Two-hour glucose and insulin responses after a standardized oral glucose load in relation to serum gamma-glutamyl transferase and alcohol consumption

1981 ◽  
Vol 18 (4) ◽  
pp. 311-317 ◽  
Author(s):  
Erik Trell ◽  
Hans Kristenson ◽  
Bo Peterson ◽  
Goran Fex ◽  
Nels Christian Henningsen ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Oral Glucose ◽  
Gamma Glutamyl Transferase ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase ◽  
Insulin Responses

scholarly journals Evaluation of role of concentration and molecular weight of oat β-glucan in determining effect of viscosity on plasma glucose and insulin following an oral glucose load

2000 ◽  
Vol 84 (1) ◽  
pp. 19-23 ◽  
Author(s):  
P. J. Wood ◽  
M. U. Beer ◽  
G. Butler
Keyword(s):  
Molecular Weight ◽  
Blood Glucose ◽  
High Performance ◽  
Size Exclusion ◽  
Postprandial Blood Glucose ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Exclusion Chromatography ◽  
Insulin Responses

Data from clinical studies established that there was an inverse linear relationship between measures of postprandial blood glucose and insulin responses to an oral glucose load, consumed in a drink, and the logarithm of viscosity of the drink. These data have been re-analysed using concentration and molecular weight as the dependent variables. Molecular weight (M) of the β-glucans used was determined using high-performance size exclusion chromatography equipped with a triple detector system of right angle light scattering, viscometry and refractive index. A significant relationship between changes in peak blood glucose and a combination of logarithm of the concentration and logarithm of M was found.

A new concept for the evaluation of the blood glucose and insulin responses of healthy subjects following an oral glucose load

1974 ◽  
Vol 11 (4) ◽  
pp. 265-276 ◽  
Author(s):  
Olga Szabo ◽  
Werner Oppermann ◽  
Rafael A. Camerini-Dávalos ◽  
Carl Victor
Keyword(s):  
Blood Glucose ◽  
Healthy Subjects ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Insulin Responses

Diurnal changes in plasma glucose and insulin responses to oral glucose load in rats

1980 ◽  
Vol 238 (5) ◽  
pp. E463-E466 ◽  
Author(s):  
E. Hara ◽  
M. Saito
Keyword(s):  
Plasma Glucose ◽  
Diurnal Variations ◽  
Oral Glucose ◽  
Diurnal Changes ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Feeding Schedule ◽  
Insulin Responses

The plasma glucose and insulin responses to an oral load of glucose were examined in the daytime and at night in unanesthetized and unrestrained rats. In rats that had been fed during the nighttime (2200-0400 h) every day for 2 wk, the plasma glucose and insulin responses were significantly greater (P less than 0.05) at night (2200-2400 h) than in the daytime (1000-1200 h). In rats that had been fed during the daytime (1000-1600 h), the plasma glucose and insulin responses were greater in the daytime than at night (P less than 0.05). It was concluded that the diurnal variations in the plasma glucose and insulin responses to an oral glucose load are closely related to the feeding schedule on which the rats are kept.

scholarly journals Clinical and biochemical aspects of coagulation control in patients with atrial fibrillation and excessive alcohol consumption

2015 ◽  
Vol 96 (5) ◽  
pp. 734-741
Author(s):  
D G Novikov ◽  
A V Indutnyy ◽  
N A Trofimovich ◽  
N I Sidenko ◽  
G A Borzenok ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Alcohol Consumption ◽  
Study Group ◽  
Gamma Glutamyl Transferase ◽  
Excessive Alcohol Consumption ◽  
Gamma Glutamyl ◽  
Target Values ◽  
Excessive Alcohol ◽  
Glutamyl Transferase ◽  
D Dimer

Aim. Reveal the influence of excessive alcohol consumption on blood coagulation system, levels of blood proteins in patients with atrial fibrillation treated with warfarin. Methods. The study included 80 patients with a diagnosis of atrial fibrillation, treated with vitamin K antagonists. The study group included 34 patients with excessive alcohol consumption (according to the questionnaire), the comparison group - 46 patients with no excessive alcohol consumption. Transferrin, hemopexin, aspartate transaminase, alanine transaminase, gamma-glutamyl transferase, carbohydrate-deficient transferrin levels were measured in venous blood serum, serum protein electrophoresis was performed. Parameters of plasma hemostasis tests and D-dimer level were also analyzed. Results. Gamma-glutamyl transferase activity in patients of study group was 1.5 times higher compared to the comparison group (p=0.021). There was no statically significant differences in aspartate transaminase and alanine transaminase activity, but their levels were increased in alcohol abusers with gamma-glutamyl transferase above normal values (55 U/l). None of the patients had increased level of carbohydrate-deficient transferrin. Absolute and relative serum β1-globulin concentrations were significantly reduced in study group patients, while hemopexin and transferrin levels were at the same level as in the control group. No differences of coagulation parameters were between the groups. In the study group, in patients with β1-globulin levels below the median values, international normalized ratio was significantly closer to the target values, but the same patients had higher D-dimer levels, which apparently indicates low effect of anticoagulants. Conclusion. The effect of anticoagulant was low in patients with excessive alcohol consumption and atrial fibrillation, as evidenced by elevated D-dimer levels at international normalized ratio close to the target values. Patients with atrial fibrillation and excessive alcohol consumption with elevated D-dimer levels had serum β1-globulin levels reduced compared to median values.

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