scholarly journals Frequency of cataract surgery and its impact on visual function—results from the German Gutenberg Health Study

2020 ◽  
Vol 258 (10) ◽  
pp. 2223-2231
Author(s):  
Alexander K. Schuster ◽  
S. Nickels ◽  
N. Pfeiffer ◽  
I. Schmidtmann ◽  
P. S. Wild ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Visual Function ◽  
Adult Population ◽  
Population Based ◽  
Health Study ◽  
Multivariable Logistic Regression Analysis ◽  
Ophthalmological Examination ◽  
Association Analyses ◽  
Bilateral Cataract ◽  
Gutenberg Health Study

Abstract Purpose To determine the frequency of cataract surgery in Germany and to evaluate its impact on visual function in an adult population. Methods The population-based Gutenberg Health Study was conducted in Germany with its baseline examination between 2007 and 2012 and a 5-year follow-up examiantion. An ophthalmological examination including slit-lamp examination, ocular biometry, and Scheimpflug imaging was carried out. Overall and age-specific frequencies of unilateral and bilateral cataract surgery within 5 years were computed including the 95% confidential intervals [95%-CI]. Association analyses were conducted to determine social and ocular associated factors using multivariable logistic regression analysis. Vision-related quality of life was assessed using NEI VFQ-25. Results A total of 10,544 people aged 35 to 74 years were bilateral phakic at baseline and had information on lens status at the 5-year examination. Of these, 168 had unilateral cataract surgery (1.6% [1.4–1.9%]), and 448 had bilateral cataract surgery (4.2% [3.9–4.7%]) in the following 5 years. The frequency of cataract surgery increased with age: 45–54-year-old subjects had twice as often cataract surgery (in at least on eye: OR = 2.32) than at age 35–44 years. The frequency further strongly increases with age (55–64 years: OR = 10.5; 65–74 years: OR = 43.8, p < 0.001). Subjects with glaucoma were more likely to have cataract surgery (OR = 2.52, p < 0.001). Visual function increased when undergoing bilateral cataract surgery. Conclusions The frequency of cataract surgery is low at younger ages and increases up to 26% at age 70–74 years. Persons with glaucoma are more likely to undergo cataract surgery at population-based level in Germany.

Prevalence of myopic maculopathy in the German population: results from the Gutenberg health study

2019 ◽  
pp. bjophthalmol-2019-315255 ◽  
Author(s):  
Susanne Hopf ◽  
Christina Korb ◽  
Stefan Nickels ◽  
Andreas Schulz ◽  
Thomas Münzel ◽  
...  
Keyword(s):  
Refractive Error ◽  
Population Based ◽  
Health Study ◽  
Multivariable Logistic Regression Analysis ◽  
German Population ◽  
Gutenberg Health Study ◽  
Diffuse Atrophy ◽  
Systemic Factors ◽  
Fundus Photographs ◽  
Myopic Maculopathy

AimsTo determine the prevalence of myopic maculopathy in the general population in Germany and to analyse potential associations with ocular and systemic factors.DesignThe Gutenberg Health Study is a population-based study, including 15 010 participants aged 35–74 years.MethodsMyopic maculopathy was graded in phakic eyes with spherical equivalent ≤−6 D by assessing fundus photographs according to a recent international photographic classification system (META-PM). 801 eyes of 519 participants (mean age 51.0±0.77 years) met the conditions and had gradable fundus photographs. Age-specific prevalence estimates were computed. Multivariable logistic regression analysis was used to assess associated factors with myopic maculopathy.ResultsMyopic maculopathy was present in 10.3% (95% CI 7.9 to 13.3) study participants. The prevalence was 8.6% (95% CI 6.1% to 11.9%) in the 397 right eyes and 8.7% (95% CI 6.2% to 12.0%) in the 404 left eyes. The most common type of pathology was diffuse atrophy (8.1%), followed by patchy atrophy (1.3%) and macular atrophy (0.5%); plus lesions were present in 3% (right eyes). Age (OR 1.07 per year, 95% CI 1.03 to 1.11, p<0.001), higher myopic refractive error (p<0.001), and male gender (p=0.02) were associated with myopic maculopathy, while cardiovascular risk factors and socioeconomic factors were not.ConclusionsThe prevalence of myopic maculopathy in the German population was 0.5%, and 10% in high myopic participants, aged 35–74 years. These population-based data are the first in Europe. Myopic maculopathy was related to severity of myopic refractive error and age.

The Correlation of Lung Function Parameters, Blood Pressure and Beta-Blocker Medication in a General Population

Pneumologie ◽  
2021 ◽  
Author(s):  
Christoph Schäper ◽  
Till Ittermann ◽  
Sven Gläser ◽  
Marcus Dörr ◽  
Henry Völzke ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Lung Function ◽  
Beta Blocker ◽  
Antihypertensive Medication ◽  
Reference Group ◽  
Beta Blockers ◽  
Adult Population ◽  
Population Based ◽  
Statistical Correlation ◽  
Association Analyses

Abstract Objectives Prior studies have investigated possible links between blood pressure, antihypertensive medication, especially beta-blockers and impairment of lung function. The aim of our study was to investigate an association between blood pressure, antihypertensive medication, focusing on beta-blockers, and its influence on lung function parameters in our adult population. Methods From the two analysed cohorts of the population-based Study of Health in Pomerania (SHIP-1 and SHIP-TREND), pooled data for interview-based information, lung function variables including bodyplethysmography and blood pressure variables were used to perform adjusted linear regression analyses. Association analyses were conducted for the pooled population. Results Within the whole pooled population we found some minor statistically significant interrelations in the multivariate analyses for blood pressure and lung function parameters. Statistical correlation between lung function and blood pressure were significant but too weak to be deemed clinically relevant.We also found interrelations between lung function and use of beta-blocker medication. Within the subgroup of individuals with antihypertensive medication containing beta-blockers compared to the reference group we found lower dynamic and static volumes e. g. for FEV1 (–70 ml), FVC (–90 ml), a reduction of TLC (–130 ml) and ITGV (–100 ml), however we did not find an increase in airway resistance (Rtot). Conclusion Based on the data of SHIP-1 and SHIP TREND our results confirm a minor association between blood pressure and lung function. More importantly, we have seen a significant decrease of lung volumes for hypertensive patients with beta- blocker medication as described in literature before. To the best of our knowledge, we are the first to examine the interrelation between blood pressure, medication and lung function in an epidemiological study using data of spirometry, body plethysmography and CO transfer.

Abstract 147: The Role of Thrombin Generation in Cardiovascular Disease and Mortality - Results from the Population-based Gutenberg Health Study

2018 ◽  
Vol 38 (Suppl_1) ◽  
Author(s):  
Pauline C van Paridon ◽  
Marina Panova-Noeva ◽  
Rene van Oerle ◽  
Andreas Schulz ◽  
Iris M Hermanns ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Thrombin Generation ◽  
Population Based ◽  
Health Study ◽  
Gutenberg Health Study

scholarly journals Vision-related quality of life considering both eyes: results from the German population-based Gutenberg Health Study (GHS)

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Stefan Nickels ◽  
Alexander K. Schuster ◽  
Heike Elflein ◽  
Christian Wolfram ◽  
Andreas Schulz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Population Based ◽  
Health Study ◽  
German Population ◽  
Gutenberg Health Study ◽  
Related Quality

scholarly journals Glaucoma following cataract surgery in the first 2 years of life: frequency, risk factors and outcomes from IoLunder2

2019 ◽  
Vol 104 (7) ◽  
pp. 967-973 ◽  
Author(s):  
Ameenat Lola Solebo ◽  
Jugnoo S Rahi
Keyword(s):  
Adverse Events ◽  
Cataract Surgery ◽  
Axial Length ◽  
Multivariable Analysis ◽  
Population Based ◽  
Secondary Glaucoma ◽  
Bilateral Cataract ◽  
Younger Age ◽  
Age At Surgery ◽  
Unilateral Disease

BackgroundWe investigated glaucoma related adverse events, predictors and impact at 5 years following surgery in the IoLunder2 cohortMethodsPopulation based observational cohort study of children undergoing cataract surgery aged 2 years or under between January 2009 and December 2010. Glaucoma was defined using internationally accepted taxonomies based on the consequences of elevated intraocular pressure (IOP). Glaucoma related adverse events were any involving elevated IOP. Multivariable analysis was undertaken to investigate potential predictors of secondary glaucoma with adjustment for within-child correlation in bilateral cataract. Unilateral and bilateral cataract were analysed separately.ResultsComplete follow-up data were available for 235 of 254, 93% of the inception cohort. By 5 years after primary cataract surgery, 20% of children with bilateral cataract and 12% with unilateral had developed secondary glaucoma. Glaucoma related complications had been diagnosed in 24% and 36% of children, respectively. Independent predictors of glaucoma were younger age at surgery (adjusted OR for reduction of week in age: 1.1, 95%C I 1.1 to 1.2, p<0.001); the presence of significant ocular comorbidity (adj OR 3.2, 95% CI 1.1 to 9.6, p=0.01); and shorter axial length (adj OR for each mm 1.7, 95% CI 10.0 to 1, p=0.05) for bilateral cataract. Shorter axial length was the single independent factor in unilateral disease (adj OR 9.6, 95% CI 1.7 to 52, p=0.009)ConclusionsBoth younger age at surgery (the strongest marker of ocular ‘immaturity’) and smaller ocular size (a marker of both immaturity and developmental vulnerability) can be used to identify those at greatest risk of glaucoma due to early life cataract surgery.

Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study)

2018 ◽  
Vol 122 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Christina Magnussen ◽  
Francisco M. Ojeda ◽  
Philipp S. Wild ◽  
Nils Sörensen ◽  
Thomas Rostock ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Sex Differences ◽  
Population Based ◽  
Health Study ◽  
Gutenberg Health Study

scholarly journals No evidence for an association of plasma homocysteine levels and refractive error – Results from the population-based Gutenberg Health Study (GHS)

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0231011
Author(s):  
Stefan Nickels ◽  
Henk J. Blom ◽  
Andreas Schulz ◽  
Lutz Joachimsen ◽  
Thomas Münzel ◽  
...  
Keyword(s):  
Refractive Error ◽  
Population Based ◽  
Plasma Homocysteine ◽  
Health Study ◽  
Gutenberg Health Study

scholarly journals Cardiovascular health outcomes of mobbing at work: results of the population-based, five-year follow-up of the Gutenberg health study

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Karla Romero Starke ◽  
Janice Hegewald ◽  
Andreas Schulz ◽  
Susan Garthus-Niegel ◽  
Matthias Nübling ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Cardiovascular Health ◽  
Population Based ◽  
Health Study ◽  
Single Item ◽  
Men And Women ◽  
Gutenberg Health Study ◽  
Increased Risk ◽  
Study Population

Abstract Background The aim of this study was to determine if there is an increased risk of incident cardiovascular disease (CVD) resulting from workplace mobbing measured with two mobbing instruments in the Gutenberg Health Study. Methods In this prospective study, we examined working persons younger than 65 years for the presence of mobbing at baseline and at a 5-year follow-up using a single-item and a 5-item instrument. We used multivariate models to investigate the association between mobbing and incident CVD, hypertension, and change in arterial stiffness and further stratified the models by sex. Results After adjustment for confounders, mobbed workers appeared to have a higher risk of incident CVD than those not mobbed (single-item HR = 1.28, 95% CI 0.73–2.24; 5-item HR = 1.57, 95% CI 0.96–2.54). With the 5-item instrument, men who reported mobbing had a higher risk of incident CVD (HR = 1.77, 95% CI 1.01–3.09), while no association was observed for women (HR = 1.05, 95% CI 0.38–2.91). There was no difference in risks between men and women with the single-item instrument. No association between mobbing and incident hypertension and arterial stiffness was seen. Conclusions Our results show an indication of an increased risk of incident CVD for those mobbed at baseline when using the whole study population. Differences in risks between men and women when using the five-item instrument may be due to the instrument itself. Still, it is essential to detect or prevent workplace mobbing, and if present, to apply an intervention to halt it in order to minimize its adverse effects on CVD.

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