Clinico-pathological correlation of lacrimal caruncle tumors: a retrospective analysis over 22 years at the University Eye Hospital Bonn

Abstract Purpose The lacrimal caruncle is composed of numerous structures including different glands as well as hair follicles. Accordingly, the spectrum of benign and malignant lesions is broad, and the clinical diagnosis is often challenging. Here we systematically analyzed excised caruncular tumors over the past 22 years with special emphasis on the clinico-pathological correlation to provide a guidance for clinicians. Methods Retrospective evaluation with clinico-pathologic correlation of surgically removed caruncular tumors between 1998 and 2020 at a tertiary referral center. Results Eighty-two caruncular tumors were identified in the respective period. The patients were between 11 and 85 years of age (mean, 46.8 years; median, 49 years). Nevi (n = 35), cystic lesions (n = 14), oncocytoma (n = 9), papilloma (n = 8), sebaceous gland hyperplasia (n = 8), and reactive lymphoid hyperplasia (n = 4) were observed most frequently. Besides, we are the first reporting herniated orbital fat accompanied by a pyogenic granuloma. 2.4% (n = 2) were malignant tumors (sebaceous gland carcinoma, conjunctival intraepithelial neoplasia with pyogenic granuloma). Conclusion Caruncular tumors show a broad spectrum of mostly benign tumors. They can occur in patients of any age. However, 8/9 oncocytomas and both malignant lesions were detected in patients older than 60 years. Although the clinical diagnosis was confirmed in only 68.3% by the histopathological analysis, the two malignant lesions were identified as such already clinically. Caruncular lesions with a history of growth or other signs of malignancy should be excised followed by detailed histopathological examination to allow a final diagnosis and exclude rare malignant tumors with lethal potential.

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APPLICATION OF ELASTOGRAPHY FOR DIAGNOSIS BREAST TUMORS

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2018.6.1 ◽

2018 ◽

Vol 8 (6) ◽

pp. 8-14

Author(s):

Huong Tran Thi Song ◽

Yen Vo Thi Kim ◽

Quan Nguyen Phuoc Bao

Keyword(s):

Breast Cancer ◽

Malignant Tumors ◽

Normal Breast ◽

Benign Tumors ◽

Breast Lesions ◽

Soft Or ◽

The Past ◽

2D Ultrasound ◽

Malignant Lesions ◽

A New Technique

Breast tumor is common in women. Benign tumors account for 80%, malignant tumors account for 20%. Breast cancer is the most common and deadly cancer among women, including Vietnam. Elastography, evaluates the stiffness of the tissue, helps to distinguish soft or hard tumors, which can help distinguish benign or malignant. Benign lesions tend to be softer than malignant lesions. There are two types of elastography: SE (Strain Elastography) and Shear Ware Elastography (SWE). In examining breast lesions, the maligne tumor tends to be stronger and the higher the velocity. Studies have shown that the SWE features should be combined with 2D ultrasound to complement the BIRADS classification. Elastography is a new technique that has emerged in the past few years, promising good diagnostic prospects, more and more research and application of elastography in diagnostics breast lesions. Breast elastogarphy, survey of hardness of breast cancer showed 4 times higher than that of benign tumor and 7 folds of normal breast tissue.

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Nasal septal pediculate carcinoma in situ: differential diagnosis

Sao Paulo Medical Journal ◽

10.1590/s1516-31801996000400004 ◽

1996 ◽

Vol 114 (4) ◽

pp. 1216-1219

Author(s):

Edmir Américo Lourenço ◽

Luís Henrique Chechinato Costa

Keyword(s):

Differential Diagnosis ◽

Female Patient ◽

Carcinoma In Situ ◽

Malignant Tumors ◽

Daily Practice ◽

Wood Dust ◽

Benign Tumors ◽

Potentially Malignant ◽

Malignant Lesions

Pediculated lesions of the nasal cavities are relatively common in daily practice, and include inflammatory polyps, benign tumors (papillomas being the most common), malignant tumors, and specific processes, such as polypoid rhinosporidiosis. The authors describe a female patient with a warty, pediculated, and asymptomatic lesion in the nasal septal mucosa. The anatomo-pathological exam showed this to be a"carcinoma in situ." The few bibliographic citations report only an association between the tumor and contact with wood dust, such as oak, ebony and beech. The patient was not exposed to these elements. It is important to emphasize the routine performance of a complete otolaryngological exam for patients seeking out specialists, in order to detect potentially malignant lesions whose early removal would permit a complete cure.

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Soft Tissue Tumor

Jurnal Syntax Fusion ◽

10.54543/fusion.v1i12.115 ◽

2021 ◽

Vol 1 (12) ◽

pp. 831-844

Author(s):

Anindhita Pangestika ◽

Lalu Wisnu R Danu N

Keyword(s):

Soft Tissue ◽

Soft Tissue Tumor ◽

Malignant Tumors ◽

Fibrous Tissue ◽

Soft Tissue Tumors ◽

Benign Tumors ◽

Environmental Carcinogens ◽

Benign Soft Tissue Tumors ◽

Malignant Lesions ◽

Chronic Lymphedema

Soft tissue tumors are a heterogeneous group of benign and malignant lesions that develop from a variety of nonepithelial, extraskeletal elements, including adipose tissue, smooth and skeletal muscle, tendons, cartilage, fibrous tissue, blood vessels, and lymphatic structures. The writing of this article includes various sources originating from scientific journals and government guidelines and related agencies. Source searches were carried out on online portals for journal publications such as Med Scape Google Scholar (scholar.google.com) and the National Centre for Biotechnology Information/NCBI (ncbi.nlm.nih.gov), with the keyword “Sensoric Nerve Trauma”. Soft tissue tumors (STT) can be benign or malignant, and benign soft tissue tumors are more common than malignant tumors with a ratio of 100: 1. In a study of 93 cases of soft tissue tumors, it was found that the incidence of benign tumors was 75.2% and malignant tumors were 24.8%. Soft tissue tumors are associated with genetic conditions, radiation, chronic lymphedema, environmental carcinogens, and infections.

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Non-Melanoma Facial Skin Tumors—The Correspondence between Clinical and Histological Diagnosis

Applied Sciences ◽

10.3390/app11167543 ◽

2021 ◽

Vol 11 (16) ◽

pp. 7543

Author(s):

Camelia Tamas ◽

Irina Mihaela Jemnoschi Hreniuc ◽

Angela Tecuceanu ◽

Bogdan Mihnea Ciuntu ◽

Clara Larisa Ibanescu ◽

...

Keyword(s):

Clinical Diagnosis ◽

Malignant Tumors ◽

Skin Tumors ◽

Histological Diagnosis ◽

Benign Tumors ◽

Facial Skin ◽

Correlation Data ◽

Clinical Differential Diagnosis ◽

Histological Results

This paper consists of a retrospective study that includes a total of 186 cases with facial skin tumors diagnosed and treated between January 2015 and December 2017. Our aim was to correlate the initial clinical diagnosis with the histological results, in order to observe the success rate of our clinical experience, but also to underline that certain clinical tumor aspects can be misleading as the histological findings can result in different final diagnostics. From the total number of cases, we counted a total of 226 tumors (both benign and malignant), from which 194 had the clinical diagnosis confirmed by the anatomopathological exam and 34 had a different laboratory result from the clinical presumption: 10 benign tumors and 22 malignant tumors (eight BCC and 14 SCC, 12 of the latter being confused with ulcerovegetant BCC). Detailed correlation data were presented, as well as different situations of incongruence between the clinical and the histological diagnosis. The long-term goal of the study was to use our experience of correlating the clinical and the histological diagnosis, in order to improve the existing knowledge on the clinical differential diagnosis of both malignant and benign facial skin tumors.

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Thermal Simulations of Cancerous Breast Tumors and Cysts on a Realistic Female Torso

Journal of Biomechanical Engineering ◽

10.1115/1.4049957 ◽

2021 ◽

Author(s):

Francisco J Gonzalez

Keyword(s):

Clinical Diagnosis ◽

Computational Models ◽

Infrared Imaging ◽

Malignant Tumors ◽

Diagnostic Technique ◽

Breast Tumors ◽

Benign Tumors ◽

Temperature Pattern ◽

Thermal Pattern ◽

Thermal Simulations

Abstract Thermography as a clinical imaging technique has been around for several decades, however it has not become a common diagnostic technique mainly due to its low specificity. The development of computational models of heat transfer in biological tissue can provide a deeper knowledge of healthy and non-healthy thermal patterns could increase the usefulness of thermography in clinical diagnosis. In this work the thermal pattern of cancerous and benign breast tumors are calculated through finite element computer simulations using a realistic female human torso. The simulation results show a thermal pattern which is consistent with infrared images of female subjects and it is not present in simulations performed using other approximate geometries of the breast. A parametric study using cancerous tumors and cysts as a function of size and depth show that the temperature over the skin closest to the tumor decreases for benign tumors while it increases for malignant tumors, also the temperature patterns show a 20% deviation from thermal simulations using a hemispherical breast model. This result indicates that there is a strong geometric component in the human temperature pattern. These results are a first step to understand benign and malignant thermal processes in the breast which might help increase the usefulness of infrared imaging in breast clinical diagnosis.

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Rectum lipoma incarcerated in anus as a cause of abundant rectorrhagia

Vojnosanitetski pregled ◽

10.2298/vsp200627025e ◽

2021 ◽

pp. 25-25

Author(s):

Katarina Eric ◽

Marko Miladinov ◽

Zoran Krivokapic

Keyword(s):

Weight Loss ◽

Case Report ◽

Incidental Findings ◽

Malignant Tumors ◽

Rare Condition ◽

Hemorrhoidal Disease ◽

Benign Tumors ◽

Histopathological Analysis ◽

Rare Entity ◽

Slow Growing

INTRODUCTION: Lipomas are slow growing, benign tumors of mesenchymal origin. In most cases, they are incidental findings during endoscopic examinations. Lipomas in the gastrointestinal tract are rare entities with the lowest rate of occurrence in the rectum. They are mostly asymptomatic, but if they are larger than 4 cm can cause pain, intussusception, bleeding, volvulus, prolapse and weight loss. The aim of presented case report is to demonstrate that abundant rectorrhagia can be caused by a rare entity such as rectal lipoma. CASE REPORT: We present the case of a fifty-year-old male patient with a soft-structure prolapse through the anus accompanied by extensive bleeding. After repositioning, the structure was endoscopically removed. Histopathological analysis confirmed the presence of a lipoma. CONCLUSION: Rectorrhagia can be a clinical manifestation of this rare condition - incarcerated rectal lipoma and should be considered in practice as a differential diagnosis in cases where existence of more common conditions like hemorrhoidal disease and malignant tumors is excluded.

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Retrospective study on parotid gland tumors

ORL ro ◽

10.26416/orl.33.4.2016.155 ◽

2016 ◽

Vol 4 (1) ◽

pp. 22-23

Author(s):

Ibric Cioranu ◽

Vlad Petrescu Seceleanu ◽

Viorel Ibric Cioranu ◽

Andreea Smarandache ◽

Sorin Vasilescu ◽

...

Keyword(s):

Malignant Tumors ◽

Maxillofacial Surgery ◽

Squamous Carcinoma ◽

Benign Tumors ◽

Warthin Tumor ◽

Parotid Tumors ◽

Non Hodgkin Lymphoma ◽

Adenoid Cystic ◽

Modal Treatment ◽

Surgery Department

During 2011-2012, 56 patients diagnosed with parotid tumors were admitted to the Maxillofacial Surgery Department of “Lucian Blaga” University and in Euroclinic Hospital. 72% were benign tumors and 28% malignant. All patients received surgical treatment (total or partial parotidectomy). For the malignant tumors, radiotherapy was added to the modal treatment (94% of the cases). Pleomorphic adenoma was encountered in 70% of the benign cases, followed by Warthin tumor in 15%. Adenoid cystic carcinoma was noticed in 31% of the malignant cases, mucoepidermoid carcinoma in 25% of the cases, and squamous carcinoma and non-Hodgkin lymphoma on 12.5% of the malignant cases.

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A prospective observational study on the effectiveness of risk of malignancy index score (RMI 3) in a tertiary care centre in Eastern India

Asian Journal of Medical Sciences ◽

10.3126/ajms.v11i5.29548 ◽

2020 ◽

Vol 11 (5) ◽

pp. 54-60

Author(s):

Apurba Mandal ◽

Shibram Chattopadhyay ◽

Sushanta Mondal ◽

Arunava Biswas

Keyword(s):

Ovarian Cancer ◽

Adnexal Mass ◽

Malignant Tumors ◽

Histopathological Examination ◽

Tertiary Care ◽

Ca 125 ◽

Tertiary Care Centre ◽

Gynecology And Obstetrics ◽

Risk Of Malignancy ◽

Malignant Lesions

Background: Adnexal mass is a common presentation in today’s gynecological practice. The incidence of ovarian cancer is increasing day by day and diagnosis is often difficult to be made pre operatively with inadequate surgical exploration is a regular occurrence. Aims and Objectives: To assess and validate the importance of RMI-3 score as pre-operative diagnostic tool of differentiating benign from malignant adnexal mass for starting first line therapy of ovarian cancer and to find out the incidences of ovarian malignancy among study population. Material and Methods: The study was conducted in the Department of Gynecology and Obstetrics on (n=115) patients attending GOPD and indoor with adnexal mass fulfilling the inclusion and exclusion criteria using purposive sampling technique. All the selected cases underwent ultrasonography and serum CA- 125 level estimation necessary for calculating RMI score. A score of >200 was taken as suggestive of malignancy and confirmatory diagnosis was performed by histopathological examination obtained from staging laparotomy of adnexal mass. The individual scores were then correlated with final outcomes with statistical analyses. Results: The study revealed benign ovarian tumors are more under 50 years (78.46%) and patients with normal BMI are diagnosed with maximum of malignancy (n = 28). History of tubal ligation carried less risk of malignancy (p<0.0001). Histologically malignant tumors found mostly in 71.4% postmenopausal group whereas 94.1% benign pathology were present in perimenopausal group and there is no association found between parity and histopathology (p=0.058). Bilateral (p=0.013), multilocular (p=0.000) tumors with solid areas (p<0.0001) and thick papillary projections (p<0.0001) had statistically significant association with malignant lesions. RMI score (>200) had more efficacy than serum CA-125 level (>46) in differentiating malignant lesions from benign one in terms of specificity (96% vs 83.87%) and positive predictive value (95% vs 79.17%). Conclusions: RMI-3 score is a simple, reliable and effective tool in differentiating benign from malignant adnexal masses thereby help in quick referral and management of cases with increase chances of survival of the patients.

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Neonatal cardiogenic shock revealing obstructive cardiac Hibernoma: case report

Journal of Cardiothoracic Surgery ◽

10.1186/s13019-021-01582-z ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Rym Gribaa ◽

Marwen Kacem ◽

Sami Ouannes ◽

Wiem Majdoub ◽

Houssem Thabet ◽

...

Keyword(s):

Cardiogenic Shock ◽

Transthoracic Echocardiography ◽

Right Atrium ◽

Benign Tumors ◽

Histopathological Analysis ◽

Tricuspid Valve Repair ◽

Flow Measurements ◽

Surgical Specimen ◽

Eosinophilic Cytoplasm ◽

The Right

Abstract Background Cardiac Hibernomas are very rare benign tumors and usually remain asymptomatic. Neonatal cardiogenic shock due to cardiac tumors is extremely very rare. Until this date a few cases of cardiac hibernoma have been reported in the literature. Transthoracic echocardiography help in the differential diagnosis, but the definitive diagnosis is histological. The management strategy is not clearly codified. The Aim is to report and discuss the clinical features of a cardiac Hibernoma and review the relevant literature. Case presentation We describe a case of a 2-day-old Caucasian full-term male neonate admitted in neonate intensive care with cardiogenic shock, having fluid resuscitation and inotropic drugs. Ventilatory support was started immediately with the subsequent reestablishment of normal blood pressure. Then he was transferred to the echocardiography laboratory. Transthoracic echocardiography showed two echogenic masses in the right atrium and right ventricle. The masses were extended to the pulmonary trunk. Pulmonary artery flow measurements showed the presence of pulmonary and tricuspid obstruction. Surgery was rapidly considered since the baby was hemodynamically unstable. Intraoperative evaluation showed a mass embedded in the interventricular septum that occupy the right ventricular cavity and the right atrium. The tumor involved also the chordae of the tricuspid. Partial resection was done. Tricuspid valve repair was performed by construction of new chordae from the autologous pericardium. The specimen was sent for histopathological analysis. The baby died immediately after surgery. Histological examination of the surgical specimen revealed clear multivacuolated cells filled with lipid droplets and granular intense eosinophilic cytoplasm which confirms the diagnosis of Hibernoma. Conclusion Cardiac Hibernomas are rare benign tumors. The prognosis and treatment strategy is closely dependent on the location, initial clinical presentation and possible complications. The prognosis can be unfavorable if the tumor was obstructive and infiltrate the myocardium.

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Multimodality imaging review of focal renal lesions

Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1186/s43055-020-00391-z ◽

2021 ◽

Vol 52 (1) ◽

Author(s):

Jonathan Lyske ◽

Rishi Philip Mathew ◽

Christopher Hutchinson ◽

Vimal Patel ◽

Gavin Low

Keyword(s):

Malignant Tumors ◽

Multimodality Imaging ◽

Lymphoproliferative Disease ◽

Benign Tumors ◽

Main Body ◽

Imaging Features ◽

Focal Lesions ◽

Renal Lesions ◽

Positron Emission ◽

Neoplastic Lesions

Abstract Background Focal lesions of the kidney comprise a spectrum of entities that can be broadly classified as malignant tumors, benign tumors, and non-neoplastic lesions. Malignant tumors include renal cell carcinoma subtypes, urothelial carcinoma, lymphoma, post-transplant lymphoproliferative disease, metastases to the kidney, and rare malignant lesions. Benign tumors include angiomyolipoma (fat-rich and fat-poor) and oncocytoma. Non-neoplastic lesions include infective, inflammatory, and vascular entities. Anatomical variants can also mimic focal masses. Main body of the abstract A range of imaging modalities are available to facilitate characterization; ultrasound (US), contrast-enhanced ultrasound (CEUS), computed tomography (CT), magnetic resonance (MR) imaging, and positron emission tomography (PET), each with their own strengths and limitations. Renal lesions are being detected with increasing frequency due to escalating imaging volumes. Accurate diagnosis is central to guiding clinical management and determining prognosis. Certain lesions require intervention, whereas others may be managed conservatively or deemed clinically insignificant. Challenging cases often benefit from a multimodality imaging approach combining the morphology, enhancement and metabolic features. Short conclusion Knowledge of the relevant clinical details and key imaging features is crucial for accurate characterization and differentiation of renal lesions.

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