Indomethacin enhances the proliferation of mitogen-stimulated T lymphocytes of homosexual males with persistent generalized lymphadenopathy

1984 ◽  
Vol 4 (5) ◽  
pp. 383-387 ◽  
Author(s):  
Frank H. Valone ◽  
Donald G. Payan ◽  
Donald I. Abrams ◽  
Jan G. Dohlman ◽  
Edward J. Goetzl
Keyword(s):  
T Lymphocytes ◽  
Generalized Lymphadenopathy ◽  
Persistent Generalized Lymphadenopathy

scholarly journals Clinical Course of Opportunistic Infections—Toxoplasmosis and Cytomegalovirus Infection in HIV-Infected Patients in Slovakia

Pathogens ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 219
Author(s):  
Šimeková ◽  
Nováková ◽  
Rosoľanka ◽  
Masná ◽  
Antolová
Keyword(s):  
T Lymphocytes ◽  
Cytomegalovirus Infection ◽  
Opportunistic Infections ◽  
Clinical Course ◽  
Clinical Signs ◽  
Cmv Infection ◽  
The Status ◽  
Generalized Lymphadenopathy ◽  
Persistent Generalized Lymphadenopathy ◽  
Immunodeficiency Syndrome

: The HIV/acquired immunodeficiency syndrome (AIDS) pandemic has affected the health status of the population in many countries. Early symptomatic HIV infection includes persistent generalized lymphadenopathy (PGL), which can be associated with opportunistic infections, e.g., toxoplasmosis and Cytomegalovirus (CMV) infection. This study followed the occurrence of PGL, toxoplasmosis, and Cytomegalovirus infection in 32 HIV-positive patients and analyzed the clinical signs of disease in relation to the number of CD4 T lymphocytes. In monitored patients, the average number of CD4 T lymphocytes was 940.8 ± 396.7/µL of blood. Severe immunodeficiency was recorded in four persons, who also suffered from colitis and/or retinitis and pneumonitis. The number of CD4 T cells in patients with PGL was significantly lower than that in patients without lymphadenopathy. In 6 (18.8%) IgM and 11 (34.4%) IgG Toxoplasma gondii seropositive patients, the number of CD4 T lymphocytes was significantly lower than that in seronegative patients. The presence of IgM and IgG antibodies to Cytomegalovirus was recorded in all examined patients, and CMV infection clinically manifested in five persons. The occurrence of PGL, the higher viral load, and seropositivity to T. gondii were significantly related to decline in the CD4 T lymphocyte number. The clinical course of the diseases was influenced by the status of the patient’s immunodeficiency and suggests ongoing immunosuppression and possible reactivation of both infections in all patients.

PROTEIN 24 HIV DAN LIMFOSIT T-CD4+ DI INFEKSI HIV TAHAP I

2016 ◽  
Vol 21 (3) ◽  
pp. 273
Author(s):  
I Made Sila Darmana ◽  
Endang Retnowati ◽  
Erwin Astha Triyono
Keyword(s):  
T Lymphocytes ◽  
Hiv Infection ◽  
T Lymphocyte ◽  
Negative Correlation ◽  
Stage I ◽  
Cross Sectional ◽  
Protein Levels ◽  
P24 Protein ◽  
Persistent Generalized Lymphadenopathy ◽  
Spearman Test

Measuring HIV p24 protein is a test which is more practical than determination of CD4+ T-lymphocyte counts and viral load, as it does not require a very sophisticated instrument and requires a lower cost. Independent predictive value of p24 to the decline of CD4+ T-lymphocytes, clinical progression and survival in HIV-infected patients have been reported. In this study, HIV-infected patients were found to have HIV p24 protein levels inversely proportional to CD4+ T-lymphocyte counts by using Spearman test (R2=0.225; p=0.0331). Studies on the correlation between HIV p24 protein levels and CD4+ T-lymphocyte counts in stage I HIV infection have not yet been reported. The aim of this study was to prove the correlation between HIV p24 protein levels and CD4+ T-lymphocytes in stage I HIV infection. Research issue was whether a correlation between HIV p24 protein levels and CD4+ T-lymphocyte counts in stage I HIVinfection existed ? The hypothesis was that a correlation between HIV p24 protein levels and CD4+ T-lymphocyte counts in stage I HIV infection existed. The study design was cross sectional observational. Subjects consisted of 30 stage I HIV-infected patients treated at the Infectious Disease Intermediate Care Unit, Dr. Soetomo Hospital and VCT Clinic of the Dr. Ramelan Naval Hospital, Surabaya from May to July 2014. Stage I HIV infection is an asymptomatic HIV infection or with persistent generalized lymphadenopathy and the patient is able to perform normal activities. Levels of p24 were measured by ELISA method and CD4+ T-lymphocyte counts using flowcytometry(BD FACSCaliburTM). The results were statistically analyzed using Pearson’s correlation test. HIV p24 protein levels in stage I of HIV infection ranged from 1.8 to 10.8 pg/mL, mean of 5.14 pg/mL and a standard deviation of 2.08 pg/mL. CD4+ T-lymphocyte counts decreased with a range of 49-559 cells /uL for absolute values and 4.42–26.02% for percentage values Correlations between blood p24 levels and CD4+ T-lymphocyte counts either absolute (r=–0.392, p=0.032) or percentage (r=–0.363, p=0.049) were found. In stage I HIV-infected patients, a negative correlation was found between p24 levels and CD4+ T-lymphocyte counts, in both CD4+T-lymphocyte counts as absolute and as well as percentage values. This negative correlation showed that the p24 HIV levels were inversely proportional to the CD4+ T-lymphocyte counts. HIV p24 protein levels have a possibility to be used predicting CD4+ T-lymphocyte counts

Results of initial lymph node biopsy in homosexual men with generalized lymphadenopathy.

1986 ◽  
Vol 4 (2) ◽  
pp. 165-169 ◽  
Author(s):  
A M Levine ◽  
P R Meyer ◽  
P S Gill ◽  
R L Burkes ◽  
M Krailo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Laboratory Data ◽  
Clinical Parameter ◽  
Lymph Node Biopsy ◽  
Homosexual Men ◽  
Laboratory Findings ◽  
Node Biopsy ◽  
Significant Difference ◽  
Generalized Lymphadenopathy ◽  
Persistent Generalized Lymphadenopathy

Persistent, generalized lymphadenopathy (PGL) is considered part of the acquired immunodeficiency syndrome (AIDS)-related complex. The clinical course is usually benign, although some patients may evolve to AIDS. Characteristic features on lymph node biopsy have been described. Recently, large series of PGL have been reported in which many study patients have not undergone initial diagnostic biopsy. The value of such biopsy has been questioned. We report the clinical, pathologic, and laboratory findings in six homosexual men initially considered as potential candidates for study of the natural history of PGL. They were excluded by initial lymph node biopsy, which revealed small-cleaved lymphoma in two, focal Kaposi's sarcoma in two, disseminated mycobacterium tuberculosis in one, and histoplasma encapsulatum in one. The clinical and laboratory data from these six patients were compared with those from 34 patients with biopsy-proven PGL; no statistically significant difference in any prebiopsy clinical parameter was found. We conclude that initial lymph node biopsy may reveal changes other than reactive hyperplasia in homosexual men with generalized lymphadenopathy.

Immunohistology of Persistent Generalized Lymphadenopathy: Evidence for Progressive Lymph Node Abnormalities in Some Patients

1987 ◽  
Vol 88 (1) ◽  
pp. 10-19 ◽  
Author(s):  
Roderick R. Turner ◽  
Paul R. Meyer ◽  
Clive R. Taylor ◽  
Parkash S. Gill ◽  
Florence M. Hofman ◽  
...  
Keyword(s):  
Lymph Node ◽  
Generalized Lymphadenopathy ◽  
Persistent Generalized Lymphadenopathy

Persistent Generalized Lymphadenopathy Syndrome vs «Aids» - Unrelated Malignant Lymphoma: Comparison of Presenting Clinical and Laboratory Findings in 88 Patients

1989 ◽  
Vol 75 (3) ◽  
pp. 222-225 ◽  
Author(s):  
Umberto Tirelli ◽  
Emanuela Vaccher ◽  
Vittorina Zagonel ◽  
Silvana Saracchini ◽  
Giulio Bertola ◽  
...  
Keyword(s):  
Malignant Lymphoma ◽  
Laboratory Data ◽  
Young Patients ◽  
Intravenous Drug ◽  
Antibody Detection ◽  
Histologic Diagnosis ◽  
Laboratory Findings ◽  
History Of ◽  
Generalized Lymphadenopathy ◽  
Persistent Generalized Lymphadenopathy

The purpose of this report is to document and compare the presenting clinical and laboratory findings of 38 patients, all intravenous drug abusers, with pathologically documented persistent generalized lymphadenopathy (PGL), and of 50 patients with AIDS-unrelated malignant lymphoma (30 with Hodgkin's disease and 20 with non-Hodgkin's lymphoma). All patients, aged 40 years or less, consecutively seen since May 1984 in a single institution in Italy, have prospectively undergone a similar clinico-pathologic approach. In addition to a history of intravenous drug abuse and HIV serology, the results indicate that a history of infection in the previous year, night sweats, weight loss, generalized lymphadenopathy, β2 microglobuline, transaminase, T4/T8 ratio < 1, and polyclonal hypergamma-globulinemia significantly increased among PGL patients compared with patients with AIDS-unrelated malignant lymphoma. In contrast, patients with malignant lymphoma had a significant increase in mediastinal lymph nodes, sedimentation rate, LDH, fibrinogen and anemia. Therefore, at this time of an AIDS epidemic, after histologic diagnosis of reactive lymphadenopathy has been performed in young patients presenting with generalized lymphadenopathy, a request for a second biopsy and other invasive procedures may be avoided if clinical and laboratory data suggest a PGL syndrome. If not already performed, HIV antibody detection should be carried out in this setting.

PERSISTENT GENERALIZED LYMPHADENOPATHY: CLINICAL CHARACTERISTICS OF A LYMPHADENOPATHY SYNDROME IN INTRAVENOUS DRUG ABUSERS

Aids Research ◽  
1986 ◽  
Vol 2 (3) ◽  
pp. 227-230 ◽  
Author(s):  
Umberto Tirelli ◽  
Emanuela Vaccher ◽  
Antonino Carbone ◽  
Rachele Volpe ◽  
Paolo De Paoli ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Intravenous Drug ◽  
Drug Abusers ◽  
Generalized Lymphadenopathy ◽  
Persistent Generalized Lymphadenopathy ◽  
Intravenous Drug Abusers

scholarly journals Epstein-Barr virus and HIV play no direct role in persistent generalized lymphadenopathy syndrome

2008 ◽  
Vol 87 (3) ◽  
pp. 357-361 ◽  
Author(s):  
M. J. BOYLE ◽  
T. B. SCULLEY ◽  
D. A. COOPER ◽  
J. J. TURNER ◽  
R. PENNY ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Direct Role ◽  
Barr Virus ◽  
Epstein Barr ◽  
Generalized Lymphadenopathy ◽  
Persistent Generalized Lymphadenopathy

scholarly journals PROTEIN 24 HIV DAN LIMFOSIT T-CD4+ DI INFEKSI HIV TAHAP I (HIV p24 Protein and CD4+ T-lymphocyte in Stage I HIV infection)

2018 ◽  
Vol 21 (3) ◽  
pp. 273
Author(s):  
I Made Sila Darmana ◽  
Endang Retnowati ◽  
Erwin Astha Triyono
Keyword(s):  
T Lymphocytes ◽  
Hiv Infection ◽  
T Lymphocyte ◽  
Negative Correlation ◽  
Stage I ◽  
Cross Sectional ◽  
Protein Levels ◽  
P24 Protein ◽  
Persistent Generalized Lymphadenopathy ◽  
Spearman Test

Measuring HIV p24 protein is a test which is more practical than determination of CD4+ T-lymphocyte counts and viral load, asit does not require a very sophisticated instrument and requires a lower cost. Independent predictive value of p24 to the decline ofCD4+ T-lymphocytes, clinical progression and survival in HIV-infected patients have been reported. In this study, HIV-infected patientswere found to have HIV p24 protein levels inversely proportional to CD4+ T-lymphocyte counts by using Spearman test (R2=0.225;p=0.0331). Studies on the correlation between HIV p24 protein levels and CD4+ T-lymphocyte counts in stage I HIV infection have notyet been reported. The aim of this study was to prove the correlation between HIV p24 protein levels and CD4+ T-lymphocytes in stageI HIV infection. Research issue was whether a correlation between HIV p24 protein levels and CD4+ T-lymphocyte counts in stage I HIVinfection existed ? The hypothesis was that a correlation between HIV p24 protein levels and CD4+ T-lymphocyte counts in stage I HIVinfection existed. The study design was cross sectional observational. Subjects consisted of 30 stage I HIV-infected patients treated at theInfectious Disease Intermediate Care Unit, Dr. Soetomo Hospital and VCT Clinic of the Dr. Ramelan Naval Hospital, Surabaya from Mayto July 2014. Stage I HIV infection is an asymptomatic HIV infection or with persistent generalized lymphadenopathy and the patientis able to perform normal activities. Levels of p24 were measured by ELISA method and CD4+ T-lymphocyte counts using flowcytometry(BD FACSCaliburTM). The results were statistically analyzed using Pearson’s correlation test. HIV p24 protein levels in stage I of HIVinfection ranged from 1.8 to 10.8 pg/mL, mean of 5.14 pg/mL and a standard deviation of 2.08 pg/mL. CD4+ T-lymphocyte countsdecreased with a range of 49-559 cells /uL for absolute values and 4.42–26.02% for percentage values Correlations between blood p24levels and CD4+ T-lymphocyte counts either absolute (r=–0.392, p=0.032) or percentage (r=–0.363, p=0.049) were found. In stageI HIV-infected patients, a negative correlation was found between p24 levels and CD4+ T-lymphocyte counts, in both CD4+T-lymphocytecounts as absolute and as well as percentage values. This negative correlation showed that the p24 HIV levels were inversely proportionalto the CD4+ T-lymphocyte counts. HIV p24 protein levels have a possibility to be used predicting CD4+ T-lymphocyte counts.

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