Clinicopathological factors associated with tumor-infiltrating lymphocyte reactivity in breast cancer

Gene expression profiling tests such as the Oncotype DX (ODX) 21-gene recurrence score (RS) assay is increasingly used in clinical practice to predict the risk of recurrence and support treatment planning for early-stage breast cancer (BC). However, this test has some disadvantages such as a high cost and a long turnaround time to get results, which may lead to disparities in access. We aim to identify clinicopathological factors associated with ODX RS in women with early-stage BC. We conducted a retrospective cohort study of women identified in the medical database of the Deschênes-Fabia Breast Disease Center of Quebec City University, Canada. Our sample consists of 425 women diagnosed with early-stage BC who have obtained an ODX RS between January 2011 and April 2015. The ODX RS has been categorized into three levels as originally defined: low (0–17), intermediate (18–30), and high (>30). The mean RS was 17.8 (SD = 9.2). Univariate analyses and multinomial logistic regressions were performed to identify factors associated with intermediate and high RS compared with low RS. A total of 237 (55.8%) patients had low RS, 148 (34.8%) had intermediate RS, and 40 (9.4%) had high RS. Women with progesterone receptor (PR)-negative (ORs ranging from 3.51 to 10.34) and histologic grade II (ORs ranging from 3.16 to 23.04) tumors were consistently more likely to have intermediate or high RS than low RS. Similar patterns of associations were observed when the RS was categorised using redefined thresholds from (i.e., from the TAILORx study or dichotomized). This study provides evidence suggesting that histologic grade and PR status are predictive factors for intermediate or high RS in women with early-stage BC. If these results are confirmed in future studies, considering these clinicopathological factors could spare women the need to get such a test before the beginning of a possible adjuvant therapy. This option could be considered in settings where the cost of testing is an issue.

Download Full-text

Clinicopathological factors associated with novel prognostic markers for patients with triple negative breast cancer

Archives of Medical Science ◽

10.5114/aoms.2018.79568 ◽

2019 ◽

Vol 15 (6) ◽

pp. 1433-1442

Author(s):

Anna Badowska-Kozakiewicz ◽

Michał Budzik ◽

Anna Liszcz ◽

Maciej Sobieraj ◽

Aleksandra Czerw ◽

...

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Prognostic Markers ◽

Clinicopathological Factors ◽

Factors Associated

Download Full-text

The Clinicopathological Factors Associated with Disease Progression in Luminal A Breast Cancer and Characteristics of Metastasis: A Retrospective Study from A Single Center in China

Anticancer Research ◽

10.21873/anticanres.11852 ◽

2017 ◽

Vol 37 (8) ◽

Cited By ~ 1

Keyword(s):

Breast Cancer ◽

Retrospective Study ◽

Disease Progression ◽

Clinicopathological Factors ◽

Single Center ◽

Luminal A ◽

Factors Associated

Download Full-text

Adjuvant systemic therapy in early breast cancer: impact of guideline changes and clinicopathological factors associated with nonadherence at a nation-wide level

Breast Cancer Research and Treatment ◽

10.1007/s10549-016-3940-7 ◽

2016 ◽

Vol 159 (2) ◽

pp. 357-365 ◽

Cited By ~ 4

Author(s):

A. M. F. Verschoor ◽

A. Kuijer ◽

J. Verloop ◽

C. H. Van Gils ◽

G. S. Sonke ◽

...

Keyword(s):

Breast Cancer ◽

Early Breast Cancer ◽

Systemic Therapy ◽

Adjuvant Systemic Therapy ◽

Clinicopathological Factors ◽

Factors Associated

Download Full-text

Triple-negative breast cancer: Pretreatment magnetic resonance imaging features and clinicopathological factors associated with recurrence

Magnetic Resonance Imaging ◽

10.1016/j.mri.2019.10.001 ◽

2020 ◽

Vol 66 ◽

pp. 36-41

Author(s):

Youn Joo Lee ◽

In Kyung Youn ◽

Sung Hun Kim ◽

Bong Joo Kang ◽

Woo-chan Park ◽

...

Keyword(s):

Breast Cancer ◽

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Imaging Features ◽

Clinicopathological Factors ◽

Resonance Imaging ◽

Factors Associated

Download Full-text

Discovery of DNA Binding Anticancer Drugs That Target Oncogenic Transcription Factors Associated With Human Breast Cancer

10.21236/ada403322 ◽

2001 ◽

Author(s):

Terry A. Beerman

Keyword(s):

Breast Cancer ◽

Transcription Factors ◽

Dna Binding ◽

Anticancer Drugs ◽

Human Breast Cancer ◽

Human Breast ◽

Factors Associated

Download Full-text

Determinan Kejadian Ca Mammae Di Poli Rawat Jalan Bedah Rsud Dr. Achmad Mochtar

Jurnal Endurance ◽

10.22216/jen.v3i3.3700 ◽

2018 ◽

Vol 3 (3) ◽

pp. 575

Author(s):

Neila Sulung ◽

Rizki Yananda ◽

Adriani Adriani

Keyword(s):

Breast Cancer ◽

Breast Cancer Incidence ◽

Hormonal Contraception ◽

Sampling Technique ◽

Case Control ◽

Female Breast Cancer ◽

Chi Square ◽

Control Approach ◽

Factors Associated ◽

Cancer Breast

Cancer is one of the leading causes of death worldwide. In Indonesia every year 1: 3 women per 1000 population are affected by breast cancer. Breast cancer is a cancer that attacks most women. The incidence of breast cancer is currently estimated at 39 per 100,000 population in 2008. The purpose of this study was to determine the factors associated with the risk of female breast cancer in surgical outpatient poly patients at Dr. Achmad Mochtar, Bukittinggi City. This study uses descriptive analytic method with a case control approach. The sampling technique in this study was accidental sampling. The sample in this study were all women diagnosed with breast cancer, amounting to 50 cases and 50 controls with data processing through computerization. The instrument used in this study is a questionnaire. Data analysis was performed using Chi-Square test (α = 0.05). The results showed that the factors associated with the incidence of breast cancer were genetic (p = 0.009), menarche (p = 0.014), menopause (p = 0.016), hormonal contraception (p = 0,045), obesity (p = 0,043), and high food fat (p = 0.028). Conclusions of the study are factors related to the risk of breast cancer incidence are genetic, menarche, menopause, hormonal contraception, obesity and high-fat foods. Penyakit kanker merupakan salah satu penyebab kematian utama di seluruh dunia. Di Indonesia setiap tahun 1:3 wanita per 1000 penduduk terserang kanker payudara. Kanker payudara merupakan kanker yang paling banyak menyerang perempuan. Angka kejadian kanker payudara saat ini diperkirakan 39 per 100.000 penduduk pada tahun 2008. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang berhubungan dengan risiko kanker payudara wanita pada pasien poli rawat jalan bedah di RSUD Dr. Achmad Mochtar Kota Bukittinggi. Penelitian ini menggunakan metode deskriptif analitik dengan pendekatan case control. Teknik pengambilan sampel dalam penelitian ini adalah accidental sampling. Sampel dalam penelitian ini adalah semua wanita yang terdiagnosis kanker payudara, berjumlah 50 kasus dan 50 kontrol dengan pengolahan data melalui komputerisasi. Instrument yang digunakan dalam penelitian ini adalah lembar kuisioner. Analisis data dilakukan menggunakan uji Chi-Square (α=0,05). Hasil penelitian menunjukkan faktor yang berhubungan dengan kejadian kanker payudara adalah genetik (p=0,009), menarche (p=0,014;), menopause (p=0,016), kontrasepsi hormonal (p=0,045), obesitas (p=0,043), dan makanan tinggi lemak (p=0,028). Simpulan penelitian adalah faktor yang berhubungan dengan risiko kejadian kanker payudara adalah genetik, menarche, menopause, kontrasepsi hormonal, obesitas dan makanan tinggi lemak.

Download Full-text