QT-Variability: Clinical Results and Prognostic Significance

Author(s):  
Hans-H. Osterhues
2021 ◽  
Vol 10 (14) ◽  
pp. 3071
Author(s):  
Bernhard Schwaab ◽  
Birna Bjarnason-Wehrens ◽  
Karin Meng ◽  
Christian Albus ◽  
Annett Salzwedel ◽  
...  

Background: Scientific guidelines have been developed to update and harmonize exercise based cardiac rehabilitation (ebCR) in German speaking countries. Key recommendations for ebCR indications have recently been published in part 1 of this journal. The present part 2 updates the evidence with respect to contents and delivery of ebCR in clinical practice, focusing on exercise training (ET), psychological interventions (PI), patient education (PE). In addition, special patients’ groups and new developments, such as telemedical (Tele) or home-based ebCR, are discussed as well. Methods: Generation of evidence and search of literature have been described in part 1. Results: Well documented evidence confirms the prognostic significance of ET in patients with coronary artery disease. Positive clinical effects of ET are described in patients with congestive heart failure, heart valve surgery or intervention, adults with congenital heart disease, and peripheral arterial disease. Specific recommendations for risk stratification and adequate exercise prescription for continuous-, interval-, and strength training are given in detail. PI when added to ebCR did not show significant positive effects in general. There was a positive trend towards reduction in depressive symptoms for “distress management” and “lifestyle changes”. PE is able to increase patients’ knowledge and motivation, as well as behavior changes, regarding physical activity, dietary habits, and smoking cessation. The evidence for distinct ebCR programs in special patients’ groups is less clear. Studies on Tele-CR predominantly included low-risk patients. Hence, it is questionable, whether clinical results derived from studies in conventional ebCR may be transferred to Tele-CR. Conclusions: ET is the cornerstone of ebCR. Additional PI should be included, adjusted to the needs of the individual patient. PE is able to promote patients self-management, empowerment, and motivation. Diversity-sensitive structures should be established to interact with the needs of special patient groups and gender issues. Tele-CR should be further investigated as a valuable tool to implement ebCR more widely and effectively.


Author(s):  
Karvita B. Ahluwalia ◽  
Nidhi Sharma

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.


1950 ◽  
Vol 14 (2) ◽  
pp. 214-227 ◽  
Author(s):  
Vernon A. Weinstein ◽  
Franklin Hollander ◽  
Frances U. Lauber ◽  
Ralph Colp

2007 ◽  
Vol 177 (4S) ◽  
pp. 127-128
Author(s):  
Michael Muntener ◽  
Jonathan I. Epstein ◽  
David J. Hernandez ◽  
Mark L. Gonzalgo ◽  
Leslie A. Mangold ◽  
...  

2005 ◽  
Vol 173 (4S) ◽  
pp. 218-218 ◽  
Author(s):  
Amir H. Arsanjani ◽  
Madhu Alagiri

2005 ◽  
Vol 2 (2) ◽  
pp. 107-109
Author(s):  
A. Mishra ◽  
M.F. Huda ◽  
V.P. Singh ◽  
S. Mohanty ◽  
A. Sodhi

1998 ◽  
Vol 5 (1) ◽  
pp. 82A-82A
Author(s):  
A MUNKARAH ◽  
L BAZZETT ◽  
F QURESHI ◽  
S JACQUES ◽  
R MORRIS ◽  
...  

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