AbstractThe novel design of a rectangular external loop airlift reactor is at present the most used large-scale reactor for microalgae culture. It has a unique future for a large surface to volume ratio for exposure of light radiation for photosynthesis reaction. The 3D simulations have been performed in rectangular EL-ALR. The Eulerian–Eulerian approach has been used with a dispersed gas phase for different turbulent models. The performance and applicability of different turbulent model’s i.e., K-epsilon standard, K-epsilon realizable, K-omega, and Reynolds stress model are used and compared with experimental results. All drag forces and non-drag forces (turbulent dispersion, virtual mass, and lift coefficient) are included in the model. The experimental values of overall gas hold-up and average liquid circulation velocity have been compared with simulation and literature results. It is seemed to give good agreements. For the different elevations in the downcomer section, liquid axial velocity, turbulent kinetic energy, and turbulent eddy dissipation experimental have been compared with different turbulent models. The K-epsilon Realizable model gives better prediction with experimental results.