Statistical investigation of large volumes of data with respect to the biological activity of compounds III. Selection of a determinant for predicting biological activity

1978 ◽  
Vol 12 (6) ◽  
pp. 775-780
Author(s):  
V. V. Avidon ◽  
V. S. Arolovich ◽  
S. P. Kozlova ◽  
L. A. Piruzyan
Keyword(s):  
Biological Activity ◽  
Statistical Investigation ◽  
Selection Of

Affinity of Calciferol Analogues for 25-Hydroxycholecalciferol Receptors

1974 ◽  
Vol 46 (1) ◽  
pp. 143-147 ◽  
Author(s):  
P. B. Greenberg ◽  
Carmel J. Hillyard ◽  
Leonora S. Galante ◽  
Kay W. Colston ◽  
Imogen M. A. Evans ◽  
...  
Keyword(s):  
Biological Activity ◽  
Competitive Binding ◽  
Binding Assays ◽  
Differential Measurement ◽  
Chicken Kidney ◽  
Competitive Binding Assays ◽  
Selection Of ◽  
25 Hydroxycholecalciferol

1. The affinity of cholecalciferol, ergocalciferol and 25-hydroxyergocalciferol for 25-hydroxycholecalciferol receptors in human, rat and chicken kidney cytosol fractions is related to the biological activity of these analogues in the three species. 2. By selection of appropriate kidney cytosol receptors for competitive binding assays, the differential measurement of cholecalciferol and ergocalciferol derivatives is possible.

Selection of Short Stem Astragalus membranaceus Lines by Assessing Agronomic Characteristics and Biological Activity

2018 ◽  
Vol 26 (6) ◽  
pp. 471-476
Author(s):  
Sang Hoon Lee ◽  
Sung Cheol Koo ◽  
Jong Won Han ◽  
Woo Moon Lee ◽  
Mok Hur
Keyword(s):  
Biological Activity ◽  
Short Stem ◽  
Astragalus Membranaceus ◽  
Agronomic Characteristics ◽  
Selection Of

scholarly journals α-Amidoamids as New Replacements of Antibiotics—Research on the Chosen K12, R2–R4 E. coli Strains

Materials ◽  
2020 ◽  
Vol 13 (22) ◽  
pp. 5169
Author(s):  
Paweł Kowalczyk ◽  
Arleta Madej ◽  
Mateusz Szymczak ◽  
Ryszard Ostaszewski
Keyword(s):  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Biological Activity ◽  
Plasmid Dna ◽  
Alkyl Chain ◽  
Antimicrobial Drugs ◽  
E Coli ◽  
Different Types ◽  
Preliminary Study ◽  
Selection Of

A preliminary study of α-amidoamids as new potential antimicrobial drugs was performed. Special emphasis was placed on selection of structure of α-amidoamids with the highest biological activity against different types of Gram-stained bacteria by lipopolysaccharide (LPS). Herein, Escherichia coli model strains K12 (without LPS in its structure) and R1–R4 (with different length LPS in its structure) were used. The presented work showed that the antibacterial activity of α-amidoamids depends on their structure and affects the LPS of bacteria. Moreover, the influence of various newly synthesized α-amidoamids on bacteria possessing smooth and rought LPS and oxidative damage of plasmid DNA caused by all newly obtained compounds was indicated. The presented studies clearly explain that α-amidoamids can be used as substitutes for antibiotics. The chemical and biological activity of the analysed α-amidoamids was associated with short alkyl chain and different isocyanides molecules in their structure such as: tetr-butyl isocyanide or 2,5-dimethoxybenzyl isocyanide. The observed results are especially important in the case of the increasing resistance of bacteria to various drugs and antibiotics.

scholarly journals Design New Compound of Meisoindigo Derivative as Anti Breast Cancer Based on QSAR Approach

2020 ◽  
Vol 23 (9) ◽  
pp. 305-311
Author(s):  
Agus Dwi Ananto ◽  
Handa Muliasari ◽  
Saprizal Hadisaputra
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Semiempirical Methods ◽  
Cyclin Dependent Kinase ◽  
Multilinear Regression ◽  
Analysis And Design ◽  
Equation Analysis ◽  
Research Procedure ◽  
New Compounds ◽  
Selection Of

Design new compounds of Meisoindigo using the QSAR approach with semiempirical methods have been successfully made with better biological activity as anti-breast cancer results. The research method used to design the new compound of meisoindigo derivatives uses the semiempirical methods. The research procedure divide into tree step, molecular modeling, QSAR equation analysis, and design of new compounds. The PM3 method was chosen as a better method because it has model results that are more representative of physicochemical aspects. The selection of the best model is made by multilinear regression statistical analysis. New compounds derived from the design are expected to bind to the Cyclin-Dependent Kinase 4 (CDK4) enzyme that helps in the cell cycle to prevent cell division. Based on the design, the compound of (E)-2-(2-oxo-1-(2-(trifluoromethyl) benzyl)indolin-3-ylidene)-N-(quinoline-7-yl) acetamide choose as a new compound with more better biological activity (log 1/IC50 = 6.992) than before (log 1/IC50 = 5.823)

scholarly journals Isolation and selection of yeasts from soursop Annona muricata for wine fermentation

2021 ◽  
Vol 63 (11) ◽  
pp. 53-57
Author(s):  
Thi Kieu Tien Doan ◽  
◽  
Thi Tuyet Nhung Do ◽  
Tri An Le ◽  
Hoang Hiep Tran ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antioxidant Capacity ◽  
Room Temperature ◽  
Initial Conditions ◽  
Wine Fermentation ◽  
Annona Muricata ◽  
High Biological Activity ◽  
Yeast Strains ◽  
Ethanol Content ◽  
Selection Of

Wine is a healthy drink and is becoming more diverse thanks to the substances with high biological activity and fully preserved the antioxidant capacity in the fruit after fermentation by yeast. This study aims to isolate yeasts that are capable of soursop fermentation. There were eight yeast strains isolated, in which five strains of yeasts NM1.1, NM1.2, NM2.1, NM3.1, NM3.2 are capable of fermenting soursop wine. Wine product after fermentation using strain NM1.1 with initial conditions of 22ºBrix, pH 4.5, supplemented yeast 1% (w/v) at room temperature (28-30ºC), in twelve-day, produced the ethanol content 10% v/v, methanol 1.304 g/l, and SO2 10.9 mg/l that meet Vietnamese standards (QCVN 6-3:2010/BYT).

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain

2011 ◽  
Vol 9 (15) ◽  
pp. 5373 ◽  
Author(s):  
Nicolas Ardes-Guisot ◽  
Dominic S. Alonzi ◽  
Gabriele Reinkensmeier ◽  
Terry D. Butters ◽  
Caroline Norez ◽  
...  
Keyword(s):  
Biological Activity ◽  
Side Chain ◽  
Length Variation ◽  
Selection Of

Studies on Aqueous Suspensions of Insecticides. Part VII. The Influence of Relative Humidity upon the Sorption of Insecticides by Soils

1958 ◽  
Vol 49 (2) ◽  
pp. 333-354 ◽  
Author(s):  
F. Barlow ◽  
A. B. Hadaway
Keyword(s):  
Biological Activity ◽  
Relative Humidity ◽  
Biological Activities ◽  
Soil Samples ◽  
High Humidity ◽  
Field Observations ◽  
Surface Layers ◽  
Marked Influence ◽  
Rapid Diffusion ◽  
Selection Of

SummaryChanges in relative humidity had a very marked influence upon the biological activities of γ BHC, dieldrin and DDT sorbed on Uganda mud blocks. In agreement with field observations, kills of mosquitos increased as the humidity increased and this effect was rapidly reversible.Disappearance of insecticide particles from the mud surface was inversely related to humidity, the rate increasing as humidity decreased. On the other hand, the rates of diffusion of sorbed insecticide away from the surface were greater at higher humidities.It is suggested, therefore, that when the biological activity of a mud surface is increased by increasing the humidity, the insects acquire a greater dose of insecticide not because the concentration of insecticide in the surface layers is greater but because the insecticide that is already present acquires a greater mobility. This greater mobility results in a more rapid diffusion in the mud itself away from the treated surface and a greater potential for diffusion into insects resting on the mud surface.Support for these conclusions was obtained by showing that on transferring dieldrin-treated mud blocks from low to high humidity the change in biological activity occurred at about the same rate as the increase in water content of the blocks.The influence of humidity upon the sorption of DDT and dieldrin on a selection of soil samples of widely differing origin was observed. Both insecticides disappeared from the surface more rapidly at low than at high humidity on all the soils.

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