2,4,6-Trihydroxybenzaldehyde as a potent antidiabetic agent alleviates postprandial hyperglycemia in normal and diabetic rats

2010 ◽  
Vol 20 (8) ◽  
pp. 1181-1187 ◽  
Author(s):  
Shruti Sancheti ◽  
Sandesh Sancheti ◽  
Mayur Bafna ◽  
Sung-Yum Seo
Keyword(s):  
Diabetic Rats ◽  
Postprandial Hyperglycemia ◽  
Antidiabetic Agent

scholarly journals Inhibition ofα-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Abdulrahman L. Al-Malki
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Hydrolytic Enzyme ◽  
Positive Control ◽  
Diabetic Rats ◽  
Postprandial Hyperglycemia ◽  
Postprandial Blood Glucose ◽  
Control Group ◽  
Albino Rats ◽  
Predisposing Factor

Postprandial hyperglycemia is a predisposing factor for vascular dysfunction and organ damage.α-glucosidase is a hydrolytic enzyme that increases the glucose absorption rate and subsequently elevates blood glucose levels. Garlic (Allium sativumL.) is a rich source of several phytonutrients, including thiosulfinate (THIO). The aim of this study was to evaluate the ability of THIO, a potent inhibitor of intestinalα-glucosidase, to reduce postprandial blood glucose. Male albino rats were randomly assigned to five different groups (n=10/group). Group 1 served as the control group. Groups 2–5 were injected intraperitoneally with a single dose of streptozotocin (STZ) to induce diabetes. Group 2 comprised untreated diabetic rats. Groups 3 and 4 contained diabetic rats that were given THIO orally (20 mg/kg body weight/day and 40 mg/kg body weight/day, resp.). Group 5 was the positive control having diabetic rats treated orally with acarbose (10 mg/kg body weight/day; positive control). Diabetic rats treated with THIO displayed a significant blood glucose reduction (p<0.001and < 0.01 by analysis of variance, resp.) and a significant elevation in insulin compared with that of untreated rats. THIO is an effective noncompetitive intestinalα-glucosidase inhibitor that promotes hypoglycemic action (p<0.001) in STZ-injected rats. THIO is a promising agent for the management of postprandial hyperglycemia.

scholarly journals Antidiabetic agent did not impair spermatogenesis in spontaneously hyperglycemic and diabetic rats

2021 ◽  
Vol 8 (4) ◽  
pp. 97-101
Author(s):  
Taiki Kobayashi ◽  
Takasumi Shimomoto ◽  
Junichi Namekawa ◽  
Masanobu Kanou ◽  
Hirotsugu Kato ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Antidiabetic Agent

scholarly journals Effects of Combination of Antidiabetic Agent and Statin on Alloxan-induced Diabetes with Cardiovascular Diseases in Rats

2012 ◽  
Vol 4 (3) ◽  
pp. 709-720 ◽  
Author(s):  
M. S. Islam ◽  
A. H. M. K. Alam ◽  
M. A. A. Rahman ◽  
Y. Ali ◽  
Al Mamun ◽  
...  
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Diabetic Rats ◽  
Free Radical Scavenging ◽  
Scavenging Activity ◽  
Antidiabetic Agent ◽  
Pathological Changes ◽  
Short Term ◽  
Combination Drugs

The present study was designed to investigate the effects of combination drugs (metformin and atorvastatin) on long-term alloxan-induced diabetes with CVD in rats. In short-term alloxan-induced diabetic rats, metformin reduced significant amount of glucose in blood, but it had no significant effect on lipid profile. Atorvastatin significantly reduced TC, TG and LDL-C, whereas it increased significant amount of HDL-C. However, pathological changes of heart were not observed after short-term induction of alloxan in rats. In long-term induction of diabetes by alloxan, LV hypertrophy was observed and cardimyocyte size in rats was increased. Atorvastatin alone and in combination with metformin significantly reduced the LV hypertrophy, cardiomyocyte size, TC, TG and LDL-C level. They increased significant amount of HDL-C level and showed significant DPPH free radical scavenging activity. Present findings may suggest that treatment with combination therapy is more effective than mono-therapy for preventing diabetes with CVD in rats.© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v4i3.9974 J. Sci. Res. 4 (3), 709-720 (2012)

Enhydrin Regulates Postprandial Hyperglycemia in Diabetic Rats by Inhibition of α-Glucosidase Activity

2017 ◽  
Vol 72 (2) ◽  
pp. 156-160 ◽  
Author(s):  
C. Serra-Barcellona ◽  
N. C. Habib ◽  
S. M. Honoré ◽  
S. S. Sánchez ◽  
S. B. Genta
Keyword(s):  
Diabetic Rats ◽  
Postprandial Hyperglycemia ◽  
Glucosidase Activity

scholarly journals Opuntia dillenii (Ker Gawl.) Haw., Seeds Oil Antidiabetic Potential Using In Vivo, In Vitro, In Situ, and Ex Vivo Approaches to Reveal Its Underlying Mechanism of Action

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1677
Author(s):  
Mohamed Bouhrim ◽  
Hayat Ouassou ◽  
Salima Boutahiri ◽  
Nour Elhouda Daoudi ◽  
Hamza Mechchate ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Ex Vivo ◽  
Ussing Chamber ◽  
Diabetic Rats ◽  
Postprandial Hyperglycemia ◽  
Antihyperglycemic Effect ◽  
Opuntia Dillenii

Opuntia dillenii Ker Gawl. is one of the medicinal plants used for the prevention and treatment of diabetes mellitus (DM) in Morocco. This study aims to investigate the antihyperglycemic effect of Opuntia dillenii seed oil (ODSO), its mechanism of action, and any hypoglycemic risk and toxic effects. The antihyperglycemic effect was assessed using the OGTT test in normal and streptozotocin (STZ)-diabetic rats. The mechanisms of action were explored by studying the effect of ODSO on the intestinal absorption of d-glucose using the intestinal in situ single-pass perfusion technique. An Ussing chamber was used to explore the effects of ODSO on intestinal sodium-glucose cotransporter 1 (SGLT1). Additionally, ODSO’s effect on carbohydrate degrading enzymes, pancreatic α-amylase, and intestinal α-glucosidase was evaluated in vitro and in vivo using STZ-diabetic rats. The acute toxicity test on mice was performed, along with a single-dose hypoglycemic effect test. The results showed that ODSO significantly attenuated the postprandial hyperglycemia in normal and STZ-diabetic rats. Indeed, ODSO significantly decreased the intestinal d-glucose absorption in situ. The ex vivo test (Ussing chamber) showed that the ODSO significantly blocks the SGLT1 (IC50 = 60.24 µg/mL). Moreover, ODSO indu\ced a significant inhibition of intestinal α-glucosidase (IC50 = 278 ± 0.01 µg/mL) and pancreatic α-amylase (IC50 = 0.81 ± 0.09 mg/mL) in vitro. A significant decrease of postprandial hyperglycemia was observed in sucrose/starch-loaded normal and STZ-diabetic ODSO-treated rats. On the other hand, ODSO had no risk of hypoglycemia on the basal glucose levels in normal rats. Therefore, no toxic effect was observed in ODSO-treated mice up to 7 mL/kg. The results of this study suggest that ODSO could be suitable as an antidiabetic functional food.

Sign in / Sign up

Export Citation Format

Share Document