Foods contributing to vitamin B6, folate, and vitamin B12 intakes and biomarkers status in European adolescents: The HELENA study

2016 ◽  
Vol 56 (4) ◽  
pp. 1767-1782 ◽  
Author(s):  
Iris Iglesia ◽  
◽  
Theodora Mouratidou ◽  
Marcela González-Gross ◽  
Inge Huybrechts ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Vitamin B6 ◽  
Folate And Vitamin B12 ◽  
Helena Study

scholarly journals Erratum to: Foods contributing to vitamin B6, folate, and vitamin B12 intakes and biomarkers status in European adolescents: The HELENA study

2016 ◽  
Vol 56 (4) ◽  
pp. 1783-1783 ◽  
Author(s):  
Iris Iglesia ◽  
◽  
Theodora Mouratidou ◽  
Marcela González-Gross ◽  
Inge Huybrechts ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Vitamin B6 ◽  
Folate And Vitamin B12 ◽  
Helena Study

Gender and age influence blood folate, vitamin B12, vitamin B6, and homocysteine levels in European adolescents: the Helena Study

2012 ◽  
Vol 32 (11) ◽  
pp. 817-826 ◽  
Author(s):  
Marcela González-Gross ◽  
Jasmin Benser ◽  
Christina Breidenassel ◽  
Ulrike Albers ◽  
Inge Huybrechts ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Vitamin B6 ◽  
Gender And Age ◽  
Helena Study

Association Between Homocysteine and Vitamin Levels in Demented Patients

2021 ◽  
pp. 1-12
Author(s):  
Jessica Hoffmann ◽  
Stefan Busse ◽  
Franz von Hoff ◽  
Katrin Borucki ◽  
Thomas Frodl ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Vitamin B6 ◽  
Homocysteine Level ◽  
Vitamin B1 ◽  
Lewy Body Dementia ◽  
Serum Levels ◽  
Elderly Persons ◽  
Total Homocysteine ◽  
Folate And Vitamin B12 ◽  
Elderly Control

Background: Although it is known that the nutritional status among elderly persons and, in particular, patients with dementia, is compromised, malnutrition that results in insufficient uptake of several vitamins is often not diagnosed. Objective: An elevated homocysteine level is a known strong risk factor for vascular dementia (VaD) and Alzheimer’s disease (AD). Several B vitamins are involved in the metabolism of homocysteine. Therefore, we investigated the serum levels of vitamin B1, vitamin B6, folate, and vitamin B12 in 97 patients with mild cognitive impairment (MCI) or different forms of dementia and 54 elderly control persons without dementia. Results: Compared to aged non-demented people, vitamins B1, B6, B12, and folate were decreased in serum of patients with AD, and patients with Lewy body dementia had reduced vitamin B12 level. Vitamin B6 was diminished in VaD. Patients with frontotemporal dementia showed no alterations in vitamin levels. Age was identified as an important factor contributing to the concentrations of vitamin B1 and B6 in serum, but not vitamin B12 and folate. Increased levels of total homocysteine were detected especially in MCI and AD. Homocysteine correlated negatively with levels of vitamins B6, B12, and folate and positively with Q Albumin. Conclusion: Our data suggest that despite increased homocysteine already present in MCI, vitamin levels are decreased only in dementia. We propose to determine the vitamin levels in patients with cognitive decline, but also elderly people in general, and recommend supplementing these nutrients if needed.

Diagnostik und Therapie der Homocystinurie

2009 ◽  
Vol 09 (05) ◽  
pp. 289-293
Author(s):  
B. Reulecke ◽  
J. Denecke
Keyword(s):  
Vitamin B12 ◽  
Vitamin B6 ◽  
Sich Eine ◽  
Diagnostik Und Therapie

ZusammenfassungDie Homocystinurie ist eine seltene angeborene Erkrankung des Methioninstoffwechsels, die mit einer pathologischen Erhöhung der nicht proteinogenen Aminosäure Homocystein und der Ausscheidung ihres Disulfids Homocystin über den Urin einhergeht. Mehrere biochemische und genetische Defekte können zu einer deutlichen Homocysteinerhö-hung führen, darunter Störungen des Vita-min-B6-, Folsäure- und Vitamin-B12-Stoffwechsels, sodass der Terminus Homocystinurie eine Erkrankungsgruppe zusammenfasst. Die häufigste Ursache der Homocystinurie, auch klassische Homocystinurie oder Homo-cystinurie Typ I genannt, stellt die hereditäre Cystathionin-β-Synthase-Defizienz dar, die mit einer Erhöhung von Homocystein und Methionin im Blut einhergeht. Die Diagnose wird durch Bestimmung von Homocystein im Plasma gestellt und kann biochemisch und genetisch gesichert werden. Unbehandelt zeigen sich eine erhebliche Morbidität und Mortalität, die durch Ausschöpfung der therapeutischen Optionen, bestehend aus Vitamin B6, Folsäure, Vitamin B12, Betain und einer Proteinrestriktion mit Aminosäuresupplementie-rung, erheblich reduziert werden können.

scholarly journals Depression and Vegetarians: Association between Dietary Vitamin B6, B12 and Folate Intake and Global and Subcortical Brain Volumes

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1790
Author(s):  
Samuel Berkins ◽  
Helgi Birgir Schiöth ◽  
Gull Rukh
Keyword(s):  
Vitamin B12 ◽  
Brain Structure ◽  
Vitamin B6 ◽  
Significant Interaction ◽  
Longitudinal Design ◽  
Folate Intake ◽  
Dietary Vitamin ◽  
Brain Volumes ◽  
Subcortical Brain ◽  
Depression Status

Deficiency of vitamin B6 and vitamin B12, mostly in vegetarians, is found to be associated with depression and adverse neurological function. We investigated whether vitamin B6, B12, and folate have an effect on brain structure, especially among depressed people who follow a specific diet. The study sample comprised 9426 participants from the UK Biobank cohort with a mean age of 62.4 years. A generalized linear model controlling for age, sex, body mass index, ethnicity, town send deprivation index, educational qualification, smoking, and alcohol intake was used to test the association between study groups and structural brain volumes. Depression was more prevalent, and intake of vitamin B6 and B12 was lower among vegetarians, while non-vegetarians had a lower intake of folate. Overall, no significant association was observed between vitamin B6, B12, and folate intakes and both global and subcortical brain volumes among participants with depression. However, vitamin B12 intake was positively associated with right pallidum among non-depressed participants, and a significant interaction between vitamin B12 intake and depression status on the right pallidum was observed. Also, a significant interaction between folate intake and depression status on grey matter (GM) volume and left thalamus was observed. Upon diet stratification, folate intake is associated with total brain volume and GM volume among vegetarians with depression. Furthermore, no significant associations were observed for subcortical regions. Our findings suggest that dietary intake of vitamin B6 and B12 might have an effect on brain structure. Vegetarians, particularly those who suffer from depression may benefit from supplementing their diets with vitamins B6, B12, and folate to ensure brain health. Further studies, especially with a larger sample size and longitudinal design, are needed to confirm these findings.

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