Application of MR morphologic, diffusion tensor, and perfusion imaging in the classification of brain tumors using machine learning scheme

2019 ◽  
Vol 61 (7) ◽  
pp. 757-765 ◽  
Author(s):  
Shai Shrot ◽  
Moshe Salhov ◽  
Nir Dvorski ◽  
Eli Konen ◽  
Amir Averbuch ◽  
...  
2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi224-vi224
Author(s):  
Alexis Morell ◽  
Daniel Eichberg ◽  
Ashish Shah ◽  
Evan Luther ◽  
Victor Lu ◽  
...  

Abstract BACKGROUND Developing mapping tools that allow identification of traditional or non-traditional eloquent areas is necessary to minimize the risk of postoperative neurologic deficits. The objective of our study is to evaluate the use of a novel cloud-based platform that uses machine learning to identify cerebral networks in patients with brain tumors. METHODS We retrospectively included all adult patients who underwent surgery for brain tumor resection or thermal ablation at our Institution between the 16th of February and the 15th of May of 2021. Pre and postoperative contrast-enhanced MRI with T1-weighted and high-resolution Diffusion Tensor Imaging (DTI) sequences were uploaded into the Quicktome platform. After processing the data, we categorized the integrity of seven large-scale brain networks: sensorimotor, visual, ventral attention, central executive, default mode, dorsal attention and limbic. Affected networks were correlated with pre and postoperative clinical data, including neurologic deficits. RESULTS Thirty-five (35) patients were included in the study. The average age of the sample was 63.2 years, and 51.4% (n=18) were females. The most affected network was the central executive network (40%), followed by the dorsal attention and default mode networks (31.4%), while the least affected were the visual (11%) and ventral attention networks (17%). Patients with preoperative deficits showed a significantly higher number of altered networks before the surgery (p=0.021), compared to patients without deficits. In addition, we found that patients without neurologic deficits had an average of 2.06 large-scale networks affected, with 75% of them not being related to traditional eloquent areas as the sensorimotor, language or visual circuits. CONCLUSIONS The Quicktome platform is a practical tool that allows automatic visualization of large-scale brain networks in patients with brain tumors. Although further studies are needed, it may assist in the surgical management of traditional and non-traditional eloquent areas.


2018 ◽  
Vol 28 (02) ◽  
pp. 1750036 ◽  
Author(s):  
Shuqiang Wang ◽  
Yong Hu ◽  
Yanyan Shen ◽  
Hanxiong Li

In this study, we propose an automated framework that combines diffusion tensor imaging (DTI) metrics with machine learning algorithms to accurately classify control groups and groups with cervical spondylotic myelopathy (CSM) in the spinal cord. The comparison between selected voxel-based classification and mean value-based classification were performed. A support vector machine (SVM) classifier using a selected voxel-based dataset produced an accuracy of 95.73%, sensitivity of 93.41% and specificity of 98.64%. The efficacy of each index of diffusion for classification was also evaluated. Using the proposed approach, myelopathic areas in CSM are detected to provide an accurate reference to assist spine surgeons in surgical planning in complicated cases.


IEEE Access ◽  
2020 ◽  
Vol 8 ◽  
pp. 218924-218935
Author(s):  
Wonsik Yang ◽  
Minsoo Joo ◽  
Yujaung Kim ◽  
Se Hee Kim ◽  
Jong-Moon Chung

2020 ◽  
Vol 10 (6) ◽  
pp. 1999 ◽  
Author(s):  
Milica M. Badža ◽  
Marko Č. Barjaktarović

The classification of brain tumors is performed by biopsy, which is not usually conducted before definitive brain surgery. The improvement of technology and machine learning can help radiologists in tumor diagnostics without invasive measures. A machine-learning algorithm that has achieved substantial results in image segmentation and classification is the convolutional neural network (CNN). We present a new CNN architecture for brain tumor classification of three tumor types. The developed network is simpler than already-existing pre-trained networks, and it was tested on T1-weighted contrast-enhanced magnetic resonance images. The performance of the network was evaluated using four approaches: combinations of two 10-fold cross-validation methods and two databases. The generalization capability of the network was tested with one of the 10-fold methods, subject-wise cross-validation, and the improvement was tested by using an augmented image database. The best result for the 10-fold cross-validation method was obtained for the record-wise cross-validation for the augmented data set, and, in that case, the accuracy was 96.56%. With good generalization capability and good execution speed, the new developed CNN architecture could be used as an effective decision-support tool for radiologists in medical diagnostics.


2021 ◽  
Vol 15 ◽  
Author(s):  
Gang Liu ◽  
Yanan Gao ◽  
Ying Liu ◽  
Yaomin Guo ◽  
Zhicong Yan ◽  
...  

Accumulating diffusion tensor imaging (DTI) evidence suggests that white matter abnormalities evaluated by local diffusion homogeneity (LDH) or fractional anisotropy (FA) occur in patients with blepharospasm (BSP), both of which are significantly correlated with disease severity. However, whether the individual severity of BSP can be identified using these DTI metrics remains unknown. We aimed to investigate whether a combination of machine learning techniques and LDH or FA can accurately identify the individual severity of BSP. Forty-one patients with BSP were assessed using the Jankovic Rating Scale and DTI. The patients were assigned to non-functionally and functionally limited groups according to their Jankovic Rating Scale scores. A machine learning scheme consisting of beam search and support vector machines was designed to identify non-functionally versus functionally limited outcomes, with the input features being LDH or FA in 68 white matter regions. The proposed machine learning scheme with LDH or FA yielded an overall accuracy of 88.67 versus 85.19% in identifying non-functionally limited versus functionally limited outcomes. The scheme also identified a sensitivity of 91.40 versus 85.87% in correctly identifying functionally limited outcomes, a specificity of 83.33 versus 83.67% in accurately identifying non-functionally limited outcomes, and an area under the curve of 93.7 versus 91.3%. These findings suggest that a combination of LDH or FA measurements and a sophisticated machine learning scheme can accurately and reliably identify the individual disease severity in patients with BSP.


2021 ◽  
Author(s):  
ANKIT GHOSH ◽  
ALOK KOLE

<p>The improvement of Artificial Intelligence (AI) and Machine Learning (ML) can help radiologists in tumor diagnostics without invasive measures. Magnetic resonance imaging (MRI) is a very useful method for diagnosis of tumors in human brain. In this paper, brain MRI images have been analyzed to detect the regions containing tumors and classify these regions into three different tumor categories: meningioma, glioma, and pituitary. This paper presents the implementation and comparison of various enhanced ML algorithms for the detection and classification of brain tumors. A brain tumor is the growth of abnormal cells in the human brain. Brain tumors can be cancerous or non-cancerous. Cancerous or malignant brain tumors can be life threatening. Hence, detection and classification of brain tumors at an early stage is extremely important. In this paper, enhanced ML algorithms have been implemented to predict the presence or the absence of brain tumors using binary classification and to predict whether a patient has brain tumor or not and if he does, detect the type of brain tumor using multi-class classification. The dataset that has been used to perform the binary classification task comprises of two types of brain MRI images with tumor and without tumor. Here nine ML algorithms namely, Support Vector Machine (SVM), Logistic Regression, K-Nearest Neighbor (KNN), Naïve Bayes (NB), Decision Tree (DT) classifier, Random Forest classifier, XGBoost classifier, Stochastic Gradient Descent (SGD) classifier and Gradient Boosting classifier have been used to classify the MRI images. A comparative analysis of the ML algorithms has been performed based on a few performance metrics such as accuracy, recall, and precision, F1-score, AUC-ROC curve and AUC-PR curve. Gradient Boosting classifier has outperformed all the other algorithms with an accuracy of 92.4%, recall of 94.4%, precision of 85%, F1-score of 89.5%, AUC-ROC of 97.2% and an AUC-PR of 91.4%. To address the multi-class classification problem, four ML algorithms namely, SVM, KNN, Random Forest classifier and XGBoost classifier have been employed. In this case, the dataset that has been used consists of four types of brain MRI images with glioma tumor, meningioma tumor, and pituitary tumor and with no tumor. The performances of the ML algorithms have been compared based on accuracy, recall, precision and the F1-score. XGBoost classifier has surpassed all the other algorithms in terms of accuracy, precision, recall and F1-score. XGBoost has produced an accuracy of 90%, precision of 90%, and recall of 90% and F1-score of 90%.</p>


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