scholarly journals Bioactive constituents from the leaves of Quercus phillyraeoides A. Gray for α-glucosidase inhibitor activity with concurrent antioxidant activity

2016 ◽  
Vol 5 (2) ◽  
pp. 85-94 ◽  
Author(s):  
Anastasia Wheni Indrianingsih ◽  
Sanro Tachibana
Keyword(s):  
Antioxidant Activity ◽  
Bioactive Constituents ◽  
Inhibitor Activity ◽  
Glucosidase Inhibitor ◽  
Quercus Phillyraeoides

scholarly journals Quantification of Major Bioactive Constituents, Antioxidant Activity, and Enzyme Inhibitory Effects of Whole Coffee Cherries (Coffea arabica) and Their Extracts

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4306
Author(s):  
Boris Nemzer ◽  
Diganta Kalita ◽  
Nebiyu Abshiru
Keyword(s):  
Antioxidant Activity ◽  
Coffea Arabica ◽  
Digestive Enzymes ◽  
Chlorogenic Acids ◽  
Inhibitory Effects ◽  
Bioactive Constituents ◽  
Caffeoylquinic Acids ◽  
Dicaffeoylquinic Acid ◽  
Ic50 Values ◽  
Control Of Diabetes

Coffee cherry is a rich source of chlorogenic acids (CGAs) and caffeine. In this study we examined the potential antioxidant activity and enzyme inhibitory effects of whole coffee cherries (WCC) and their two extracts on α-amylase, α-glucosidase and acetylcholinesterase (AChE) activities, which are targets for the control of diabetes and Alzheimer’s diseases. Whole coffee cherry extract 40% (WCCE1) is rich in chlorogenic acid compounds, consisting of a minimum of 40% major isomers, namely 3-caffeoylquinic acids, 4-caffeoylquinic acids, 5-caffeoylquinic acids, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid, 4-feruloylquinc acid, and 5-feruloylquinc acid. Whole coffee cherry extract 70% (WCCE2) is rich in caffeine, with a minimum of 70%. WCCE1 inhibited the activities of digestive enzymes α-amylase and α-glucosidase, and WCCE2 inhibited acetylcholinesterase activities with their IC50 values of 1.74, 2.42, and 0.09 mg/mL, respectively. Multiple antioxidant assays—including DPPH, ABTS, FRAP, ORAC, HORAC, NORAC, and SORAC—demonstrated that WCCE1 has strong antioxidant activity.

ASSESSMENT OF PHYTOCHEMICALS, TOTAL PHENOL, FLAVONOID CONTENT AND IN VITRO ANTIOXIDANT PROPERTY OF LARGE CARDAMOM EXTRACTS

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (10) ◽  
pp. 34-41
Author(s):  
Kanthlal S. K. ◽  
Jipnomon Joseph ◽  
Bindhu P. Paul ◽  
Vijayakumar M ◽  
Rema Shree A. B. ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Antioxidant Property ◽  
Bioactive Constituents ◽  
Preliminary Assessment ◽  
Reducing Power Assay ◽  
Large Cardamom

Amomum subulatum, commonly known as large or black cardamom, is a commonly used spice in Indian kitchens and is traditionally used to treat various ailments. To add more knowledge about the medicinal values of the fruit, this study was conducted to evaluate the in vitro antioxidant activities of aqueous, methanol, ethanol, hydro alcohol, ethyl acetate, acetone and chloroform extracts of the fruit. Preliminary assessment was done to detect the presence of phytoconstituents using identification tests. The antioxidant activity was measured by employing methods such as diphenylpicrylhydrazyl (DPPH) radical scavenging assay, total antioxidant activity equivalent to ascorbic acid, reducing power assay and superoxide anion scavenging assay. The antioxidant activities were compared with their respective phenol and flavonoid contents. Preliminary assessment revealed that large cardamom fruit is a good source of all the bioactive constituents as well as phenol and flavonoid essential for medicinal values. The extract obtained by polar solvents showed the highest antioxidant efficacy in relation to its phenol content. Also, all the solvent-soluble fractions showed a concentration-dependent antioxidant effect. Results from our study prove that large cardamom can alleviate oxidative stress, suggesting the potential of large cardamom as a functional food

Produksi Dan Ekstraksi Inhibitor Alfa Glukosidase Dari Isolat Aktinomiset Jp-3

2016 ◽  
Vol 17 (2) ◽  
pp. 123
Author(s):  
Sri Pujiyanto ◽  
Rejeki Siti Ferniah ◽  
Sunarno S
Keyword(s):  
Ethyl Acetate ◽  
Active Compound ◽  
Inhibitor Activity ◽  
Glucosidase Inhibitor ◽  
Glucosidase Inhibitors ◽  
Complex Carbohydrates ◽  
Diabetes Drug ◽  
Chloroform Methanol ◽  
Alpha Glucosidase

Alpha-glucosidase inhibitors are compounds that can prevent the digestion of complex carbohydrates into glucose, so potentially used as a diabetes drug. This study aims to examine the production and extraction of alpha-glucosidase inhibitor compound from Isolate Aktinomiset JP-3 from the sea. The supernatant obtained from the culture of the JP-3 isolate was extracted using various solvents to obtain the active compound. The solvents used were chloroform, methanol, and ethyl acetate. An assay of inhibitor activity of the α-glucosidase using p-nitrophenyl α-D-glucopyranoside substrate. The activity of the enzyme is measured based on the absorbance of p-nitrophenol produced from the breaking reaction of the substrate. The results showed that extraction of alpha-glucosidase inhibitor compound with ethyl acetate yielded extract with highest inhibitor activity. Keywords: alpha-glucosidase inhibitors, actinomycetes, diabetes, extraction, fractionation

scholarly journals Iminosugars With Endoplasmic Reticulum α-Glucosidase Inhibitor Activity Inhibit ZIKV Replication and Reverse Cytopathogenicity in vitro

2020 ◽  
Vol 11 ◽  
Author(s):  
Gitanjali Bhushan ◽  
Levina Lim ◽  
Ian Bird ◽  
Shubhada K. Chothe ◽  
Ruth H. Nissly ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Inhibitor Activity ◽  
Glucosidase Inhibitor

scholarly journals HUMIC SUBSTANCES AND MOISTURE CONTENT IN THE PRODUCTION OF BIOMASS AND BIOACTIVE CONSTITUENTS OF Th ymus vulgaris L.

2011 ◽  
Vol 34 (3) ◽  
pp. 183
Author(s):  
Cecilia R. Juárez R. ◽  
Lyle E. Craker ◽  
Ma. de las Nieves Rodríguez-Mendoza ◽  
Juan A. Aguilar-Castillo
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Humic Substances ◽  
Direct Interaction ◽  
Field Capacity ◽  
Total Phenolic ◽  
Thymus Vulgaris ◽  
Bioactive Constituents ◽  
Positive Effects ◽  
Phenolic And Flavonoid

Thyme (Thymus vulgaris L.) is an aromatic and medicinal plant with antioxidant, antimicrobial and antinfungical properties that have attracted the interest of pharmacological and food industries. Humic substances (HS) are a natural product that has shown beneficial effects on soil and on plant growth. These positive effects are explained by the direct interaction of HS with physiological processes. But it is unknown their effect on the composition of the thyme bioactive constituents. To test the effect of humic substances, seeds of T. vulgaris were germinated and grown at different rates of HS (100, 200, 300 and 400 mg L-1). Th yme plants were also grown at three levels of moisture (20, 40 and 60 % of field capacity). At harvest plant height and shoot fresh and dry weight were measured. Bioactive constituents were determined in terms of yield and principal components of essential oil (by distillation in Clevenger apparatus and gas chromatography). Antioxidant activity, total phenolic and flavonoid content were determined with spectrophotometric techniques. Morphological variables, except for shoot fresh weight, showed signifi cant differences (P ≤ 0.05) among treatments. The essential oil yield and composition, as well as antioxidant activity and total phenolic and flavonoid contents, were higher at the highest levels of HS and substrate moisture.

scholarly journals At A Glance On Kothala himbutu

2019 ◽  
Vol 4 (3) ◽  
Keyword(s):  
Insulin Resistance ◽  
Medicinal Plant ◽  
Hormone Sensitive Lipase ◽  
Ayurvedic Medicine ◽  
Inhibitor Activity ◽  
Glucosidase Inhibitor ◽  
Hormone Sensitive ◽  
Reduce Insulin Resistance ◽  
Diabetes And Obesity ◽  
Alpha Glucosidase

Kothala himbutu (Salacia reticulate; SR) is a very useful medicinal plant in Sri Lanka and the southern region of India. SR contains salacinol and kotalanol neosalacinol and neokotalanol which can isolated from the Salacia species by using iron pair chromatography [1& 2]. It is a woody climber and widely used in Ayurvedic medicine for diabetes and obesity treatment. Previously, the action of SR for diabetes is not described properly. Researchers tried to explore the effect of SR and found that it has an alpha glucosidase inhibitor activity in invitro study. Moreover, SR may increase lipolysis and reduce insulin resistance by enhancing mRNA expression for hormone sensitive lipase (HSL) and adiponectin [3].

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