor antagonist in Han Chinese hypertensive patients. Methods Totally 2419 Han Chinese hypertensive patients and 126 normotensive controls were recruited in this study. Venous blood samples were collected from each patient, and the genetic polymorphisms of CYP2C9 and AGTR1 were assessed using a gene chip platform. The allele and genotype frequency of each gene and the combined genotypes in this study were analyzed respectively. Results The gene chip analysis identified an allelic frequency of 96.51% for CYP2C9*1 and 3.49% for CYP2C9*3 in the cohort of Han Chinese hypertensive patients. Statistical analysis showed that the frequency of wild-type homozygous for CYP2C9*1/*1 was 93.30%, while the frequency of heterozygous for *1/*3 or mutant homozygous for *3/*3 was 6.41% or 0.29%. Meanwhile, we detected allelic frequencies of 95.06% and 4.94% for the A and C allele of AGTR1, respectively. While the genotype frequency of wild-type homozygous for AA was 90.41%, the frequency of heterozygous for AC or mutant homozygous for CC was 9.30% or 0.29%. Notably, we observed that 84.66% (2048/2419) of the subjects exhibited a combined genotype of CYP2C9 and AGTR1 as *1/*1 + AA, while the combined genotypes *3/*3 + AC or *3/*3 + CC were not detected in hypertension patients. Besides, no significant association was found between normotensive controls and hypertensive patients, or among the three grades of hypertensive patients. Conclusions These data revealed the polymorphisms characteristics of CYP2C9 and AGTR1 in Han Chinese hypertensive patients, providing valuable information for genotype-based antihypertension therapy in prospective clinical studies in the future.

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