Role of Composite Materials in Automotive Sector: Potential Applications

2021 ◽  
pp. 193-217
Author(s):  
Dipen Kumar Rajak ◽  
D. D. Pagar ◽  
A. Behera ◽  
Padeep L. Menezes
Keyword(s):  
Composite Materials ◽  
Automotive Sector ◽  
Potential Applications

The application of virtual reality in health professions� digital education: a narrative review (Preprint)

2018 ◽  
Author(s):  
Lorraine Tudor Car ◽  
Bhone Myint Kyaw ◽  
Josip Car
Keyword(s):  
Virtual Reality ◽  
Professional Education ◽  
Health Professions ◽  
Health Professions Education ◽  
Narrative Review ◽  
Current Evidence ◽  
Future Research ◽  
Educational Content ◽  
Potential Applications

BACKGROUND Digital technology called Virtual Reality (VR) is increasingly employed in health professions’ education. Yet, based on the current evidence, its use is narrowed around a few most applications and disciplines. There is a lack of an overview that would capture the diversity of different VR applications in health professions’ education and inform its use and research. OBJECTIVE This narrative review aims to explore different potential applications of VR in health professions’ education. METHODS The narrative synthesis approach to literature review was used to analyse the existing evidence. RESULTS We outline the role of VR features such as immersion, interactivity and feedback and explain the role of VR devices. Based on the type and scope of educational content VR can represent space, individuals, objects, structures or their combination. Application of VR in medical education encompasses environmental, organ and micro level. Environmental VR focuses on training in relation to health professionals’ environment and human interactions. Organ VR educational content targets primarily human body anatomy; and micro VR microscopic structures at the level of cells, molecules and atoms. We examine how different VR features and health professional education areas match these three VR types. CONCLUSIONS We conclude by highlighting the gaps in the literature and providing suggestions for future research.

scholarly journals Focused ultrasound in neuro-oncology: the role of the Focused Ultrasound Foundation in driving adoption and innovation

2021 ◽  
Author(s):  
Emily C. Whipple ◽  
Camille A. Favero ◽  
Neal F. Kassell
Keyword(s):  
Drug Delivery ◽  
Brain Tumors ◽  
Focused Ultrasound ◽  
Clinical Evidence ◽  
Neurological Injury ◽  
High Concentration ◽  
Potential Applications ◽  
Tumor Agent

Abstract Introduction Intra-arterial (lA) delivery of therapeutic agents across the blood-brain barrier (BBB) is an evolving strategy which enables the distribution of high concentration therapeutics through a targeted vascular territory, while potentially limiting systemic toxicity. Studies have demonstrated lA methods to be safe and efficacious for a variety of therapeutics. However, further characterization of the clinical efficacy of lA therapy for the treatment of brain tumors and refinement of its potential applications are necessary. Methods We have reviewed the preclinical and clinical evidence supporting superselective intraarterial cerebral infusion (SSJACI) with BBB disruption for the treatment of brain tumors. In addition, we review ongoing clinical trials expanding the applicability and investigating the efficacy of lA therapy for the treatment of brain tumors. Results Trends in recent studies have embraced the use of SSIACI and less neurotoxic chemotherapies. The majority of trials continue to use mannitol as the preferred method of hyperosmolar BBB disruption. Recent preclinical and preliminary human investigations into the lA delivery of Bevacizumab have demonstrated its safety and efficacy as an anti-tumor agent both alone and in combination with chemotherapy. Conclusion lA drug delivery may significantly affect the way treatment are delivered to patients with brain tumors, and in particular GBM. With refinement and standardization of the techniques of lA drug delivery, improved drug selection and formulations, and the development of methods to minimize treatment-related neurological injury, lA therapy may offer significant benefits for the treatment of brain tumors.

scholarly journals Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases

2021 ◽  
pp. 030098582199932
Author(s):  
Laura Bongiovanni ◽  
Anneloes Andriessen ◽  
Marca H. M. Wauben ◽  
Esther N. M. Nolte-’t Hoen ◽  
Alain de Bruin
Keyword(s):  
Extracellular Vesicles ◽  
Biologically Active ◽  
Liquid Biopsies ◽  
Donor Cells ◽  
Recent Developments ◽  
Veterinary Pathology ◽  
Cell Components ◽  
Potential Applications ◽  
Intercellular Communications

With a size range from 30 to 1000 nm, extracellular vesicles (EVs) are one of the smallest cell components able to transport biologically active molecules. They mediate intercellular communications and play a fundamental role in the maintenance of tissue homeostasis and pathogenesis in several types of diseases. In particular, EVs actively contribute to cancer initiation and progression, and there is emerging understanding of their role in creation of the metastatic niche. This fact underlies the recent exponential growth in EV research, which has improved our understanding of their specific roles in disease and their potential applications in diagnosis and therapy. EVs and their biomolecular cargo reflect the state of the diseased donor cells, and can be detected in body fluids and exploited as biomarkers in cancer and other diseases. Relatively few studies have been published on EVs in the veterinary field. This review provides an overview of the features and biology of EVs as well as recent developments in EV research including techniques for isolation and analysis, and will address the way in which the EVs released by diseased tissues can be studied and exploited in the field of veterinary pathology. Uniquely, this review emphasizes the important contribution that pathologists can make to the field of EV research: pathologists can help EV scientists in studying and confirming the role of EVs and their molecular cargo in diseased tissues and as biomarkers in liquid biopsies.

scholarly journals Chinese and Indian FDI in Hungary and the role of Eastern Opening policy

2021 ◽  
Author(s):  
Katalin Völgyi ◽  
Eszter Lukács
Keyword(s):  
Renewable Energy ◽  
Location Choice ◽  
Investment Decision ◽  
Energy Sector ◽  
Foreign Direct Investments ◽  
Automotive Sector ◽  
Supportive Services ◽  
High Ranking ◽  
Strategic Cooperation

AbstractThe aim of this paper is to assess the main features of Chinese and Indian investments in Hungary and the role of the Hungarian Government’s Eastern Opening policy in the attraction of investments from these two Asian giants. This paper covers the sectoral distribution, modes of market entry, and motivations of Chinese and Indian foreign direct investments. The automotive sector is the most attractive sector for investors from both countries. ICT manufacturing (electronics) and services, and the renewable energy sector are also very attractive for Chinese companies. The same is true for IT/BPO services and the chemical sector in the case of Indian companies. Chinese and Indian companies enter the Hungarian economy mainly through green-field investments or acquisitions. Market-seeking and strategic asset-seeking motives are dominant in the case of investors from both countries. This paper also puts a special emphasis on studying the impacts of Hungary’s Eastern Opening policy (launched in 2012) on Chinese and Indian investments. The findings show that the Eastern Opening policy has had a significant impact on the investment decision (location choice) of new Chinese and Indian investors and further expansion of investments by Chinese and Indian companies located in Hungary due to four factors, namely high-ranking political meetings, strategic cooperation agreements, cash grants from the Hungarian Government and supportive services of HIPA.

scholarly journals Modeling Gastrointestinal Diseases Using Organoids to Understand Healing and Regenerative Processes

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1331
Author(s):  
Alexane Ollivier ◽  
Maxime M. Mahe ◽  
Géraldine Guasch
Keyword(s):  
Molecular Mechanisms ◽  
Gastrointestinal Disease ◽  
3D Culture ◽  
Gastrointestinal Diseases ◽  
Continuous Series ◽  
Regenerative Therapy ◽  
Disease Mechanisms ◽  
Epithelial Wound Healing ◽  
Potential Applications

The gastrointestinal tract is a continuous series of organs from the mouth to the esophagus, stomach, intestine and anus that allows digestion to occur. These organs are frequently associated with chronic stress and injury during life, subjecting these tissues to frequent regeneration and to the risk of developing disease-associated cancers. The possibility of generating human 3D culture systems, named organoids, that resemble histologically and functionally specific organs, has opened up potential applications in the analysis of the cellular and molecular mechanisms involved in epithelial wound healing and regenerative therapy. Here, we review how during normal development homeostasis takes place, and the role of the microenvironmental niche cells in the intestinal stem cell crypt as an example. Then, we introduce the notion of a perturbed niche during disease conditions affecting the esophageal–stomach junction and the colon, and describe the potential applications of organoid models in the analysis of human gastrointestinal disease mechanisms. Finally, we highlight the perspectives of organoid-based regenerative therapy to improve the repair of the epithelial barrier.

scholarly journals The Potential Applications of Peroxisome Proliferator-Activated ReceptorδLigands in Assisted Reproductive Technology

PPAR Research ◽  
2008 ◽  
Vol 2008 ◽  
pp. 1-6 ◽  
Author(s):  
Jaou-Chen Huang
Keyword(s):  
Assisted Reproductive Technology ◽  
Reproductive Function ◽  
Reproductive Technology ◽  
Embryonic Cell ◽  
Preimplantation Embryos ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Potential Applications ◽  
And Function

Peroxisome proliferator-activated receptorδ(PPARδ, also known as PPARβ) has ubiquitous distribution and extensive biological functions. The reproductive function of PPARδwas first revealed in the uterus at the implantation site. Since then, PPARδand its ligand have been discovered in all reproductive tissues, including the gametes and the preimplantation embryos. PPARδin preimplantation embryos is normally activated by oviduct-derived PPARδligand. PPARδactivation is associated with an increase in embryonic cell proliferation and a decrease in programmed cell death (apoptosis). On the other hand, the role of PPARδand its ligand in gamete formation and function is less well understood. This review will summarize the reproductive functions of PPARδand project its potential applications in assisted reproductive technology.

Effect of size and shape of nanofillers on electrostatic and thermal behavior of epoxy-based composites

2021 ◽  
pp. 096739112110324
Author(s):  
Mihir N Velani ◽  
Ritesh R Patel
Keyword(s):  
Thermal Properties ◽  
Breakdown Strength ◽  
Electrical Power ◽  
Filler Loading ◽  
Filler Concentration ◽  
Computational Technique ◽  
Electrical Power System ◽  
Potential Applications ◽  
Different Shapes

The role of nanodielectrics in the electrical power system is becoming crucial owing to its superior properties and potential applications in the field. Yet, the materials face limited breakdown strength and thermal properties. Further, the nanodielectrics have not found a comprehensive commercial platform because of the costly manufacturing process, and characterization and testing facilities. Therefore, to reduce the involved cost, in this work, an FE (finite element) based computational technique has been implemented to visualize the effect of shape, size, and filler concentration under the application of high voltage (HV). The epoxy-based nanodielectrics have been modeled incorporating a range of different shapes and size nanofillers—Al2O3, BN, BeO, SiO2, and TiO2. The paper discusses the 2D-analysis of the modeled nanodielectric in the steady-state electrostatic fields and thermal domains. It shows the insights of the nanofillers’ choice to ensure a perfect blend of electrical and thermal properties. The epoxy with square-shaped BeO fillers showed a rise in the electric field of nearly 1.5 times than unfilled neat epoxy, which indicates a significant surge in thermal conductivity at specific filler loading.

Is it time to move from mandatory stretching? We need to differentiate “Can I” from “Do I Have To?”

2021 ◽  
Author(s):  
José Afonso ◽  
Jesús Olivares-Jabalera ◽  
Renato Andrade
Keyword(s):  
Range Of Motion ◽  
Injury Risk ◽  
Warm Up ◽  
Alternative Interventions ◽  
Passive Stretching ◽  
Effective Interventions ◽  
Potential Applications ◽  
The Times ◽  
The Many

The effects and usefulness of active and passive static stretching have raised heated debates. Over the years, the pendulum has swung from a glorified vision to their vilification. As most of the times, the truth often lies somewhere in-between. But even if there was no controversy surrounding the effects of static and passive stretching (which there is), and even if their effects were homogeneously positive (which they are not), that would not be sufficient to make stretching mandatory for practicing physical exercise, for most populations. Amidst the many discussions, an important issue has remained underexplored: the prerequisites to answer the question “Can I?” are not sufficient to answer the question “Do I have to?”, especially when alternative interventions are available. In this current opinion paper, we address four potential applications of stretching: (i) warm-up; (ii) cool-down; (iii) range of motion; and (iv) injury risk. We argue that while stretching can be used in the warm-up and cool-down phases of the training, its inclusion is not mandatory, and its effectiveness is still questionable. Stretching can be used to improve range of motion, but alternative and effective interventions are available. The role of stretching in injury risk is also controversial, and the literature often misinterprets association with causation and assumes that stretching is the only intervention to improve flexibility and range of motion. Overall, the answer to the question “Can I stretch?” is “yes”. But the answer to the question “Do I have to?” is “no, not really”.

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