Autologous EBV-specific T cell treatment results in sustained responses in patients with advanced extranodal NK/T lymphoma: results of a multicenter study

2021 ◽  
Author(s):  
Won Seog Kim ◽  
Yasuhiro Oki ◽  
Seok Jin Kim ◽  
Sang Eun Yoon ◽  
Kirit M. Ardeshna ◽  
...  
Keyword(s):  
T Cell ◽  
Multicenter Study ◽  
Treatment Results ◽  
T Lymphoma ◽  
Sustained Responses

Gi and Gq/11 proteins are involved in dissemination of myeloid leukemia cells to the liver and spleen, whereas bone marrow colonization involves Gq/11 but not Gi

Blood ◽  
2000 ◽  
Vol 96 (2) ◽  
pp. 691-698 ◽  
Author(s):  
Ron D. M. Soede ◽  
Yvonne M. Wijnands ◽  
Marga Kamp ◽  
Martin A. van der Valk ◽  
Ed Roos
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Pertussis Toxin ◽  
Myeloid Leukemia ◽  
Leukemia Cells ◽  
Hybridoma Cells ◽  
Defective Mutant ◽  
Gi Protein ◽  
T Lymphoma ◽  
Gi Proteins

Abstract The migration of leukocytes into tissues is regulated by chemokines and other chemotactic factors that act on receptors that signal through Gi proteins. It seems likely that the colonization of tissues during dissemination of hematopoietic tumor cells is similarly regulated. In fact, dissemination of a T-cell hybridoma, a model for T lymphoma, was blocked when Gi proteins were inactivated by the S1 catalytic subunit of pertussis toxin that had been transfected into those cells. Pertussis toxin S1 blocked dissemination of MDAY-D2 murine myeloid leukemia cells to the liver and spleen, as in T-cell hybridoma cells, but it did not prevent bone marrow colonization. In contrast, overexpression of a function-defective mutant of the Gq/11 protein blocked dissemination to the bone marrow and also prevented Gq/11 dissemination to the liver and spleen. This indicates that the influx of these myeloid cells into all tissues requires the Gq/11 protein in addition to the Gi protein in the liver and spleen.

scholarly journals Correlated expression of T cell growth factor dependence, sensitivity to Vicia villosa lectin, and cytolytic activity in hybrids between cytolytic T cells and T lymphomas.

1982 ◽  
Vol 156 (5) ◽  
pp. 1335-1351 ◽  
Author(s):  
A Conzelmann ◽  
A Silva ◽  
M Cianfriglia ◽  
C Tougne ◽  
R P Sekaly ◽  
...  
Keyword(s):  
T Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Cytolytic Activity ◽  
Genetic Element ◽  
Vicia Villosa ◽  
Vicia Villosa Lectin ◽  
T Lymphoma ◽  
T Lymphomas ◽  
T Cell Growth Factor

Somatic cell fusion between cytolytically active, T cell growth factor- (TCGF) dependent murine T cell lines (CTL lines) and noncytolytic, TCGF-independent murine T lymphoma lines has yielded two types of somatic cell hybrids (5): cytolytic hybrids, growth of which is dependent on TCGF, and hybrids with very weak or undetectable cytolytic activity which grow at the same rate with or without TCGF. Here we report that the former can produce stable variants that resemble the latter type. Some of these TCGF-independent variants still have TCGF receptors. High susceptibility to the cytotoxic effects of Vicia villosa lectin, a marker distinguishing the parental CTL lines from T lymphomas, is expressed by the TCGF-dependent hybrids but not by the TCGF-independent variants. The two types of hybrids also differ in the expression of surface glycoproteins. We propose that there exists a genetic element in the CTL line that represses the TCGF-independent replication mechanism of the T lymphoma parent in the TCGF-dependent hybrids and that this genetic element is lost or switched off in the TCGF-independent variants.

scholarly journals Prognostic nomogram for overall survival in previously untreated patients with extranodal NK/T-cell lymphoma, nasal-type: a multicenter study

Leukemia ◽  
2015 ◽  
Vol 29 (7) ◽  
pp. 1571-1577 ◽  
Author(s):  
Y Yang ◽  
Y-J Zhang ◽  
Y Zhu ◽  
J-Z Cao ◽  
Z-Y Yuan ◽  
...  
Keyword(s):  
Overall Survival ◽  
T Cell ◽  
Multicenter Study ◽  
Cell Lymphoma ◽  
Type A ◽  
T Cell Lymphoma ◽  
Nasal Type ◽  
Nk T Cell

A phase 1 multicenter study evaluating KITE-585, an autologous anti-BCMA CAR T-cell therapy, in patients with relapsed/refractory multiple myeloma.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. TPS3103-TPS3103 ◽  
Author(s):  
Robert F. Cornell ◽  
Frederick Lundry Locke ◽  
Michael Russell Bishop ◽  
Robert Z. Orlowski ◽  
Sarah Marie Larson ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
T Cell ◽  
Cell Therapy ◽  
Multicenter Study ◽  
Phase 1 ◽  
T Cell Therapy ◽  
Refractory Multiple Myeloma ◽  
Car T Cell ◽  
Car T Cell Therapy ◽  
Car T

scholarly journals The expression of several T cell-specific and novel genes is repressed by trans-acting factors in immature T lymphoma clones.

1991 ◽  
Vol 174 (1) ◽  
pp. 269-280 ◽  
Author(s):  
M F Wilkinson ◽  
J Doskow ◽  
R von Borstel ◽  
A M Fong ◽  
C L MacLeod
Keyword(s):  
T Cell ◽  
Somatic Cell ◽  
Cell Lines ◽  
Hybrid Cells ◽  
Somatic Cell Hybrids ◽  
Novel Genes ◽  
Mrna Accumulation ◽  
Cell Hybrids ◽  
T Lymphoma ◽  
Cell Ontogeny

Cell surface proteins encoded by members of the immunoglobulin supergene family are sequentially expressed during T cell ontogeny. The molecular mechanisms responsible for the regulation of these surface molecules are not well understood. To investigate this issue, we used a series of well characterized T lymphoma cell clones with phenotypes characteristic of distinct stages of early thymocyte maturation. Somatic cell hybrids formed from these cell lines were employed to detect the presence of negative regulatory molecules. The expression of CD4 and CD8 was strongly repressed in hybrids formed between a CD4+ CD8+ lymphoma clone and "immature" CD4- CD8- lymphoma clones. Individual subunits of the T cell receptor (TCR)/CD3 complex displayed independent regulation in unique patterns in hybrid cells. Hybrids formed by fusing CD3+ and CD3- cells completely repressed CD3-delta mRNA expression while CD3-gamma, -epsilon, and -zeta transcripts were moderately inhibited or codominantly regulated. Similar to CD3-delta, interleukin 2R-alpha(IL-2R-alpha), and TCR-beta mRNA accumulation was trans-negatively regulated. Transcription rate measurements demonstrated that the inhibition of CD4, CD8, CD3-gamma, CD3-epsilon, TCR-beta, and IL-2R-alpha mRNA accumulation in hybrid cells was exerted, at least in part, at the transcriptional level. To test whether repressional regulation is a general feature of T cells, we examined the regulation of six novel genes which were selected solely on the basis of their differential expression between two of the cell lines used in this study. Five of the six novel gene transcripts were repressed in the somatic cell hybrids. Thus, inhibitor factors appear to play a general role in controlling T cell gene expression. The model system presented here may be useful for the identification and characterization of repressor molecules responsible for the regulation of genes expressed during T cell ontogeny.

Autologous Stem-Cell Transplantation As First-Line Therapy in Peripheral T-Cell Lymphomas: Results of a Prospective Multicenter Study

2009 ◽  
Vol 27 (1) ◽  
pp. 106-113 ◽  
Author(s):  
Peter Reimer ◽  
Thomas Rüdiger ◽  
Eva Geissinger ◽  
Florian Weissinger ◽  
Christoph Nerl ◽  
...  
Keyword(s):  
Stem Cell ◽  
T Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
Multicenter Study ◽  
Prospective Multicenter Study ◽  
Free Survival ◽  
T Cell Lymphomas ◽  
Peripheral T Cell Lymphomas

PurposePeripheral T-cell lymphomas (PTCLs) are rare malignancies with poor outcome after conventional chemotherapy. The role of myeloablative therapy and autologous stem-cell transplantation (autoSCT) is still unclear. Therefore, we initiated the first prospective multicenter study on upfront autoSCT in PTCL and recently reported good feasibility and efficacy of this approach. Here, we present the final analysis of the study.Patients and MethodsThe treatment regimen consisted of four to six cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone followed by mobilizing therapy with either the dexamethasone, carmustine, melphalan, etoposide, and cytarabine protocol or the etoposide, methylprednisolone, cytarabine, and cisplatin protocol and stem-cell collection. Patients in complete remission (CR) or partial remission (PR) underwent myeloablative chemoradiotherapy (fractionated total-body irradiation and high-dose cyclophosphamide) and autoSCT.ResultsFrom June 2000 to April 2006, 83 patients were enrolled onto the study. Main subgroups were PTCL not specified (n = 32) and angioimmunoblastic T-cell lymphoma (n = 27). Fifty-five (66%) of the 83 patients received transplantation. The main reason for not receiving autoSCT was progressive disease. In an intent-to-treat analysis, the overall response rate after myeloablative therapy was 66% (56% CR and 8% PR). With a median follow-up time of 33 months, 43 patients are alive; the estimated 3-year overall and disease-free survival rates for patients in CR (calculated from CR to the date of relapse) and 3-year progression-free survival rate were 48%, 53%, and 36%, respectively.ConclusionThe results of this prospective study suggest a substantial impact on outcome for upfront autoSCT in PTCL and should be further evaluated in randomized trials. Pretransplantation treatment needs to be improved to increase the transplantation rate.

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