Clinical Research Work with Computerized, Structured Records and Advanced Computer Programs

Author(s):  
M. Levander-Lindgren ◽  
O. Gardfjell
2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 161s-161s
Author(s):  
J. Khader

Background and context: The need for international and regional collaboration in cancer care has grown stronger as we have made progress in both cancer treatment and screening. We sought to share our unique and successful experience at King Hussein Cancer Center (KHCC) in Jordan and to identify those efforts already underway, which facilitate such collaboration and lead to raise up the cancer care in Jordan to highest levels. Aim: To strengthen cancer care in Jordan. Strategy/Tactics: Over 15 years, KHCC succeeded in binding with well reputed international cancer centers, like MD Anderson Cancer Center, Princess Margret Hospital, St June Cancer Center, Sick Hospital Cancer Center and Moffit Cancer Center, through twinning programs and collaborative agreements to improve capacity building, holding joint scientific activities like joint telemedicine tumor boards, symposia, workshops, and clinical research. Outcomes: Through such international collaboration, KHCC could reach a highest level of cancer care and considered as a hub in the region for cancer treatment, training and research. This great achievement was not possible without this effective collaboration with these international cancer centers. Many clinical programs have been initiated at KHCC because of this collaboration, which lead to joint clinical research work and publication. What was learned: International collaboration between cancer centers in developing countries and developed countries is very beneficial and can reduce the gap in cancer care. The successful experience of KHCC in this regard should admire cancer centers in developing countries to consider it and adopt it.


2016 ◽  
Vol 7 (2) ◽  
Author(s):  
Tahera Ahmed Ahmed

Hello readers! Hope everyone is fine especially in this season where we often are prone to attacks of cold or flu. The holiday season is at our threshold, and we wish everyone to be in the best of health and happiness.This issue of the BJB is very interesting with topics stretching from Non Communicable Diseases to the ethical issues related to the habitation of the planet Mars, and proves how forward looking are our readers and authors.Mohammad Rashedul Islam et al discuss the application of the SARA method in a district in Bangladesh. The method is based on the principle of Service Availability and Readiness Assessment of WHO. The study in a district in Bangladesh found that about 62% of all the facilities were ready to provide general services like basic amenities with basic equipment, standard precautions for infection prevention, diagnostic capacity and essential medicines. However in case of Non-Communicable Diseases (NCD), only 40% of the health facilities had chronic respiratory disease and cardiovascular diseases diagnosis/management and only 32% had availability of diabetes diagnosis/management. Therefore, service availability and readiness of the health facilities to provide NCD related health services were not satisfactory. The authors emphasize that SARA which is a tool to monitor facilities to be ready for provision of services including NCD, should be used by all clinic managers.The very scientific and forward looking article titled “SCNT Method and the Application for Patent Eligibility on Cloned Animals” by Norman K. Swazo reviews US federal court decisions regarding applications for patent in the case of live-born animal clones. A decision issued from the United States Court of Appeals for the Federal Circuit established an earlier decision of the Patent Trial and Appeal Board that live-born animals cloned by the somatic cell nuclear transfer method (SCNT) like cattle, sheep, pigs, and goats are not patentable, so a scientist using the method is not eligible for a patent claim on the animals. The author feels that this decision has ethical implications related to the moral status of cloned animals. The author argues whether the end product of a SCNT (somatic cell nuclear transfer) application is same as an invention or   only a revelation of nature at the cellular level. The author quotes Article 11 of Universal Declaration on the Human Genome and Human Rights UNDHGR “Practices which are contrary to human dignity, such as reproductive cloning of human beings, shall not be permitted.” He concludes that the judicial assessments in the USA deciding on the question of patenting of animal clones provide important barriers to human reproductive cloning research, safeguarding moral and legal commitment to human dignity.  The article on Ethics in Public Health Research and Clinical Research by Muhammad Waseem Khanet al discusses on the need to continue to focus on ethical values in conducting any research. Tha authors stress the importance, either in public health research or clinical research, of the need to  recognize an ethical standard that respects individual’s autonomy and community’s wellbeing. This can be achieved through collective collaboration for the protection of individual’s autonomy, dignity and wellbeing. Research ethics is a fundamental criterion to be complied with throughout a research study. The very interesting article on Planetary Protection for Mars: Time for Reconsideration by Svetoslav Alexandrov looks into the ethical questions beyond mother earth but which could be affected by people from our planet. In this manuscript the author discusses the ethics of the protection of hypothetical organisms on Mars in terms of planned manned space missions and subsequent colonization. The author discusses the possible problems related to a process called terraformation where the planet is converted to make it suitable for Earth life. He argues that terraformation will change the whole condition of the planet. The author quotes Carl Sagan, of The Planetary Society: “If there is life, then I believe we should do nothing to disturb that life. Mars then, belongs to the Martians, even if they are microbes” . I think we all agree with this brilliant recommendation.The article ‘We Still Need to Improve Our Research Writing Ethics’ by Sheikh Arslan Sehgal looks into the value of maintaining professional integrity of research work. Particularly with issues like plagiarism, ethics, authorship and data fabrication. He argues that the scientific community must obey the scientific ethical norms and rules. He feels that ethical problems must be resolved for the advancement of research in countries including Pakistan. The author recommends teaching students the international, institutional and professional standards regarding research and authorship issue. Thus from the beginning researchers will know the key components of ethics in conducting research and the end product will be research work of quality and acceptability.Dear Readers, we look forward to your articles, commentaries, observations on different issues which touch our lives and will help in broadening our knowledge and understanding of Bioethics.


Author(s):  
Mohammad Anas ◽  
Mohiuddeen Khan ◽  
Hammad Basit

Usually, evolutionary algorithms are used to provide strong approximations to problems that are difficult to solve with other methods. Gene expression programming (GEP) is a type of evolutionary algorithm used in computer programming to generate computer programs or models. These computer programs are complex tree structures that, like a living organism, learn and adapt by modifying their sizes, shapes, and composition. In the present work, a comparison study was made among GEP and the standard prediction techniques to find the best predicting model on the BOSTON HOUSING dataset. Three approaches viz. GEP, ANN and polynomial regression were implemented on the dataset. The study showed how the three methods solve the problem of high bias and high variance and which one outperforms the other. The research work, however, gave a glimpse of the actual limitations and advantages of the methods on one another indicating the dependency of method on the type of data used. The results conclude the comparison of different methods on different performance metrics. The GEP model however reduced the problem of high bias and high variance by giving a slight difference between the train and test accuracy but was not able to outperform ANN and polynomial regression in terms of performance metrics.


2020 ◽  
Vol 8 (10) ◽  
pp. 4858-4865
Author(s):  
Anita 1 ◽  
Sujata Kadam ◽  
Meenakshi Pandey

Background: Yonidhoopana means the fumigation of vulva and vagina is the special local therapy men-tioned in Ayurveda classics in different yonivyapada, sukhprasava and sutika. It is an inseparable part of therapeutics in gynaecological disorders maintain sterilized external and internal environment of genitals. Various dhoopana drugs has been described in Bruhatrayi and Kashyapa Samhita that have Katu, Tikta, Laghu, Ruksha and Ushna properties on heating, get converted into volatile fumes cause dilatation and ox-idation of blood vessels and increase tissue perfusion. This antiseptic and sterilised environment of vagina is depicted by analgesic, anti-inflammatory and antimicrobial effect of Dhoopana. Various clinical research work related to yonidhoopana and antimicrobial effect of dhoopana has been conducted. Materials & Methods: Ayurvedic Samhita (Bruhtrayi), Kashyapa Samhita and literatures of striroga & prasuti tantra were studied out thoroughly. Original clinical research works, and review articles related to dhoopana were searched through online database search engine like Pubmed online, Researchgate, and Google scholar. Eight articles were selected and concluded. Discussion & Results: Yonidhoopana is very effective Sthani-ka chikitsa in yoniroga chikitsa, sukhprasava and sutikaparicharya due to its krimighna, kandughna, shothahara, vranaropaka, kledashoshaka effect in vulva and vagina. Hence, it is significantly proved in clinical research work of YONIDHOOPANA and antimicrobial dhoopana karma. Conclusion: Yonidhoopana has bacteriostatic action, economical, easy to perform and effective antimicrobial and anti-inflammatory procedure without any harmful effects.


1992 ◽  
Vol 25 (1) ◽  
pp. 29-42 ◽  
Author(s):  
Leslie A. Lenert ◽  
Jon Lurie ◽  
Lewis B. Sheiner ◽  
Robert Coleman ◽  
Heidrun Klostermann ◽  
...  

1897 ◽  
Vol 43 (180) ◽  
pp. 106-109 ◽  

We conceive that the ideal position of a pathologist is that in which his laboratory stands in direct communication with the wards of an institution—whether hospital or asylum—rendering intercourse with those engaged in clinical research easy, whilst he himself is absolutely free to prosecute his special studies. To expect the laboratory worker to undertake clinical, a fortiori, administrative duties appears unphilosophical, an incongruity, an indication of imperfect appreciation of the value of time and specialised energy. Those who have experience of the exacting nature of research work will, we believe, at once concede that nothing can be more irritating nor more detrimental to good work than to have to relinquish temporarily some absorbing laboratory pursuit in order to engage in the work of the office or the wards. In medical circles in this country we are unfortunately only too familiar with this mélange of occupations, this professional polymorphism, in consequence of which our leading men are compelled to appear in various characters during the course of a day, exchanging frock-coat for laboratory blouse, and this again for lecturer's gown, throughout manifesting an adaptability truly astonishing. But such versatility, admirable in itself, is necessarily inconsistent with steady progress in special directions. It is therefore no wonder that in research work there is danger of lagging behind our continental confrères, labouring consistently in special departments of science, and less concerned with the commercial potentialities of professional life, as we know it.


1989 ◽  
Vol 34 (5) ◽  
pp. 364-368 ◽  
Author(s):  
Paul E. Garfinkel ◽  
Sidney H. Kennedy ◽  
Allan S. Kaplan ◽  
David S. Goldbloom

The Clinical Investigation Unit has served as a natural focus for clinical research; as such it has a number of advantages and specific problems. On such units a variety of themes may occur. Some of these have the potential to interfere with the integration of clinical and research work. These include the theme that the research itself is therapy, or that research will find all the answers. Both may result in problems for the functioning of the ward. Most problematic of all is the theme that research is harmful and exploitative. Optimally, the unit develops an attitude that the research is compatible with excellent patient care. Problems of patients, staff, ethical issues, admissions policies and problems of the clinician-scientists are reviewed with recommendations on how to minimize difficulties.


Radiology ◽  
1933 ◽  
Vol 20 (2) ◽  
pp. 99-102 ◽  
Author(s):  
Albert Soiland

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