Effect of long-term alcohol abuse on male sexual function and serum gonadal hormone levels

1998 ◽  
Vol 30 (6) ◽  
pp. 755-759 ◽  
Author(s):  
B. Gümüs ◽  
M. R. Yiĝitoĝlu ◽  
M. Lekili ◽  
B. S. Uyanik ◽  
T. Müezzinoĝlu ◽  
...  
Keyword(s):  
Alcohol Abuse ◽  
Sexual Function ◽  
Gonadal Hormone ◽  
Hormone Levels ◽  
Male Sexual Function

scholarly journals Gender Differences in Depression and Sex Hormones among Patients Receiving Long-Term Opioid Treatment for Chronic Noncancer Pain in Taiwan—A Multicenter Cross-Sectional Study

2021 ◽  
Vol 18 (15) ◽  
pp. 7837
Author(s):  
Shung-Tai Ho ◽  
Tso-Chou Lin ◽  
Chun-Chang Yeh ◽  
Kuang-I Cheng ◽  
Wei-Zen Sun ◽  
...  
Keyword(s):  
Sexual Function ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Cross Sectional ◽  
Chronic Noncancer Pain ◽  
Depression Diagnosis ◽  
Opioid Treatment ◽  
Hormone Levels ◽  
Noncancer Pain

Background: Long-term use of opioids for chronic noncancer pain is associated with sex hormone disturbances. The interferences with sex hormones, sexual function, and depression were investigated in patients with chronic noncancer pain. Methods: A cross-sectional multicenter survey was conducted on 170 officially registered outpatients receiving long-term opioid treatment in nine medical centers in Taiwan between October 2018 and July 2019. Serum sex hormone levels were examined after the collection of self-administered questionnaires containing the Taiwanese version of the Brief Pain Inventory, depressive status, and sexual function interference. Results: Among 117 (68.8%) questionnaire responses from 170 enrolled outpatients, 38 women and 62 men completed the sex hormone tests, among whom only 23 (23%) had previously received blood hormone tests. Low serum total testosterone levels were detected in 34 (89.5%) women (<30 ng/dL) and 31 (50%) men (<300 ng/dL). Over 60% of women and men reported reduced sexual desire and function despite a nearly 50% reduction in pain intensity and daily function interference over the previous week after opioid treatment. Women generally had higher risks of a depression diagnosis (p = 0.034) and severe depressive symptoms (p = 0.003) and nonsignificantly lower opioid treatment duration (median 81 vs. 120 months) and morphine milligram equivalent (median 134 vs. 165 mg/day) compared with men. Conclusions: This survey demonstrated the high prevalence of depression diagnosis, low sex hormone levels, and reduced sexual function among Taiwanese patients with chronic noncancer pain receiving prolonged opioid therapy. Regular hypogonadal screenings are recommended for further management.

scholarly journals Comparison of Gonadal Hormone Levels in Turkey Embryos Incubated in Long-Term Shell-Less Culture and In Ovo

2001 ◽  
Vol 80 (5) ◽  
pp. 666-669 ◽  
Author(s):  
M.A. Abdelnabi ◽  
M.P. Richards ◽  
M.A. Ottinger
Keyword(s):  
Gonadal Hormone ◽  
In Ovo ◽  
Hormone Levels

The Long-Term Hormone Levels and Sexual Function of Monorchid Patients

2006 ◽  
Vol 73 (4) ◽  
pp. 317-321
Author(s):  
L. Carmignani ◽  
G Galasso ◽  
P. Acquati ◽  
F. Gadda ◽  
S. Zambito ◽  
...  
Keyword(s):  
Sexual Function ◽  
Hormone Levels

scholarly journals PENGARUH VASEKTOMI TERHADAP FUNGSI SEKSUAL PRIA

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Mir'atul Fitri ◽  
Benny Wantouw ◽  
Lydia Tendean
Keyword(s):  
Sexual Dysfunction ◽  
Elementary Education ◽  
Sexual Function ◽  
Drug Users ◽  
Univariate Analysis ◽  
Target Population ◽  
Cross Sectional ◽  
Male Sexual Function ◽  
Excessive Stress

Abstract: Vasectomy in the community are still poorly understood, such as vasectomy can affect sexual function (sexual dysfunction). The purpose of this study was to determine the effect of vasectomy on male sexual function and the mechanisms of sexual function in men due to vasectomy. This study is a cross sectional analytic survey with a target population of men who have vasectomy totaling 67 people selected by proportional sampling of Manado City BKKBN January to August 2012. Instruments in this study using the questionnaire International Index Erectile Function (IIEF), the analysis of the data in this study using univariate analysis and Mann Whitney Sub Menu 2 Independent simple (SPSS 20 for Windows). The results, the majority of respondents aged > 35 years were 63 people (94.03%), elementary education as many as 48 people (62.34%), earning Rp. 500,000 - Rp. 1.000.000 by 47 people (70.1%), having more than one child as many as 64 people (95.5%), vasectomy contraceptive users with better sexual function by 56 people (83.60%), significant results statistics between vasectomy contraceptive users who have comorbidities, consuming drugs and having stress with sexual function. Contraception has no effect on male sexual function and sexual dysfunction occurs due to men having comorbidities, smoking and excessive alkohol consuming in the long term, drug users, and have excessive stress. Keywords: Vasectomy, Sexual Function, Male.     ABSTRAK: Vasektomi dikalangan masyarakat masih kurang dipahami, seperti vasektomi dapat berdampak terhadap fungsi seksual (disfungsi seksual). Tujuan penelitian ini untuk mengetahui pengaruh vasektomi terhadap fungsi seksual pria dan mekanisme fungsi seksual pada pria akibat vasektomi. Penelitian ini bersifat survei analitik pendekatan cross sectional dengan populasi target pria yang telah divasektomi berjumlah 67 orang dipilih secara proporsional sampling dari data BKKBN Kota Manado Januari-Agustus 2012. Instrumen dalam penelitian ini menggunakan Kuesioner Indeks Fungsi Ereksi Internasional (IIEF), analisa data dalam penelitian ini menggunakan analisa univariat dan analisa Mann Whitney Sub Menu 2 Independent simple (SPSS 20 for Windows). Hasil penelitian didapatkan mayoritas responden usia >35 tahun sebanyak 63 orang (94,03%), berpendidikan SD sebanyak 48  orang (62,34%), berpenghasilan Rp. 500.000 – Rp. 1.000.000 sebanyak 47 orang (70,1%), memiliki anak lebih dari satu orang sebanyak 64 orang (95,5%), pengguna kontrasepsi vasektomi dengan fungsi seksual baik sebanyak 56 orang (83,60%), hasil yang bermakna secara statistik antara pengguna kontrasepsi vasektomi yang memiliki penyakit penyerta, mengkonsumsi narkoba dan mengalami stres dengan fungsi seksual. Kontrasepsi vasektomi tidak berpengaruh pada fungsi seksual pria dan disfungsi seksual terjadi diakibatkan oleh pria memiliki penyakit penyerta, merokok dan mengkonsumsi alhokol dalam jangka waktu panjang dan volume berlebihan, pengguna narkoba, dan memiliki stress berlebihan. Kata kunci: Vasektomi, Fungsi seksual, Pria.

Sexual function in male lymphoma survivors versus matched controls: Relationship to age, gonadal hormones, and quality of life

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 9510-9510
Author(s):  
C. E. Kiserud ◽  
L. R. Schover ◽  
A. Fossaa ◽  
A. A. Dahl ◽  
J. H. Loge ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sexual Function ◽  
Mental Distress ◽  
Gonadal Hormones ◽  
Self Report ◽  
Gonadal Hormone ◽  
Multivariate Linear Regression Analysis ◽  
Hormone Levels ◽  
Lymphoma Survivors

9510 Background: Sexual function in male lymphoma survivors (LS) was examined and compared to age-matched controls from the general population (CTR). Methods: The study includes 294 LSs, diagnosed 1980–2002, treated at the Norwegian Radium Hospital, ≤50 years at diagnosis, with recent gonadal hormone levels [testosterone (T), SHBG, LH, and FSH]. Sexual function was assessed using the Brief Male Sexual Function Inventory (BSFI) consisting of 11 self-report items covering five domains: sexual drive, erectile function, ejaculatory function, problem assessment and overall satisfaction. Lower scores indicate impaired sexual function. A total BSFI score (T-BSFI) was constructed by summing all items except overall satisfaction. Mean and median scores for the BSFI domains and T-BSFI were compared across age groups (21–39, 40–49, 50–59, 60–69 years at survey), gonadal hormone levels [normal (n=144), elevated FSH only (n=60), low T and/or elevated LH (n=90)], cancer treatment intensity, comorbidity, relationship status, fatigue score, mental distress (HADS) and quality of life (SF-36, mental and physical health components). Multivariate linear regression analysis was performed with T-BSFI as the dependent variable including independent variables significant in univariate analyses. Each LS was matched to two CTRs (n=506). Results: Valid T-BSFI scores were available for 253 LSs (86%). Median age at survey was 48 years, median duration of follow-up 15 years, and 78% were in a committed relationship. LSs aged 40–59 years had significantly lower T-BSFIs compared to their CTRs (p≤0.01). All BSFI domain scores and T-BSFI decreased significantly with ageing. LSs with low T and/or elevated LH had the lowest BSFI domain and T-BSFI scores. Survivors with normal hormone levels had the highest scores. Low T and/or elevated LH (p=0.03), age ≥50 years at survey (p≤ 0.001) and mental distress (p< 0.001) were significantly associated with male sexual dysfunction (T-BSFI) in the multivariate analysis. Conclusions: LSs aged 40–59 years reported poorer sexual function than age-matched CTRs. Impaired sexual function was significantly associated with age ≥ 50 years at survey, having low T and/or elevated LH and being distressed. No significant financial relationships to disclose.

Long-term effects of ageing and ovariectomy on aversive and recognition memory and DNA damage in the hippocampus of female rats

2013 ◽  
Vol 26 (3) ◽  
pp. 161-169 ◽  
Author(s):  
Daniela Dimer Leffa ◽  
Adriani Paganini Damiani ◽  
Daiane Dal Col Damazio ◽  
Naiana Pereira Guerra ◽  
Morgana Moretti ◽  
...  
Keyword(s):  
Dna Damage ◽  
The Body ◽  
Female Rats ◽  
Ageing Process ◽  
Gonadal Hormone ◽  
Long Term Effects ◽  
Tissue Samples ◽  
Hormone Levels ◽  
Group I

ObjectiveThis study investigated the influence of ageing – in particular the decrease of gonadal hormone levels during the ageing process – on the memory and the levels of DNA damage in the hippocampus of female rats.MethodsThree groups of female Wistar rats were investigated: Group I consisted of non-ovariectomised, adult animals (6 months old); Group II consisted of non-ovariectomised, aged animals (18 months old); and Group III consisted of ovariectomised, aged animals (18 months old). The memory of the animals in these groups was examined via novel object recognition and inhibitory avoidance tests. The hippocampus tissue samples of all animals were obtained via biopsy and used to quantify the DNA damage using a Comet Assay.ResultsAccording to our findings, the process of ageing results in a change during the behavioural tests. To prevent genotoxic damage to the hippocampus caused by the ageing process, lowered hormone levels seem to be part of a protective biochemical mechanism in the body of rats. Animals that were previously submitted to an ovariectomy adapted better to these lower levels of hormones.ConclusionOur results indicate that ovariectomy can provide beneficial long-term effects on the memory. However, this could be specific to the kind of memory examined, as the aversive memory deficits caused by ageing were not affected by ovariectomy.

Do Male Lymphoma Survivors Have Impaired Sexual Function?

2009 ◽  
Vol 27 (35) ◽  
pp. 6019-6026 ◽  
Author(s):  
Cecilie E. Kiserud ◽  
Leslie R. Schover ◽  
Alv A. Dahl ◽  
Alexander Fosså ◽  
Trine Bjøro ◽  
...  
Keyword(s):  
Sexual Function ◽  
Emotional Distress ◽  
Gonadal Hormones ◽  
Sex Hormone Binding Globulin ◽  
Gonadal Hormone ◽  
Cross Sectional ◽  
Hormone Levels ◽  
Low Testosterone ◽  
Lymphoma Survivors ◽  
Domain Scores

Purpose Sexual function in male lymphoma survivors was examined and compared with that of age-matched controls. Patients and Methods This cross-sectional study included serum gonadal hormone levels (testosterone, sex hormone–binding globulin, luteinizing hormone [LH], and follicle-stimulating hormone) and responses to questionnaires assessing sexual function (Brief Sexual Function Inventory [BSFI]), socioeconomic factors, quality of life, emotional distress, and fatigue. The lymphoma group included 246 men ≤ 50 years old at diagnosis who were diagnosed from 1980 to 2002 and treated at the Norwegian Radium Hospital. For each lymphoma survivor, two age-matched controls (n = 492) were drawn from a normative sample with BSFI scores. Results The lymphoma survivors had a mean age at survey of 47.4 years, the mean duration of follow-up was 14.8 years, and 79% lived in committed relationships. All BSFI domain scores decreased significantly with age. Lymphoma survivors having low testosterone and/or elevated LH had lower BSFI scores than survivors with normal gonadal hormones. Multivariate analyses showed that increasing age, more emotional distress, poor physical health, and low testosterone and/or elevated LH were significantly associated with reduced sexual function within the lymphoma group. Lymphoma survivors had significantly lower BSFI domain scores than did controls on erection, ejaculation, and sexual satisfaction. Conclusion Lymphoma survivors had significantly poorer sexual function than normative controls. It is unclear whether the abnormal hormone levels directly cause the reduced sexual function within the lymphoma group or if a mediating factor is involved, such as aging, emotional distress, or perceived health status.

scholarly journals Sexual function outcomes following fracture of the penis.

2013 ◽  
Vol 7 (7-8) ◽  
pp. 252 ◽  
Author(s):  
Gregory J Nason ◽  
Barry B McGuire ◽  
Stephen Liddy ◽  
Aisling Looney ◽  
Gerald M Lennon ◽  
...  
Keyword(s):  
Sexual Function ◽  
Time Frame ◽  
Long Term Outcomes ◽  
Patient Reported ◽  
Male Sexual Function ◽  
Grading Scale ◽  
Urological Emergency ◽  
Short Time

Introduction: Fracture of the penis is a rare urological emergency which occurs as a result of abrupt trauma to an erect penis. There is paucity of data regarding long-term sexual function or erectile potency following fracture of the penis. The aim of this study is to objectively assess the overall sexual function following fracture of the penis.Methods: A retrospective analysis of 21 penile fractures was performed. A voluntary telephone questionnaire was performed to assess long term outcomes using three validated questionnaires-the Erection Hardness Grading Scale, the International Index of Erectile Function (IIEF-5) and the Brief Male Sexual Function inventory (BMSFI).Results: The mean age was 33.1 years (range: 19-63). The median follow up was 46 months (range: 3-144). All fractures were a result of sexual misadventure and all were surgically repaired. There were two concomitant urethral injuries. Seventeen patients were contactable. Fourteen patients demonstrated no evidence of erectile dysfunction (ED) (IIEF-5>22), 1 patient reported symptoms of mild ED (IIEF-5, 17-21) and one patient reported mild to moderate ED (IIEF-5, 12-16). No patients reported insufficient erection for penetration (EHGS: 1 or 2). Regarding the overall BMSFI, 13 (83%) patients were mostly satisfied or very satisfied with their sex life within the previous month.Conclusion: In a small surgical series of men with penile fracture managed within a short time frame from presentation, we demonstrate erectile potency is maintained. Long-term overall sexual satisfaction is promising.

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