Indicators of Alcohol Consumption: Comparisons Between a Questionnaire (Mm-MAST), Interviews and Serum gamma-Glutamyl Transferase (GGT) in a Health Survey of Middle-aged Males

Addiction ◽  
1982 ◽  
Vol 77 (3) ◽  
pp. 297-304 ◽  
Author(s):  
Hans Kristenson ◽  
Erik Trell
Keyword(s):  
Alcohol Consumption ◽  
Health Survey ◽  
Gamma Glutamyl Transferase ◽  
Middle Aged ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals Serum Gamma-Glutamyl Transferase Is Associated with Epicardial Fat Thickness in Middle Aged Women

2020 ◽  
Vol 71 (1) ◽  
pp. 430-435
Author(s):  
Adriana Albu ◽  
Anca Moldovan ◽  
Cristian Petra ◽  
Ioana Para
Keyword(s):  
Visceral Adiposity ◽  
Skewed Distribution ◽  
Epicardial Fat ◽  
Abdominal Circumference ◽  
Gamma Glutamyl Transferase ◽  
Middle Aged ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
Cardiovascular Morbidity And Mortality ◽  
Glutamyl Transferase

Accumulating data indicate that gamma-glutamyl transferase (GGT) is associated with cardiovascular morbidity and mortality. A positive correlation between GGT levels and various cardiometabolic risk factors has been previously found. The aim of this study was to investigate the relationship between GGT and epicardial fat tissue thickness (EFTT) a marker of visceral adiposity. A total of one hundred five middle-aged (40-60 years) women were included in this cross-sectional study. EFTT was measured using 2-dimensional echocardiography, on the free wall of the right ventricle perpendicularly to the aortic annulus. Biochemical parameters were determined with an automated biochemical analyzer. Values of GGT were logarithmically transformed (log-GGT) because of their skewed distribution. We found that log-GGT correlated with age, body mass index, abdominal circumference, EFTT, triglycerides, fasting plasma glucose and uric acid. In multivariate regression analysis, log-GGT levels were independently associated with EFTT (�=0.27, p=0.004), postmenopausal status (�=0.25, p=0.008) and triglycerides (�=0.23, p=0.01). In conclusion, in middle-aged women, GGT independently correlated with EFTT and may be a marker of visceral adiposity and increased cardiovascular risk.

Serum Gamma-Glutamyl Transferase and a Somatic Health Score in Middle-Aged Men

1980 ◽  
Vol 17 (3) ◽  
pp. 134-139 ◽  
Author(s):  
E Trell ◽  
B Petersson ◽  
H Kristenson ◽  
G Fex ◽  
P Larme ◽  
...  
Keyword(s):  
Health Screening ◽  
Screening Tests ◽  
Gamma Glutamyl Transferase ◽  
Hepatic Enzyme ◽  
Middle Aged ◽  
Normal Distributions ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase ◽  
Descriptive Method ◽  
Score Index

In an ongoing population investigation of middle-aged men in Malmö, Sweden, several health screening variables showed strong but crude individual covariations with the level of the hepatic enzyme, serum gamma-glutamyl transferase (GGT). These variables were combined, according to an analysis of their normal distributions, into a score index which exhibited a much smoother correlation with low, normal, and elevated levels of GGT when tested in a random population subsample. It is concluded that this scoring system may find further utilisation as a general descriptive method of recording statistical covariations between health screening tests and sum them up.

scholarly journals Clinical and biochemical aspects of coagulation control in patients with atrial fibrillation and excessive alcohol consumption

2015 ◽  
Vol 96 (5) ◽  
pp. 734-741
Author(s):  
D G Novikov ◽  
A V Indutnyy ◽  
N A Trofimovich ◽  
N I Sidenko ◽  
G A Borzenok ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Alcohol Consumption ◽  
Study Group ◽  
Gamma Glutamyl Transferase ◽  
Excessive Alcohol Consumption ◽  
Gamma Glutamyl ◽  
Target Values ◽  
Excessive Alcohol ◽  
Glutamyl Transferase ◽  
D Dimer

Aim. Reveal the influence of excessive alcohol consumption on blood coagulation system, levels of blood proteins in patients with atrial fibrillation treated with warfarin. Methods. The study included 80 patients with a diagnosis of atrial fibrillation, treated with vitamin K antagonists. The study group included 34 patients with excessive alcohol consumption (according to the questionnaire), the comparison group - 46 patients with no excessive alcohol consumption. Transferrin, hemopexin, aspartate transaminase, alanine transaminase, gamma-glutamyl transferase, carbohydrate-deficient transferrin levels were measured in venous blood serum, serum protein electrophoresis was performed. Parameters of plasma hemostasis tests and D-dimer level were also analyzed. Results. Gamma-glutamyl transferase activity in patients of study group was 1.5 times higher compared to the comparison group (p=0.021). There was no statically significant differences in aspartate transaminase and alanine transaminase activity, but their levels were increased in alcohol abusers with gamma-glutamyl transferase above normal values (55 U/l). None of the patients had increased level of carbohydrate-deficient transferrin. Absolute and relative serum β1-globulin concentrations were significantly reduced in study group patients, while hemopexin and transferrin levels were at the same level as in the control group. No differences of coagulation parameters were between the groups. In the study group, in patients with β1-globulin levels below the median values, international normalized ratio was significantly closer to the target values, but the same patients had higher D-dimer levels, which apparently indicates low effect of anticoagulants. Conclusion. The effect of anticoagulant was low in patients with excessive alcohol consumption and atrial fibrillation, as evidenced by elevated D-dimer levels at international normalized ratio close to the target values. Patients with atrial fibrillation and excessive alcohol consumption with elevated D-dimer levels had serum β1-globulin levels reduced compared to median values.

Two-hour glucose and insulin responses after a standardized oral glucose load in relation to serum gamma-glutamyl transferase and alcohol consumption

1981 ◽  
Vol 18 (4) ◽  
pp. 311-317 ◽  
Author(s):  
Erik Trell ◽  
Hans Kristenson ◽  
Bo Peterson ◽  
Goran Fex ◽  
Nels Christian Henningsen ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Oral Glucose ◽  
Gamma Glutamyl Transferase ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase ◽  
Insulin Responses

scholarly journals Serum gamma-glutamyl transferase, a marker of alcohol intake, is associated with telomere length and cardiometabolic risk in young adulthood

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Esmée M. Bijnens ◽  
Catherine Derom ◽  
Evert Thiery ◽  
Dries S. Martens ◽  
Ruth J. F. Loos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alcohol Consumption ◽  
Telomere Length ◽  
Young Adulthood ◽  
Alcohol Intake ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

AbstractStudies based on self-reported alcohol consumption and telomere length show inconsistent results. Therefore, we studied the association between gamma-glutamyl transferase (GGT), a widely used biomarker of alcohol intake, and telomere length. The possible health relevance in young adulthood was explored by investigating cardiometabolic risk factors. Mixed modelling was performed to examine GGT and alcohol consumption in association with telomere length in buccal cells of 211 adults between 18 and 30 years old of the East Flanders Prospective Twin Survey. In addition, we investigated the association between GGT and cardiometabolic risk factors; waist circumference, systolic blood pressure, fasting glucose, HDL cholesterol, and triglycerides. Although we did not observe an association between self-reported alcohol consumption and telomere length, our results show that a doubling in serum GGT is associated with 7.80% (95% CI − 13.9 to − 1.2%; p = 0.02) shorter buccal telomeres, independently from sex, chronological age, educational level, zygosity and chorionicity, waist-to-hip ratio and smoking. The association between GGT was significant for all five cardiometabolic risk factors, while adjusting for age. We show that GGT, a widely used biomarker of alcohol consumption, is associated with telomere length and with risk factors of cardiometabolic syndrome, despite the young age of this study population.

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