α-Glucosidase inhibitor compounds from Aspergillus terreus RCC1 and their antioxidant activity

2014 ◽  
Vol 24 (2) ◽  
pp. 737-743 ◽  
Author(s):  
Rizna Triana Dewi ◽  
Sanro Tachibana ◽  
Sofa Fajriah ◽  
Muhammad Hanafi
Keyword(s):  
Antioxidant Activity ◽  
Aspergillus Terreus ◽  
Glucosidase Inhibitor ◽  
Inhibitor Compounds

Chemical Investigations and Optimization Studies on Aspergillus terreus-18 Showing Antioxidant Activity

2018 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Alaa Saleh ◽  
Heba Elrefaie ◽  
Abdelgawad Hashem ◽  
Hassaan EL-Menoufy ◽  
Nahla Mansour ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Aspergillus Terreus

Isolation of Bioactive Compounds from Aspergillus terreus

2004 ◽  
Vol 59 (3) ◽  
pp. 324-328 ◽  
Author(s):  
Muhammad I. Choudhary ◽  
Syed G. Musharraf ◽  
Talat Mukhmoor ◽  
Farzana Shaheen ◽  
Shamsher Ali ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
13C Nmr ◽  
Culture Medium ◽  
Aspergillus Terreus ◽  
Ethyl Acetate Extract ◽  
Microsporum Canis ◽  
Spectroscopic Techniques ◽  
Significant Activity ◽  
Nmr Data ◽  
First Time

A new metabolite, 6-(4’-hydroxy-2’-methyl phenoxy)-(-)-(3R)-mellein (1) was isolated from the ethyl acetate extract of Aspergillus terreus culture medium along with three known isocoumarin derivatives, (-)-(3R)-6-methoxymellein (2), (-)-(3R)-6,7-dimethoxymellein (Kigelin) (3) and (3R, 4R)-6,7-dimethoxy-4-hydroxymellein (4). Metabolites 1 and 4 showed significant activity against human pathogenic dermatophytes, Microsporum canis and Trichophyton longifusus. Metabolite 1 also exhibited potent antioxidant activity. The structures of metabolites were characterized on the basis of spectroscopic techniques. 13C NMR data of metabolites 2 - 4 are also being reported for the first time

scholarly journals TLC-MS Bioautography-Based Identification of Free-Radical Scavenging, α-Amylase, and α-Glucosidase Inhibitor Compounds of Antidiabetic Tablet BGR-34

ACS Omega ◽  
2020 ◽  
Vol 5 (46) ◽  
pp. 29688-29697
Author(s):  
Gaurav ◽  
Sultan Zahiruddin ◽  
Bushra Parveen ◽  
Mohammad Ibrahim ◽  
Ikshit Sharma ◽  
...  
Keyword(s):  
Free Radical ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Glucosidase Inhibitor ◽  
Inhibitor Compounds

A facile approach synthesis of benzoylaryl benzimidazole as potential α-amylase and α-glucosidase inhibitor with antioxidant activity

2021 ◽  
pp. 105073
Author(s):  
Lotfi M. Aroua ◽  
Hind R. Almuhaylan ◽  
Fahad M. Alminderej ◽  
Sabri Messaoudi ◽  
Sridevi Chigurupati ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Glucosidase Inhibitor

scholarly journals Antioxidant Activity Study And Α-glucosidase Inhibitor Phenolic Leaf Extract Bungur (Lagerstroemia speciosa) From Meru National Park Betiri

2017 ◽  
Vol 17 (1) ◽  
pp. 39 ◽  
Author(s):  
Jainur Rochman ◽  
Tri Agus Siswoyo ◽  
A.A. Istri Ratnadewi
Keyword(s):  
Antioxidant Activity ◽  
Superoxide Anion ◽  
National Park ◽  
Digestive System ◽  
Methanol Extract ◽  
Ethyl Acetate Extract ◽  
Total Phenolic ◽  
Dpph Radical ◽  
Glucosidase Inhibitor ◽  
Phenolic Extract

Study activities phenolic extract of bungur leaf as an antioxidant and inhibitor for the enzyme α-glucosidase was performed by spectrophotometric method. The extraction was carried out by three solvents with different polarity level in order to get three types of extracts namely hexane extract Bungur (HB), ethyl acetate extract Bungur (EAB), and the methanol extract Bungur (MB). The units, used in the analysis, is the total phenolic that standardized in gallic acid. The antioxidant activity of phenolic extracts Bungur leaf can be seen from its ability to reduce free radicals through the damping test DPPH radical, superoxide anion, and hydroxyl. Potential extract phenolic leaf Bungur as an inhibitor of α-glucosidase were analyzed by inhibition of α-glucosidase, but in this study also tested the inhibition of the enzyme α-amylase because both of these enzymes worked on the digestive system and hydrolyze carbohydrates. The results generally showed that the methanol extract of leaves Bungur potential as antioxidants that compared with standard vitamin C. In addition, it had as well as potential for inhibitors of α-glucosidase and α-amylase that compared akarbosa standard, which is expected to be a natural antidiabetic agent.Keywords: phenolic, bungur, antioxidant, inhibitor, α-amilase, α-glukosidase 

Efficient Synthesis of 2-[(3,4-Dichlorophenyl)methyl]-1H-benzimidazole Derivatives, and their α-Glucosidase Inhibitory and Antioxidant Activities

2020 ◽  
Vol 17 (10) ◽  
pp. 806-814
Author(s):  
Emre Menteşe ◽  
Fatih Yılmaz ◽  
Nimet Baltaş
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Benzimidazole Derivatives ◽  
Efficient Synthesis ◽  
Antioxidant Power ◽  
Glucosidase Inhibitor ◽  
Ferric Reducing Antioxidant Power ◽  
Inhibitory Activities

In this work, some new 2-[(3,4-dichlorophenyl)methyl]-1H-benzimidazole derivatives containing different five-membered heterocycles like 1,3,4-oxadiazole, 1,3,4-triazole, and 1,3,4- thiadiazole moieties were designed and efficiently synthesized starting from 2-[(3,4-dichlorophenyl) methyl]-1H-benzimidazole. The products were screened for their in vitro antioxidant and α-glucosidase inhibitory activities. Among the synthesized compounds, some of them showed efficient α-glucosidase inhibition with IC50 values ranging between 16.05 ± 0.94 and 77.02 ± 1.12 μg/mL when they were compared with the standard α-glucosidase inhibitor acarbose having IC50 value 12.04 ± 0.68 μg/mL. The antioxidant activity of all products was screened by using various in vitro antioxidant assays, including CUPric Reducing Antioxidant Capacity (CUPRAC) and Ferric Reducing Antioxidant Power (FRAP) assays. Also, the radical scavenging activities of the products were assayed by using the ABTS method. method.

ANTI-DIABESITY PRINCIPLE FROM THE SEEDS OF PHYLLANTHUS EMBLICA L.

INDIAN DRUGS ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 41-50
Author(s):  
Priyanka Rathod ◽  
Chandana Kulkarni ◽  
Raman P. Yadav
Keyword(s):  
Antioxidant Activity ◽  
Pancreatic Lipase ◽  
Inhibitory Activity ◽  
Methanolic Extract ◽  
Scavenging Activity ◽  
Phyllanthus Emblica ◽  
Natural Substrate ◽  
Glucosidase Inhibitor ◽  
Pancreatic Lipase Inhibition ◽  
Lipase Inhibition

In recent years, pancreatic lipase inhibitor and α- glucosidase inhibitor have been highlighted as potential anti-diabesity principles. In the present study, seeds of Phyllanthus emblica L. (Family: Phyllanthaceae) was studied for anti-diabesity potential in terms of pancreatic lipase inhibitory activity, α-glucosidase inhibitory activity and antioxidant activity. At 100μg/ml concentration, pancreatic lipase inhibition of the methanolic extract using synthetic substrate obtained was 73.2±0.1% (IC50 59.1μg/ml), whereas pancreatic lipase inhibition using natural substrate was 87.9 ± 2.62%. α- glucosidase inhibition of the extract at 50μg/ml was measured as 94.4±0.37% (IC50 34.4μg/ml). The superoxide scavenging activity of the extract was found to be 81.5±0.41%. Interestingly, upon TLC fingerprinting, only one band with Rf 0.70 showed multifunctional activity. The phytochemical found to be present was an alkaloid. The results evidenced the presence of multifunctional smart molecule in methanolic extract of P. emblica L and showed an alkaloid as the component responsible for anti-diabesity potential.

scholarly journals Isolation and screening of the endophytes possessing antioxidant activity from Rutaceae and Zingiberaceae plants

2016 ◽  
Vol 19 (3) ◽  
pp. 57-64
Author(s):  
My Thi Ngoc Vo ◽  
Thanh Van Nguyen ◽  
Nga Dinh Nguyen
Keyword(s):  
Antioxidant Activity ◽  
Essential Oils ◽  
Aspergillus Terreus ◽  
Antioxidant Activities ◽  
Streptomyces Sp ◽  
Plant Parts ◽  
Penicillium Sp

Zingiberaceae and Rutaceae have been many applications in the treatment of diseases. Their leaves, stems, rhizomes and fruits… containing essential oils which could offer useful habitats for different endophyte groups. In this research, the strains of endophyte Streptomyces sp., Aspergillus terreus, Cladosporium sp., Penicillium sp. were isolated from different plant parts of galangal, ginger, laurel and their antioxidant activities were determined. The antioxidant activity by using DPPH methos applied on these strain was with the following results: R-TN3 strain showed the highest antioxidant activity (62.32 %), followed by G1- TL3 and NQ-TN3 and the T-TG3 was the lowest (30.95 %).

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