Systems models of retinal cells: A classical example

1997 ◽  
pp. 178-194 ◽  
Author(s):  
Roberto Moreno-Díaz
Keyword(s):  
Retinal Cells ◽  
Systems Models

Studying dynamic systems models in Simulink

2016 ◽  
Author(s):  
Galina Ivanovna Popova ◽  
◽  
Yuliya Nikolaevna Prilepskaya ◽  
Keyword(s):  
Dynamic Systems ◽  
Systems Models

The Effect of Claudin-5 Overexpression on the Interactions of Claudin-1 and -2 and Barrier Function in Retinal Cells

2014 ◽  
Vol 14 (9) ◽  
pp. 1226-1237 ◽  
Author(s):  
R. Tian ◽  
Y. Luo ◽  
Q. Liu ◽  
M. Cai ◽  
J. Li ◽  
...  
Keyword(s):  
Barrier Function ◽  
Retinal Cells

Enhancement in productivity and income sustainability through Integrated farming system approaches for small and marginal farmers of Eastern India

2017 ◽  
Vol 4 (2) ◽  
Author(s):  
SANJEEV KUMAR ◽  
SHIVANI . ◽  
S. K. SAMAL ◽  
S. K. DWIVEDI ◽  
MANIBHUSHAN .
Keyword(s):  
Nutrient Recycling ◽  
Farming Systems ◽  
Fruit Trees ◽  
Farming System ◽  
Eastern Region ◽  
Net Income ◽  
System Productivity ◽  
Integrated Farming ◽  
Systems Models ◽  
The Cost

Integration of different components viz. livestock, fishery, horticulture, mushroom etc. along with field crops not only enhanced productivity but by-products (waste) of one component act as input for another component through resource recycling within the system. Six integrated farming systems models with suitable combinations of Crop, vegetables, fruit trees, fish, livestock, mushroom etc. were made and evaluated at the experimental farm of ICAR Research Complex for Eastern Region, Patna during 2012-16 for harness maximum income, nutrient recycling and employment. Among six combinations, crop + fish + duck + goat resulted as most profitable combination in terms of productivity (RGEY- 22.2t), net income (Rs. 2,15,900/ha), additional employment (170 days/year) with income sustainability index (ISI) by 90.2. Upon nutrient recycling prepared from different wastes from the system Crop + fish + duck + goat combination added N (56.5 kg), P (39.6 kg) and K (42.7 kg) into the soil and reduced the cost of cultivation by 24 percent and was followed by crop + fish + goat combination. Crops grown under IFS mode with different types of manures produced 31 percent higher yield over conventional rice- wheat system. The contribution of crops towards the system productivity ranged from 36.4 to 56.2 %, while fish ranged from 22.0-33.5 %; for goat 25.4-32.9 %; for poultry 38.7 %; for duck 22.0-29.0 %; for cattle 32.2% and for mushroom 10.3 %.

scholarly journals Effects of heterogeneity in infection-exposure history and immunity on the dynamics of a protozoan parasite

2007 ◽  
Vol 4 (16) ◽  
pp. 841-849 ◽  
Author(s):  
Maite Severins ◽  
Don Klinkenberg ◽  
Hans Heesterbeek
Keyword(s):  
Dynamic Behaviour ◽  
Protozoan Parasite ◽  
Host Population ◽  
Infection Process ◽  
Control Measures ◽  
Complex Dynamic ◽  
Systems Models ◽  
Exposure History ◽  
The Relationship ◽  
Initial Contamination

Infection systems where traits of the host, such as acquired immunity, interact with the infection process can show complex dynamic behaviour with counter-intuitive results. In this study, we consider the traits ‘immune status’ and ‘exposure history’, and our aim is to assess the influence of acquired individual heterogeneity in these traits. We have built an individual-based model of Eimeria acervulina infections, a protozoan parasite with an environmental stage that causes coccidiosis in chickens. With the model, we simulate outbreaks of the disease under varying initial contaminations. Heterogeneity in the traits arises stochastically through differences in the dose and frequency of parasites that individuals pick up from the environment. We find that the relationship between the initial contamination and the severity of an outbreak has a non-monotonous ‘wave-like’ pattern. This pattern can be explained by an increased heterogeneity in the host population caused by the infection process at the most severe outbreaks. We conclude that when dealing with these types of infection systems, models that are used to develop or evaluate control measures cannot neglect acquired heterogeneity in the host population traits that interact with the infection process.

scholarly journals Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats

2021 ◽  
Author(s):  
Jee Myung Yang ◽  
Sunho Chung ◽  
KyungA Yun ◽  
Bora Kim ◽  
Seongjun So ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Transplantation ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Histological Evaluation ◽  
Long Term Effects ◽  
Retinal Cells ◽  
Rpe Cells ◽  
Induced Pluripotent

AbstractRetinal degenerative disorders, including age-related macular degeneration and retinitis pigmentosa (RP), are characterized by the irreversible loss of photoreceptor cells and retinal pigment epithelial (RPE) cells; however, the long-term effect of implanting both human induced pluripotent stem cell (hiPSC)-derived RPE and photoreceptor for retinal regeneration has not yet been investigated. In this study, we evaluated the long-term effects of hiPSC-derived RPE and photoreceptor cell transplantation in Pde6b knockout rats to study RP; cells were injected into the subretinal space of the right eyes of rats before the appearance of signs of retinal degeneration at 2–3 weeks of age. Ten months after transplantation, we evaluated the cells using fundus photography, optical coherence tomography, and histological evaluation, and no abnormal cell proliferation was observed. A relatively large number of transplanted cells persisted during the first 4 months; subsequently, the number of these cells decreased gradually. Notably, immunohistochemical analysis revealed that the hiPSC-derived retinal cells showed characteristics of both RPE cells and photoreceptors of human origin after transplantation. Functional analysis of vision by scotopic electroretinogram revealed significant preservation of vision after transplantation. Our study suggests that the transplantation of hiPSC-derived retinal cells, including RPE cells and photoreceptors, has a potential therapeutic effect against irreversible retinal degenerative diseases.

scholarly journals Carbon Dot Nanoparticles: Exploring the Potential Use for Gene Delivery in Ophthalmic Diseases

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 935
Author(s):  
Manas R. Biswal ◽  
Sofia Bhatia
Keyword(s):  
Gene Delivery ◽  
Therapeutic Option ◽  
Retinal Dystrophy ◽  
Retinal Cells ◽  
Adeno Associated Virus ◽  
Inherited Retinal Dystrophies ◽  
Retinal Dystrophies ◽  
Efficient Gene ◽  
New Type ◽  
Viral Nanoparticles

Ocular gene therapy offers significant potential for preventing retinal dystrophy in patients with inherited retinal dystrophies (IRD). Adeno-associated virus (AAV) based gene transfer is the most common and successful gene delivery approach to the eye. These days, many studies are using non-viral nanoparticles (NPs) as an alternative therapeutic option because of their unique properties and biocompatibility. Here, we discuss the potential of carbon dots (CDs), a new type of nanocarrier for gene delivery to the retinal cells. The unique physicochemical properties of CDs (such as optical, electronic, and catalytic) make them suitable for biosensing, imaging, drug, and gene delivery applications. Efficient gene delivery to the retinal cells using CDs depends on various factors, such as photoluminescence, quantum yield, biocompatibility, size, and shape. In this review, we focused on different approaches used to synthesize CDs, classify CDs, various pathways for the intake of gene-loaded carbon nanoparticles inside the cell, and multiple studies that worked on transferring nucleic acid in the eye using CDs.

Human primary retinal cells as an in-vitro model for investigating defective signalling caused by OPTN mutants associated with glaucoma

2021 ◽  
pp. 105075
Author(s):  
Zuberwasim Sayyad ◽  
Sushma Vishwakarma ◽  
Tarjani Vivek Dave ◽  
Milind N. Naik ◽  
Vegesna Radha ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Retinal Cells ◽  
Vitro Model

scholarly journals Photoelectric Dye, NK-5962, as a Potential Drug for Preventing Retinal Neurons from Apoptosis: Pharmacokinetic Studies Based on Review of the Evidence

Life ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 591
Author(s):  
Toshihiko Matsuo ◽  
Shihui Liu ◽  
Tetsuya Uchida ◽  
Satomi Onoue ◽  
Shinsaku Nakagawa ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pharmacokinetic Studies ◽  
Retinal Neurons ◽  
Retinal Cells ◽  
Intravitreous Injection ◽  
Rcs Rats ◽  
Photoelectric Dye ◽  
Dark Conditions

NK-5962 is a key component of photoelectric dye-based retinal prosthesis (OUReP). In testing the safety and efficacy, NK-5962 was safe in all tests for the biological evaluation of medical devices (ISO 10993) and effective in preventing retinal cells from death even under dark conditions. The long-term implantation of the photoelectric dye-coupled polyethylene film in the subretinal space of hereditary retinal dystrophic (RCS) rats prevented neurons from apoptosis in the adjacent retinal tissue. The intravitreous injection of NK-5962 in the eyes of RCS rats, indeed, reduced the number of apoptotic cells in the retinal outer nuclear layer irrespective of light or dark conditions. In this study, we reviewed the in vitro and in vivo evidence of neuroprotective effect of NK-5962 and designed pharmacokinetic experiments. The in vitro IC50 of 1.7 μM, based on the protective effect on retinal cells in culture, could explain the in vivo EC50 of 3 μM that is calculated from concentrations of intravitreous injection to prevent retinal neurons from apoptosis. Pharmacokinetics of NK-5962 showed that intravenous administration, but not oral administration, led to the effective concentration in the eye of rats. NK-5962 would be a candidate drug for delaying the deterioration of retinal dystrophy, such as retinitis pigmentosa.

scholarly journals Fashion Recommendation Systems, Models and Methods: A Review

Informatics ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 49
Author(s):  
Samit Chakraborty ◽  
Md. Saiful Hoque ◽  
Naimur Rahman Jeem ◽  
Manik Chandra Biswas ◽  
Deepayan Bardhan ◽  
...  
Keyword(s):  
Recommendation System ◽  
Recommendation Systems ◽  
Fast Fashion ◽  
Potential Models ◽  
Scholarly Article ◽  
Enormous Amount ◽  
Shopping Experience ◽  
Tremendous Amount ◽  
Systems Models ◽  
Filtering Techniques

In recent years, the textile and fashion industries have witnessed an enormous amount of growth in fast fashion. On e-commerce platforms, where numerous choices are available, an efficient recommendation system is required to sort, order, and efficiently convey relevant product content or information to users. Image-based fashion recommendation systems (FRSs) have attracted a huge amount of attention from fast fashion retailers as they provide a personalized shopping experience to consumers. With the technological advancements, this branch of artificial intelligence exhibits a tremendous amount of potential in image processing, parsing, classification, and segmentation. Despite its huge potential, the number of academic articles on this topic is limited. The available studies do not provide a rigorous review of fashion recommendation systems and the corresponding filtering techniques. To the best of the authors’ knowledge, this is the first scholarly article to review the state-of-the-art fashion recommendation systems and the corresponding filtering techniques. In addition, this review also explores various potential models that could be implemented to develop fashion recommendation systems in the future. This paper will help researchers, academics, and practitioners who are interested in machine learning, computer vision, and fashion retailing to understand the characteristics of the different fashion recommendation systems.

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