Using patients’ descriptions of alcohol consumption, diet, medication compliance, and cigarette smoking

1989 ◽  
Vol 4 (2) ◽  
pp. 160-166 ◽  
Author(s):  
Victor J. Strecher ◽  
Marshall H. Becker ◽  
Noreen M. Clark ◽  
Patricia Prasada-Rao
Keyword(s):  
Alcohol Consumption ◽  
Cigarette Smoking ◽  
Medication Compliance

scholarly journals Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA (nc886)

2021 ◽  
Vol 118 (12) ◽  
pp. e2026580118
Author(s):  
Brittany L. Carpenter ◽  
Tanaka K. Remba ◽  
Stacey L. Thomas ◽  
Zachary Madaj ◽  
Lucy Brink ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Cigarette Smoking ◽  
Noncoding Rna ◽  
Environmental Influence ◽  
Differentially Methylated Region ◽  
Older Mothers ◽  
Environmental Perturbations ◽  
Human Genes ◽  
Apparent Relationship ◽  
Highly Correlated

Genomic imprinting occurs before fertilization, impacts every cell of the developing child, and may be sensitive to environmental perturbations. The noncoding RNA, nc886 (also called VTRNA2-1) is the only known example of the ∼100 human genes imprinted by DNA methylation, that shows polymorphic imprinting in the population. The nc886 gene is part of an ∼1.6-kb differentially methylated region (DMR) that is methylated in the oocyte and silenced on the maternal allele in about 75% of humans worldwide. Here, we show that the presence or absence of imprinting at the nc886 DMR in an individual is consistent across different tissues, confirming that the imprint is established before cellular differentiation and is maintained into adulthood. We investigated the relationships between the frequency of imprinting in newborns and maternal age, alcohol consumption and cigarette smoking before conception in more than 1,100 mother/child pairs from South Africa. The probability of imprinting in newborns was increased in older mothers and decreased in mothers who drank alcohol before conception. On the other hand, cigarette smoking had no apparent relationship with the frequency of imprinting. These data show an epigenetic change during oocyte maturation which is potentially subject to environmental influence. Much focus has been placed on avoiding alcohol consumption during pregnancy, but our data suggest that drinking before conception may affect the epigenome of the newborn.

scholarly journals Frequency and effects of food intake, cigarette smoking and alcohol consumption among the residents in Hisayama, Kyushu Island, Japan

Nosotchu ◽  
1986 ◽  
Vol 8 (2) ◽  
pp. 159-166
Author(s):  
Yasuo Hirota ◽  
Toshirou Yanai ◽  
Yutaka Hasuo ◽  
Junichi Wada ◽  
Yutaka Kiyohara
Keyword(s):  
Food Intake ◽  
Alcohol Consumption ◽  
Cigarette Smoking ◽  
Kyushu Island

scholarly journals Genetic Polymorphism of Glutathione S Transferases M1 and T1 in Indian Patients with Hepatocellular Carcinoma

2010 ◽  
Vol 28 (6) ◽  
pp. 369-376 ◽  
Author(s):  
Mohammad Asim ◽  
Luqman A. Khan ◽  
S. A. Husain ◽  
Sajid Husain ◽  
Manash P. Sarma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Alcohol Consumption ◽  
Liver Cancer ◽  
Cigarette Smoking ◽  
Case Control Study ◽  
Smoking Habit ◽  
Case Control ◽  
Gstt1 Null Genotype ◽  
Increased Risk ◽  
Control Study

Objective:Our aim was to evaluate whether the association of GSTM1/T1 gene polymorphisms modifies the risk of Hepatocellular carcinoma (HCC) and what is its correlation with other predisposing risk factors like alcohol intake, cigarette smoking and hepatitis B and C infections.Study design/setting:It was a case-control study, included 254 HCC cases compared with 525 hospital-based age and sex matched cases of chronic liver disease without HCC as controls from Indian population. The GSTM1 and GSTT1 genotypes were detected using conventional multiplex PCR method.Results:In this case-control study, we observed a positive correlation between age, HBV and HCV infection, smoking habit of > 20 packs/year, alcohol consumption of > 100 g/day and risk of liver cancer. We found significantly increased risk associated with GSTM1 null genotype (OR = 3.49; 95% CI = 2.52–4.84) as well as GSTT1 null genotype (OR = 3.12; 95% CI = 2.19–4.45), respectively. However, an increased risk of HCC was observed among heavy drinkers with GSTM1 (OR = 2.01; 95% CI = 1.11–3.66). Further, cigarette smoking showed a non-significant association with GSTT1 (OR = 1.49; CI = 0.69–3.25).Conclusion:Our results suggest that the variants in low penetrance gene such as GSTM1 and GSTT1 are associated with an increased liver cancer risk. Further, an influence of GSTM1/T1 null genotypes may contribute in the etiology of HCC in patients with higher cigarette and alcohol consumption.

scholarly journals The burden of disease preventable by risk factor reduction in Serbia

2013 ◽  
Vol 70 (5) ◽  
pp. 445-451 ◽  
Author(s):  
Sandra Sipetic ◽  
Vesna Bjegovic-Mikanovic ◽  
Hristina Vlajinac ◽  
Jelena Marinkovic ◽  
Slavenka Jankovic ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Alcohol Consumption ◽  
Cigarette Smoking ◽  
Physical Inactivity ◽  
Fruit And Vegetables ◽  
Blood Cholesterol ◽  
Years Of Life Lost ◽  
High Blood Cholesterol ◽  
Avoidable Risk

Background/Aim. Reliable and comparable analysis of health risks is an important component of evidence-based and preventive programs. The aim of this study was to analyze the impact of the most relevant avoidable risk factors on the burden of the selected conditions in Serbia. Methods. Attributable fractions were calculated from the survey information on the prevalence of a risk factor and the relative risk of dying if exposed to a risk factor. The population-attributable risks were applied to deaths, years of life lost due to premature mortality (YLL), years of life with disability (YLD) and disability adjusted life years (DALY). Results. More than 40% of all deaths and of the total YLL are attributable to cigarette smoking, overweight, physical inactivity, inadequate intake of fruit and vegetables, hypertension and high blood cholesterol. Alcohol consumption has in total a beneficial effect. According to the percent of DALY for the selected conditions attributable to the observed risk factors, their most harmful effects are as follows: alcohol consumption on road traffic accidents; cigarette smoking on lung cancer; physical inactivity on cerebrovascular disease (CVD), ischemic heart disease (IHD) and colorectal cancer; overweight on type 2 diabetes; hypertension on renal failure and CVD; inadequate intake of fruit and vegetables on IHD and CVD, and high blood cholesterol on IHD. Conclusions. This study shows that a high percentage of disease and injury burden in Serbia is attributable to avoidable risk factors, which emphasizes the need for improvement of relevant preventive strategies and programs at both individual and population levels. Social preferences should be determined for a comprehensive set of conditions and cost effectiveness analyses of potential interventions should be carried out. Furthermore, positive measures, derived from health, disability and quality of life surveys, should be included.

scholarly journals Effects of alcohol consumption, cigarette smoking, and betel quid chewing on upper digestive diseases: a large cross-sectional study and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 78011-78022 ◽  
Author(s):  
Yun-Shiuan Chuang ◽  
Meng-Chieh Wu ◽  
Fang-Jung Yu ◽  
Yao-Kuang Wang ◽  
Chien-Yu Lu ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Cigarette Smoking ◽  
Meta Analysis ◽  
Cross Sectional Study ◽  
Betel Quid ◽  
Sectional Study ◽  
Cross Sectional ◽  
Digestive Diseases ◽  
Betel Quid Chewing

scholarly journals Relationship of Cigarette Smoking and Alcohol Consumption to Incidence of Systemic Lupus Erythematosus in a Prospective Cohort Study of Black Women

2019 ◽  
Vol 71 (5) ◽  
pp. 671-677 ◽  
Author(s):  
Yvette C. Cozier ◽  
Medha Barbhaiya ◽  
Nelsy Castro‐Webb ◽  
Carolyn Conte ◽  
Sara K. Tedeschi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cohort Study ◽  
Black Women ◽  
Alcohol Consumption ◽  
Cigarette Smoking ◽  
Prospective Cohort Study ◽  
Lupus Erythematosus ◽  
Prospective Cohort ◽  
Systemic Lupus ◽  
Relationship Of

scholarly journals Cigarette smoking, alcohol intake and the risk of diabetes mellitus in Gombe State, northeast Nigeria

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Sule J. Bathna ◽  
Jacob A. Dunga ◽  
Nura H. Alkali ◽  
Jafiada J. Musa ◽  
Abubakar A. Gombe ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Alcohol Consumption ◽  
Cigarette Smoking ◽  
Cross Sectional Survey ◽  
Chronic Lung Diseases ◽  
Increased Risk ◽  
Northeast Nigeria

Alcohol is consumed in almost all countries worldwide. Heavy drinking can reduce the body’s sensitivity to insulin, which can trigger type 2 diabetes mellitus. Diabetes can complicate chronic pancreatitis, which is overwhelmingly caused by heavy alcohol drinking. Alcohol is also high in calories, with heavy drinkers liable to obesity and a higher risk of type 2 diabetes mellitus. Similarly, cigarette smoking is associated with increased risk of type 2 diabetes mellitus among both middle-aged and elderly men and women. Nigeria is one of the three largest tobacco markets in Africa with a population of almost 13 million smokers. Northeast Nigeria ranks 3rd among the six geopolitical zones, with a smoking rate of 6.1%. In this study, we evaluated the risks of diabetes mellitus associated with alcohol consumption and cigarette smoking in Gombe State, Northeast Nigeria. This cross-sectional survey was conducted in a two-stage cluster sampling scheme based on existing administrative divisions. Study subjects were males and females aged 16 years and older who resided in the Jekadafari Ward of Gombe Metropolis. Subjects were excluded from this study if they were less than 16 years of age, pregnant women or suffered chronic conditions such as chronic kidney disease, chronic liver disease or chronic lung diseases based on clinical history and laboratory results. The calculated sample size was 1600 based on a 3.1% prevalence rate of DM, with a power of 85% and precision of 5%. We obtained complete data on 1302 subjects, of whom 50 (3.8%) had DM. (5.1% in males and 2.86% in females). Alcohol use was prevalent among 365 (28.03%) subjects, and was higher in males (49.4%) compared to females (11.4%). The risk of DM was significantly higher among alcoholusers compared to non-users, with an odds ratio of 4.1 (95%CI: 2.3- 7.3; P=0.0001). Eighty-eight subjects were cigarette smokers, of whom 87 were males and only one was female. We found no significant association between cigarette smoking and DM (OR=0.34, 95%CI 0.05-2.48; P=0.29). The overall prevalence of DM was 3.9%. Alcohol consumption, but not cigarette smoking, was associated with a higher risk of DM in this study.

Alcohol consumption or cigarette smoking and cardiovascular disease risk in youth with type 1 diabetes

2019 ◽  
Vol 56 (12) ◽  
pp. 1315-1321 ◽  
Author(s):  
Giuliana Valerio ◽  
Enza Mozzillo ◽  
Eugenio Zito ◽  
Elena De Nitto ◽  
Giulio Maltoni ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Alcohol Consumption ◽  
Cigarette Smoking ◽  
Disease Risk ◽  
Cardiovascular Disease Risk
Sign in / Sign up

Export Citation Format

Share Document