Meta-analysis of case–control studies on the relationship between lung cancer and indoor radon exposure

2018 ◽  
Vol 58 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Georgy Malinovsky ◽  
Ilia Yarmoshenko ◽  
Aleksey Vasilyev
Keyword(s):  
Lung Cancer ◽  
Indoor Radon ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Radon Exposure ◽  
The Relationship

scholarly journals Combined analysis of onco-epidemiological studies of the relationship between lung cancer and indoor radon exposure

Nukleonika ◽  
2020 ◽  
Vol 65 (2) ◽  
pp. 83-88 ◽  
Author(s):  
Ilia V. Yarmoshenko ◽  
Georgy P. Malinovsky
Keyword(s):  
Lung Cancer ◽  
Reference Group ◽  
Indoor Radon ◽  
Meta Analysis ◽  
The United States ◽  
Case Control ◽  
Case Control Studies ◽  
Radon Exposure ◽  
Combined Analysis ◽  
Aggregated Data

AbstractObjectives: Recent results of epidemiological and medical statistics studies of lung cancer and indoor radon in different regions of the world make a relevant new combined analysis of residential exposure health effects. In particular, new data were obtained by means of a meta-analysis of case-control studies as well as taking into account a confounding effect of human papillomavirus infection in studies of geographically aggregated data.Materials and methods: Two sources of epidemiological data are considered: (1) studies of ecological design and (2) case-control studies. Ecological studies included the analysis performed for the USA counties and Russian oblasts with adjusting for the main confounders. Data on the case-control studies were gained from the meta-analysis of 31 individual studies with a weighting of obtained odds ratios according to the quality of radon exposure reconstruction and size of the reference group. Estimations of lung cancer excess relative risk (ERR) associated with indoor radon exposure are combined.Results: Two types of epidemiological study design provided generally consistent EER estimations. The combined value of ERR due to radon exposure is 0.14 (90% CI: 0.10–0.18) per 100 Bq/m3.Conclusion: Available geographically aggregated data in regions of Russia and the United States and the meta-analysis of case-control studies conducted in a large number of countries confirm the association of lung cancer with indoor radon exposure.

Indoor radon exposure and lung cancer risk: a meta-analysis of case-control studies

2017 ◽  
Vol 6 (S5) ◽  
pp. S934-S943 ◽  
Author(s):  
Carmine Garzillo ◽  
Mariagabriella Pugliese ◽  
Filomena Loffredo ◽  
Maria Quarto
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Indoor Radon ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Radon Exposure

A meta-analysis of oncoepidemiological data on possible link between radon exposure and lung cancer

2019 ◽  
pp. 92-96
Author(s):  
I. V. Yarmoshenko ◽  
G. P. Malinovskiy ◽  
A. V. Vasil’yev
Keyword(s):  
Lung Cancer ◽  
Meta Analysis ◽  
Lung Cancer Mortality ◽  
Case Control ◽  
Case Control Studies ◽  
Natural Factor ◽  
Medical Statistic ◽  
Radon Exposure ◽  
Study Results ◽  
The World

Radon and its derivatives are a global natural factor of radiation infl uence on humans. New data on risk factors of lung cancer and signifi cant volume of epidemiologic and medical statistic data collected recently in various parts of the world prove that meta-analysis of information of link between lung cancer and radon exposure in living area is topical. Th e authors analyzed the most complete set of data on radon infl uence on human health, based on use of territory-wise aggregation of medical statistic materials and case-control research results. Summary covered also results of regression analysis of dependence of lung cancer mortality on average level of radon accumulation in buildings of Russian and US regions, and meta-analysis of over 30 case-control studies performed in various parts of the world. Th e study results support relations between lung cancer and radon irradiation in houses. To evaluate risk of lung cancer induced by radon, one can recommend value of 0.14 (with 90% confi dence interval 0.10–0.18) normalized for exposure to radon derivatives and corresponding to radon volumetric activity of 100 Bq/m3. Radon causes nearly 6% of lung cancer morbidity and mortality in Russia — that is over 3,000 new cases per year.

scholarly journals The MPO−463G>A Polymorphism and Lung Cancer Risk: A Meta-Analysis Based on 22 Case–Control Studies

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65778 ◽  
Author(s):  
Jun-Ping Yang ◽  
Wen-Bo Wang ◽  
Xiao-Xi Yang ◽  
Lei Yang ◽  
Li Ren ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

Assessment of the relationship between methylenetetrahydrofolate reductase polymorphism and acute lymphoblastic leukemia: Evidence from an updated meta-analysis

2020 ◽  
Vol 26 (7) ◽  
pp. 1598-1610
Author(s):  
Rim Frikha
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Methylenetetrahydrofolate Reductase ◽  
Lymphoblastic Leukemia ◽  
Meta Analysis ◽  
Case Control ◽  
C677t Polymorphism ◽  
Case Control Studies ◽  
Gene Environment ◽  
Reductase Gene ◽  
The Relationship

Objective The methylenetetrahydrofolate reductase gene C677T polymorphism is closely related to the acute lymphoblastic leukemia. Several case–control studies have investigated this association; however, no conclusions could be drawn. A comprehensive updated meta-analysis is established to explain these contradictions and clarify the overall impact of this variant on the susceptibility to acute lymphoblastic leukemia. Methods Electronic searches were conducted to select published studies prior to June 2018. Pooled odds ratios and stratification analysis were performed under different genetic comparison models, age, and ethnicity. Results Totally, 66 case–control studies including 9619 acute lymphoblastic leukemia cases and 17,396 controls were selected. Our analyses showed that methylenetetrahydrofolate reductase C677T polymorphism was protective mainly in Asian and European countries, under all genetic models and regardless of age, but leukemogenic in mixed population. Conclusion Thus, C677T polymorphism may be a promising acute lymphoblastic leukemia biomarker, but they should be interpreted with caution considering other factors such as folic acid intake, gene–gene and gene–environment interactions.

scholarly journals Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Fereshteh Aliakbari ◽  
Farkhondeh Pouresmaeili ◽  
Nahal Eshghifar ◽  
Zahra Zolghadr ◽  
Faezeh Azizi
Keyword(s):  
Male Infertility ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Case Control ◽  
Inclusion Criteria ◽  
Case Control Studies ◽  
Crude Odds Ratio ◽  
Mthfr Polymorphism ◽  
Gene Environment ◽  
The Relationship

Abstract Background and objectives One of the possible male sterility risk factors are polymorphisms of Methylenetetrahydrofolate reductase (MTHFR). However, the epidemiologic investigations described inconsistent results regarding MTHFR polymorphism and the risk of male infertility. For that reason, we carried out a meta-analysis of published case-control studies to re-examine the controversy. Methods Electronic searches of Cochrane, EMBASE, Google Scholar, and PubMed were conducted to select eligible studies for this meta-analysis (updated to May 2019). According to our exclusion and inclusion criteria, only high-quality studies that remarked the association between MTHFR polymorphisms and male infertility risk were included. The Crude odds ratio (OR) with a confidence interval of 95% (CI) was used to assess the relationship between MTHFR polymorphism and male infertility risk. Results Thirty-four case-control studies with 9662 cases and 9154 controls concerning 677C/T polymorphism and 22 case-control studies with 5893 cases and 6303 controls concerning 1298A/C polymorphism were recruited. Both MTHFR polymorphisms had significant associations with male infertility risk (CT + TT vs. CC: OR = 1.37, 95% CI: 1.21–1.55, P = 0.00, I2 = 41.9%); (CC vs. CA + AA: OR = 0.82, 95% CI: 0.52–1.30, P = 0.04, I2 = 50.1%). Further, when stratified by ethnicity, the significant association results were observed in Asians and Caucasians for 677C/T and just Asians for 1298A/C. Conclusions Some of MTHFR polymorphisms like MTHFR 677C > T are associated with an elevated male infertility risk. To confirm our conclusion and to provide more accurate and complete gene-environment communication with male infertility risk, more analytical studies are needed.

scholarly journals Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Hai-Xia Duan ◽  
You-Yi Chen ◽  
Juan-Zi Shi ◽  
Nan-Nan Ren ◽  
Xiao-Juan Li
Keyword(s):  
Cervical Cancer ◽  
Large Scale ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Cervical Cancer Risk ◽  
Hardy Weinberg Equilibrium ◽  
The Relationship ◽  
Multifunctional Cytokine

Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the etiology of cancer. Several case–control studies have been conducted to assess the association of IL-6 -174G>C (rs1800795) polymorphism with the risk of cervical cancer, yet with conflicting conclusions. To derive a more precise estimation of the relationship, we performed this meta-analysis updated to June 2018. A total of seven original publications were identified covering IL-6 -174G>C (rs1800795) polymorphism. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the relationship strengths. Statistically significant relationship was observed between IL-6 -174G>C polymorphism and cervical cancer risk (OR = 0.61, 95% CI: 0.40–0.94 for GG vs. CC, and OR = 0.77, 95% CI: 0.64–0.93 for G vs. C). Moreover, the significant association was found among Asians (OR = 0.46, 95% CI: 0.29–0.75 for GG vs. CC, and OR = 0.70, 95% CI: 0.57–0.89 for G vs. C); hospital-based subgroup (OR = 0.53, 95% CI: 0.38–0.72 for GG vs. CC, and OR = 0.73, 95% CI: 0.61–0.87 for G vs. C); and Hardy–Weinberg equilibrium ≤0.05 (OR = 0.56, 95% CI: 0.37–0.86 for GG vs. GC, and OR = 0.66, 95% CI: 0.47–0.93 for G vs. C). This meta-analysis showed the evidence that the IL-6 -174G>C polymorphism was a low-penetrance susceptibility variant for cervical cancer. Further large-scale case–control studies are needed to confirm these results.

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