Potential applications of three-dimensional ultrasound in the pediatric urinary tract: pictorial demonstration based on preliminary results

: Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form derived from amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three dimensional honeycombs like structure provided with two internal aqueous channels for incorporation of number of biologically active ingredients. In contrast liposomes they provide large surface area for incorporation of different types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes have remained the first preference as method of choice in the sustained release, controlled release and targeted release dosage forms as new drug delivery system for the better release of the drugs. As lot of advancement in the new form of dosage form has bring the novel avenues in drug delivery mechanisms so it was matter of worth to compile the latest updates on the various aspects of mentioned therapeutic delivery system including its structure, routes of applications along with the potential applications to encapsulate variety drugs to serve health related benefits.

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A Novel Pseudomonas geniculata AGE Family Epimerase/Isomerase and Its Application in d-Mannose Synthesis

Foods ◽

10.3390/foods9121809 ◽

2020 ◽

Vol 9 (12) ◽

pp. 1809

Author(s):

Zhanzhi Liu ◽

Ying Li ◽

Jing Wu ◽

Sheng Chen

Keyword(s):

3D Structure ◽

Three Dimensional ◽

Optimal Temperature ◽

Reaction Conditions ◽

Enzymatic Production ◽

Physiological Properties ◽

Potential Applications ◽

Kinetics Of ◽

Optimal Reaction ◽

Gene Age

d-mannose has exhibited excellent physiological properties in the food, pharmaceutical, and feed industries. Therefore, emerging attention has been applied to enzymatic production of d-mannose due to its advantage over chemical synthesis. The gene age of N-acetyl-d-glucosamine 2-epimerase family epimerase/isomerase (AGEase) derived from Pseudomonas geniculata was amplified, and the recombinant P. geniculata AGEase was characterized. The optimal temperature and pH of P. geniculata AGEase were 60 °C and 7.5, respectively. The Km, kcat, and kcat/Km of P. geniculata AGEase for d-mannose were 49.2 ± 8.5 mM, 476.3 ± 4.0 s−1, and 9.7 ± 0.5 s−1·mM−1, respectively. The recombinant P. geniculata AGEase was classified into the YihS enzyme subfamily in the AGE enzyme family by analyzing its substrate specificity and active center of the three-dimensional (3D) structure. Further studies on the kinetics of different substrates showed that the P. geniculata AGEase belongs to the d-mannose isomerase of the YihS enzyme. The P. geniculata AGEase catalyzed the synthesis of d-mannose with d-fructose as a substrate, and the conversion rate was as high as 39.3% with the d-mannose yield of 78.6 g·L−1 under optimal reaction conditions of 200 g·L−1d-fructose and 2.5 U·mL−1P. geniculata AGEase. This novel P. geniculata AGEase has potential applications in the industrial production of d-mannose.

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Three-dimensional bio-printing and bone tissue engineering: technical innovations and potential applications in maxillofacial reconstructive surgery

Maxillofacial Plastic and Reconstructive Surgery ◽

10.1186/s40902-020-00263-6 ◽

2020 ◽

Vol 42 (1) ◽

Cited By ~ 5

Author(s):

Muhja Salah ◽

Lobat Tayebi ◽

Keyvan Moharamzadeh ◽

Farhad B. Naini

Keyword(s):

Tissue Engineering ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Reconstructive Surgery ◽

Three Dimensional ◽

Potential Applications ◽

Technical Innovations

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Giant Magnetoresistance and Magneto-Thermopower in 3D Interconnected NixFe1−x/Cu Multilayered Nanowire Networks

Nanomaterials ◽

10.3390/nano11051133 ◽

2021 ◽

Vol 11 (5) ◽

pp. 1133

Author(s):

Nicolas Marchal ◽

Tristan da Câmara Santa Clara Gomes ◽

Flavio Abreu Araujo ◽

Luc Piraux

Keyword(s):

Giant Magnetoresistance ◽

Nanowire Array ◽

Three Dimensional ◽

Strong Increase ◽

Thermoelectric Effect ◽

Heat Management ◽

Thermoelectric Effects ◽

Nanowire Network ◽

Potential Applications ◽

Nanowire Networks

The versatility of the template-assisted electrodeposition technique to fabricate complex three-dimensional networks made of interconnected nanowires allows one to easily stack ferromagnetic and non-magnetic metallic layers along the nanowire axis. This leads to the fabrication of unique multilayered nanowire network films showing giant magnetoresistance effect in the current-perpendicular-to-plane configuration that can be reliably measured along the macroscopic in-plane direction of the films. Moreover, the system also enables reliable measurements of the analogous magneto-thermoelectric properties of the multilayered nanowire networks. Here, three-dimensional interconnected NixFe1−x/Cu multilayered nanowire networks (with 0.60≤x≤0.97) are fabricated and characterized, leading to large magnetoresistance and magneto-thermopower ratios up to 17% and −25% in Ni80Fe20/Cu, respectively. A strong contrast is observed between the amplitudes of magnetoresistance and magneto-thermoelectric effects depending on the Ni content of the NiFe alloys. In particular, for the highest Ni concentrations, a strong increase in the magneto-thermoelectric effect is observed, more than a factor of 7 larger than the magnetoresistive effect for Ni97Fe3/Cu multilayers. This sharp increase is mainly due to an increase in the spin-dependent Seebeck coefficient from −7 µV/K for the Ni60Fe40/Cu and Ni70Fe30/Cu nanowire arrays to −21 µV/K for the Ni97Fe3/Cu nanowire array. The enhancement of the magneto-thermoelectric effect for multilayered nanowire networks based on dilute Ni alloys is promising for obtaining a flexible magnetic switch for thermoelectric generation for potential applications in heat management or logic devices using thermal energy.

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Three-dimensional conformal radiation therapy in locally advanced carcinoma of the prostate: Preliminary results of a phase I dose-escalation study

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/0360-3016(94)90141-4 ◽

1994 ◽

Vol 28 (1) ◽

pp. 55-65 ◽

Cited By ~ 137

Author(s):

Steven A. Leibel ◽

Ruth Heimann ◽

Gerald J. Kutcher ◽

Michael J. Zelefsky ◽

Chandra M. Burman ◽

...

Keyword(s):

Radiation Therapy ◽

Phase I ◽

Dose Escalation ◽

Locally Advanced ◽

Three Dimensional ◽

Dose Escalation Study ◽

Conformal Radiation Therapy ◽

Advanced Carcinoma ◽

Preliminary Results ◽

Carcinoma Of The Prostate

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Influence of the Infill Geometry of 3D-Printed Tablets on Drug Dissolution

Medical Sciences Forum ◽

10.3390/msf2021005015 ◽

2021 ◽

Vol 5 (1) ◽

pp. 15

Author(s):

Nuno Venâncio ◽

Gabriela G. Pereira ◽

João F. Pinto ◽

Ana I. Fernandes

Keyword(s):

Three Dimensional ◽

Drug Dissolution ◽

Fused Deposition Modelling ◽

Three Dimensional Printing ◽

Preliminary Results ◽

Fused Deposition ◽

3D Printed ◽

Dimensional Printing ◽

Hot Melt ◽

Patient Centric

Patient-centric therapy is especially important in pediatrics and may be attained by three-dimensional printing. Filaments containing 30% w/w of theophylline were produced by hot-melt extrusion and printed using fused deposition modelling to produce tablets. Here, preliminary results evaluating the effect of infill geometry (cross, star, grid) on drug content and release are reported.

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