Analysis of C∞-singularities for a class of operators with varying multiple characteristics

Author(s):  
Qiu Qing-jiu ◽  
Qian Si-xin
Think India ◽  
2019 ◽  
Vol 22 (2) ◽  
pp. 507-511
Author(s):  
S.SOPHIA CHRISTINA

Diaspora Theory has affected the literature of every language of the globe with its multiple characteristics. This literature is commonly referred to as Diasporic or Expatriate Literature. Diasporic Literature is a very broad idea and a paragliding term that involves all those literary works published by writers outside their home nation, but these works are linked to indigenous culture and background. All those authors can be considered as diasporic authors in this broad context, who write outside their nation but through their work stayed linked to their homeland. Diasporic literature has its origins in the sense of loss and alienation resulting from migration and expatriation. Diasporic literature generally deals with alienation, displacement, existential rootlessness, nostalgia, identity quest. Migrants suffer from the pain of being away from their homes, their motherland memories, the anguish of leaving behind everything familiar agonizes migrants ' minds. The diasporic Indians, too, are not breaking their ancestral land connection. There is a search for continuity and an astral impulse, an attempt to search for their origins. Settlement in alien territory leads to dislocation for them. Dislocation can be seen as a rupture with the ancient identity. By debating characteristics of expatriate or diasporic literature, the article tried to examine the reflection of Diaspora Theory and its multiple aspects in literature. The Indian contribution to diasporic literature was also evaluated in English.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
S. M. Lehmann ◽  
R. E. Leube ◽  
R. Windoffer

AbstractIntermediate filament polypeptides (IFPs) are prominent components of cytoplasmic aggregates, which are pathognomonic for multiple diseases. Recent observations in cultured cells suggest that they are dynamic and subject to regulated turnover. The emerging concept is that multiple factors contribute to motility and turnover of IFP-containing aggregates. To understand their relative contribution, quantitative tools are needed. The current study addresses this need using epithelial cells producing mutant keratin IFPs that have been identified as the cause of the hereditary blister-forming skin disease epidermolysis bullosa simplex. Digital image analysis of individual granules allowed mapping of their complete life cycle, with information on multiple characteristics at any given time-point. The deduced signet features revealed rapid granule fusion and directed transport from the periphery towards the cell centre, and a limited, ~ 30 min lifetime with a slow, continuous growth phase followed by fast disassembly. As paradigmatic proof-of-principle, we demonstrate that inhibition of myosin II selectively reduces granule movement, linking keratin granule motility to retrograde cortical acto-myosin flow. The newly developed methods and established parameters will help in the characterization of known and the identification of novel regulators of IFP-containing aggregates.


Heat Transfer ◽  
2021 ◽  
Author(s):  
Hafiz Abdul Wahab ◽  
Syed Zahir Hussain Shah ◽  
Assad Ayub ◽  
Zulqurnain Sabir ◽  
Muhammad Bilal ◽  
...  

2021 ◽  
Vol 13 (14) ◽  
pp. 7957
Author(s):  
Marco Haid ◽  
Julia N. Albrecht

This study examines sustainable tourism products in tourism destinations. Based on concepts of sustainable product design, our study proposes a framework for sustainable tourism products by adapting an existing Design for Sustainability Framework to consider and analyze the characteristics and themes of sustainable (tourism) products as well as their impact and scope. Using a pragmatic qualitative approach, 15 semi-structured interviews with destination managers from the German-speaking Alpine region formed the empirical basis of the study. The results emphasize key themes and multiple characteristics associated with sustainable tourism products in tourist destinations, addressing all sustainability components and design innovation levels. This study is the first to apply existing sustainable product design concepts to destination contexts and discuss their applicability for sustainable tourism products. For practitioners, this study provides support for the development of sustainable tourism products and contributes to a better understanding of the effects and levels of these products as well as sustainability marketing.


Endocrinology ◽  
2010 ◽  
Vol 151 (3) ◽  
pp. 1375-1380 ◽  
Author(s):  
Brasilina Caroccia ◽  
Ambrogio Fassina ◽  
Teresa Maria Seccia ◽  
Chiara Recarti ◽  
Lucia Petrelli ◽  
...  

We detected intense CD56 immunostaining in the zona glomerulosa (ZG) and medulla of the normal human adrenal gland and therefore identified CD56, the neural cell adhesion molecule, as a membrane antigen specific for the ZG, aldosterone-producing adenoma (APA), and chromaffin cells. The APA and pheochromocytoma cells, which are histogenetically derived from the ZG and medulla, respectively, also showed intense CD56 immunostaining. Based on these findings we developed a strategy for isolating cells from the ZG and APA using CD56 immunobinding to magnetic beads. Morphology, gene expression studies, and aldosterone measurement confirmed that CD56 positive (+) cells were ZG and APA cells. Analysis of CD56+ cells under light and phase contrast microscopy evidenced that these cells formed clumps, as the ZG cells usually do; with electron microscopy they showed multiple features typical of a steroidogenic phenotype. Expression levels of the CD56 and the aldosterone synthase (CYP11B2) gene were markedly higher in CD56+ cells than CD56− cells (+1600 and +2100% increase, respectively). Moreover, aldosterone secretion was higher (+1380%) from CD56+ cells than from CD56− cells. Hence, this novel methodology allows isolation of a pure population of ZG and APA cells exhibiting multiple characteristics of the aldosterone-producing cells.


2014 ◽  
Vol 513-517 ◽  
pp. 1621-1624
Author(s):  
Zhi Jian Diao

with the computer technology development, software expands the application layer and shows the multiple characteristics of requirement. In recent years, the summarized scale of software system obtains the development and the development technology becomes complicated. Under this condition, software quality receives more attention. The accepted route can distinct the software quality level. Moreover, the created relative use cases will promote the test. Therefore, develop the test automatic layer can decrease the test cost, increase the software summarization quality. We can explore the test case, create the schema, and build the available model.


Author(s):  
Pantelis Samartsidis ◽  
Natasha N. Martin ◽  
Victor De Gruttola ◽  
Frank De Vocht ◽  
Sharon Hutchinson ◽  
...  

Abstract Objectives The causal impact method (CIM) was recently introduced for evaluation of binary interventions using observational time-series data. The CIM is appealing for practical use as it can adjust for temporal trends and account for the potential of unobserved confounding. However, the method was initially developed for applications involving large datasets and hence its potential in small epidemiological studies is still unclear. Further, the effects that measurement error can have on the performance of the CIM have not been studied yet. The objective of this work is to investigate both of these open problems. Methods Motivated by an existing dataset of HCV surveillance in the UK, we perform simulation experiments to investigate the effect of several characteristics of the data on the performance of the CIM. Further, we quantify the effects of measurement error on the performance of the CIM and extend the method to deal with this problem. Results We identify multiple characteristics of the data that affect the ability of the CIM to detect an intervention effect including the length of time-series, the variability of the outcome and the degree of correlation between the outcome of the treated unit and the outcomes of controls. We show that measurement error can introduce biases in the estimated intervention effects and heavily reduce the power of the CIM. Using an extended CIM, some of these adverse effects can be mitigated. Conclusions The CIM can provide satisfactory power in public health interventions. The method may provide misleading results in the presence of measurement error.


Author(s):  
A. Martínez-González ◽  
S.-I. Niculescu ◽  
J. Chen ◽  
C. F. Méndez-Barrios ◽  
J. G. Romero ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document