Early development in mice. IV. Age at disappearance of the rooting response: Genetic analysis in newborn mice

1987 ◽  
Vol 17 (5) ◽  
pp. 453-464 ◽  
Author(s):  
Pierre L. Roubertoux ◽  
Laurence Baumann ◽  
Sylvie Ragueneau ◽  
Catherine Semal
Keyword(s):  
Genetic Analysis ◽  
Early Development ◽  
Newborn Mice ◽  
Rooting Response

Mutations affecting tail and notochord development in the ascidian Ciona savignyi

Development ◽  
1999 ◽  
Vol 126 (15) ◽  
pp. 3293-3301 ◽  
Author(s):  
Y. Nakatani ◽  
R. Moody ◽  
W.C. Smith
Keyword(s):  
Genetic Analysis ◽  
Early Development ◽  
Nerve Cord ◽  
Induced Mutations ◽  
Ciona Savignyi ◽  
New Information ◽  
Nerve Tracts ◽  
Notochord Cells ◽  
Dorsal Nerve

Ascidians are among the most distant chordate relatives of the vertebrates. However, ascidians share many features with vertebrates including a notochord and hollow dorsal nerve cord. A screen for N-ethyl-N-nitrosourea (ENU)-induced mutations affecting early development in the ascidian Ciona savignyi resulted in the isolation of a number of mutants including the complementing notochord mutants chongmague and chobi. In chongmague embryos the notochord fails to develop, and the notochord cells instead adopt a mesenchyme-like fate. The failure of notochord development in chongmague embryos results in a severe truncation of tail, although development of the tail muscles and caudal nerve tracts appears largely normal. Chobi embryos also have a truncation of the tail stemming from a disruption of the notochord. However, in chobi embryos the early development of the notochord appears normal and defects occur later as the notochord attempts to extend and direct elongation of the tail. We find in chobi tailbud embryos that the notochord is often bent, with cells clumped together, rather than extended as a column. These results provide new information on the function and development of the ascidian notochord. In addition, the results demonstrate how the unique features of ascidians can be used in genetic analysis of morphogenesis.

Vocalizations in newborn mice: Genetic analysis

1996 ◽  
Vol 26 (4) ◽  
pp. 427-437 ◽  
Author(s):  
Pierre L. Roubertoux ◽  
Benoît Martin ◽  
Isbelle Le Roy ◽  
Jacques Beau ◽  
Fernando Perez-Diaz ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Newborn Mice

Early development in mice: II. Sensory motor behavior and genetic analysis

1985 ◽  
Vol 35 (5) ◽  
pp. 659-666 ◽  
Author(s):  
Pierre Roubertoux ◽  
Catherine Semal ◽  
Sylvie Ragueneau
Keyword(s):  
Genetic Analysis ◽  
Early Development ◽  
Motor Behavior ◽  
Sensory Motor

CpG-Induced Th1-Type Response in the Downmodulation of Early Development of Allergy and Inhibition of B7 Expression on T Cells of Newborn Mice

2010 ◽  
Vol 30 (2) ◽  
pp. 280-291 ◽  
Author(s):  
Cyro A. de Brito ◽  
Ana E. Fusaro ◽  
Jefferson R. Victor ◽  
Paula O. Rigato ◽  
Adriana L. Goldoni ◽  
...  
Keyword(s):  
T Cells ◽  
Early Development ◽  
Newborn Mice ◽  
Type Response

Insect embryogenesis – what is ancestral and what is derived?

Development ◽  
1994 ◽  
Vol 1994 (Supplement) ◽  
pp. 193-199
Author(s):  
Diethard Tautz ◽  
Markus Friedrich ◽  
Reinhard Schröder
Keyword(s):  
Pattern Formation ◽  
Genetic Analysis ◽  
Early Development ◽  
Molecular Mechanisms ◽  
Early Embryogenesis ◽  
Molecular Pathways ◽  
Deep Insight ◽  
Insect Embryogenesis ◽  
Definitive Answer ◽  
Insight Into

The systematic genetic analysis of Drosophila development has provided us with a deep insight into the molecular pathways of early embryogenesis. The question arises now whether these insights can serve as a more general paradigm of early development, or whether they apply only to advanced insect orders. Though it is too early to give a definitive answer to this question, we suggest that there is currently no firm reason to believe that the molecular mechanisms that were elucidated in Drosophila may not also apply to other forms of insect embryogenesis. Thus, many of the Drosophila genes involved in early pattern formation may have comparable functions in other insects and possibly throughout the arthropods.

Genetic Analysis of Oogenesis and the Role of Maternal Gene Expression in Early Development

Oogenesis ◽  
1985 ◽  
pp. 577-617 ◽  
Author(s):  
Kenneth D. Konrad ◽  
Lee Engstrom ◽  
Norbert Perrimon ◽  
Anthony P. Mahowald
Keyword(s):  
Gene Expression ◽  
Genetic Analysis ◽  
Early Development ◽  
Maternal Gene

Individual differences, social attention, and the history of the social motivation hypotheses of autism

2019 ◽  
Vol 42 ◽  
Author(s):  
Peter C. Mundy
Keyword(s):  
Individual Differences ◽  
Early Development ◽  
Emotional Development ◽  
Social Motivation ◽  
Social Attention ◽  
Social Emotional Development ◽  
Social Emotional ◽  
Precise Understanding ◽  
The Social ◽  
History Of

Abstract The stereotype of people with autism as unresponsive or uninterested in other people was prominent in the 1980s. However, this view of autism has steadily given way to recognition of important individual differences in the social-emotional development of affected people and a more precise understanding of the possible role social motivation has in their early development.

Classical social reward signatures in infants with later ASD

2019 ◽  
Vol 42 ◽  
Author(s):  
Teodora Gliga ◽  
Mayada Elsabbagh
Keyword(s):  
Early Development ◽  
Social Motivation ◽  
Self Report ◽  
Social Reward ◽  
Socially Motivated

Abstract Autistic individuals can be socially motivated. We disagree with the idea that self-report is sufficient to understand their social drive. Instead, we underscore evidence for typical non-verbal signatures of social reward during the early development of autistic individuals. Instead of focusing on whether or not social motivation is typical, research should investigate the factors that modulate social drives.

Early Development of Drug-Induced Hepatic Necrosis

1971 ◽  
Vol 29 ◽  
pp. 576-577
Author(s):  
F. G. Zaki ◽  
E. Detzi ◽  
C. H. Keysser
Keyword(s):  
Early Development ◽  
Hepatic Necrosis ◽  
Screening Tests ◽  
Dense Matrix ◽  
Sprague Dawley ◽  
Electron Microscopic ◽  
Drug Induced ◽  
Hepatocellular Damage ◽  
Sprague Dawley Rats ◽  
Microscopic Studies

This study represents the first in a series of investigations carried out to elucidate the mechanism(s) of early hepatocellular damage induced by drugs and other related compounds. During screening tests of CNS-active compounds in rats, it has been found that daily oral administration of one of these compounds at a dose level of 40 mg. per kg. of body weight induced diffuse massive hepatic necrosis within 7 weeks in Charles River Sprague Dawley rats of both sexes. Partial hepatectomy enhanced the development of this peculiar type of necrosis (3 weeks instead of 7) while treatment with phenobarbital prior to the administration of the drug delayed the appearance of necrosis but did not reduce its severity.Electron microscopic studies revealed that early development of this liver injury (2 days after the administration of the drug) appeared in the form of small dark osmiophilic vesicles located around the bile canaliculi of all hepatocytes (Fig. 1). These structures differed from the regular microbodies or the pericanalicular multivesicular bodies. They first appeared regularly rounded with electron dense matrix bound with a single membrane. After one week on the drug, these vesicles appeared vacuolated and resembled autophagosomes which soon developed whorls of concentric lamellae or cisterns characteristic of lysosomes (Fig. 2). These lysosomes were found, later on, scattered all over the hepatocytes.

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