Theoretical Analysis of the Role of Rydberg States in the Photochemistry of Some Small molecules

1980 ◽  
pp. 261-284 ◽  
Author(s):  
E. M. Evleth ◽  
E. Kassab
Keyword(s):  
Theoretical Analysis ◽  
Small Molecules ◽  
Rydberg States

The role of S and Mo doping on the dissociation of water molecule on FeOCl surface: Experimental and theoretical analysis

2021 ◽  
pp. 131353
Author(s):  
Xiao Liu ◽  
Wenyi Zhang ◽  
Mingguo Peng ◽  
Guangqun Zhai ◽  
Linchao Hu ◽  
...  
Keyword(s):  
Theoretical Analysis ◽  
Water Molecule ◽  
Mo Doping

The role of high Rydberg states in enhanced O-formation in a pulsed O2discharge

1999 ◽  
Vol 8 (3) ◽  
pp. 384-391 ◽  
Author(s):  
W X Ding ◽  
L A Pinnaduwage ◽  
C Tav ◽  
D L McCorkle
Keyword(s):  
Rydberg States

scholarly journals Role of SpoVA Proteins in Release of Dipicolinic Acid during Germination of Bacillus subtilis Spores Triggered by Dodecylamine or Lysozyme

2006 ◽  
Vol 189 (5) ◽  
pp. 1565-1572 ◽  
Author(s):  
Venkata Ramana Vepachedu ◽  
Peter Setlow
Keyword(s):  
Bacillus Subtilis ◽  
Small Molecules ◽  
Spore Germination ◽  
Dipicolinic Acid ◽  
Temperature Sensitive ◽  
Wild Type ◽  
Ph Optimum ◽  
Inner Membrane ◽  
Temperature Sensitive Mutants

ABSTRACT The release of dipicolinic acid (DPA) during the germination of Bacillus subtilis spores by the cationic surfactant dodecylamine exhibited a pH optimum of ∼9 and a temperature optimum of 60°C. DPA release during dodecylamine germination of B. subtilis spores with fourfold-elevated levels of the SpoVA proteins that have been suggested to be involved in the release of DPA during nutrient germination was about fourfold faster than DPA release during dodecylamine germination of wild-type spores and was inhibited by HgCl2. Spores carrying temperature-sensitive mutants in the spoVA operon were also temperature sensitive in DPA release during dodecylamine germination as well as in lysozyme germination of decoated spores. In addition to DPA, dodecylamine triggered the release of amounts of Ca2+ almost equivalent to those of DPA, and at least one other abundant spore small molecule, glutamic acid, was released in parallel with Ca2+ and DPA. These data indicate that (i) dodecylamine triggers spore germination by opening a channel in the inner membrane for Ca2+-DPA and other small molecules, (ii) this channel is composed at least in part of proteins, and (iii) SpoVA proteins are involved in the release of Ca2+-DPA and other small molecules during spore germination, perhaps by being a part of a channel in the spore's inner membrane.

Evaluation-driven design of a robust coreference resolution system

2003 ◽  
Vol 9 (3) ◽  
pp. 281-306 ◽  
Author(s):  
ANDREI POPESCU-BELIS
Keyword(s):  
Working Memory ◽  
Theoretical Analysis ◽  
Coreference Resolution ◽  
Knowledge Sources ◽  
Narrative Texts ◽  
Data Annotation ◽  
Evaluation Measures ◽  
Optimal Behavior ◽  
Resolution System

In this paper, we describe a system for coreference resolution and emphasize the role of evaluation for its design. The goal of the system is to group referring expressions (identified beforehand in narrative texts) into sets of coreferring expressions that correspond to discourse entities. Several knowledge sources are distinguished, such as referential compatibility between a referring expression and a discourse entity, activation factors for discourse entities, size of working memory, or meta-rules for the creation of discourse entities. For each of them, the theoretical analysis of its relevance is compared to scores obtained through evaluation. After looping through all knowledge sources, an optimal behavior is chosen, then evaluated on test data. The paper also discusses evaluation measures as well as data annotation, and compares the present approach to others in the field.

Interactions of small molecules with TiO2(110) surfaces: The role of defects

1996 ◽  
Vol 14 (3) ◽  
pp. 1532-1538 ◽  
Author(s):  
Li‐Qiong Wang ◽  
A. N. Shultz ◽  
D. R. Baer ◽  
M. H. Engelhard
Keyword(s):  
Small Molecules

The Role of Membranes in the Transport of Small Molecules

2018 ◽  
pp. 1-52 ◽  
Author(s):  
J. E. Leonard ◽  
C. A. Lee ◽  
A. J. Apperson ◽  
S. S. Dills ◽  
M. H. Saier
Keyword(s):  
Small Molecules

scholarly journals Minimal mechanistic component of proteasome activation and prevention of impairment by pathological oligomers

2021 ◽  
Author(s):  
Janelle Chuah ◽  
Tifffany Thibaudeau ◽  
David Smith
Keyword(s):  
Small Molecules ◽  
Conformational Changes ◽  
Bound State ◽  
Proof Of Concept ◽  
Α Subunit ◽  
Gate Opening ◽  
Allosteric Mechanism ◽  
Dependent Mechanism ◽  
Degradation Of Peptides

Abstract Impairment of proteasomal function has been implicated in neurodegenerative diseases, justifying the need to understand how the proteasome is activated for protein degradation. Here, using biochemical and structural (cryo-EM) strategies in both archaeal and mammalian proteasomes, we further determine the HbYX(-motif)-dependent mechanism of proteasomal activation used by multiple proteasome-activating complexes including the 19S Particle. We identify multiple proteasome α subunit residues involved in HbYX-dependent activation, a point mutation that activates the proteasome by partially mimicking a HbYX-bound state, and conformational changes involved in gate-opening with a 2.0A structure. Through an iterative process of peptide synthesis, we successfully design a HbYX-like dipeptide mimetic as a robust tool to elucidate how the motif autonomously activates the proteasome. The mimetic induces near complete gate-opening at saturating concentration, activating mammalian proteasomal degradation of peptides and proteins. Findings using our peptide mimetic suggest the HbYX-dependent mechanism requires cooperative binding in at least two intersubunit pockets of the α ring. Collectively, the results presented here unambiguously demonstrate the lone role of the HbYX tyrosine in the allosteric mechanism of proteasome activation and offer proof of concept for the robust potential of HbYX-like small molecules to activate the proteasome.

scholarly journals Causal role of L-glutamine in sickle cell disease painful crises: a Mendelian randomization analysis

2019 ◽  
Author(s):  
Yann Iboudo ◽  
Melanie E. Garrett ◽  
Pablo Bartolucci ◽  
Carlo Brugnara ◽  
Clary B. Clish ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Small Molecules ◽  
Causal Relationship ◽  
Sickle Cell ◽  
Drug Targets ◽  
Mendelian Randomization ◽  
Cell Disease ◽  
Aseptic Necrosis ◽  
Randomization Analysis

ABSTRACTIn a recent clinical trial, the metabolite L-glutamine was shown to reduce painful crises in sickle cell disease (SCD) patients. To confirm this observation and identify other metabolites implicated in SCD clinical heterogeneity, we profiled 129 metabolites in the plasma of 705 SCD patients. We tested correlations between metabolite levels and six SCD-related complications (painful crises, cholecystectomy, retinopathy, leg ulcer, priapism, aseptic necrosis) or estimated glomerular filtration rate (eGFR), and used Mendelian randomization (MR) to assess causality. We found a causal relationship between L-glutamine levels and painful crises (N=1,278, odds ratio (OR) [95% confidence interval] = 0.68 [0.52 – 0.89], P=0.0048). In two smaller SCD cohorts (N=299 and 406), the protective effect of L-glutamine was observed (OR=0.82 [0.50-1.34]), although the MR result was not significant (P=0.44). We identified 66 significant correlations between the levels of other metabolites and SCD-related complications or eGFR. We tested these correlations for causality using MR analyses and found no significant causal relationship. The baseline levels of quinolinic acid was associated with prospectively ascertained survival in SCD patients, and this effect was dependent on eGFR. Metabolomics provide a promising approach to prioritize small molecules that may serve as biomarkers or drug targets in SCD.

scholarly journals Peranan Tuan Guru Ormas Islam Nahdlatul Wathan di Lombok Wadah Ajaran Keagamaan dan Sosial (Islam)

2021 ◽  
Vol 5 (2) ◽  
pp. 221
Author(s):  
Jun Mawalidin
Keyword(s):  
Theoretical Analysis ◽  
Research Method ◽  
Religious Life ◽  
Religious Expression ◽  
Religious Traditions ◽  
Library Research ◽  
Mass Organization ◽  
Very High ◽  
High Place

<p class="05Abstrak">Abstract</p><p class="06IsiAbstrak">The teachings of Islam for the Sasak people get a very high place in carrying out their daily religious life in accordance with the teachings of their religion. The purpose of this study is to analyze theoretical analysis on Islamic religious traditions that have existed in the Sasak community since the beginning of their entry, placing more emphasis on strengthening religious practices or rituals that at a glance place great importance on religious expression. This research method uses the library research method about the role of the Nahdlatul Wathan Islamic mass organization figure in Lombok. The results showed that Nahdlatul Wathan focused on three areas of development, namely education, social and da'wah. The presence of Tuan Guru on the island of a thousand mosques gives a different feel. Bahklan is a characteristic of society, its influence can be felt in various fields, not only in the field of education, in politics but also in the executive field. </p><p class="06IsiAbstrak"><strong>Keywords:</strong> Tuan Guru, Community, Lombok, Nahdlatul Wathan.</p><p class="061AbstrakIndonesia">Abstrak</p><p class="061IsiAbstrakIndoneia">Ajaran Islam bagi masyarakat sasak mendapatkan tempat yang sangat tinggi dalam menjalankan kehidupan keagamaannya sehari-hari sesuai dengan ajaran agama yang dianut. Tujuan dari penelitian ini adalah melakukan telaah teori analisis pada Tradisi keagamaan Islam yang terdapat di masyarakat Sasak sejak awal masuknya, lebih menekankan pada penguatan-penguatan amalan atau ritual keagamaan yang secara sepintas sangat mementingkan ekspresi keagamaan. Metode penelitian ini menggunakan metode <em>library research</em> tentang peranan tokoh ormas islam nahdlatul wathan yang ada di lombok. Hasil penelitian menunjukkan bahwa Nahdlatul Wathan fokus pada tiga bidang pembangunan, yaitu pendidikan, sosial dan dakwah. Kehadiran Tuan Guru di pulau seribu masjid memberikan nuansa yang berbeda. Bahklan merupakan ciri khas masyarakat, pengaruhnya dapat dirasakan di berbagai bidang, tidak hanya di bidang pendidikan, di bidang politik tetapi juga di bidang eksekutif.  </p><p class="05Abstrak"><strong>Kata kunci:</strong> Tuan Guru,<em> </em>Masyarakat, Lombok, Nahdlatul Wathan.</p>

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