Conserving Biodiversity of a Potent Anticancer Plant, Catharanthus roseus Through In Vitro Biotechnological Intercessions: Substantial Progress and Imminent Prospects

2018 ◽  
pp. 83-107 ◽  
Author(s):  
Umme Salma ◽  
Suprabuddha Kundu ◽  
Saikat Gantait
Keyword(s):  
Catharanthus Roseus ◽  
Substantial Progress

Time-Course Studies on The Use of Secologanin by Catharanthus roseus Cells Cultured in vitro

1989 ◽  
Vol 134 (5) ◽  
pp. 608-612 ◽  
Author(s):  
F. Naudascher ◽  
P. Doireau ◽  
A. Guillot ◽  
C. Viel ◽  
M. Thiersault
Keyword(s):  
Catharanthus Roseus ◽  
Time Course ◽  
Cells Cultured

In vitro Production of Secondary Metabolites Using Elicitor in Catharanthus roseus: A Case Study

2013 ◽  
pp. 401-419 ◽  
Author(s):  
Zahid Hameed Siddiqui ◽  
Abdul Mujib ◽  
Mahmooduzzafar ◽  
Junaid Aslam ◽  
Khalid Rehman Hakeem ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Catharanthus Roseus ◽  
In Vitro Production ◽  
Vitro Production

scholarly journals Genetic Correction of Sickle Cell Anemia and β-Thalassemia: Progress and New Perspective

2010 ◽  
Vol 10 ◽  
pp. 644-654 ◽  
Author(s):  
Ajay Perumbeti ◽  
Punam Malik
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Globin Genes ◽  
Induced Pluripotent Cells ◽  
Substantial Progress ◽  
Lentivirus Vectors ◽  
New Perspective ◽  
Induced Pluripotent ◽  
New Strategies

Gene therapy for β-globinopathies, particularly β-thalassemia and sickle cell anemia, holds promise for the future as a definitive corrective approach for these common and debilitating disorders. Correction of the β-globinopathies using lentivirus vectors carrying the β- or γ-globin genes and elements of the locus control region has now been well established in murine models, and an understanding of "what is required to cure these diseases" has been developed in the first decade of the 21st century. A clinical trial using one such vector has been initiated in France with intriguing results, while other trials are under development. Vector improvements to enhance the safety and efficiency of lentivirus vectors are being explored, while new strategies, including homologous recombination in induced pluripotent cells, for correction of sickle cell anemia have shown proof-of-conceptin vitro. Here, a review is provided of the current substantial progress in genetic correction of β-globin disorders.

5-Methyltryptophan Resistant Cells of Catharanthus roseus

1979 ◽  
Vol 34 (7-8) ◽  
pp. 541-545 ◽  
Author(s):  
Jürgen Schallenberg ◽  
Jochen Berlin
Keyword(s):  
Catharanthus Roseus ◽  
Indole Alkaloids ◽  
Indole Alkaloid ◽  
Synthetase Activity ◽  
Wild Type ◽  
Free Tryptophan ◽  
Alkaloid Synthesis ◽  
Resistant Cells

Several cell lines resistant to 5-methyltryptophan were selected from wild type cells of different Catharanthus roseus suspension cultures. The resistant cells had up to 30 times tne normal levels of free tryptophan. Despite the increased pool size of tryptophan anthranilate synthetase activity of resistant cells was as sensitive to inhibition by ʟ-tryptophan as wild type cells. The overproduction of tryptophan did not lead to intensified accumulation of tryptamine nor of indole alkaloids. This was supported by a low conversion of tryptophan to tryptamine in vivo and in vitro. The overpro­duction of one of the primary precursors was evidently not sufficient to stimulate the rate of indole alkaloid synthesis in Catharanthus cells.

scholarly journals Contact Allergy to Fragrances: In Vitro Opportunities for Safety Assessment

Cosmetics ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. 3 ◽  
Author(s):  
Emanuela Corsini ◽  
Valentina Galbiati
Keyword(s):  
Safety Assessment ◽  
Contact Allergy ◽  
Hazard Identification ◽  
Quantitative Risk Assessment ◽  
Cosmetic Products ◽  
Animal Testing ◽  
Cosmetic Ingredients ◽  
Substantial Progress ◽  
Allergic Contact

The majority of cosmetic products contain fragrances to make products more pleasant to the consumer, as we all like goods that smell nice. Unfortunately, contact allergy to fragrance compounds is among the most frequent findings in patients with suspected allergic contact dermatitis. In order to revert this and to reduce contact allergy to cosmetics, it is imperative to improve safety assessment of cosmetic products for skin sensitization. In the era of animal ban for cosmetic ingredients, this represents a challenge. Luckily, in the last decades, substantial progress has been made in the understanding of the mechanism of chemical-induced contact allergy and several in vitro methods are available for hazard identification. The purpose of this manuscript is to explore the possibility of non-animal testing for quantitative risk assessment of fragrance-induced contact allergy, essential for cosmetic products, which cannot be tested on animals.

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