Study group 9 physical, physiological and therapeutic effects of ionized air and electroaerosols

1975 ◽  
Vol 19 (S1) ◽  
pp. 129-139 ◽  
Author(s):  
A. P. Wehner
Keyword(s):  
Therapeutic Effects ◽  
Study Group ◽  
Ionized Air

Which Inotropic Drug, Dobutamine or Milrinone, Is Clinically More Effective in the Treatment of Postligation Cardiac Syndrome in Preterm Infants?

2020 ◽  
Author(s):  
Levent Korkmaz ◽  
Ahmet Ozdemir ◽  
Özge Pamukçu ◽  
Tamer Güneş ◽  
Mehmet Adnan Ozturk
Keyword(s):  
Blood Pressure ◽  
Operating Characteristic ◽  
Ductus Arteriosus ◽  
Area Under The Curve ◽  
Therapeutic Effects ◽  
Study Group ◽  
Cardiac Syndrome ◽  
Before And After ◽  
The Difference

Objective This study aimed to detect which of the two main medicines suggested in the treatment of postligation cardiac syndrome (PLCS)—dobutamine or mirinone—possesses a more therapeutic effect. While doing this, clinicians are provided with a broader perspective on the treatment and follow-up of cases. The desire was to increase the treatability and monitor ability of the cases in question and hence their survivability. Study Design A retrospective review of a cohort of infants with PLCS was conducted between March 2012 and December 2018. In the treatment of infants with PLCS, dobutamine (dobutamine study group-DSG) or milrinone (milrinone study group-MSG) was used. The respiration, cardiac, echocardiography, and perfusion parameters of the cases were assessed both before and after ligation. Based on the data obtained, both the effects of the medicines on PLCS and the difference between their therapeutic effects were studied. The accuracy of prognostication was assessed with receiver operating characteristic analyses. Results PLCS was detected in 29 (34.1%) of 85 patent ductus arteriosus ligation cases in total. Of all the PLCS cases, 13 (44.8%) were treated with dobutamine and 16 (55.2%) with milrinone. It was observed that the effects of the medicines on the respiratory system and cardiovascular system manifested in the third and 6th hour, respectively. It was detected that both medicines had more effect on the systolic blood pressure (SBP) (area under the curve [AUC]: 0.997/0.996, p = 0.001/0.002) than on the diastolic blood pressure (AUC: 0.911/0.843, p = 0.032/0.046). Conclusion Dobutamine and milrinone, two primary medicines that can be used in the treatment of cases with PLCS, possess similar therapeutic effects on this pathology. In addition, their postoperative therapeutic effects on the SBP are more in the foreground.

scholarly journals The effect of enteral nutrition on intra-abdominal pressure in severe acute pancreatitis patients

2017 ◽  
Author(s):  
Mingjie Zhang ◽  
Li-Ping Cao ◽  
Guoping Ding
Keyword(s):  
Acute Pancreatitis ◽  
Enteral Nutrition ◽  
Severe Acute Pancreatitis ◽  
Occurrence Rate ◽  
Control Group ◽  
Abdominal Pressure ◽  
Therapeutic Effects ◽  
Study Group ◽  
Time Operation ◽  
Operation Rate

Abstract BACKGROUND: To investigate the effect of enteral nutrition (EN) on intra-abdominal pressure (IAP) in severe acute pancreatitis (SAP) patients and the relationship between the decreasion of IAP and the the therapeutic effect of EN. METHODS: Eighty SAP patients were randomly divided into study group and control group (40 patients in each group). Patients in the study group received EN and Patients in the control group received total parenteral nutrition (TPN) for 7 days. Intra-cystic pressure (ICP) of the two groups was measured during treatment period. The outcomes of treatment were observed, APACHE Ⅱ scores, NB data were applied in analysis. RESULTS: The ICP data was lower in the study group than in the control group on days 4 and 5 of treatment (P < 0.05). On days 3-5 of treatment, the APACHE Ⅱ scores of the study group were lower than which of the control group (P < 0.05). Nitrogen balance (NB) date increased significantly in study group than in the control group (P < 0.05). abdominalgia relief time, operation rate were different between the two groups (P < 0.05). The abdominal compartment syndrome (ACS) occurrence rate of the two groups have no significant difference. The ICP data and APACHE Ⅱscores, abdominalgia relief time, operation rate of pancreas debridement show positive correlation (P < 0.05). ICP and NB date show negative correlation (P < 0.05). CONCLUSION: EN can decrease the IAP of SAP, which may be the reason for EN show preventive and therapeutic effects on SAP.

G-protein coupled receptor auto-antibodies in thromboangiitis obliterans (Buerger’s disease) and their removal by immunoadsorption

VASA ◽  
2014 ◽  
Vol 43 (5) ◽  
pp. 347-352 ◽  
Author(s):  
Peter F. Klein-Weigel ◽  
Marion Bimmler ◽  
Petra Hempel ◽  
Sebastian Schöpp ◽  
Siegrid Dreusicke ◽  
...  
Keyword(s):  
G Protein ◽  
Adrenergic Receptor ◽  
G Protein Coupled Receptors ◽  
Thromboangiitis Obliterans ◽  
Therapeutic Effects ◽  
Study Group ◽  
Eta Receptor ◽  
Serological Data ◽  
Agonistic Autoantibodies ◽  
G Protein Coupled

Background: Immunhistopathological and serological data favors an immunopathogenesis of thromboangiitis onliterans(TAO, Buerger’s disease). Autoantbodies seem to play a major role. Immunoadsorption (IA) proved to be therapeutically effective. We focused on agonistic autoantibodies (agAAB) directed against G-protein coupled receptors (GPCR) and proved the hypothesis, that these agAAB might be present in TAO and that a five day course of IA might be able to eliminate these agAAB effectively. Patients and methods: Between December 2012 and May 2014 11 TAO-patients were treated by IA in a five day course. AgAAB-analysis was performed using specific ELISA techniques. Results: AgAAB were detected in 9 out of 11 patients (81.8 %).Multiple agAAB were present in 7 patients (63.6 %). A clustering of agAAB directed against loop1 of the adrenergic α1-receptor and the endothelin-A-(ETA)receptor was identified, representing 72.7 % resp. 54.5 % of the patients. AgAAB directed against the angiotensin-1 (AT-1) epitope 1 or 2 were detected in 3 patients and agAAB directed against protease-activated receptor (PAR) loop1/2 were seen in 2 patients. AgAAB directed against ETA-receptor loop1 never appeared without agAAB directed against α1-receptor loop1. Immediately after a five day-course of IA agAAB were absent in 81.8 % of the total study group and in 77.8 % of all cases tested positive for agAAB before IA. Conclusions: AgAAB directed against GPCR were identified in TAO patients with a clustering of agAAB directed against α-1-adrenergic receptor loop1 and ETA-receptor loop1. AgAA were eliminated by IA in the majority of cases. We suggest that these agAA play an important role in the pathogenesis of TAO and that their elimination might be responsible for the positive therapeutic effects reported in patients treated with IA.

scholarly journals Treatment of Yunnan Baiyao plus Kangfuxin Solution Reduces Inflammatory Response and Prevents Patients with Nasopharyngeal Carcinoma against Radiation-Induced Oral Mucositis

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Xiuyu Tang ◽  
Jiahui Sun ◽  
Jie Deng ◽  
Bin Shi
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Inflammatory Response ◽  
Oral Mucositis ◽  
Additional Treatment ◽  
Inflammatory Factors ◽  
Control Group ◽  
Therapeutic Effects ◽  
Study Group ◽  
Radiation Induced ◽  
Yunnan Baiyao

Oral mucositis refers to secondary mucosal damage, which usually occurs during cancer treatment. Generally, patients with head and neck cancers receiving radiotherapy will develop mucositis. Oral mucositis usually begins with mucosal inflammation and is characterized by erythema and confluent ulcers. The purpose of the study is to explore the therapeutic effects of Yunnan Baiyao combined with Kangfuxin solution on radiation-induced oral mucositis and the influence on production of inflammatory factors in patients with nasopharyngeal carcinoma (NPC) after radiotherapy. Clinical variables of 90 NPC patients were retrospectively analyzed. All patients underwent combined treatment (normal saline and inhalation of dexamethasone, gentamicin, and vitamin B12) 1st after radiotherapy, among which 45 patients received additional treatment of Yunnan Baiyao plus Kangfuxin solution and assigned as the study group. We found that additional treatment of Yunnan Baiyao plus Kangfuxin solution remarkably attenuated pain and dry mouth and reduced the degree of mucosal hyperaemia, edema, and ulceration in NPC patients undergoing radiotherapy ( P < 0.05 ). It was also found that additional treatment of Yunnan Baiyao plus Kangfuxin solution notably inhibited the release of inflammatory factors and cancer-related markers, as evidenced by lower serum levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), matrix metalloproteinase-9 (MMP-9), serum hypoxia-inducible factor-1 α (HIF-1α), and vascular endothelial growth factor (VEGF) detected in the study group than the control group ( P < 0.05 ). Additionally, the numbers of CD+3 and CD+4 subpopulations of T lymphocytes and the ratio of CD+4/CD+8 in the study group were significantly higher than those in the control group ( P < 0.05 ), and the number of CD+8 subpopulations in the study group was significantly lower than those in the control group ( P < 0.05 ). In conclusion, these results indicated that additional treatment of Yunnan Baiyao plus Kangfuxin solution reduces inflammatory response and prevents patients with NPC against radiation-induced oral mucositis.

scholarly journals Effect of acupuncture combined with Astragalus injection on peripheral blood inflammatory factors in children with diarrhea-predominant irritable bowel syndrome

2019 ◽  
Vol 17 ◽  
pp. 205873921985368 ◽  
Author(s):  
Huimin Xue ◽  
Shan Shao
Keyword(s):  
Irritable Bowel Syndrome ◽  
Acupuncture Therapy ◽  
Peripheral Blood ◽  
Inflammatory Factors ◽  
Control Group ◽  
Therapeutic Effects ◽  
Study Group ◽  
Calcitonin Gene ◽  
Irritable Bowel ◽  
Better Than

The objective of this article is to explore the clinical efficacy of acupuncture therapy of Traditional Chinese Medicine (TCM) combined with Astragalus injection in the treatment of children with diarrhea-predominant irritable bowel syndrome (IBS), and its effects on 5-hydroxytryptamine (5-HT), neuropeptide Y (NPY), and calcitonin gene-related peptide (CGRP) in peripheral blood. A total of 116 children with diarrhea-predominant IBS admitted to our hospital from January 2017 to January 2018 were randomly divided into two groups. The control group was treated with Astragalus injection, while the research group was treated with acupuncture therapy of TCM combined with Astragalus injection. The therapeutic effects, the concentrations of CGRP, NPY, and 5-HT in peripheral blood were compared between the two groups. The therapeutic efficacy of the study group was better than that of the control group ( P < 0.05). The concentrations of CGRP, NPY, and 5-HT in the peripheral blood of the study group were less than those of the control group ( P < 0.05). Acupuncture therapy of TCM combined with Astragalus injection has a satisfactory effect in the treatment of children with diarrhea-predominant IBS, which is worthy of more publicity and application in the clinic.

scholarly journals A Randomized Controlled Trial on the Effectiveness of Epidermal Growth Factor-Containing Ointment on the Treatment of Solar Lentigines as Adjuvant Therapy

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 166
Author(s):  
Hye One Kim ◽  
Hye Ran Kim ◽  
Jin Cheol Kim ◽  
Seok Young Kang ◽  
Min Je Jung ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Nd:Yag Laser ◽  
Controlled Trial ◽  
Control Group ◽  
Therapeutic Effects ◽  
Study Group ◽  
Patient’S Satisfaction ◽  
Epidermal Growth ◽  
532 Nm

Background and Objective: Little is known about the anti-pigmentation effects of whitening agents on solar lentigines. Epidermal growth factor (EGF) has been used as a booster for wound healing in the skin, and it has been suggested to have anti-pigmentation effects. This study aimed to evaluate the effect and safety of EGF-containing ointment for treating solar lentigines with a Q-switched (QS) 532 nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (Bluecore company, Seoul, Republic of Korea). Materials and Methods: Subjects who underwent QS 532 nm Nd:YAG laser treatment of solar lentigines were randomly assigned to treatment with an EGF ointment or petrolatum. After the laser procedure, the subjects were administered the test ointment twice a day for 4 weeks. The physician’s assessment of the degree of pigment clearance and patient’s satisfaction were assessed after 4 and 8 weeks. Additionally, the melanin index (MI), erythema index (EI), transepidermal water loss (TEWL), and post-inflammatory hyperpigmentation (PIH) were evaluated. This trial was registered with ClinicalTrials.gov (NCT04704245). Results: The blinded physician’s assessment using 5-grade percentage improvement scale and patient’s satisfaction were significantly higher in the study group than in the control group at the 4th and 8th weeks. The MI was significantly higher in the control group than in the study group at the 4th and 8th weeks. The EI and TEWL did not differ significantly between the two groups at either time point. The incidence of PIH was higher in the control group (37.5%) than in the EGF group (7.14%) at the 8th week. Conclusions: The application of EGF-containing ointment on facial solar lentigines with a QS 532 nm Nd:YAG laser showed efficient and safe therapeutic effects, with less PIH. Thus, EGF-containing ointment could be suggested as the promising adjuvant treatment strategy with a QS laser for solar lentigines.

scholarly journals Investigation of the Therapeutic Effects of Hot Springs Waters Sourced from Afyonkarahisar Region on Experimentally-induced Myocardial infarctus in Rats

2020 ◽  
Vol 11 (Vol.11, no.3) ◽  
pp. 244-251
Author(s):  
Constantin Munteanu ◽  
Mehmet Ali EMEKSIZ ◽  
Yavuz ULUSOY ◽  
Bahadir KİLİC
Keyword(s):  
Myocardial Infarction ◽  
Hot Springs ◽  
Hot Spring ◽  
Tap Water ◽  
Public Health Problem ◽  
Study Groups ◽  
Control Group ◽  
Therapeutic Effects ◽  
Study Group ◽  
Blood Biochemical

Myocardial infarction is an important public health problem in human and animals. In this study, myocardial infarction was induced by intraperitoneally injected isoproterenol hydrochloride in saline solution at a dose of 85 mg/kg body weight for 2 days. After myocardial infarction formation, three animals were exed to collect blood and histopathological specimens. The remaining 32 rats were divided into control and study groups for treatment. In the treatment stage; the control group animals were treated with tap water, while the study group animals were received Süreyya I hot spring mineral water. Clinical, hematological, blood biochemical and histopathological examinations was performed in all the animals before study, after myocardial infarction, and on 1st, 7th, 14th and 21st days after treatment. In terms of T, P and R, there were significant differences (p <0.05) with respect to time periods between control and study groups (p <0.05). WBC, NOTR, MON MCH, HCT ve MCV levels decreased, while RBC, HG, HCT, LENF, MCH and MCHC levels increased following treatmen in both groups. These changes were significant in study group comaper to control. It was also seen that ALT, AST, CK and CRP levels of blood biochemical parameters were significantly increased (p <0.05) after myocardial infarction formation. By begining treatment, TP, ALB and GLU levels increased, whereas ALT, AST, CK and CRP levels decreased, especially on the 21st day of the study in the SG. It was concluded that in the correct temperature and time to use Süreyya I hot spring water as drinking and bathing was very successful in the treatment of myocardial infarction, either itself or along with other medical treatments.

scholarly journals Clinical Effect of Lung Qi-Diffusing and Tumor-Clearing Decoction in the Treatment of Advanced Lung Cancer

2021 ◽  
Vol 5 (6) ◽  
pp. 38-42
Author(s):  
Limei Qin
Keyword(s):  
Lung Cancer ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Reference Group ◽  
Advanced Lung Cancer ◽  
Control Group ◽  
Therapeutic Effects ◽  
Study Group ◽  
Conventional Chemotherapy

Objective: The main purpose of this study is to explore the efficacy of lung qi-diffusing and tumor-clearing decoction in the treatment of advanced lung cancer. Methods: Eight patients with advanced lung cancer in Inner Mongolia Baicaotang Qin’s Zhong Meng Medical Hospital from February 2017 to October 2020 were randomly selected and divided into two groups, a control group and a study group, by the digital table method. The control group was treated with conventional chemotherapy, while the study group was treated with lung qi-diffusing and tumor-clearing decoction on this basis. The therapeutic effects of the two groups were observed. Results: The improvement in symptoms of the patients in the study group was higher than that of the reference group, and the incidence of adverse reactions was lower among patients in the study group compared to the reference group, P < 0.05. The serum immunological indexes, CD3+, CD4+, and CD4+/CD8+, of study group were higher than those of the reference group, and the quality-of-life score of the study group was higher than that of the reference group, P < 0.05. Conclusion: The clinical effect of lung qi-diffusing and tumor-clearing decoction in the treatment of patients with advanced lung cancer is significant. It effectively improves the immune indicators and reduces adverse reactions.

scholarly journals Effect of autologous NK cell immunotherapy on advanced lung adenocarcinoma with EGFR mutations

2019 ◽  
Vol 2 (4) ◽  
pp. 235-245 ◽  
Author(s):  
Guodai Hong ◽  
Xuemei Chen ◽  
Xizhuo Sun ◽  
Meiling Zhou ◽  
Bing Liu ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Lung Adenocarcinoma ◽  
Egfr Mutation ◽  
Nk Cell ◽  
Egfr Mutations ◽  
Therapeutic Effects ◽  
Study Group ◽  
Cell Immunotherapy ◽  
Group A ◽  
Nk Cell Therapy

Abstract This study investigated the efficiency of natural killer (NK) cell immunotherapy on non-small cell lung cancer with and without EGFR mutations in order to evaluate the response rate (RR) and progression-free survival (PFS). Among the 48 patients recruited, 24 were clinically confirmed to be EGFR mutation positive. The study group was treated with autologous NK cell immunotherapy. Comparisons of the lymphocyte number, serum tumour-related biomarkers, circulating tumour cells (CTC), Karnofsky Performance Status (KPS) and survival curves were carried out before and after NK cell immunotherapy. The safety and short-term effects were evaluated, followed by median PFS and RR assessments. The serum CEA and CA125 values were found lower in the NK cell therapy group than that of the non-NK treatment group (p &lt; 0.05). The χ2 test showed a 75% RR of the study group A, significantly higher than that of the control group B (16.7%; p &lt; 0.01). The RR of groups C (58.3%) and D (41.7%) were not statistically significant. The p values of the 4 groups were 0.012, 0.012, 0.166 and 1 from group A to group D, respectively. The median PFS was 9 months in EGFR mutation positive group undergoing NK cell infusion interference. By evaluating the changes in immune function, tumour biomarkers, CTC, KPS and PFS, we demonstrated that NK cell therapy had better clinical therapeutic effects on EGFR mutation-positive lung adenocarcinoma.

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