Domain-Specific Marker Recognition Method to Improve Marker Efficiency and Reusability

Recent studies on the development of face processing argue for a late, quantitative, domain-specific development of face processing, and face memory in particular. Most previous findings were based on separately tracking the developmental course of face perception skills, comparing performance across different age groups. Here, we adopted a different approach studying the mechanisms underlying the development of face processing by focusing on how different face skills are interrelated over the years (age 6 to adulthood). Specifically, we examined correlations within and between different categories of tasks: face domain-specific skills involving face recognition based on long-term representations (famous face), and short-term memory retention (Cambridge Face Memory Test), perceptual face-specific marker (inversion effect), global effects in scene perception (global–local task), and the perception of facial expressions. Factor analysis revealed that face identity skills have a similar pattern of interrelations throughout development, identifying two factors: a face domain-specific factor comprising adultlike markers of face processing and a general factor incorporating related, but nonspecific perceptual skills. Domain-specific age-related changes in face recognition entailing short- and long-term retention of face representations were observed, along with mature perceptual face-specific markers and more general perceptual effects predicting face perception skills already at age 6. The results suggest that the domain-specific changes in face processing are unlikely to result from developmental changes in perceptual skills driving face recognition. Instead, development may either involve improvement in the ability to retain face representations in memory or changes in the interactions between the perceptual representations of faces and their representations in long-term memory.

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A domain-specific marker for the hepatocyte plasma membrane: localization of leucine aminopeptidase to the bile canalicular domain.

The Journal of Cell Biology ◽

10.1083/jcb.96.6.1548 ◽

1983 ◽

Vol 96 (6) ◽

pp. 1548-1558 ◽

Cited By ~ 58

Author(s):

L M Roman ◽

A L Hubbard

Keyword(s):

Plasma Membrane ◽

Plasma Membranes ◽

Leucine Aminopeptidase ◽

Soluble Fraction ◽

Specific Marker ◽

Intracellular Staining ◽

Chemical Similarity ◽

Major Band ◽

Domain Specific ◽

Sds Page

Indirect immunofluorescence was used to establish a domain-specific marker for hepatocyte plasma membranes. In frozen sections of fixed rat liver (0.5-4 microns), antibodies directed against rat intestinal leucine aminopeptidase (LAP) recognized an antigen that was restricted to the bile canalicular plasma membrane. Fluorescence was not observed on the sinusoidal or lateral membranes, and intracellular staining was not detected. The liver antigen was identified as LAP, based on its chemical similarity to intestinal LAP. First, immunoprecipitation experiments using trypsin-solubilized intestinal LAP (G-200 fraction, 91% pure) established a correlation between the loss of LAP enzyme activity from the soluble fraction and the appearance in the specific immunoprecipitates of polypeptides migrating on SDS PAGE between 110,000 and 130,000 daltons. The antigen precipitated from a detergent extract of liver plasma membranes had the same electrophoretic mobility. Second, the chymotryptic map of the major band in the liver immunoprecipitate was similar to that of purified intestinal LAP.

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A domain-specific marker for the hepatocyte plasma membrane. III. Isolation of bile canalicular membrane by immunoadsorption.

The Journal of Cell Biology ◽

10.1083/jcb.98.4.1497 ◽

1984 ◽

Vol 98 (4) ◽

pp. 1497-1504 ◽

Cited By ~ 15

Author(s):

L M Roman ◽

A L Hubbard

Keyword(s):

Plasma Membrane ◽

Solid Phase ◽

Companion Paper ◽

Specific Marker ◽

Membrane Phospholipids ◽

Domain Specific ◽

Cell Biol ◽

Bile Canalicular Membrane ◽

Nadh Cytochrome ◽

Uniform Membrane

Previous immunolabeling studies (Roman, L.M., and A.L. Hubbard, 1983, J. Cell Biol., 96:1548-1558; Roman, L.M., and A.L. Hubbard, 1984, J. Cell Biol., 98:1488-1496, companion paper) established leucine aminopeptidase (LAP) as a specific marker for the bile canalicular (BC) domain of the rat hepatocyte plasma membrane (PM). In this study, we have isolated membrane from a sonicated PM vesicle fraction using anti-LAP-coated Staphylococcus aureus cells as a solid-phase immunoadsorbent. The extent and specificity of the immunoadsorption were assessed by following the behavior of LAP (the BC marker) and 32P-labeled membrane phospholipids (a uniform membrane marker). The BC fraction obtained was significantly enriched in LAP (yield: greater than 70% of PM-LAP). Alkaline phosphatase, 5'-nucleotidase, and a 110,000-dalton glycoprotein, HA-4, were enriched in the BC fraction to the same extent as LAP (enzyme or antigen/LAP = 1.0). However, alkaline phosphodiesterase I was not enriched to the same degree (enzyme/LAP = 0.5). Contamination of this BC fraction by membrane derived from the sinusoidal domain and endoplasmic reticulum, as determined from the distribution of the asialoglycoprotein receptor and NADH cytochrome c reductase, respectively, was small (less than 13%).

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Improving term candidates selection using terminological tokens

Terminology ◽

10.1075/term.00016.vaz ◽

2018 ◽

Vol 24 (1) ◽

pp. 122-147

Author(s):

Mercè Vàzquez ◽

Antoni Oliver

Keyword(s):

Candidate Selection ◽

Recognition Method ◽

Candidate List ◽

Filtering Method ◽

Domain Specific ◽

Term Extraction ◽

Automatic Term Extraction ◽

Statistical Approaches ◽

Term Candidate ◽

Statistical Term

Abstract The identification of reliable terms from domain-specific corpora using computational methods is a task that has to be validated manually by specialists, which is a highly time-consuming activity. To reduce this effort and improve term candidate selection, we implemented the Token Slot Recognition method, a filtering method based on terminological tokens which is used to rank extracted term candidates from domain-specific corpora. This paper presents the implementation of the term candidates filtering method we developed in linguistic and statistical approaches applied for automatic term extraction using several domain-specific corpora in different languages. We observed that the filtering method outperforms term candidate selection by ranking a higher number of terms at the top of the term candidate list than raw frequency, and for statistical term extraction the improvement is between 15% and 25% both in precision and recall. Our analyses further revealed a reduction in the number of term candidates to be validated manually by specialists. In conclusion, the number of term candidates extracted automatically from domain-specific corpora has been reduced significantly using the Token Slot Recognition filtering method, so term candidates can be easily and quickly validated by specialists.

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Elevated plasma MB creatine phosphokinase activity. A specific marker for myocardial infarction in perioperative patients

Archives of Internal Medicine ◽

10.1001/archinte.136.4.421 ◽

1976 ◽

Vol 136 (4) ◽

pp. 421-424 ◽

Cited By ~ 6

Author(s):

R. Roberts

Keyword(s):

Myocardial Infarction ◽

Creatine Phosphokinase ◽

Specific Marker ◽

Elevated Plasma

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Scientific Problem Solving in a Virtual Laboratory: A Comparison Between Individuals and Pairs

Swiss Journal of Psychology ◽

10.1024/1421-0185.67.2.71 ◽

2008 ◽

Vol 67 (2) ◽

pp. 71-83 ◽

Cited By ~ 5

Author(s):

Yolanda A. Métrailler ◽

Ester Reijnen ◽

Cornelia Kneser ◽

Klaus Opwis

Keyword(s):

Visual Search ◽

Problem Solving ◽

Process Data ◽

Scientific Problem ◽

Domain Specific ◽

Scientific Problem Solving ◽

Before And After ◽

Verbal Data ◽

Psychological Knowledge ◽

Problem Solving Task

This study compared individuals with pairs in a scientific problem-solving task. Participants interacted with a virtual psychological laboratory called Virtue to reason about a visual search theory. To this end, they created hypotheses, designed experiments, and analyzed and interpreted the results of their experiments in order to discover which of five possible factors affected the visual search process. Before and after their interaction with Virtue, participants took a test measuring theoretical and methodological knowledge. In addition, process data reflecting participants’ experimental activities and verbal data were collected. The results showed a significant but equal increase in knowledge for both groups. We found differences between individuals and pairs in the evaluation of hypotheses in the process data, and in descriptive and explanatory statements in the verbal data. Interacting with Virtue helped all students improve their domain-specific and domain-general psychological knowledge.

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Emotions and health: The impact of emotions, emotions regulation, music, and acculturation on health

Zeitschrift für Gesundheitspsychologie ◽

10.1026/0943-8149.16.3.112 ◽

2008 ◽

Vol 16 (3) ◽

pp. 112-115 ◽

Cited By ~ 1

Author(s):

Stephan Bongard ◽

Volker Hodapp ◽

Sonja Rohrmann

Keyword(s):

Stress Responses ◽

Physiological Stress ◽

Anger Expression ◽

Domain Specific ◽

Cardiovascular Stress ◽

Expression Behavior ◽

Cardio Vascular ◽

And Coping ◽

Relationship Of ◽

The Impact

Abstract. Our unit investigates the relationship of emotional processes (experience, expression, and coping), their physiological correlates and possible health outcomes. We study domain specific anger expression behavior and associated cardio-vascular loads and found e.g. that particularly an open anger expression at work is associated with greater blood pressure. Furthermore, we demonstrated that women may be predisposed for the development of certain mental disorders because of their higher disgust sensitivity. We also pointed out that the suppression of negative emotions leads to increased physiological stress responses which results in a higher risk for cardiovascular diseases. We could show that relaxation as well as music activity like singing in a choir causes increases in the local immune parameter immunoglobuline A. Finally, we are investigating connections between migrants’ strategy of acculturation and health and found e.g. elevated cardiovascular stress responses in migrants when they where highly adapted to the German culture.

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Measurement Invariance of Divergent Thinking Across Gender, Age, and School Forms

European Journal of Psychological Assessment ◽

10.1027/1015-5759.25.1.1 ◽

2009 ◽

Vol 25 (1) ◽

pp. 1-7 ◽

Cited By ~ 12

Author(s):

Jörg-Tobias Kuhn ◽

Heinz Holling

Keyword(s):

Measurement Invariance ◽

Divergent Thinking ◽

Factor Model ◽

Age Groups ◽

Thinking Skills ◽

Specific Model ◽

Confirmatory Factor Analyses ◽

Domain Specific ◽

Gender And Age ◽

Confirmatory Factor

The present study explores the factorial structure and the degree of measurement invariance of 12 divergent thinking tests. In a large sample of German students (N = 1328), a three-factor model representing verbal, figural, and numerical divergent thinking was supported. Multigroup confirmatory factor analyses revealed that partial strong measurement invariance was tenable across gender and age groups as well as school forms. Latent mean comparisons resulted in significantly higher divergent thinking skills for females and students in schools with higher mean IQ. Older students exhibited higher latent means on the verbal and figural factor, but not on the numerical factor. These results suggest that a domain-specific model of divergent thinking may be assumed, although further research is needed to elucidate the sources that negatively affect measurement invariance.

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