Studies on sweeteners requiring the simultaneous presence of both the NO2/CN and COO? groups

1981 ◽  
Vol 68 (3) ◽  
pp. 143-143 ◽  
Author(s):  
J. M. Tinti ◽  
C. Nofre ◽  
D. Durozard
Keyword(s):  
Simultaneous Presence

Kinetic Study of the Effect of Heparin on the Amidase Activity of Trypsin, Plasmin and Urokinase

1983 ◽  
Vol 49 (03) ◽  
pp. 199-203 ◽  
Author(s):  
V M Yomtova ◽  
N A Stambolieva ◽  
B M Blagoev
Keyword(s):  
Kinetic Study ◽  
Active Center ◽  
Simultaneous Presence ◽  
Amidase Activity ◽  
Competitive Inhibitors ◽  
Uncompetitive Inhibitor

SummaryIt was found that the effect of heparin on the amidase activity of urokinase (E C 3.4.21.31), plasmin (E C 3.4.21.7) and trypsin (E C 3.4.21.4) depended on the substrate used. No effect of heparin on the amidase activity of urokinase and trypsin was observed when Pyro Glu-Gly-Arg-p-nitroanilide (S-2444) and α-N-acetyl-L-lysine-p-nitroanilide (ALNA) were used as substrates. Heparin acted as a uncompetitive inhibitor of trypsin (Ki = 1.2×10-6 M), plasmin (Ki = 4.9×10-6 M) and urokinase (Ki = l.0×10-7 M) when Bz-Phe-Val-Arg-p-nitroanilide (S-2160), H-D-Val-Leu-Lys-p-nitroanilide (S-2251) and plasminogen, respectively, were used as substrates. These results, as well as the data obtained by studying the effect of the simultaneous presence of heparin and competitive inhibitors suggest that although heparin is not bound at the active center of these enzymes, it may influence the effectivity of catalysis.

scholarly journals Prediction of Endometrial Hyperplasia and Cancer among Premenopausal Women with Abnormal Uterine Bleeding

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Luca Giannella ◽  
Lillo Bruno Cerami ◽  
Tiziano Setti ◽  
Ezio Bergamini ◽  
Fausto Boselli
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Prediction Model ◽  
Endometrial Hyperplasia ◽  
Premenopausal Women ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Stepwise Logistic Regression ◽  
Simultaneous Presence ◽  
Endometrial Pathology

Objective. To create a prediction model including clinical variables for the prediction of premalignant/malignant endometrial pathology in premenopausal women with abnormal uterine bleeding (AUB). Methods. This is an observational retrospective study including 240 premenopausal women with AUB referred to diagnostic hysteroscopy. Based on the presence of endometrial hyperplasia (EH) or cancer (EC), the women were divided into cases (EH/EC) and controls (no EH/EC). Univariate, stepwise logistic regression and ROC curve analysis were performed. Results. 12 women had EH/EC (5%). Stepwise logistic regression analysis showed that EH/EC associated significantly with BMI ≥ 30 (OR=7.70, 95% CI 1.90 to 31.17), diabetes (OR=9.71, 95% CI 1.63 to 57.81), and a thickened endometrium (OR=1.20, 95% CI 1.08 to 1.34, criterion > 11 mm). The AUC was 0.854 (95% confidence intervals 0.803 to 0.896, p<0.0001). Considering the pretest probability for EH/EC of 5%, the prediction model with a positive likelihood ratio of 8.14 showed a posttest probability of 30%. The simultaneous presence of two or three risk factors was significantly more common in women with EH/EC than controls (50% vs. 6.6 and 25% vs. 0%, respectively, p<0.0001). Conclusion. When premenopausal vaginal bleeding occurs in diabetic obese women with ET > 11 mm, the percentage of premalignant/malignant endometrial pathology increases by 25%. It is likely that the simultaneous presence of several risk factors is necessary to significantly increase the probability of endometrial pathology.

scholarly journals Extrachromosomal elements cause a reduced division potential in nib 1 strains of Saccharomyces cerevisiae.

Genetics ◽  
1989 ◽  
Vol 122 (4) ◽  
pp. 749-757
Author(s):  
R Sweeney ◽  
V A Zakian
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Open Reading Frames ◽  
Simultaneous Presence ◽  
Extrachromosomal Elements ◽  
Severe Reduction ◽  
Extrachromosomal Element ◽  
Generalized Sensitivity ◽  
Reading Frames

Abstract The nib 1 allele of yeast confers a sensitivity to an endogenous plasmid, 2 mu DNA, in that nib 1 strains bearing 2 mu DNA (cir+) exhibit a reduction in division potential. In the present study, the reduction in division potential characteristic of nib 1 cir+ strains is shown to be dependent on the simultaneous presence of both the A and the D open reading frames of 2 mu DNA as well as on the presence of an unidentified extrachromosomal element other than 2 mu DNA. Furthermore, in nib 1 strains, an uncharacterized extrachromosomal element can cause a less severe reduction of division potential in the absence of intact 2 mu DNA. Thus, the nib 1 allele may confer a generalized sensitivity to extrachromosomal elements.

scholarly journals CONFORMAL HOUSE

2010 ◽  
Vol 25 (24) ◽  
pp. 4603-4621 ◽  
Author(s):  
THOMAS A. RYTTOV ◽  
FRANCESCO SANNINO
Keyword(s):  
Fixed Point ◽  
Fixed Points ◽  
Gauge Group ◽  
Gauge Theories ◽  
Simultaneous Presence ◽  
Consistency Check ◽  
Effective Lagrangian ◽  
Anomalous Dimensions ◽  
Mass Terms

We investigate the gauge dynamics of nonsupersymmetric SU (N) gauge theories featuring the simultaneous presence of fermionic matter transforming according to two distinct representations of the underlying gauge group. We bound the regions of flavors and colors which can yield a physical infrared fixed point. As a consistency check we recover the previously investigated bounds of the conformal windows when restricting to a single matter representation. The earlier conformal windows can be imagined to be part now of the new conformal house. We predict the nonperturbative anomalous dimensions at the infrared fixed points. We further investigate the effects of adding mass terms to the condensates on the conformal house chiral dynamics and construct the simplest instanton induced effective Lagrangian terms.

Simultaneous presence of O3and CO bands in the troposphere

Tellus ◽  
1980 ◽  
Vol 32 (5) ◽  
pp. 456-463 ◽  
Author(s):  
JACK FISHMAN ◽  
WOLFGANG SEILER ◽  
PHILIP HAAGENSON
Keyword(s):  
Simultaneous Presence

Infrastructure Profiles and Knowledge Sharing

2017 ◽  
Vol 13 (3) ◽  
pp. 1-12 ◽  
Author(s):  
Mírian Oliveira ◽  
Antonio Carlos Gastaud Maçada ◽  
Carla Curado ◽  
Felipe Nodari
Keyword(s):  
Information Technology ◽  
Knowledge Sharing ◽  
Survey Method ◽  
Top Management ◽  
Management Support ◽  
Simultaneous Presence ◽  
Top Management Support ◽  
Adequate Information ◽  
Significant Difference ◽  
Technology Focus

Information technology and top management support are considered infrastructure for knowledge sharing. This research aims to identify infrastructure profiles and their relationship with knowledge sharing. A survey method was adopted involving 231 respondents working in information technology teams in Brazil. The analysis identified four profiles, namely: focus on information technology; focus on top management support; adrift; and knowledge sharing oriented. The latter was identified as being the most effective, while no significant difference was found between the other clusters in relation to knowledge sharing. This finding is a supplement to this field of knowledge because, in addition to confirming the relevance of the two constructs, it shows that their simultaneous presence contributes to knowledge sharing. This result also helps managers by highlighting that in order to leverage knowledge sharing it is necessary to signal the importance of the process for the company, as well as provide adequate information technology.

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