Alcohol, cigarette smoking, dietary factors and the risk of colorectal adenomas and hyperplastic polyps – a case control study

2002 ◽  
Vol 41 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Juergen Georg Erhardt ◽  
Heinz Peter Kreichgauer ◽  
Christoph Meisner ◽  
Johann Christian Bode ◽  
Christiane Bode
Keyword(s):  
Cigarette Smoking ◽  
Case Control Study ◽  
Case Control ◽  
Dietary Factors ◽  
Colorectal Adenomas ◽  
Hyperplastic Polyps ◽  
Control Study

Diet-dependent acid load and the risk of colorectal cancer and adenoma: a case–control study

2020 ◽  
pp. 1-8
Author(s):  
Saeede Jafari Nasab ◽  
Pegah Rafiee ◽  
Alireza Bahrami ◽  
Nasim Rezaeimanesh ◽  
Bahram Rashidkhani ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Epidemiological Studies ◽  
Case Control ◽  
Dietary Factors ◽  
Colorectal Adenomas ◽  
Newly Diagnosed ◽  
Acid Base Balance ◽  
Acid Load ◽  
Control Study

Abstract Objectives: Colorectal cancer (CRC) is the third and second most prevalent cancer in men and women, respectively. Various epidemiological studies indicated that dietary factors are implicated in the aetiology of CRC and its precursor, colorectal adenomas (CRA). Recently, much attention has been given to the role of acid–base balance in the development of chronic diseases including cancers. Therefore, the aim of the current study is to examine the association of diet-dependent acid load and the risk of CRC and CRA. Design: In this case–control study, potential renal acid load (PRAL) was computed based on dietary intake of participants assessed via a validated FFQ. Negative PRAL values indicated a base-forming potential, while positive values of PRAL implied acid-forming potential of diet. Logistic regression was used to derive OR and 95 % CI after adjusting for confounders. Setting: Tehran, Iran. Participants: A total of 499 participants aged 30–70 years were included in the study (240 hospital controls, 129 newly diagnosed CRC and 130 newly diagnosed CRA). The current study was conducted between December 2016 and September 2018. Results: After adjusting for potential confounders, a higher PRAL was associated with increased odds of CRC and CRA. The highest v. the lowest tertile of PRAL for CRC and CRA was OR 4·82 (95 % CI 2·51–9·25) and OR 2·47 (95 % CI 1·38–4·42), respectively. Conclusions: The findings of the current study suggested that higher diet-dependent acid load is associated with higher risk of CRC and CRA.

Exocrine Pancreatic Cancer, Cigarette Smoking, and Diabetes Mellitus: A Case-Control Study in Northern Italy

Pancreas ◽  
2003 ◽  
Vol 27 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Luigina Bonelli ◽  
Hugo Aste ◽  
Paolo Bovo ◽  
Giorgio Cavallini ◽  
Martina Felder ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Cancer ◽  
Cigarette Smoking ◽  
Case Control Study ◽  
Case Control ◽  
Northern Italy ◽  
Control Study ◽  
Exocrine Pancreatic Cancer

scholarly journals Cigarette Smoking and Breast Cancer: a Case-control Study in Serbia

2013 ◽  
Vol 14 (11) ◽  
pp. 6643-6647 ◽  
Author(s):  
Milena Ilic ◽  
Hristina Vlajinac ◽  
Jelena Marinkovic
Keyword(s):  
Breast Cancer ◽  
Cigarette Smoking ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Determinants of preterm birth in public hospitals in central Ethiopia: an unmatched case-control study

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 773
Author(s):  
Berhanu Senbeta Deriba ◽  
Agumas Fentahun Ayalew ◽  
Addis Adera Gebru
Keyword(s):  
Preterm Birth ◽  
Cigarette Smoking ◽  
Birth Outcomes ◽  
Case Control Study ◽  
Case Control ◽  
Public Hospitals ◽  
Medical Illness ◽  
Adverse Birth Outcomes ◽  
Central Ethiopia ◽  
Control Study

Background: Around 15 million babies are born prematurely in the world every year. The most common cause of neonatal death in Ethiopia is premature birth. To reduce the rate of preterm delivery by correcting modifiable or preventable causes, the availability of local data is important. Hence, this study aimed to identify the determinants of preterm birth among women who gave birth in public hospitals in central Ethiopia. Methods: An Institutional-based unmatched case-control study was conducted at public hospitals in central Ethiopia to select 170 cases and 340 controls. The collected data were entered into EPI INFO and transferred to SPSS for analysis. Tables, graphs, and proportions were used to present the results. Binary and multiple logistic regressions analysis were computed to identify determinants of preterm birth. Adjusted Odds Ratio (AOR), 95% Confidence Interval (CI), and a p-value < 0.05 were computed to determine the presence of an association between preterm birth and independent variables. Results: A total of 166 cases and 332 controls participated in the study, giving a response rate of 97.6%. Cigarette smoking (AOR=3.77, 95% CI=1.35,10.56), alcohol consumption (AOR=1.85, 95% CI=1.11,3.10), wanted but unplanned pregnancy (AOR=3,95% CI=1.68,5.34), neither wanted nor planned pregnancy(AOR=3.61% CI=1.62,8.06), lack of antenatal care (ANC) visits (AOR=4.13, 95% CI=1.95, 8.74), adverse birth outcomes (AOR=5.66, 95% CI=2.88,11.12), presence of a diagnosed illness (AOR=2.81, 95% CI=1.37, 5.76), presence of one or more of obstetrics complications(AOR=6.44, 95% CI=5.49, 3.35, 9), and hemoglobin level < 11g/dl  (AOR=2.78, 95% CI=1.48, 5.22) were determinants of preterm birth. Conclusion:-In this study, cigarette smoking status, alcohol drinking status, pregnancy status, adverse birth outcomes, ANC visits, obstetric complications,  presence of medical illness, and anemia were identified as determinants of preterm birth. It is important to encourage such women to attend ANC visits, stop smoking, and abstain from alcohol.

scholarly journals Occupation, smoking, opium, and bladder cancer: A case–control study

2015 ◽  
Vol 04 (03) ◽  
pp. 111-114 ◽  
Author(s):  
Tayeb Ghadimi ◽  
Bahman Gheitasi ◽  
Sayran Nili ◽  
Mohammad Karimi ◽  
Ebrahim Ghaderi
Keyword(s):  
Bladder Cancer ◽  
Risk Factor ◽  
Cigarette Smoking ◽  
Case Control Study ◽  
Case Control ◽  
Cancer Drug ◽  
Control Group ◽  
Occupational Risk Factors ◽  
Opium Abuse ◽  
Control Study

Abstract Purpose: The aim of this study was to investigate occupational risk factors associated with bladder cancer. Materials and Methods: In this case–control study, control group included patients who referred to a specialized clinic in the same city and hospitals where patients had been registered. Data were entered into SPSS software. Odds ratios (OR) were calculated for occupational variables and other characteristics. Then, using logistic regression, the association between cancer and drugs was studied while smoking was controlled. Results: Cigarette smoking, even after quitting, was also associated with bladder cancer (OR = 2.549). Considering the classification of occupations, the OR of working in metal industry in patients was 10.629. Multivariate analysis showed that use of the drug by itself can be a risk factor for bladder cancer. Drug abuse together with the control of smoking increased the risk of bladder cancer by 4.959. Conclusion: According to the findings of this study, contact with metal industries such as welding, and working with tin was found as a risk factor for bladder cancer. In addition, cigarette smoking and opium abuse individually were associated with bladder cancer.

A population-based case-control study of the relationship between cigarette smoking and nasopharyngeal cancer (United States)

1995 ◽  
Vol 6 (6) ◽  
pp. 507-512 ◽  
Author(s):  
Kangmin Zhu ◽  
Robert S. Levine ◽  
Edward A. Brann ◽  
Douglas R. Gnepp ◽  
Marianna K. Baum
Keyword(s):  
United States ◽  
Cigarette Smoking ◽  
Case Control Study ◽  
Nasopharyngeal Cancer ◽  
Population Based ◽  
Case Control ◽  
The Relationship ◽  
Control Study

scholarly journals Genetic Polymorphism of Glutathione S Transferases M1 and T1 in Indian Patients with Hepatocellular Carcinoma

2010 ◽  
Vol 28 (6) ◽  
pp. 369-376 ◽  
Author(s):  
Mohammad Asim ◽  
Luqman A. Khan ◽  
S. A. Husain ◽  
Sajid Husain ◽  
Manash P. Sarma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Alcohol Consumption ◽  
Liver Cancer ◽  
Cigarette Smoking ◽  
Case Control Study ◽  
Smoking Habit ◽  
Case Control ◽  
Gstt1 Null Genotype ◽  
Increased Risk ◽  
Control Study

Objective:Our aim was to evaluate whether the association of GSTM1/T1 gene polymorphisms modifies the risk of Hepatocellular carcinoma (HCC) and what is its correlation with other predisposing risk factors like alcohol intake, cigarette smoking and hepatitis B and C infections.Study design/setting:It was a case-control study, included 254 HCC cases compared with 525 hospital-based age and sex matched cases of chronic liver disease without HCC as controls from Indian population. The GSTM1 and GSTT1 genotypes were detected using conventional multiplex PCR method.Results:In this case-control study, we observed a positive correlation between age, HBV and HCV infection, smoking habit of > 20 packs/year, alcohol consumption of > 100 g/day and risk of liver cancer. We found significantly increased risk associated with GSTM1 null genotype (OR = 3.49; 95% CI = 2.52–4.84) as well as GSTT1 null genotype (OR = 3.12; 95% CI = 2.19–4.45), respectively. However, an increased risk of HCC was observed among heavy drinkers with GSTM1 (OR = 2.01; 95% CI = 1.11–3.66). Further, cigarette smoking showed a non-significant association with GSTT1 (OR = 1.49; CI = 0.69–3.25).Conclusion:Our results suggest that the variants in low penetrance gene such as GSTM1 and GSTT1 are associated with an increased liver cancer risk. Further, an influence of GSTM1/T1 null genotypes may contribute in the etiology of HCC in patients with higher cigarette and alcohol consumption.

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