Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by antagonists of adipogenesis

1993 ◽  
Vol 123 (1-2) ◽  
pp. 63-71 ◽  
Author(s):  
Jacqueline M. Stephens ◽  
Michelle Butts ◽  
Randy Stone ◽  
Philip H. Pekala ◽  
David A. Bernlohr
Keyword(s):  
Transcription Factor ◽  
Regulation Of Transcription ◽  
Preadipocyte Differentiation ◽  
Mrna Accumulation

scholarly journals Critical Role and Regulation of Transcription Factor FoxM1 in Human Gastric Cancer Angiogenesis and Progression

2009 ◽  
Vol 69 (8) ◽  
pp. 3501-3509 ◽  
Author(s):  
Qiang Li ◽  
Nu Zhang ◽  
Zhiliang Jia ◽  
Xiangdong Le ◽  
Bingbing Dai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Critical Role ◽  
Regulation Of Transcription ◽  
Human Gastric Cancer

scholarly journals Antitumorigenic effect of insect-derived peptide poecilocorisin-1 in human skin cancer cells through regulation of Sp1 transcription factor

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ra Ham Lee ◽  
Jae-Don Oh ◽  
Jae Sam Hwang ◽  
Hak-Kyo Lee ◽  
Donghyun Shin
Keyword(s):  
Cell Cycle ◽  
Transcription Factor ◽  
Side Effects ◽  
Epithelial Cell Line ◽  
Regulation Of Transcription ◽  
Anticancer Efficacy ◽  
Anticancer Mechanism ◽  
Tumor Selectivity ◽  
Antitumorigenic Effect ◽  
New Treatments

AbstractMalignant melanoma is highly resistant to conventional treatments and is one of the most aggressive types of skin cancers. Conventional cancer treatments are limited due to drug resistance, tumor selectivity, and solubility. Therefore, new treatments with fewer side effects and excellent effects should be developed. In previous studies, we have analyzed antimicrobial peptides (AMPs), which showed antibacterial and anti-inflammatory effects in insects, and some AMPs also exhibited anticancer efficacy. Anticancer peptides (ACPs) are known to have fewer side effects and high anticancer efficacy. In this study, the insect-derived peptide poecilocorisin-1 (PCC-1) did not induce toxicity in the human epithelial cell line HaCaT, but its potential as an anticancer agent was confirmed through specific effects of antiproliferation, apoptosis, and cell cycle arrest in two melanoma cell lines, SK-MEL-28 and G361. Additionally, we discovered a novel anticancer mechanism of insect-derived peptides in melanoma through the regulation of transcription factor Sp1 protein, which is overexpressed in cancer, apoptosis, and cell cycle-related proteins. Taken together, this study aims to clarify the anticancer efficacy and safety of insect-derived peptides and to present their potential as future therapeutic agents.

scholarly journals The THO/TREX Complex Component RAE2/TEX1 Is Involved in the Regulation of Aluminum Resistance and Low Phosphate Response in Arabidopsis

2021 ◽  
Vol 12 ◽  
Author(s):  
Yi-Fang Zhu ◽  
Jinliang Guo ◽  
Yang Zhang ◽  
Chao-Feng Huang
Keyword(s):  
Arabidopsis Thaliana ◽  
Transcription Factor ◽  
Mrna Export ◽  
Critical Role ◽  
Core Component ◽  
Mrna Accumulation ◽  
Zinc Finger Transcription Factor ◽  
Phosphate Response ◽  
Encoding Gene ◽  
Malate Transporter

The C2H2-type zinc finger transcription factor SENSITIVE TO PROTON RHIZOTOXICITY 1 (STOP1) plays a critical role in aluminum (Al) resistance and low phosphate (Pi) response mainly through promoting the expression of the malate transporter-encoding gene ARABIDOPSIS THALIANA ALUMINUM ACTIVATED MALATE TRANSPORTER 1 (AtALMT1). We previously showed that REGULATION OF ATALMT1 EXPRESSION 3 (RAE3/HPR1), a core component of the THO/TREX complex, is involved in the regulation of nucleocytoplasmic STOP1 mRNA export to modulate Al resistance and low Pi response. Here, we report that RAE2/TEX1, another core component of the THO complex, is also involved in the regulation of Al resistance and low Pi response. Mutation of RAE2 reduced the expression of STOP1-downstream genes, including AtALMT1. rae2 was less sensitive to Al than rae3, which was consistent with less amount of malate secreted from rae3 roots than from rae2 roots. Nevertheless, low Pi response was impaired more in rae2 than in rae3, suggesting that RAE2 also regulates AtALMT1-independent pathway to modulate low Pi response. Furthermore, unlike RAE3 that regulates STOP1 mRNA export, mutating RAE2 did not affect STOP1 mRNA accumulation in the nucleus, although STOP1 protein level was reduced in rae2. Introduction of rae1 mutation into rae2 mutant background could partially recover the deficient phenotypes of rae2. Together, our results demonstrate that RAE2 and RAE3 play overlapping but distinct roles in the modulation of Al resistance and low Pi response.

scholarly journals Limits on information transduction through amplitude and frequency regulation of transcription factor activity

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Anders S Hansen ◽  
Erin K O'Shea
Keyword(s):  
Transcription Factor ◽  
Target Genes ◽  
Frequency Regulation ◽  
Regulation Of Transcription ◽  
Limited Information ◽  
Dynamic Information ◽  
Extrinsic Noise ◽  
Intensity Information ◽  
Single Target ◽  
Activation Dynamics

Signaling pathways often transmit multiple signals through a single shared transcription factor (TF) and encode signal information by differentially regulating TF dynamics. However, signal information will be lost unless it can be reliably decoded by downstream genes. To understand the limits on dynamic information transduction, we apply information theory to quantify how much gene expression information the yeast TF Msn2 can transduce to target genes in the amplitude or frequency of its activation dynamics. We find that although the amount of information transmitted by Msn2 to single target genes is limited, information transduction can be increased by modulating promoter cis-elements or by integrating information from multiple genes. By correcting for extrinsic noise, we estimate an upper bound on information transduction. Overall, we find that information transduction through amplitude and frequency regulation of Msn2 is limited to error-free transduction of signal identity, but not signal intensity information.

scholarly journals Expression of miR159 Is Altered in Tomato Plants Undergoing Drought Stress

Plants ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 201 ◽  
Author(s):  
María José López-Galiano ◽  
Inmaculada García-Robles ◽  
Ana I. González-Hernández ◽  
Gemma Camañes ◽  
Begonya Vicedo ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Drought Stress ◽  
Regulatory Networks ◽  
Crop Yields ◽  
Insect Pest ◽  
Regulatory Function ◽  
Myb Transcription Factor ◽  
Regulation Of Transcription ◽  
Tomato Plants

In a scenario of global climate change, water scarcity is a major threat for agriculture, severely limiting crop yields. Therefore, alternatives are urgently needed for improving plant adaptation to drought stress. Among them, gene expression reprogramming by microRNAs (miRNAs) might offer a biotechnologically sound strategy. Drought-responsive miRNAs have been reported in many plant species, and some of them are known to participate in complex regulatory networks via their regulation of transcription factors involved in water stress signaling. We explored the role of miR159 in the response of Solanum lycopersicum Mill. plants to drought stress by analyzing the expression of sly-miR159 and its target SlMYB transcription factor genes in tomato plants of cv. Ailsa Craig grown in deprived water conditions or in response to mechanical damage caused by the Colorado potato beetle, a devastating insect pest of Solanaceae plants. Results showed that sly-miR159 regulatory function in the tomato plants response to distinct stresses might be mediated by differential stress-specific MYB transcription factor targeting. sly-miR159 targeting of SlMYB33 transcription factor transcript correlated with accumulation of the osmoprotective compounds proline and putrescine, which promote drought tolerance. This highlights the potential role of sly-miR159 in tomato plants’ adaptation to water deficit conditions.

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